0. DOCID:10579 SCORE: 0.00307752590194078
DOCNO: 6297705
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosome Deletion
DESCRIPTOR: Chromosomes, Human, 13-15
QUALIFIER: complications
QUALIFIER: genetics
AUTHOR: T E Goffman TE
AUTHOR: J J Mulvihill JJ
AUTHOR: D N Carney DN
AUTHOR: T J Triche TJ
AUTHOR: J Whang-Peng J
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer genetics and cytogenetics.
COUNTRY: UNITED STATES
TITLE: Fatal hypereosinophilia with chromosome 15q- in a patient with multiple primary and familial neoplasms.
PUBDATE: 19830301
A man with large-cell carcinoma of the lung, cerebral meningioma, occult adenocarcinoma of the prostate, and follicular adenoma of the thyroid developed symptomatic, rapidly progressive hypereosinophilia with abnormalities of eosinophil ultrastructure and bone marrow karyotype (45,X,15q22-). Although the patient's eosinophilia defied strict classification as idiopathic hypereosinophilic syndrome (HES), simple tumor-associated eosinophilia, or eosinophilic leukemia, it appeared to be incited by the lung cancer and quickly acquired malignant independence. The family had an excess of prostate cancer and lymphoproliferative neoplasms.


1. DOCID:11065 SCORE: 0.00270413365919373
DOCNO: 4054832
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: J T Emerman JT
AUTHOR: M Leahy M
AUTHOR: P W Gout PW
AUTHOR: N Bruchovsky N
PUBTYPE: Journal Article
JOURNALTITLE: Hormone and metabolic research. Hormon- und Stoffwechselforschung. Hormones et métabolisme.
COUNTRY: GERMANY, WEST
TITLE: Elevated growth hormone levels in sera from breast cancer patients.
PUBDATE: 19850801
The concentrations of growth hormone (GH) and prolactin (PRL) in the serum of 42 breast cancer patients were determined by radioimmunoassay (RIA). Forty percent of the patients had elevated GH levels while only 17% had elevated PRL levels. These findings suggest a relationship between GH and breast cancer; a weaker correlation exists between PRL and this malignancy. In addition, total lactogens in the serum were measured by a bioassay (BA). The BA/RIA (GH + PRL) ratio was greater in the breast cancer patients than the controls, indicating that variant forms of the hormones with higher than normal biological activity might be present.


2. DOCID:9726 SCORE: 0.00230137749579058
DOCNO: 6142253
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: J Cuzick J
AUTHOR: R Harris R
AUTHOR: P S Mortimer PS
PUBTYPE: Journal Article
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: Palmar keratoses and cancers of the bladder and lung.
PUBDATE: 19840301
In a case control study of the prevalence of palmar keratoses in 69 bladder cancer patients, 66 lung cancer patients, and 218 hospital controls palmar keratoses were more common in the cases, especially among those with cancer of the bladder. Above the age of 50 years, 87% of bladder cancer patients and 71% of lung cancer patients but only 36% of the controls had one or more keratoses. The prevalence increased with age and keratoses were more common in males. No features could be found which distinguished the keratoses in cases from those in controls.


3. DOCID:10170 SCORE: 0.00220032163705593
DOCNO: 6889522
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasm Recurrence, Local
QUALIFIER: urine
QUALIFIER: urine
QUALIFIER: urine
AUTHOR: B S Thomas BS
AUTHOR: R D Bulbrook RD
AUTHOR: J L Hayward JL
AUTHOR: R R Millis RR
PUBTYPE: Journal Article
JOURNALTITLE: European journal of cancer & clinical oncology.
COUNTRY: ENGLAND
TITLE: Urinary androgen metabolites and recurrence rates in early breast cancer.
PUBDATE: 19820501
Androsterone and aetiocholanolone were measured in urine specimens obtained from 218 women with early breast cancer. Patients who excreted less than the median amount of these steroids had a significantly higher recurrence rate (P less than 0.005) than patients excreting more than the median value. The relationship between androgen excretion and recurrence is stronger in pre-menopausal women that in the post-menopausal group. The androgen assays are still associated with recurrence rates when patients are stratified by pathological stage, but no clear relationship was found with histological grade.


4. DOCID:10203 SCORE: 0.00193736937819044
DOCNO: 6241846
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: F Pannuti F
AUTHOR: A Martoni A
AUTHOR: E Piana E
AUTHOR: L Tomasi L
AUTHOR: A Grieco A
AUTHOR: A Farris A
AUTHOR: F Saccani F
AUTHOR: M Baroni M
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Chemioterapia : international journal of the Mediterranean Society of Chemotherapy.
COUNTRY: ITALY
TITLE: Clinical trial of combined hormone therapy (MAP + TAM) for metastatic breast cancer.
PUBDATE: 19840801
High dose MAP (medroxyprogesterone acetate) and TAM (tamoxifen) were administered orally to 31 postmenopausal patients with advanced breast cancer. CR (complete remission) was achieved in 1 (3%) and PR (partial remission) in 11 (32%) patients for a median duration of 12 months. The treatment was well tolerated and in no instance was interrupted because of toxicity. This study does not support the hypothesis that the combination of MAP and TAM gives better results than the single agents.


5. DOCID:10307 SCORE: 0.00192476332787497
DOCNO: 6683896
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: P Faul P
PUBTYPE: Journal Article
JOURNALTITLE: Der Urologe. Ausg. A.
COUNTRY: GERMANY, WEST
TITLE: [Diagnostic and prognostic significance of cytological malignancy grading of prostatic carcinoma]
PUBDATE: 19830501
Clinical staging and morphological grading are very important for treatment of prostatic carcinoma. In 1980 a German pathological-urological study group of prostate cancer completed a new cytological grading system. This system has grades I-III of malignancy, based on six cellular criteria, whose relevance for prognosis was shown by cellkinetical investigations. The present study demonstrates less "undergrading" from transrectal fine needle biopsy and cytological diagnosis than from punch-biopsy and histological diagnosis. The cytological grade correlates well with the local extent of the tumor and metastases to pelvic lymph nodes. Despite of the wellknown problems with morphological grading on a biopsy it gives us very important information.


6. DOCID:10153 SCORE: 0.00186819304564816
DOCNO: 6644699
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Health
DESCRIPTOR: Health Status
QUALIFIER: complications
AUTHOR: J H Mason JH
AUTHOR: J L Weener JL
AUTHOR: P M Gertman PM
AUTHOR: R F Meenan RF
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of rheumatology.
COUNTRY: CANADA
TITLE: Health status in chronic disease: a comparative study of rheumatoid arthritis.
PUBDATE: 19831001
A self-administered questionnaire has been used to measure and compare health status in rheumatoid arthritis (RA) and 5 other chronic diseases. Subjects with RA, hypertension, cancer, diabetes, cardiac disease, or pulmonary disease were assessed along 11 aspects of health status. Results showed significant differences in health status across the 6 diseases, particularly for physical function and pain. The psychological status measures were similar. A summary estimate indicated that RA and pulmonary diseases produced poorer health status than the others. This study confirms the severe negative health status associated with chronic RA.


7. DOCID:10034 SCORE: 0.0018630968116417
DOCNO: 4042070
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: R B Pasterz RB
AUTHOR: A U Buzdar AU
AUTHOR: G N Hortobagyi GN
AUTHOR: G R Blumenschein GR
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Mitomycin in metastatic breast cancer refractory to hormonal and combination chemotherapy.
PUBDATE: 19851101
Forty-three patients with evaluable metastatic breast cancer refractory to hormonal agents and extensive combination chemotherapy including doxorubicin were treated with mitomycin, 20 mg/m2 intravenously every 6 weeks. There were five partial responses (12%) and three minor responses (7%), with a mean time to progression of 5 months and 3.5 months, respectively. Thrombocytopenia was the major dose-limiting toxicity, and myelosuppression was cumulative. Cardiac dysfunction was observed in 12% of patients. Mitomycin had some antitumor activity in this group of metastatic breast cancer patients refractory to extensive combination chemotherapy including doxorubicin.


8. DOCID:11936 SCORE: 0.00180591789854687
DOCNO: 7099061
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Carcinogens
QUALIFIER: etiology
QUALIFIER: metabolism
QUALIFIER: adverse effects
QUALIFIER: adverse effects
AUTHOR: L F Lombard LF
PUBTYPE: Journal Article
JOURNALTITLE: Medical hypotheses.
COUNTRY: ENGLAND
TITLE: Selenium, estradiol 17 beta, nitrites, and human breast cancer.
PUBDATE: 19820401
Breast cancer is the most common cancer in women in the United States. Although there is a large body of studies dealing with selenium, estrogens and nitrites in relation to cancer, most of them are correlated singly and the dynamics of carcinogenesis are overly simplified. The epidemiologic and etiologic effects of selenium, estrogens and nitrites in human breast cancer are traced in their important dimensions. A hypothesis for the interaction of these factors, especially in relation to the erythrocyte is presented within a multi-stage focus of carcinogenesis. A biochemical process for breast cell carcinogenesis in general is postulated and the erythrocyte interaction with breast cancer is diagramed. An enzyme "X" is postulated (estradiase) as a facilitator in vivo of the necessary biochemical conversion of estradiol 17 to a carcinogen.


9. DOCID:10968 SCORE: 0.00176509546241341
DOCNO: 6832116
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: complications
QUALIFIER: analysis
QUALIFIER: complications
QUALIFIER: analysis
AUTHOR: M Szendröi M
AUTHOR: L Németh L
AUTHOR: G Vajta G
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Environmental research.
COUNTRY: UNITED STATES
TITLE: Asbestos bodies in a bile duct cancer after occupational exposure.
PUBDATE: 19830401
A case of asbestosis after 5 years of occupational asbestos exposure is presented. At the postmortem examination, cholelithiasis and a cancer developing from the cystic duct were found and identified histologically as a squamous cell carcinoma. After digesting the tumor tissue, short asbestos bodies and fragments could be identified having a similar shape as those observed in the lung. The possible role of asbestos in the carcinogenesis of the observed bile duct cancer is proposed. The digestive examination of all malignant tumors of any origin after an asbestos exposure is suggested for the identification of the possible presence of ingested asbestos fibers, and to obtain further comprehensive human pathological data.


10. DOCID:11393 SCORE: 0.00170426036723893
DOCNO: 6137880
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
AUTHOR: G B Talpos GB
AUTHOR: C E Jackson CE
AUTHOR: J B Yott JB
AUTHOR: D L Van Dyke DL
PUBTYPE: Journal Article
JOURNALTITLE: Surgery.
COUNTRY: UNITED STATES
TITLE: Phenotype mapping of the multiple endocrine neoplasia type II syndrome.
PUBDATE: 19831001
The multiple endocrine neoplasia (MEN) IIb syndrome has been differentiated from MEN IIa by the presence of various phenotypic characteristics such as mucosal neuromas, marfanoid habitus, congenital skeletal anomalies, and prominent corneal nerves, as well as the lack of parathyroid involvement. Analysis of a kindred with some characteristics of both syndromes (including an associated chromosomal deletion) tends to unify the MEN II syndromes as a single disorder with variable expressivity. The linear map of the genetic determinants is postulated to conform with the following phenotype order: parathyroid tumors, medullary thyroid cancer, pheochromocytomas, skeletal changes, prominent corneal nerves, mucosal neuromas, and marfanoid habitus. Appreciation of this sequence can allow earlier identification and treatment of affected individuals.


11. DOCID:11225 SCORE: 0.00160807512196214
DOCNO: 6685804
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: chemically induced
QUALIFIER: pathology
AUTHOR: M Strauss M
AUTHOR: J Towfighi J
AUTHOR: S Lord S
AUTHOR: A Lipton A
AUTHOR: H A Harvey HA
AUTHOR: B Brown B
PUBTYPE: Journal Article
JOURNALTITLE: The Laryngoscope.
COUNTRY: UNITED STATES
TITLE: Cis-platinum ototoxicity: clinical experience and temporal bone histopathology.
PUBDATE: 19831201
A clinical and pathologic study of cis-platinum ototoxicity was performed. Twenty-four patients treated with cis-platinum for head and neck cancer were studied prospectively. Post cis-platinum hearing losses were subclinical, detected in 25% of patients, isolated to 4 and 8 kHz, and did not exceed 25 dB at any frequency. Temporal bones from a 9-year-old with frontal lobe astrocytoma and with cis-platinum ototoxicity were studied with routine and special techniques to elucidate oto and neurotoxicity. Degenerative changes in the outer hair cells in the lower turns of the cochlea, in the spiral ganglion, and cochlear nerve were the most striking findings.


12. DOCID:8220 SCORE: 0.00155785586892393
DOCNO: 3841627
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: H Wascher H
PUBTYPE: Journal Article
JOURNALTITLE: Wiener medizinische Wochenschrift (1946)
COUNTRY: AUSTRIA
TITLE: [Chemotherapy of metastasizing breast cancer]
PUBDATE: 19851201
Treatment strategies for metastatic breast cancer are determined by various prognostic factors. The main two factors are if the patients are of high or low risk. Primary treatment consists of combinations of various drugs with (VAC) or without adriamycin (CMF). Advantages, disadvantages and side effects of these treatment regimens of those (above) as well as other treatment strategies are being discussed.


13. DOCID:11149 SCORE: 0.00155164508030395
DOCNO: 6482019
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
AUTHOR: K Miwa K
PUBTYPE: Journal Article
JOURNALTITLE: Japanese journal of clinical oncology.
COUNTRY: JAPAN
TITLE: Evaluation of the TNM classification of stomach cancer and proposal for its rational stage-grouping.
PUBDATE: 19840901
The present TNM Classification with the provisional stage-grouping for stomach cancer, which was adopted in 1978, was evaluated for compatibility in respect to survival by using 15,589 stomach cancer patients registered in Japan from 1969 to 1973. Adequacy and usefulness were shown in all categories of T, N, M, pT and pN, individually. Important irrationality in accordance with the TNM General Rules was recognized in both the provisional TNM and p.TNM stage-groupings. More adequate stage-grouping was searched for and is discussed according to the results of statistical analysis of the patients' survival and the principle of the TNM General Rules. New TNM and p.TNM stage-groupings were proposed as the best ones at present.


14. DOCID:8152 SCORE: 0.00154798671969964
DOCNO: 6174901
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: P Deregibus P
AUTHOR: G Battezzati G
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Minerva medica.
COUNTRY: ITALY
TITLE: [2 cases of sebaceous cancer observed at the Holy Spirit Hospital in Casale Monferrato in 1980]
PUBDATE: 19820201
Two clinical cases of carcinoma of the sebaceous gland treated symptomatically are presented. There are, for extra-ocular forms, slow developing cancers, diagnosed bioptically. Recommended treatment is removal of the neoplasia where possible. If this cannot be done, radiotherapy or chemotherapy are recommended.