0. DOCID:29894 SCORE: 0.00390258738703932
DOCNO: 14738975
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: chemical synthesis
QUALIFIER: metabolism
QUALIFIER: chemical synthesis
QUALIFIER: metabolism
AUTHOR: Natacha Malecki N
AUTHOR: Pascal Carato P
AUTHOR: Benoît Rigo B
AUTHOR: Jean-François Goossens JF
AUTHOR: Raymond Houssin R
AUTHOR: Christian Bailly C
AUTHOR: Jean-Pierre Hénichart JP
AFFILIATION: Institut de Chimie Pharmaceutique Albert Lespagnol, Université de Lille 2, EA 2692, 3 rue du Professeur Laguesse, BP 83, F-59006 Lille, France.
PUBTYPE: Journal Article
JOURNALTITLE: Bioorganic & medicinal chemistry.
COUNTRY: England
TITLE: Synthesis of condensed quinolines and quinazolines as DNA ligands.
PUBDATE: 20040201
Among new condensed quinolines and quinazolines the design of which were inspired by anti-cancer DNA-binding alkaloids such as camptothecin and batracyclin, DNA binding tests identify the 8-methoxy-7-piperazinylpropoxyindeno[1,2-b]quinolin-11-one tetracyclic system as a new motif for DNA recognition.

1. DOCID:28377 SCORE: 0.00328310801417324
DOCNO: 15955688
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Review Literature
QUALIFIER: therapy
AUTHOR: K M Fong KM
AUTHOR: I A Yang IA
AUTHOR: P V Zimmerman PV
AUTHOR: R V Bowman RV
AFFILIATION: Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Australia. Kwun_fong@health.qld.gov.au
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Respiratory medicine.
COUNTRY: England
TITLE: Cochrane systematic reviews of treatments for lung cancer.
PUBDATE: 20050901
Morbidity and mortality from lung cancer is a major burden to global health. The integration of expert clinical experience, patient preference and high-quality evidence, including Cochrane systematic reviews, can only help improve outcomes from this highly lethal condition.

2. DOCID:28373 SCORE: 0.00328310711267359
DOCNO: 12087710
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Nurse-Patient Relations
QUALIFIER: psychology
AUTHOR: Donna Higgins D
AFFILIATION: Frimley Park Hospital NHS Trust, Surrey.
PUBTYPE: Journal Article
JOURNALTITLE: Professional nurse (London, England)
COUNTRY: England
TITLE: Breaking bad news in cancer care.
PUBDATE: 20020601
When a diagnosis of cancer, such as prostate cancer, is made nurses may be involved in presenting the news to the patient. How that news is given can make the experience a distressing or reassuring process. In the first part of this paper, the authors examines the human qualities required by professionals and the barriers to breaking bad news.

3. DOCID:28305 SCORE: 0.00328310563525725
DOCNO: 15996935
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: blood
AUTHOR: Rosanna Ciancia R
AUTHOR: Vincenzo Martinelli V
AUTHOR: Elena Cosentini E
AUTHOR: Marco Picardi M
AUTHOR: Fara Petruzziello F
AUTHOR: Elide Matano E
AUTHOR: Bruno Rotoli B
PUBTYPE: Letter
JOURNALTITLE: Haematologica.
COUNTRY: Italy
TITLE: High number of circulating CD34+ cells in patients with myelophthisis.
PUBDATE: 20050701
Six patients with bone marrow micrometastases from solid cancers presented with increased numbers of circulating CD34+ cells; the CD34+ cell counts were very high in some cases. By contrast, no patient with metastatic cancer without bone marrow involvement showed raised numbers of circulating hemopoietic progenitors.

4. DOCID:28627 SCORE: 0.00324826058141094
DOCNO: 16287993
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: antagonists & inhibitors
AUTHOR: Bradley S Miller BS
AUTHOR: Douglas Yee D
AFFILIATION: Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer research.
COUNTRY: United States
TITLE: Type I insulin-like growth factor receptor as a therapeutic target in cancer.
PUBDATE: 20051101
Data from experimental model systems and population studies have implicated type I insulin-like growth factor receptor (IGF1R) signaling in many different human cancers. Drugs to disrupt IGF1R function have been developed and are now entering clinical trial. This brief review will identify key areas to consider as these clinical trials move forward.

5. DOCID:30691 SCORE: 0.00279016527388989
DOCNO: 15613443
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: R I Nicholson RI
AUTHOR: C Staka C
AUTHOR: F Boyns F
AUTHOR: I R Hutcheson IR
AUTHOR: J M W Gee JM
AFFILIATION: Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Cardiff, UK. nicholsonri@cardiff.ac.uk
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Endocrine-related cancer.
COUNTRY: England
TITLE: Growth factor-driven mechanisms associated with resistance to estrogen deprivation in breast cancer: new opportunities for therapy.
PUBDATE: 20041201
There is an increasing body of evidence demonstrating that elevated growth signaling in breast cancer cells can promote forms of endocrine resistance in either an estrogen receptor-dependent or -independent manner. The current article reviews what is known about such growth factor signaling networks and resistance to estrogen withdrawal and considers the many novel therapeutic opportunities that stem from this knowledge.

6. DOCID:30594 SCORE: 0.00279015629815176
DOCNO: 16204992
OWNER: NLM
STATUS: In-Process
AUTHOR: Atchara Tempeam A
AUTHOR: Nopporn Thasana N
AUTHOR: Chitkavee Pavaro C
AUTHOR: Wongsatit Chuakul W
AUTHOR: Pongpun Siripong P
AUTHOR: Somsak Ruchirawat S
AFFILIATION: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
PUBTYPE: Journal Article
JOURNALTITLE: Chemical & pharmaceutical bulletin.
COUNTRY: Japan
TITLE: A new cytotoxic daphnane diterpenoid, rediocide G, from Trigonostemon reidioides.
PUBDATE: 20051001
Rediocide G (7), a new daphnane diterpenoid, was isolated from the roots of Trigonostemon reidioides (Euphorbiaceae), together with two congeners, rediocide A and rediocide B, (+)-syringaresinol, scopoletin, tomentin and stigmasterol. The structure of the new natural product was elucidated by comparison of its NMR and mass spectral data with those of previously known rediocides and confirmed by extensive 2D NMR spectral analysis. Rediocide G (7) was found to be cytotoxic to various cancer cell lines.

7. DOCID:29381 SCORE: 0.00225857105389565
DOCNO: 12762437
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cluster Analysis
DESCRIPTOR: Data Interpretation, Statistical
DESCRIPTOR: Likelihood Functions
AUTHOR: Catalina Stefanescu C
AUTHOR: Bruce W Turnbull BW
AFFILIATION: London Business School, Regent's Park, London NW1 4SA, UK.
PUBTYPE: Journal Article
JOURNALTITLE: Biometrics.
COUNTRY: United States
TITLE: Likelihood inference for exchangeable binary data with varying cluster sizes.
PUBDATE: 20030301
This article investigates maximum likelihood estimation with saturated and unsaturated models for correlated exchangeable binary data, when a sample of independent clusters of varying sizes is available. We discuss various parameterizations of these models, and propose using the EM algorithm to obtain maximum likelihood estimates. The methodology is illustrated by applications to a study of familial disease aggregation and to the design of a proposed group randomized cancer prevention trial.

8. DOCID:28776 SCORE: 0.00201813202689325
DOCNO: 12071811
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
AUTHOR: Thomas E Goffman TE
AUTHOR: Eli Glatstein E
AFFILIATION: Department of Radiation Oncology, Eastern Virginia Medical School, Norfolk, Virginia, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Radiation research.
COUNTRY: United States
TITLE: Intensity-modulated radiation therapy.
PUBDATE: 20020701
Intensity-modulated radiation therapy (IMRT) is an increasingly popular technical means of tightly focusing the radiation dose around a cancer. As with stereotactic radiotherapy, IMRT uses multiple fields and angles to converge on the target. The potential for total dose escalation and for escalation of daily fraction size to the gross cancer is exciting. The excitement, however, has greatly overshadowed a range of radiobiological and clinical concerns.

9. DOCID:31029 SCORE: 0.00190798620883676
DOCNO: 16176885
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: methods
AUTHOR: D Corsetti D
AUTHOR: A Bellière A
AUTHOR: P Romestaing P
AFFILIATION: Département d'oncologie radiothérapie, centre hospitalier Lyon-Sud, 69495 Lyon-Pierre-Bénite cedex, France. dominique.corsetti@chu-lyon.fr
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer radiothérapie : journal de la Société française de radiothérapie oncologique.
COUNTRY: France
TITLE: [Radiotherapy optimization in breast cancer: filtration, electronic compensation, intensity modulation]
PUBDATE: 20051101
Purpose of radiation treatment after conservative surgery for breast cancer is improvement of long-term local control rate and reduction of heart and pulmonary toxic events for women with long life expectancy. Breast irradiation with intensity modulation might be promising, as results of treatment planning (dose-volume histogram and normal tissue complication probability) showed. Project of our study is to evaluate the advantage of each following techniques: wedged plans, electronic compensation and intensity modulation.

10. DOCID:30804 SCORE: 0.00190798372542206
DOCNO: 16107660
OWNER: NLM
STATUS: In-Process
AUTHOR: Julien Sage J
AFFILIATION: Stanford University School of Medicine, CA 94305, USA. julsage@stanford.edu
PUBTYPE: Journal Article
JOURNALTITLE: Science of aging knowledge environment [electronic resource] : SAGE KE
COUNTRY: United States
TITLE: Making young tumors old: a new weapon against cancer?
PUBDATE: 20050801
As the population of industrial nations ages, the incidence of cancer and cancer mortality is increasing. Intuitively, older organisms may be less able to cope with accumulated damage and thus be more prone to develop cancer. However, so far, the links between aging and cancer have been only partially explored. Strikingly, four recent studies now indicate that premature senescence accompanied by cell cycle arrest occurs in tumors initiated by an oncogenic mutation. Thus, senescence may act as a key tumor suppressor mechanism in young tumors in vivo.

11. DOCID:30388 SCORE: 0.00186047518235514
DOCNO: 14980618
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemical synthesis
QUALIFIER: drug effects
QUALIFIER: drug effects
QUALIFIER: chemical synthesis
QUALIFIER: pharmacology
AUTHOR: Yu-Hsiang Lo YH
AUTHOR: Chi-Fong Lin CF
AUTHOR: Ming-Chu Hsieh MC
AUTHOR: Ming-Jung Wu MJ
AFFILIATION: School of Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan.
PUBTYPE: Journal Article
JOURNALTITLE: Bioorganic & medicinal chemistry.
COUNTRY: England
TITLE: Remarkable G2/M phase arrest and apoptotic effect performed by 2-(6-aryl-3-hexen-1,5-diynyl) benzonitrile antitumor agents.
PUBDATE: 20040301
2-(6-aryl-3-hexen-1,5-diynyl)benzonitriles 3a-j showed growth inhibition effects on a full panel of 60 human cancer cell lines in low micro-concentrations, in which compounds 3c,d displayed a significant G2/M arrest in the cell growth cycle compared with other derivatives and an apoptotic progress induction were also shown by 3a-d.

12. DOCID:31070 SCORE: 0.0018384805110716
DOCNO: 15387641
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemistry
QUALIFIER: isolation & purification
QUALIFIER: analogs & derivatives
QUALIFIER: isolation & purification
QUALIFIER: isolation & purification
AUTHOR: Ali A H El-Gamal AA
AUTHOR: Shang-Kwei Wang SK
AUTHOR: Chang-Feng Dai CF
AUTHOR: Chang-Yih Duh CY
AFFILIATION: Department of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of natural products.
COUNTRY: United States
TITLE: New nardosinanes and 19-oxygenated ergosterols from the soft coral Nephthea armata collected in Taiwan.
PUBDATE: 20040901
Five new nardosinane sesquiterpenoids, armatins A-E, lemnal-1(10)-ene-2,12-dione (a new natural product), and two new cytotoxic 19-oxygenated ergosterols, armatinols A and B, were isolated from the methylene chloride extract of the soft coral Nephthea armata, collected in Taiwan. The structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity was determined against selected cancer cells.

13. DOCID:28941 SCORE: 0.00178963031006141
DOCNO: 15110680
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Diet
QUALIFIER: administration & dosage
QUALIFIER: administration & dosage
AUTHOR: Teresa Cornwell T
AUTHOR: Wendie Cohick W
AUTHOR: Ilya Raskin I
AFFILIATION: Biotech Center, Cook College, Rutgers University, New Brunswick, NJ, 08901-8520, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Phytochemistry.
COUNTRY: United States
TITLE: Dietary phytoestrogens and health.
PUBDATE: 20040401
The interest in the potential health effects of dietary phytoestrogens has increased with the findings that hormone replacement therapy is not as safe or effective as previously thought. This review summarizes the dietary sources of the phytoestrogens; isoflavonoids, stilbenes, coumestans and lignans. It also examines 105 clinical studies related to effects of phytoestrogens on bone density, cardiovascular health, cancer prevention, cognitive ability and menopausal symptoms.

14. DOCID:28365 SCORE: 0.00178310545612498
DOCNO: 15029751
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Laparoscopy
QUALIFIER: pathology
QUALIFIER: surgery
QUALIFIER: pathology
QUALIFIER: surgery
AUTHOR: Dagmara Klasa-Mazurkiewicz D
AUTHOR: Janusz Emerich J
AUTHOR: Tomasz Milczek T
AFFILIATION: Kliniki Ginekologii AM w Gdańsku.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Ginekologia polska.
COUNTRY: Poland
TITLE: [Clinical course of clarocellular ovarian cancer in 27-year old woman. Laparoscopy in management of malignant ovarian tumors]
PUBDATE: 20031201
A case of clarocellular ovarian cancer in 27-year old woman is reported. Authors present the diagnostic and management problems, their experience and the review of current literature. The place of laparoscopy in management of malignant ovarian tumors is discussed.