0. DOCID:22826 SCORE: 0.00313246548125337
DOCNO: 7773901
AUTHOR: A Mullens A
PUBTYPE: Journal Article
JOURNALTITLE: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.
COUNTRY: CANADA
TITLE: The Dutch experience with euthanasia: lessons for Canada?
PUBDATE: 19950601
Anne Mullens used a recent fellowship provided by the Atkinson Foundation to take an in-depth look at euthanasia in the Netherlands. During her time in Holland, she discussed the issue with doctors who support and oppose euthanasia. She accompanied a doctor as he visited a patient who was dying of cancer and was beginning to consider the possibility of euthanasia. She talked to a nonphysician who is adamantly opposed to euthanasia and carries a card stating that. She visited a hospital in Amsterdam that has received requests from foreigners seeking euthansia. Mullens offers a comprehensive look at an issue that continues to provoke strong feelings among Canadian physicians and patients.

1. DOCID:21463 SCORE: 0.00301199782222056
DOCNO: 7998012
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: H J Haga HJ
AUTHOR: J H Magnus JH
AFFILIATION: Revmatologisk avdeling, Regionsykehuset i Tromsø.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Tidsskrift for den Norske laegeforening.
COUNTRY: NORWAY
TITLE: [Polymyalgia rheumatica and temporal arteritis. New aspects of diagnosis, treatment, prognosis and risk of cancer]
PUBDATE: 19940901
The incidence of polymyalgia rheumatica and temporal arteritis is increasing, mainly in elderly people. The risk of cancer during a lifetime is high in patients with positive biopsy of the temporal artery, but polymyalgia rheumatica and temporal arteritis are not to be considered as paraneoplastic syndromes. Temporal arteritis can appear in patients under treatment for polymyalgia rheumatica, and polymyalgia rheumatica can be accompanied by arthritis. Various new aspects of diagnoses and treatment are discussed.

2. DOCID:23018 SCORE: 0.00262136741733637
DOCNO: 8000210
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Nursing Assessment
DESCRIPTOR: Pain Measurement
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: nursing
AUTHOR: M McCaffery M
AUTHOR: B R Ferrell BR
PUBTYPE: Journal Article
JOURNALTITLE: Contemporary nurse : a journal for the Australian nursing profession.
COUNTRY: AUSTRALIA
TITLE: Nurses' assessment of pain intensity and choice of analgesic dose.
PUBDATE: 19940601
Under-treatment of all types of pain has been identified in many countries throughout the world. For example, the World Health Organization states that unrelieved cancer pain is an international problem. Lack of education of health care professionals, including nurses, is frequently cited as a major reason for under-treatment of pain. This survey of 517 Australian nurses suggests that they have some of the same educational needs as nurses in North America, such as how to assess pain intensity and how to select a dose of an opioid analgesic that is appropriate for the individual patient.

3. DOCID:23462 SCORE: 0.00245430065688027
DOCNO: 9371276
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Blood Substitutes
DESCRIPTOR: Erythrocytes
QUALIFIER: methods
AUTHOR: R P Goodrich RP
AUTHOR: S O Sowemino-Coker SO
AUTHOR: R Weinstein R
AFFILIATION: Cryopharm Corporation, Pasadena, California, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in hematology.
COUNTRY: UNITED STATES
TITLE: Advances in erythrocyte preservation and hemoglobin substitutes.
PUBDATE: 19940301
The desirability of extending the therapeutic benefits of erythrocyte transfusions beyond the currently available options is well established. Extended frozen storage of rare blood types, hemoglobin-based or artificial blood substitutes for treatment of short-term deficits in oxygen-carrying capacity, novel approaches to tissue oxygenation for cancer therapy, and efficient storage and availability of erythrocytes in military field installations are all potential applications of ongoing research and development efforts. This review explains the need for improvement in erythrocyte storage and development of blood substitutes, the current problems in the field, and the progress made toward solving these problems in the past year.

4. DOCID:20190 SCORE: 0.00233682564935899
DOCNO: 9238814
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: L Juncker L
AUTHOR: J Blondon J
AUTHOR: A de Gayffier A
AFFILIATION: Service chirurgical et gynécologique, Groupe hospitalier Pitié-Salpêtrière, Paris.
PUBTYPE: Journal Article
JOURNALTITLE: La Revue du praticien.
COUNTRY: FRANCE
TITLE: [Diagnosis of cancers of the ovary]
PUBDATE: 19970601
Early diagnosis of ovarian cancer is difficult and is still a matter of chance. Diagnosis rests on pelvic examination, ultrasonography and serum CA125 levels. Surgery establishes a definitive diagnosis and allows accurate staging and primary cytoreduction. No technique suitable for routine screening is currently available.

5. DOCID:22083 SCORE: 0.00221453577939171
DOCNO: 7988255
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Quality of Life
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: J C Ruckdeschel JC
AUTHOR: S Piantadosi S
AFFILIATION: H. Lee Moffitt Cancer Center & Research Institute, Tampa, Fla.
PUBTYPE: Journal Article
JOURNALTITLE: Chest.
COUNTRY: UNITED STATES
TITLE: Quality of life in lung cancer surgical adjuvant trials.
PUBDATE: 19941201
The Functional Living Index-Cancer (FLIC) was administered to 438 patients in the Lung Cancer Study Group on whom long-term follow-up was available in 1993. Across all trials, the total FLIC score was predictive for survival even when corrected for extent of disease, although individual items on the FLIC were not. There was no significant impact of a short course of chemotherapy on quality of life. The FLIC is a reliable means of assessing quality of life in lung cancer surgical adjuvant trials.

6. DOCID:22261 SCORE: 0.0022040070749084
DOCNO: 9251238
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemistry
QUALIFIER: physiology
AUTHOR: J S Mort JS
AUTHOR: D J Buttle DJ
AFFILIATION: Joint Diseases Laboratory, Shriners Hospital for Crippled Children, Montreal, Quebec, Canada.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The international journal of biochemistry & cell biology.
COUNTRY: ENGLAND
TITLE: Cathepsin B.
PUBDATE: 19970501
Cathepsin B is a lysosomal cysteine protease of the papain family. It functions in intracellular protein catabolism and in certain situations may also be involved in other physiological processes, such as processing of antigens in the immune response, hormone activation and bone turnover. There is also evidence that cathepsin B is implicated in the pathology of chronic inflammatory diseases of airways and joints, and in cancer and pancreatitis. In this short review we outline the major structural features of the enzyme, and describe how these relate to its synthesis, trafficking, processing and function.

7. DOCID:21572 SCORE: 0.00217996701259505
DOCNO: 7735548
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Laparoscopy
DESCRIPTOR: Neoplasms, Multiple Primary
QUALIFIER: surgery
QUALIFIER: methods
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: A M Lacy AM
AUTHOR: J C García-Valdecasas JC
AUTHOR: P Taurá P
AUTHOR: J M Bordas JM
AUTHOR: L Grande L
AUTHOR: J Fuster J
AUTHOR: E Cugat E
AUTHOR: J Visa J
AFFILIATION: Department of Surgery, Hospital clínic, University of Barcelona, Spain.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Surgical laparoscopy & endoscopy.
COUNTRY: UNITED STATES
TITLE: Is laparoscopic colectomy a safe procedure in synchronous colorectal carcinoma? Report of a case.
PUBDATE: 19950201
This clinical report describes a patient with sigmoid cancer who underwent a laparoscopic-assisted sigmoidectomy while also having an unsuspected carcinoma of cecum. We discuss the necessity of a complete preoperative evaluation (total colonoscopy and barium enema) in patients with colon cancers amenable to treatment by laparoscopic approach.

8. DOCID:23594 SCORE: 0.00197447080036216
DOCNO: 9438012
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Meta-Analysis
DESCRIPTOR: Stomach Neoplasms
AUTHOR: J Sakamoto J
AUTHOR: S Teramukai S
AUTHOR: H Nakazato H
AUTHOR: Y Ohashi Y
AFFILIATION: Department of Surgery, Aichi Prefectural Hospital, Japan.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Japanese journal of clinical oncology.
COUNTRY: JAPAN
TITLE: A re-analysis of a randomized clinical trial for gastric cancer using interval censoring.
PUBDATE: 19971201
In a previous randomized clinical trial against curatively resected gastric cancer, we compared the effect of immunochemotherapy to chemotherapy and obtained significantly better survival and disease-free survival time (DFS) in a combined therapy group. Although DFS was analysed with a conventional approach in which the onset of relapse was defined as the diagnosis of relapse, we considered it necessary to re-analyse the data and compare the results of an interval-censored approach with the conventional approach, in order to examine whether the conclusion might be altered depending on the approach.

9. DOCID:21959 SCORE: 0.00190211492768949
DOCNO: 7773744
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: DNA Repair
DESCRIPTOR: Proteins
AUTHOR: J A Tainer JA
AUTHOR: M M Thayer MM
AUTHOR: R P Cunningham RP
AFFILIATION: Department of Molecular Biology, Scripps Research Institute, La Jolla, California 92037, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in structural biology.
COUNTRY: ENGLAND
TITLE: DNA repair proteins.
PUBDATE: 19950201
DNA repair proteins act to correct mutagenic and toxic DNA damage, which can lead to cancer, aging and death. These proteins and their mechanisms of action have been found to be widely conserved between species, often from bacteria to man. Structural and biochemical studies on several bacterial enzymes involved in direct reversal and base excision repair have provided insights into the molecular basis of the recognition of damaged DNA and have also highlighted the novel roles that transition metals play in DNA repair.

10. DOCID:22080 SCORE: 0.00183901100259179
DOCNO: 7893950
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: trends
QUALIFIER: trends
QUALIFIER: trends
AUTHOR: D W Laube DW
AFFILIATION: Department of Obstetrics and Gynecology, University of Wisconsin Medical School, Madison.
PUBTYPE: Journal Article
JOURNALTITLE: Current opinion in obstetrics & gynecology.
COUNTRY: UNITED STATES
TITLE: Changing patterns in ambulatory care: a more broad-based approach.
PUBDATE: 19941201
The obstetrician-gynecologist must assume a dual role in the future provision of health care to women. Not only should the obstetrician-gynecologist function as a consultant for medical and surgical problems peculiar to the female reproductive tract, but also assume a broader-based role for preventive medicine and health maintenance functions. This includes the provision of care which traditionally had not been offered in our specialty. To this end, a summary of preventive medicine measures is provided, including cardiovascular disease, cancer screening and nongynecologic metabolic disorders.

11. DOCID:23704 SCORE: 0.00180232945855823
DOCNO: 9587366
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug effects
QUALIFIER: therapeutic use
QUALIFIER: therapy
QUALIFIER: therapeutic use
AUTHOR: M F Chiron MF
AFFILIATION: Rhône-Poulenc Rorer Gencell, Centre de recherche de Vitry-Alfortville, France.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Bulletin du cancer.
COUNTRY: FRANCE
TITLE: [Recombinant immunotoxins and chimeric toxins for targeted therapy in oncology]
PUBDATE: 19971201
Immunotoxins and chimeric toxins are hybrid molecules constituted of antibodies, growth factor or cytokines coupled to peptide toxins. They are designed to selectively eliminate tumor cells. Some of these chimera have been shown to induce complete tumor regressions of human tumor xenografts in immunodeficient mice. In clinical trials, higher anti tumor response were observed in lymphoma, brain tumor, breast and colon cancers. Problems arose with normal tissue toxicity and the production of neutralising antibodies. Should the latest recombinant toxins conceived by rationale designed, solved these problems, chimeric toxins would be an alternative approach to target tumor cells and vascular endothelial cells in solid tumors.

12. DOCID:21484 SCORE: 0.00175170854886238
DOCNO: 9382543
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: adverse effects
QUALIFIER: adverse effects
QUALIFIER: adverse effects
QUALIFIER: etiology
QUALIFIER: drug therapy
AUTHOR: N Matsumoto N
AUTHOR: N Umekita N
AUTHOR: T Maeshiro T
AUTHOR: S Miyamoto S
AUTHOR: Y Awane Y
AFFILIATION: Dept. of Surgery, Tokyo Metropolitan Bokutoh Hospital.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Liver abscess caused by hepatic artery infusion chemotherapy]
PUBDATE: 19970901
A 48-year-old man underwent left hemicolectomy and right extended hepatectomy for colon cancer and its synchronous multiple liver metastasis. Sixteen months after, multiple metastases in the remnant liver were found, so he was given bolus hepatic infusion of 5-FU 1,000 mg/week, total amount, 25 g. The response was CR, but he developed a liver abscess in segment 4.

13. DOCID:23942 SCORE: 0.00163492115869345
DOCNO: 8820396
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Vaginal Smears
QUALIFIER: diagnosis
AUTHOR: P Broso P
AFFILIATION: M. International Academy of Cytology, Ivrea (TO).
PUBTYPE: Journal Article
JOURNALTITLE: Minerva ginecologica.
COUNTRY: ITALY
TITLE: [Cervico-vaginal and endometrial cytology in the screening for endometrial cancer]
PUBDATE: 19951101
In contrast to cervical cancer, no routine mass screening programs for the early detection of endometrial cancer have been organized. All of the methods used by cytologists for studying endometrial changes have limitations. Cervicovaginal smears allow diagnosis of, at best, 60% to 70% of carcinomas of the endometrium. Intrauterine sampling is another possible method. It consists of direct aspiration of uterine cavity, scraping or brushing of the mucosa or uterine washing. Any method of endometrial sampling is imperfect, even dilatation and curettage has been shown to miss endometrial carcinoma. The lack of an effective, inexpensive and easy-to-use sampling method is the reason for the nonexistent decline in the incidence of invasive endometrial carcinoma.

14. DOCID:23536 SCORE: 0.00162843906763224
DOCNO: 8826714
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiation effects
QUALIFIER: standards
AUTHOR: D L Thiele DL
AUTHOR: A R Craig AR
AFFILIATION: Department of Diagnostic Physics, Royal Brisbane Hospital, Herston, Qld.
PUBTYPE: Journal Article
JOURNALTITLE: Australasian physical & engineering sciences in medicine / supported by the Australasian College of Physical Scientists in Medicine and the Australasian Association of Physical Sciences in Medicine.
COUNTRY: AUSTRALIA
TITLE: Mean glandular dose and the standard breast.
PUBDATE: 19960601
Mean glandular dose limits in mammography are defined in terms of a "standard breast". However, accrediting bodies do not always use the same standard breast. In this study, dose was measured following the guidelines of the National Program for the Early Detection of Breast Cancer (NPEDBC) and the Royal Australasian College of Radiologists (RACR). The RACR dose was found to be 32% less than the NPEDBC dose. This highlights the need for breast characteristics to be included in any statement of mean glandular dose.