0. DOCID:10589 SCORE: 0.00364350010497809
DOCNO: 7083243
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: analogs & derivatives
AUTHOR: S L Luedke SL
AUTHOR: D W Luedke DW
AUTHOR: P Petruska P
AUTHOR: G O Broun GO
AUTHOR: G Reed G
AUTHOR: J Leavitt J
PUBTYPE: Journal Article
JOURNALTITLE: Cancer treatment reports.
COUNTRY: UNITED STATES
TITLE: Vindesine (VDS) monochemotherapy for non-small cell lung cancer: a report of 45 cases.
PUBDATE: 19820601
Fifty-three patients with non-small cell lung cancer were treated with vindesine. Of the 45 evaluable patients, 11 (24%) had a partial response. Responses were all evident within 6 weeks. Median duration of response was 8 weeks from documentation. Median survival was not improved significantly among responders (P less than 0.10, two-tailed test of significance). The most frequent toxic effect was leukopenia. The most troublesome toxic effect was peripheral neuropathy, with patients greater than 60 years old experiencing this more frequently.

1. DOCID:3611 SCORE: 0.00352011262177456
DOCNO: 956938
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Alloys
DESCRIPTOR: Mortality
DESCRIPTOR: Occupational Medicine
DESCRIPTOR: Steel
AUTHOR: H E Rockette, HE
AUTHOR: C K Redmond CK
PUBTYPE: Journal Article
JOURNALTITLE: Journal of occupational medicine. : official publication of the Industrial Medical Association.
COUNTRY: UNITED STATES
TITLE: Long-term mortality study of steelworkers.
PUBDATE: 19760801
This study examines the cause-specific mortality of men employed as masons in the steel industry. Their mortality experience is compared with the mortality predicted by the age--and race--specific death rates for a control group consisting of those steelworkers whose first job in 1953 was not in the mason department. The relative risks of dying from selected causes were highly dependent on race. The most important observations are: (1) The nonwhites have an overall excess risk when compared to the nonmason group. This excess is not confined to any particular category and appears to be due to the cumulative effect of an excess in many different categories. (2) The white masons have an excess risk for nonmalignant respiratory disease. Furthermore, this risk increases with length of exposure. (3) The whites have an excess risk for respiratory cancer when compared to the nonmason group. This excess is not present in the later years of the follow-up period. (4) The interpretation of the findings for cardiovascular disease remain unclear. Results for cerebral vascular disease and hypertensive disease in nonwhites are suggestive, but need further investigation before any strong statements can be made.

2. DOCID:3988 SCORE: 0.00344773681583241
DOCNO: 184556
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Receptors, Cell Surface
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: A J Walt AJ
AUTHOR: A Singhakowinta A
AUTHOR: S C Brooks SC
AUTHOR: A Cortez A
PUBTYPE: Journal Article
JOURNALTITLE: Surgery.
COUNTRY: UNITED STATES
TITLE: The surgical implications of estrophile protein estimations in carcinoma of the breast.
PUBDATE: 19761001
Assays of estrophile protein (ER) in 161 patients with no previous additive or ablative hormonal therapy have been analyzed; 47.2 percent were ER positive; 52.8 percent ER negative. A total of 37.5 percent of premenopausal and 50.8 percent of postmenopausal patients had ER-positive tumors. The effects of additive and ablaive hormonal therapy were observed in 75 patients; 63.5 percent of the ER-positive group and 8.6 percent of the ER-negative group responded, but the incidence in the ER-negative group is thought to be spuriously high. The level of the ER content in the ER-positive group did not influence the degree of response. The ER-negative group had a shorter life span after discovery of the tumor and was more likely to develop dominant visceral metastases. Of 15 patients followed with sequential ER assays after hormonal therapy (additive and/or ablative), 14 demonstrated substantial falls in ER levels but these did not correlate with the clinical response. Tumor assayed in nine patients after irradiation of the lesion contained no demonstrable ER. ER assays of breast cancer tissue proved to be a useful but imperfect tool in predicting clinical progress following hormonal maneuvers but some readings may be spuriously low due to imperfect techniques of measurement, prior exogenous hormonal administration or hormonal ablation, and previous irradiation of the tumor.

3. DOCID:13869 SCORE: 0.0032781278055507
DOCNO: 3569806
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hematoporphyrin Photoradiation
DESCRIPTOR: Photochemotherapy
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: H Tajiri H
AUTHOR: N Daikuzono N
AUTHOR: S N Joffe SN
AUTHOR: Y Oguro Y
PUBTYPE: Journal Article
JOURNALTITLE: Gastrointestinal endoscopy.
COUNTRY: UNITED STATES
TITLE: Photoradiation therapy in early gastrointestinal cancer.
PUBDATE: 19870401
Endoscopic photodynamic therapy has been used in the treatment of 19 cases of upper gastrointestinal cancer of which six were superficial esophageal and 13 were early gastric cancer. Six patients subsequently underwent surgical resection. Residual tumors were found in the resected specimens of one esophageal carcinoma and in the two early gastric carcinomas. Technical problems resulted in one failure. Follow-up ranged from 4 months to 3 years and 11 months with no tumor recurrence in either the operated or unoperated patients. Other delivery systems are currently under investigation.

4. DOCID:15488 SCORE: 0.00315802025208877
DOCNO: 2677576
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ultrasonography
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: I B Voronetskiĭ IB
AUTHOR: G A Zubovskiĭ GA
AUTHOR: L I Smetanina LI
PUBTYPE: Journal Article
JOURNALTITLE: Meditsinskaia radiologiia.
COUNTRY: USSR
TITLE: [An ultrasonic study in the differential diagnosis of thyroid diseases]
PUBDATE: 19890901
The correlation of clinical, echo and morphological findings demonstrated ultrasound potentialities in the differential diagnosis of thyroid cancer. Ultrasound permitted the detection of nodes up to 3 cm in diameter. False-negative results were obtained in 6.5% of cases, there were no true false positive results. Adenomas are often characterized by mixed echogenicity of a node and hypoechogenic lining around it. Chronic nonspecific thyroid diseases are characterized by inhomogeneous echogenicity of the organ. Thyroid cancer is characterized by hypoechogenicity of a node with its inhomogeneous structure and irregular contours as if consisting of several nodules. The probability of malignancy grows with an increase in the number of these features combining in a particular patient.

5. DOCID:3697 SCORE: 0.00314506368600656
DOCNO: 132269
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Continental Population Groups
QUALIFIER: blood
AUTHOR: P Hill P
AUTHOR: E L Wynder EL
AUTHOR: P Helman P
AUTHOR: R Hickman R
AUTHOR: G Rona G
AUTHOR: K Kuno K
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Plasma hormone levels in different ethnic populations of women.
PUBDATE: 19760701
It has been suggested that the urinary hormone profile is subject to environmental changes, such as urbanization and Westernization, and that the composition of the hormones can be used as a discriminate in determining the patient at risk for breast cancer. In this study, a comparison of the plasma hormone levels in Bantu and Japanese women, low-risk populations, and Caucasian women, a high-risk population, showed a higher level of 17 beta-estradiol in prepubertal girls and young Bantu and Japanese women. The higher estrogen level in the Bantu was evident in the early luteal and late follicular phases of the menstrual cycle. The difference in the dehydroepiandrosterone and testosterone levels in Bantu young women and prepubertal Bantu girls, suggests differences in adrenal activity between Bantu and Caucasian women. A fall in the plasma androstenedione was evident in postmenopausal Bantu and Japanese but not Caucasian women. Data suggest that the hormone profile is different among the 3 ethnic groups in both the pre- and postmenopausal women. Since the daily life-style of the women is comparable, it is suggested that the composition of the hormone profile is partially dependent on dietary on dietary factors.

6. DOCID:7449 SCORE: 0.00311379487923719
DOCNO: 7026459
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: G Todd G
AUTHOR: C W Chan CW
AUTHOR: A J Cochran AJ
AUTHOR: R Kennedy R
AUTHOR: R M Mackie RM
AUTHOR: L J Morrison LJ
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: In vitro reaction of cancer patients and others to Bacillus Calmette-Gueérin.
PUBDATE: 19800901
We examined the in vitro reaction of leukocytes from 71 cancer patients and 121 control donors (disease-free individuals or patients with non-malignant non-debilitating conditions) against Bacillus Calmette-Guérin using a one-stage capillary leukocyte migration assay. The proportion of reactive cancer patients and control donors increased with increasing BCG concentration, but the proportion of patients who reacted was less than that of control donors at all concentrations of BCG. As cancer stage advanced and the volume of clinically detectable tumor increased, the proportion of reactive patients decreased. There was a small age-related decline in reactivity in the control population. The results of simultaneous in vitro tests and Mantoux reactions were concurrent in a majority of normal individuals so tested.

7. DOCID:3579 SCORE: 0.00305825304304884
DOCNO: 962393
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mass Screening
QUALIFIER: methods
QUALIFIER: diagnosis
AUTHOR: J D Lewis JD
AUTHOR: J R Milbrath JR
AUTHOR: K A Shaffer KA
AUTHOR: J C Darin JC
AUTHOR: J J DeCosse JJ
PUBTYPE: Journal Article
JOURNALTITLE: Annals of surgery.
COUNTRY: UNITED STATES
TITLE: Which breast to biopsy: an expanding dilemma.
PUBDATE: 19760901
To provide insight into the significance of findings reported from screening asymptomatic women for breast cancer, we reviewed 19,928 mammographic studies with the accompanying physical examination and correlated these findings with 554 breast biopsies. Of 83 breast biopsies with suspicious findings on both physical examination and mammography, 72 demonstrated breast cancer (87%). Of 155 biopsies for suspicious changes on mammography alone, 50 (32%) demonstrated breast cancer. The accuracy of suspicious mammography was independent of findings limited to physical examination, 34 (17%) had breast cancer; 31 were in 152 biopsies of patients with mammography interpreted as normal (20%) and three were in biopsies of 52 patients (6%) in whom a visualized mass was interpreted as benign. One hundred and twelve breast biopsies were performed for changes interpreted as normal or benign. Six malignancies were discovered (5%). No cancer was found in 31 biopsies for nonpalpable benign mammographic abnormalities. Our results emphasize the importance of discriminating between nonvisualization of a mass and mammographic recognition of either a benign or malignant tumor. The reliability of interpretation is considerably greater for a visualized lesion than a nonvisualized one.

8. DOCID:11637 SCORE: 0.00305272915122831
DOCNO: 7166678
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mass Screening
QUALIFIER: prevention & control
AUTHOR: A J Silman AJ
AUTHOR: C M Locke CM
PUBTYPE: Journal Article
JOURNALTITLE: Journal of epidemiology and community health.
COUNTRY: ENGLAND
TITLE: Blood pressure distribution in responders and initial non-responders in a population screening study.
PUBDATE: 19821201
The distribution of diastolic blood pressure (DBP) was compared between those who responded to a first written request to attend at their general practitioner's surgery for screening for hypertension and those who need more intensive effort encouraging them to attend. After excluding 25% of the population whose current address could not be traced, 92% of the remainder were eventually seen and screened. There was no association between diastolic blood pressure and effort needed to bring the patient to screening, and this applied to all patients both with and without a history of hypertension. Thus it appears that unlike screening for cervical cancer, screening for hypertension may not selectively tend to miss the groups most at risk.

9. DOCID:3808 SCORE: 0.00301773430086202
DOCNO: 809048
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: C J Grubbs CJ
AUTHOR: R C Moon RC
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: ENGLAND
TITLE: Effect of age and parity upon the uptake of 9,10-dimethyl-1,2-benzanthracene-9-14C by mammary parenchymal cells of the rat.
PUBDATE: 19750201
The radioactivity of the parenchymal cell intracellular lipid obtained from 200-day old multiparous animals was significantly less than that of both 50- and 200-day old virgin rats at all time intervals. Furthermore, the parenchymal cell dry, fat-free tissue of the multiparous animals ocntained significantly less DMBA-9-14C than this fraction obtained from young or old virgin rats. Since there was a decrease in both the uptake and binding of DMBA-9-14C by the mammary parenchymal cells of multiparous animals, it would appear that factors associated with pregnancy and/or lactation result in an altered susceptibility of the parenchymal cell to this carcinogen. Binding of DMBA-9-14C by parenchymal cells of old virgin rats was significantly less than that of younger animals at 3 and 6 h post feeding but did not differ statistically at the later time intervals. The possibility exists that neoplastic transformation may require the interaction between high levels of DMBA and the constitutents of the mammary parenchymal cells for extended periods of time. Therefore, the decreased exposure of the cellular constituents to DMBA could account for the decrease in mammary cancer incidence observed in older rats.

10. DOCID:7520 SCORE: 0.00300583861535427
DOCNO: 6992969
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
AUTHOR: H Ulfelder H
PUBTYPE: Historical Article
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: The stilbestrol disorders in historical perspective.
PUBDATE: 19800601
In the late 1960's when a series of adolescent girls with adenocarcinoma of the vagina presented themselves to our hospital, we did not immediately suspect the cause. Previous experience with radical hysterectomy and with vaginal reconstruction had prepared us technically to treat them sucessfully. Then a clue to etiology from one mother's observation regarding DES as a pregnancy supportive medication was quickly and conclusively converted into fact by an investigation with case controls. Rapid expansion of our knowledge came about through information accumulated in a Registry, and untoward effects other than cancer soon came to notice as young asymptomatic women presented themselves for examination because of known fetal exposure. The dominant event is clearly recognizable ss teratogenic, resulting in anomalous development of the vagina and cervix. Although the appearance of clear cell adenocarcinoma in a small fraction of DES-daughters is a consequence, the role of DES in its carcinogenesis is still unproved.

11. DOCID:3876 SCORE: 0.00299697414837928
DOCNO: 320049
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Appetite Regulation
QUALIFIER: physiopathology
QUALIFIER: physiopathology
AUTHOR: S D Morrison SD
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Federation proceedings.
COUNTRY: UNITED STATES
TITLE: The hypothalamic syndrome in rats.
PUBDATE: 19770201
The original conception of the hypothalamus controlling feeding by the activity of two specific and reciprocally inhibitory centers has now been largely abandoned. Detailed neural research using a wide variety of methods has demonstrated the complex morphological and functional organization of this part of the brain and has modified the earlier simplistic approach. However, examination of the feeding responses to a variety of stimuli that represent components of control of feeding indicates that much or even most feeding control is extrahypothalamic. As demonstrated by the obesity or aphagia resulting from hypothalamic damage or from reversible hypothalamic interference, the hypothalamus influences or modulates feeding control, possibly by an enabling action, but it does not itself substantially control food intake either in the short or the long term. In the cachaxia of cancer, which can tentatively be regarded as a negative obesity, and which is closely reproducible in a rat model, the decline of food intake can be attributed to failure of control components that are all extrahypothalamic, and the deterioration of control of feeding appears to be quite independent of the hypothalamus. The very detailed reconstruction of intrahypothalamic circuitry that has been developed in recent years has not yet had any real impact on the problem of where or how the active control of food intake is generated or the way in which the hypothalamus influences this control.

12. DOCID:11241 SCORE: 0.00298711970676645
DOCNO: 7155012
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosome Mapping
DESCRIPTOR: Gene Expression Regulation
QUALIFIER: genetics
QUALIFIER: analysis
QUALIFIER: genetics
AUTHOR: R L Hancock RL
PUBTYPE: Journal Article
JOURNALTITLE: Medical hypotheses.
COUNTRY: ENGLAND
TITLE: Theoretical mechanisms for synthesis of carcinogen-induced embryonic proteins: IX. V-type position effect.
PUBDATE: 19821001
By the use of a simplistic concept of the structure of heterochromatin, one can derive a formulation for the mechanism by which the phenomenon of V-type position effect can repress genic activity. This notion would explain how the Bar locus and other position effect examples cause genic repression. The mechanism, when extended, may also explain the process of cancer induction by hereditary means. In its most concise form the theory states that heterochromatin has a stabilized structure through special proteins, such as phosphorylated species that allows it the capacity to induce new domains of a "pseudo-heterochromatic" conformation to juxta-positional euchromatic segments for short distances by virtue of electrostatic and hydrogen bond forces.

13. DOCID:15453 SCORE: 0.00298039960154456
DOCNO: 3531728
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: B A Morton BA
AUTHOR: J Scholes J
AUTHOR: J G Kral JG
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of surgical oncology.
COUNTRY: UNITED STATES
TITLE: An unusual presentation of colon cancer.
PUBDATE: 19861001
A rare case of asymptomatic cancer of the ascending colon presenting as a subcutaneous groin mass is reported. At the time of right hemicolectomy with resection of the groin mass there was no sign of incontinuity spread or lymph blockage. Sequential determination of carcinoembryonic antigen levels (CEA) in serum reflected the reduction in tumor mass after surgery as well as subsequent recurrences of disease in the groin and in the lung after 2 years. Immunoperoxidase staining of the primary tumor and the metastases showed strong positivity for CEA confirming the origin of the serum CEA. There have been no signs of liver involvement. The route of spread of this unusual metastasis is not known.

14. DOCID:3738 SCORE: 0.00297061274376008
DOCNO: 922708
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
AUTHOR: S Lesher S
AUTHOR: L M Schiffer LM
AUTHOR: M Phanse M
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Human colonic tumor cell kinetics: potential for therapy.
PUBDATE: 19771101
Using new in vitro techniques developed at the Cancer Research Unit, cell kinetic measurements were obtained in primary and metastatic human colonic tumors, polyps and normal bowel that did not require in vivo 3HTdR and required only single samples of tissue. These techniques included the measurement of the number of cells in DNA synthesis (LI), an estimate of the DNA synthesis time (Ts) and the growth fraction of tissues by means of the primer-available DNA-dependent DNA polymerase assay (PDP). From these data, the potential doubling time and the cell cycle time (Tc) of the tumors were calculated. Early preliminary data on human colonic specimens presented in Tables 1 and 2 indicate that there is an increase in LI from the low polyps to higher adenocarcinomas. There is little difference between primary and metastatic tumor cell kinetics. Growth fraction estimates (PDP) of the various colonic tissue types are also not significantly different and except for villous adenomas, DNA synthesis times are constant. The median 3HTdR labeling indices of 7% primary adenocarcinomas include a number of samples (approximately 20% of all samples) with high labeling indices (in the 10--20% range). These high labeling tumors may be those that show objective response to S-phase active drugs, e.g., 5-FU.