0. DOCID:3611 SCORE: 0.00352011262177456
DOCNO: 956938
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Alloys
DESCRIPTOR: Mortality
DESCRIPTOR: Occupational Medicine
DESCRIPTOR: Steel
AUTHOR: H E Rockette, HE
AUTHOR: C K Redmond CK
PUBTYPE: Journal Article
JOURNALTITLE: Journal of occupational medicine. : official publication of the Industrial Medical Association.
COUNTRY: UNITED STATES
TITLE: Long-term mortality study of steelworkers.
PUBDATE: 19760801
This study examines the cause-specific mortality of men employed as masons in the steel industry. Their mortality experience is compared with the mortality predicted by the age--and race--specific death rates for a control group consisting of those steelworkers whose first job in 1953 was not in the mason department. The relative risks of dying from selected causes were highly dependent on race. The most important observations are: (1) The nonwhites have an overall excess risk when compared to the nonmason group. This excess is not confined to any particular category and appears to be due to the cumulative effect of an excess in many different categories. (2) The white masons have an excess risk for nonmalignant respiratory disease. Furthermore, this risk increases with length of exposure. (3) The whites have an excess risk for respiratory cancer when compared to the nonmason group. This excess is not present in the later years of the follow-up period. (4) The interpretation of the findings for cardiovascular disease remain unclear. Results for cerebral vascular disease and hypertensive disease in nonwhites are suggestive, but need further investigation before any strong statements can be made.


1. DOCID:3988 SCORE: 0.00344773681583241
DOCNO: 184556
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Receptors, Cell Surface
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: A J Walt AJ
AUTHOR: A Singhakowinta A
AUTHOR: S C Brooks SC
AUTHOR: A Cortez A
PUBTYPE: Journal Article
JOURNALTITLE: Surgery.
COUNTRY: UNITED STATES
TITLE: The surgical implications of estrophile protein estimations in carcinoma of the breast.
PUBDATE: 19761001
Assays of estrophile protein (ER) in 161 patients with no previous additive or ablative hormonal therapy have been analyzed; 47.2 percent were ER positive; 52.8 percent ER negative. A total of 37.5 percent of premenopausal and 50.8 percent of postmenopausal patients had ER-positive tumors. The effects of additive and ablaive hormonal therapy were observed in 75 patients; 63.5 percent of the ER-positive group and 8.6 percent of the ER-negative group responded, but the incidence in the ER-negative group is thought to be spuriously high. The level of the ER content in the ER-positive group did not influence the degree of response. The ER-negative group had a shorter life span after discovery of the tumor and was more likely to develop dominant visceral metastases. Of 15 patients followed with sequential ER assays after hormonal therapy (additive and/or ablative), 14 demonstrated substantial falls in ER levels but these did not correlate with the clinical response. Tumor assayed in nine patients after irradiation of the lesion contained no demonstrable ER. ER assays of breast cancer tissue proved to be a useful but imperfect tool in predicting clinical progress following hormonal maneuvers but some readings may be spuriously low due to imperfect techniques of measurement, prior exogenous hormonal administration or hormonal ablation, and previous irradiation of the tumor.


2. DOCID:3697 SCORE: 0.00314506368600656
DOCNO: 132269
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Continental Population Groups
QUALIFIER: blood
AUTHOR: P Hill P
AUTHOR: E L Wynder EL
AUTHOR: P Helman P
AUTHOR: R Hickman R
AUTHOR: G Rona G
AUTHOR: K Kuno K
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Plasma hormone levels in different ethnic populations of women.
PUBDATE: 19760701
It has been suggested that the urinary hormone profile is subject to environmental changes, such as urbanization and Westernization, and that the composition of the hormones can be used as a discriminate in determining the patient at risk for breast cancer. In this study, a comparison of the plasma hormone levels in Bantu and Japanese women, low-risk populations, and Caucasian women, a high-risk population, showed a higher level of 17 beta-estradiol in prepubertal girls and young Bantu and Japanese women. The higher estrogen level in the Bantu was evident in the early luteal and late follicular phases of the menstrual cycle. The difference in the dehydroepiandrosterone and testosterone levels in Bantu young women and prepubertal Bantu girls, suggests differences in adrenal activity between Bantu and Caucasian women. A fall in the plasma androstenedione was evident in postmenopausal Bantu and Japanese but not Caucasian women. Data suggest that the hormone profile is different among the 3 ethnic groups in both the pre- and postmenopausal women. Since the daily life-style of the women is comparable, it is suggested that the composition of the hormone profile is partially dependent on dietary on dietary factors.


3. DOCID:7449 SCORE: 0.00311379487923719
DOCNO: 7026459
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: G Todd G
AUTHOR: C W Chan CW
AUTHOR: A J Cochran AJ
AUTHOR: R Kennedy R
AUTHOR: R M Mackie RM
AUTHOR: L J Morrison LJ
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: In vitro reaction of cancer patients and others to Bacillus Calmette-Gueérin.
PUBDATE: 19800901
We examined the in vitro reaction of leukocytes from 71 cancer patients and 121 control donors (disease-free individuals or patients with non-malignant non-debilitating conditions) against Bacillus Calmette-Guérin using a one-stage capillary leukocyte migration assay. The proportion of reactive cancer patients and control donors increased with increasing BCG concentration, but the proportion of patients who reacted was less than that of control donors at all concentrations of BCG. As cancer stage advanced and the volume of clinically detectable tumor increased, the proportion of reactive patients decreased. There was a small age-related decline in reactivity in the control population. The results of simultaneous in vitro tests and Mantoux reactions were concurrent in a majority of normal individuals so tested.


4. DOCID:3579 SCORE: 0.00305825304304884
DOCNO: 962393
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mass Screening
QUALIFIER: methods
QUALIFIER: diagnosis
AUTHOR: J D Lewis JD
AUTHOR: J R Milbrath JR
AUTHOR: K A Shaffer KA
AUTHOR: J C Darin JC
AUTHOR: J J DeCosse JJ
PUBTYPE: Journal Article
JOURNALTITLE: Annals of surgery.
COUNTRY: UNITED STATES
TITLE: Which breast to biopsy: an expanding dilemma.
PUBDATE: 19760901
To provide insight into the significance of findings reported from screening asymptomatic women for breast cancer, we reviewed 19,928 mammographic studies with the accompanying physical examination and correlated these findings with 554 breast biopsies. Of 83 breast biopsies with suspicious findings on both physical examination and mammography, 72 demonstrated breast cancer (87%). Of 155 biopsies for suspicious changes on mammography alone, 50 (32%) demonstrated breast cancer. The accuracy of suspicious mammography was independent of findings limited to physical examination, 34 (17%) had breast cancer; 31 were in 152 biopsies of patients with mammography interpreted as normal (20%) and three were in biopsies of 52 patients (6%) in whom a visualized mass was interpreted as benign. One hundred and twelve breast biopsies were performed for changes interpreted as normal or benign. Six malignancies were discovered (5%). No cancer was found in 31 biopsies for nonpalpable benign mammographic abnormalities. Our results emphasize the importance of discriminating between nonvisualization of a mass and mammographic recognition of either a benign or malignant tumor. The reliability of interpretation is considerably greater for a visualized lesion than a nonvisualized one.


5. DOCID:3808 SCORE: 0.00301773430086202
DOCNO: 809048
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: C J Grubbs CJ
AUTHOR: R C Moon RC
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: ENGLAND
TITLE: Effect of age and parity upon the uptake of 9,10-dimethyl-1,2-benzanthracene-9-14C by mammary parenchymal cells of the rat.
PUBDATE: 19750201
The radioactivity of the parenchymal cell intracellular lipid obtained from 200-day old multiparous animals was significantly less than that of both 50- and 200-day old virgin rats at all time intervals. Furthermore, the parenchymal cell dry, fat-free tissue of the multiparous animals ocntained significantly less DMBA-9-14C than this fraction obtained from young or old virgin rats. Since there was a decrease in both the uptake and binding of DMBA-9-14C by the mammary parenchymal cells of multiparous animals, it would appear that factors associated with pregnancy and/or lactation result in an altered susceptibility of the parenchymal cell to this carcinogen. Binding of DMBA-9-14C by parenchymal cells of old virgin rats was significantly less than that of younger animals at 3 and 6 h post feeding but did not differ statistically at the later time intervals. The possibility exists that neoplastic transformation may require the interaction between high levels of DMBA and the constitutents of the mammary parenchymal cells for extended periods of time. Therefore, the decreased exposure of the cellular constituents to DMBA could account for the decrease in mammary cancer incidence observed in older rats.


6. DOCID:7520 SCORE: 0.00300583861535427
DOCNO: 6992969
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
AUTHOR: H Ulfelder H
PUBTYPE: Historical Article
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: The stilbestrol disorders in historical perspective.
PUBDATE: 19800601
In the late 1960's when a series of adolescent girls with adenocarcinoma of the vagina presented themselves to our hospital, we did not immediately suspect the cause. Previous experience with radical hysterectomy and with vaginal reconstruction had prepared us technically to treat them sucessfully. Then a clue to etiology from one mother's observation regarding DES as a pregnancy supportive medication was quickly and conclusively converted into fact by an investigation with case controls. Rapid expansion of our knowledge came about through information accumulated in a Registry, and untoward effects other than cancer soon came to notice as young asymptomatic women presented themselves for examination because of known fetal exposure. The dominant event is clearly recognizable ss teratogenic, resulting in anomalous development of the vagina and cervix. Although the appearance of clear cell adenocarcinoma in a small fraction of DES-daughters is a consequence, the role of DES in its carcinogenesis is still unproved.


7. DOCID:3876 SCORE: 0.00299697414837928
DOCNO: 320049
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Appetite Regulation
QUALIFIER: physiopathology
QUALIFIER: physiopathology
AUTHOR: S D Morrison SD
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Federation proceedings.
COUNTRY: UNITED STATES
TITLE: The hypothalamic syndrome in rats.
PUBDATE: 19770201
The original conception of the hypothalamus controlling feeding by the activity of two specific and reciprocally inhibitory centers has now been largely abandoned. Detailed neural research using a wide variety of methods has demonstrated the complex morphological and functional organization of this part of the brain and has modified the earlier simplistic approach. However, examination of the feeding responses to a variety of stimuli that represent components of control of feeding indicates that much or even most feeding control is extrahypothalamic. As demonstrated by the obesity or aphagia resulting from hypothalamic damage or from reversible hypothalamic interference, the hypothalamus influences or modulates feeding control, possibly by an enabling action, but it does not itself substantially control food intake either in the short or the long term. In the cachaxia of cancer, which can tentatively be regarded as a negative obesity, and which is closely reproducible in a rat model, the decline of food intake can be attributed to failure of control components that are all extrahypothalamic, and the deterioration of control of feeding appears to be quite independent of the hypothalamus. The very detailed reconstruction of intrahypothalamic circuitry that has been developed in recent years has not yet had any real impact on the problem of where or how the active control of food intake is generated or the way in which the hypothalamus influences this control.


8. DOCID:3738 SCORE: 0.00297061274376008
DOCNO: 922708
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
AUTHOR: S Lesher S
AUTHOR: L M Schiffer LM
AUTHOR: M Phanse M
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Human colonic tumor cell kinetics: potential for therapy.
PUBDATE: 19771101
Using new in vitro techniques developed at the Cancer Research Unit, cell kinetic measurements were obtained in primary and metastatic human colonic tumors, polyps and normal bowel that did not require in vivo 3HTdR and required only single samples of tissue. These techniques included the measurement of the number of cells in DNA synthesis (LI), an estimate of the DNA synthesis time (Ts) and the growth fraction of tissues by means of the primer-available DNA-dependent DNA polymerase assay (PDP). From these data, the potential doubling time and the cell cycle time (Tc) of the tumors were calculated. Early preliminary data on human colonic specimens presented in Tables 1 and 2 indicate that there is an increase in LI from the low polyps to higher adenocarcinomas. There is little difference between primary and metastatic tumor cell kinetics. Growth fraction estimates (PDP) of the various colonic tissue types are also not significantly different and except for villous adenomas, DNA synthesis times are constant. The median 3HTdR labeling indices of 7% primary adenocarcinomas include a number of samples (approximately 20% of all samples) with high labeling indices (in the 10--20% range). These high labeling tumors may be those that show objective response to S-phase active drugs, e.g., 5-FU.


9. DOCID:3914 SCORE: 0.00294234162188244
DOCNO: 323505
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antigen-Antibody Complex
DESCRIPTOR: Complement C1
DESCRIPTOR: Complement System Proteins
QUALIFIER: immunology
AUTHOR: R D Rossen RD
AUTHOR: M A Reisberg MA
AUTHOR: E M Hersh EM
AUTHOR: J U Gutterman JU
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: The C1q binding test for soluble immune complexes: clinical correlations obtained in patients with cancer.
PUBDATE: 19770501
Sera from 134 selected patients with various types of cancer were tested for soluble antigen-antibody complexes by the C1q binding method. Sera from 85 healthy blood bank donors served as normal controls. C1q binding activity (C1q BA) values above the 95th percentile for healthy subjects were found in 83% of sera from patients with neoplastic diseases. The incidence of abnormal C1q BA values among patients with malignant melanoma was 83%, with breast cancer 74%, with colon cancer 75%, with lung cancer 88%, with leukemia and lymphoma 85%, and with miscellaneous tumors 94%. High C1q BA values were found most frequently in sera of patients who had been diagnosed relatively recently (within 5 mo) and who had evident residual disease after surgical treatment. Recurrence or progression of tumor growth occurred significantly more frequently in lung cancer patients with high C1q BA. DNA was not detected in cancer patients' sera and treatment with DNase did not decrease in C1q BA. C1q BA in sera could not be explained by the presence of antiglobulin antibodies. Sucrose density gradient ultracentrifugation studies of the serum C1q BA in 4 cancer patients showed that the major binding activity was found between 19S and 7S.


10. DOCID:7805 SCORE: 0.00289937380942868
DOCNO: 7448715
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: J G Schenker JG
AUTHOR: J Tal J
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Adenocarcinoma of the endometrium in Israel, 1960-1968.
PUBDATE: 19801201
Data gathered during an epidemiologic study of endometrial cancer in Israel are presented. In the nine-year period of this survey, 877 new cases of primary cancer of the endometrium were diagnosed, representing an incidence of 17.8/100,00 females over the age of 25. Two thirds of the patients were in the sixth and seventh decades of life at diagnosis of the tumor. Endometrial carcinoma was two to three times more prevalent in women of European-American origin than in those of Asian-African Background. In 85% of the patients, diagnosis was made while the disease was in Stage I. A strong correlation was found between endometrial cancer, diabetes (14%), hypertension (18%), and infertility (25%). The five-year survival rate in the present survey was 69.2%. Factors affecting prognosis are clinical stage of the disease at diagnosis, degree of myometrial invasion, tumor differentiation, age of the patient, and type of treatment.


11. DOCID:7700 SCORE: 0.00286919902464386
DOCNO: 6273014
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: enzymology
QUALIFIER: blood
QUALIFIER: enzymology
QUALIFIER: enzymology
AUTHOR: T Goffman T
AUTHOR: J Cantrell J
AUTHOR: P Schein P
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Clinical chemistry.
COUNTRY: UNITED STATES
TITLE: Unexplained increase in serum creatine kinase isoenzyme MB activity in a lung cancer patient.
PUBDATE: 19811201
In this case of mixed small cell--large cell cancer of the lung in an elderly woman, creatine kinase (EC 2.7.3.2) isoenzymes were assayed serially because of chest pain. The proportions of serum CK-BB and CK-MB isoenzyme activities were persistently above normal (CK-MB 10-18%, normal less than 5%). Electrocardiograms revealed no signs of ischemia or infarction. At autopsy no gross or microscopic infarction or inflammation of the heart was seen. There was also no infarction of smooth or skeletal muscle. The tumor was the probable source of most of the circulating CK-MB isoenzyme. Future cases may pose a similar diagnostic dilemma: differentiating creatine kinase that is present as a result of myocardial infarction from tumor-related CK-MB. Whether or not CK-MB assay could be useful in detecting tumors remains to be investigated.


12. DOCID:7816 SCORE: 0.00286100490329121
DOCNO: 264088
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: A Spira A
AUTHOR: P Lazar P
PUBTYPE: Journal Article
JOURNALTITLE: European journal of obstetrics, gynecology, and reproductive biology.
COUNTRY: NETHERLANDS
TITLE: Spontaneous abortions in sibship of children with congenital malformation or malignant disease.
PUBDATE: 19790401
Parents of 751 children affected by cancer/leukemia, congenital heart disease, strawberry nevus or mental retardation have been investigated with respect to their reproductive history and their exposure to risk factors for spontaneous abortion. Differences between the four groups were established for the number of children in the sibship, the proportion of multigravidae and the spontaneous abortion rate among these women. The greatest differences were observed in the two groups of malformed children compared with the other two groups, being as marked in those with a severe malformation (heart defect) as in those with a benign one (strawberry nevus). Taking known risk factors for spontaneous abortion into account did not explain the observed differences. An etiological hypothesis is put forward which takes account of the high proportion of quantitative abnormalities of the karyotype associated with congenital heart disease and spontaneous abortion.


13. DOCID:3397 SCORE: 0.00285785605885163
DOCNO: 825178
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: immunology
AUTHOR: R J Ablin RJ
PUBTYPE: Journal Article
JOURNALTITLE: British journal of urology.
COUNTRY: ENGLAND
TITLE: Serum antibody in patients with prostatic cancer.
PUBDATE: 19761001
130 serum specimens were evaluated. None of 24 serum specimens from patients with prostatic cancer yielded precipitation of haemagglutination reactions with extracts of normal human prostatic tissue or with preparations of prostatic fluid. In 1 of 5 patients from whom autologous prostatic tissue was available, precipitation was observed. By indirect immunofluroescence 13 (54%) patients with prostatic cancer possessed antibodies reactive with the cytoplasmic membrane (intercellular area?) of primate prostatic secretory epithelium. Membranous autoantibodies were observed in 2 patients from whom autologous tissue was available as substrate. Antibodies to nuclei were observed but these have been considered in view of their ubiquitous nature, as perhaps being representative of non-specific indicators of other immunologic aberrations. In contrast, only 11 (10%) of 106 patients with other than prostatic cancer possessed membranous antibodies; of these, 11 (73%) possessed a genito-urinary disorder (5 benign prostatic hypertrophy, considered by some as predisposing to prostatic cancer and 3 carcinoma of the bladder). While not possessing sufficient specificity for diagnosis, the high incidence of this antibody, 92% positive in patients with advanced disease (Stage III), suggests it may be useful as a prognostic index of patients with metastatic disease.


14. DOCID:2609 SCORE: 0.0028444169660164
DOCNO: 1246980
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Diet Surveys
DESCRIPTOR: Nutrition Surveys
DESCRIPTOR: Polysaccharides
AUTHOR: S H Dorfman SH
AUTHOR: M Ali M
AUTHOR: M H Floch MH
PUBTYPE: Journal Article
JOURNALTITLE: The American journal of clinical nutrition.
COUNTRY: UNITED STATES
TITLE: Low fiber content of Connecticut diets.
PUBDATE: 19760101
Recent theories have postulated that low fiber diets are related to colon cancer and diverticulosis, and to atherosclerosis. These theories are based on British and African diet history information. There has been no recent assessment of fiber intake in an area of high incidence of colonic disease in the United States. Using recall diet histories in subjects with no disease and with colon disease, and correcting our data to account for any loss in recall history, we find a low daily fiber intake in all 21 subjects evaluated, mean 3.5 g, range 1.6 to 11 g. There was no statistical difference in intake among patients with or without colon disease. The data agree with the British findings. Since the incidence of the diseases in question is not uniform in the United States it is suggested that diet surveys are needed in areas where colon carcinoma is of low incidence.