0. DOCID:3379 SCORE: 0.00339032569469796
DOCNO: 782652
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: biosynthesis
AUTHOR: J O Drife JO
AUTHOR: D B McClelland DB
AUTHOR: A Pryde A
AUTHOR: M M Roberts MM
AUTHOR: I I Smith II
PUBTYPE: Journal Article
JOURNALTITLE: British medical journal.
COUNTRY: ENGLAND
TITLE: Immunoglobulin synthesis in the "resting" breast.
PUBDATE: 19760801
Nulliparous women have a greater risk of developing breast cancer than women who have borne children, but so far no functional differences in breast tissue have been reported between parous women and nulliparae. Macroscopically and histologically normal breast tissue was obtained from 74 women of reproductive age during biopsy of benign breast lesions and was examined for the presence of plasma cells by immunfluorescence. Immunoglobulin synthesis was detected by an in-vitro culture technique. Synthesis of IgA was detected in 81% of specimans of IgG in 45%, and of IgM in 3%. IgA synthesis much more intense than IgG or IgM synthesis. Plasma cells containing IgA were seen in 71% of the specimens examined, and 88% of specimens had deposits of IgA in the ductules. The findings were not significantly incluenced by the nature of the condition necessitating biopsy or by oral contraception. Nulliparous women showed no cyclical changes, but among parous women IgA synthesis was more intense during luteal phase of the menstrual cycle. This suggests that after the first pregnancy the breast is more sensitive to progesterone.


1. DOCID:3437 SCORE: 0.00281805847615284
DOCNO: 4457397
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Endometrium
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: J E Dunn JE
PUBTYPE: Journal Article
JOURNALTITLE: Gynecologic oncology.
COUNTRY: UNITED STATES
TITLE: Geographic considerations of endometrial cancer.
PUBDATE: 19740801
There are certain problems associated with investigation of the geographic variation in the occurrence of cancer of the uterine corpus. Mortality rates are especially unsuitable for this because of the large proportion of deaths from uterine cancer which are not specified as to whether they originated in the cervix or the corpus. Incidence rates may be somewhat inflated if cytology screening is being extensively used in a population of women, but the designation between corpus and cervix is nearly complete. Incidence rates compiled by the International Union Against Cancer indicate much variation in the frequency of this cancer and that of the ovary and breast, but not with cervical cancer. In the United States southern white women tend to have cancers of the uterine corpus, breast, and ovary less frequently and of the cervix more frequently than women of the north and west. American born Japanese women are developing breast cancer nearly as frequently in California as white women, which may also be true for ovarian cancer. Uterine corpus cancer may be increasing but the population is still too young, since this cancer reaches its highest rates at older ages. All these cancers are less frequent in Japan.


2. DOCID:3508 SCORE: 0.00222676758080196
DOCNO: 865367
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Blood Transfusion
DESCRIPTOR: Leukocyte Transfusion
QUALIFIER: complications
QUALIFIER: therapeutic use
QUALIFIER: therapy
QUALIFIER: transplantation
QUALIFIER: therapy
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: J F Bishop JF
AUTHOR: R McLennan R
AUTHOR: M G Whiteside MG
PUBTYPE: Journal Article
JOURNALTITLE: The Medical journal of Australia.
COUNTRY: AUSTRALIA
TITLE: The management of febrile episodes in-neutropenic cancer.
PUBDATE: 19770401
The management of 33 febrile episodes in neutropenic patients suffering from acute leukaemia and other cancers is described. In 32 out of 33 episodes, the fever subsided. One patient died of cerebral haemorrhage while infected. The most common clinical sites of infection were, in order of frequency, the chest, the throat and the skin. Positive cultures were obtained in about half the episodes, the most common site being the throat followed by blood and sputum. The most common organisms isolated were Gram negative. Eighty-four per cent of febrile episodes occurred with neutrophil counts of less than 500/mm3, and in the majority of these, less than 100 neutrophils per cubic millmetre. All patients were reverse barrier nursed and on becoming febrile were given 48 hours of parenteral antibiotic therapy. The most common antibiotic combination used was gentamicin and cephalothin. At 48 hours, granulocyte transfusion and a third antibiotic were added to the regimen of patients not responding. The percentage response to antibiotics alone, in this series, at 58% was similar to that of other series, but the mortality experienced was lower.


3. DOCID:2851 SCORE: 0.00218989166244034
DOCNO: 1177638
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Glottis
DESCRIPTOR: Laryngectomy
DESCRIPTOR: Radioisotope Teletherapy
QUALIFIER: therapeutic use
QUALIFIER: therapy
AUTHOR: A Ennuyer A
AUTHOR: P Bataini P
PUBTYPE: Journal Article
JOURNALTITLE: The Laryngoscope.
COUNTRY: UNITED STATES
TITLE: Laryngeal carcinomas.
PUBDATE: 19750901
This study is based upon 214 cases of laryngeal carcinoma treated at the Foundation Curie, Paris, France, from January, 1958, to 1968. The results in terms of five-year survival have been: (see article). A statistical study of these results was made by Professor Daudel and demonstrated the absence of significant difference for the groups of tumors classed T1 and in Stage I and II treated either by radiocobalt or by surgery, whether followed or not by radiotherapy. By contrast there was a clearly significant difference in favor of surgery for the group of tumors classified as T2, T3, T4, or in Stage III. This significant difference in favor of primary surgery disappeared if we excluded the patients who died of intercurrent illnesses or of a second cancer not involving the larynx, and when we took into account those cures obtained by surgery in the event of failure of radiation and inversely, of those cures having been obtained by radiation therapy in the event of failure of surgery.


4. DOCID:3689 SCORE: 0.00214338518232816
DOCNO: 142934
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hypophysectomy
QUALIFIER: metabolism
AUTHOR: G C Lachelin GC
AUTHOR: S C Yen SC
AUTHOR: J F Alksne JF
PUBTYPE: Journal Article
JOURNALTITLE: Obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Hormonal changes following hypophysectomy in humans.
PUBDATE: 19770901
Pituitary function was studied before and after surgery in 1 patient who underwent chryohypophysectomy and 5 patients who underwent transsphenoidal excision hypophysectomy for metastatic breast cancer ablation therapy. Changes in serum luteinizing hormone, follicle stimulating hormone, growth hormone, thyrotropin stimulating hormone, pituitary prolactin (PRL), and steroid hormone levels of estrone, estradiol, testosterone, and rostenedione, and dehydroepiandrosterone levels were determined. All of the above were assessed before and from 6 weeks to 10 months after hypophysectomy. Pituitary hormone release in response to sequential stimuli of arginine infusion, thyrotropic releasing factor (TRF), and luteinizing hormone-releaseing factor was analyzed. In 3 patients, hypophysectomy was considered incomplete because of the presence of measurable amounts of circulating pituitary hormones and their release in response to stimuli, although all levels except PRL were markedly reduced. In 3 patients, hypophysectomy was considered nearly complete. Basal PRL levels remained unchanged whether the procedure was considered complete or not. PRL release was absent in response to TRF or arginine stimulation in 4 patients with substantial residual pituitary function. Hypophysectomy was followed by a marked reduction in circulating levels of estrogens and androgens. The assessment of quantitative release of pituitary hormones in response to stimuli is an improved direct measure of residual functioning pituitary tissue.


5. DOCID:3565 SCORE: 0.00209918074329607
DOCNO: 942247
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Sterilization, Reproductive
AUTHOR: S D Court SD
AUTHOR: J K Lloyd JK
PUBTYPE: Journal Article
JOURNALTITLE: Archives of disease in childhood.
COUNTRY: ENGLAND
TITLE: Letter: Sterilization of children under 16 years of age.
PUBDATE: 19760601
This is an official response by the British Paediatric Association t o a discussion paper prepared by the Dept. of Health and Social Security . Sterilization in children falls into 2 groups: 1) those for whom ster ilization is unavoidable in the course of treatment of a serious medical condition, and (2) sterilization of children with a severe mental handicap to avoid pregnancy. In the 1st case a 2nd opinion should be sought if at all possible, but in some cases of cancer when the decision must be made at operation, this is not always feasible. In genetic conditions the presence of the condition alone cannot justify sterilization. A full consultation involving medical social workers, psychologists, and others should be sought. In no case should a parent be able to secure a daughter's sterilization because it is feared she may become promiscuous. Whenever possible sterilization should be postponed until age of consent. In cases of severe mental handicap there should be procedures which safeguard the interest of the person regardless of age. The Association opposes a central registry, as well as ethical committees. If consensus cannot be reached a Ward of the Court Procedure should be followed.


6. DOCID:3552 SCORE: 0.00207404408051049
DOCNO: 960093
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Proctoscopy
DESCRIPTOR: Sigmoidoscopy
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: H Watanabe H
AUTHOR: M Numazawa M
AUTHOR: S Yamagata S
PUBTYPE: Journal Article
JOURNALTITLE: The Tohoku journal of experimental medicine.
COUNTRY: JAPAN
TITLE: Analysis of 6,293 routine proctosigmoidoscopies.
PUBDATE: 19760701
7,679 proctosigmoidoscopies were performed on 6,293 patients during a period from 1962 to 1974 at the Third Department of Internal Medicine, Tohoku University Hospital. Results were summarized as follows: Polyps were observed in 470 patients (7.5%) and cancer was found in 178 patients (2.8%). 129 patients (2.0%) were observed to have ulcerative colitis. There were 57 patients with melanosis coli, 12 radiation proctitis, 7 amebic colitis, 5 granulomatous colitis, 2 endometriosis coli, 2 carcinoid and 2 intestinal tuberculosis. Thus, 879 out of 6,293 patients examined had some forms of disease, an over-all incidence being 14.0%. Biopsies were performed under the proctosigmoidoscopic observation in 82.4% out of 273 patients with polyps during the 6-year period from 1969 to 1974 and 105 patients (46.7%) were observed to have adenomatous polyps. The age-specific distribution pattern and incidences of these patients with adenomatous polyps were mostly consistent with those of 178 patients with cancer of the large bowel, which were observed by proctosigmoidoscopy during the 13-year period from 1962 to 1974. Thus, it is suggested that etiological correlation exists between polyps of adenomatous type and cancer of the large bowel.


7. DOCID:3820 SCORE: 0.00199423247155558
DOCNO: 998552
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cellulose
DESCRIPTOR: Colonic Neoplasms
DESCRIPTOR: Diet
DESCRIPTOR: Dietary Fiber
AUTHOR: A R Walker AR
PUBTYPE: Journal Article
JOURNALTITLE: The American journal of clinical nutrition.
COUNTRY: UNITED STATES
TITLE: Colon cancer and diet, with special reference to intakes of fat and fiber.
PUBDATE: 19761201
Colon cancer, rare in the past, and in developing populations, currently accounts for 2 to 4% of all deaths in Western populations. Evidence suggests the primary cause to be changes in diet, which affect the bowel milieu intérieur. It is possible that in sophisticated populations, the higher concentrations of fecal bile acids and sterols, and longer transit time, favor the production of potentially carcinogenic metabolites. Of secular changes in diet, evidence suggests that the following may have etiological importance: 1) the fall in intake of fiber-containing foods with its effects on bowel physiology, and 2) the decreased fiber but increased fat intakes, in their respective capacities to raise concentrations of fecal bile acids, sterols, and other noxious substances. For possible prophylaxis against colon cancer, recommendations for a lower fat intake, or a higher intake of fiber-containing foods (apart from fiber ingestion from bran) are extremely unlikely to be adopted. For future research, western populations with considerably lower than average mortality rates, e.g., Seventh Day Adventists, Mormons, the rural Finnish population, as well as developing populations, demand intensive study. Also requiring elucidation are the respective roles of diet and of genetic constitution on concentrations of fecal bile acids, etc., and on transit time, in prone and nonprone populations.


8. DOCID:3671 SCORE: 0.00182916647631348
DOCNO: 590684
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: etiology
AUTHOR: F Hirose F
AUTHOR: K Fukazawa K
AUTHOR: H Watanabe H
AUTHOR: Y Terada Y
AUTHOR: I Fujii I
AUTHOR: S Otsuka S
PUBTYPE: Journal Article
JOURNALTITLE: Gann = Gan.
COUNTRY: JAPAN
TITLE: Induction of rectal carcinoma in mice by local x-irradiation.
PUBDATE: 19771001
The pelvic region of random bred female ICR-JCL mice and CF1 mice was irradiated with various doses of X-rays at 1-week intervals to determine the relationship between the X-ray dose and induction of rectal carcinoma. The incidence of rectal carcinoma in ICR mice was zero after a single dose of 2,000 rad of X-rays, but 31% after a single dose of 3,000 rad, 6% after 2 doses of 1,500 rad, 25% after 3 doses of 1,500 rad, 42% after 2 doses of 2,000 rad, and 95% after 3 doses of 2,000 rad. This cancer developed in 70% of CF1 mice exposed to 2 doses of 2,000 rad. No case of this tumor was observed in the control animals not exposed to X-rays. The development of this tumor was found to depend on the X-ray exposure dose. Local X-irradiation of the pelvic region is one of the effective methods for inducing rectal carcinoma in mice. Rectal cancers induced by X-irradiation were adenocarcinoma of the tubular, papillary, and mucinous type, and frequently showed invasive growth into the deep layers of the rectal wall.


9. DOCID:1836 SCORE: 0.00182090447140089
DOCNO: 1166941
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Vocal Cords
QUALIFIER: surgery
AUTHOR: C J Daly CJ
AUTHOR: E W Strong EW
PUBTYPE: Journal Article
JOURNALTITLE: American journal of surgery.
COUNTRY: UNITED STATES
TITLE: Carcinoma of the glottic larynx.
PUBDATE: 19751001
During the years 1955 through 1964, 535 patients with histologically proved squamous cell cancer of the glottic larynx were recorded in the Tumor Registry of the Memorial Sloan-Kettering Cancer Center. Of these 521 were treated and form the basis of this report. All were retrospectively staged. Possible etiologic factors were tabulated associated diseases recorded, and results of treatment evaluated. In this almost wholly surgically treated series, the determinate five and ten year survival rates for previously untreated patients were 81.5 and 80 per cent, respectively. The incidence of cervical lymph node metastases increased and the prognosis worsened with increasing stage of disease. The previously treated patients had a much worse prognosis than did the primary patientsmcancer of the glottic larynx is eminently curable if detected early and treated adequately.


10. DOCID:3219 SCORE: 0.00181835663794082
DOCNO: 1018115
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mortality
AUTHOR: I Waldron I
AUTHOR: S Johnston S
PUBTYPE: Journal Article
JOURNALTITLE: Journal of human stress.
COUNTRY: UNITED STATES
TITLE: Why do women live longer than men?
PUBDATE: 19760601
In the contemporary United States, males have 60 percent higher mortality than females. In Part I, published in the previous issue, we showed that 40 percent of this sex differential in mortality is due to a twofold elevation of arteriosclerotic heart disease among men. Major causes of higher rates of arteriosclerotic heart disease in men include greater cigarette smoking among men; probably a greater prevalence of the competitive, aggressive Coronary Prone Behavior Pattern among men; and possibly a protective role of female hormones. In addition, men have higher death rates for lung cancer and emphysema, primarily because more men smoke cigarettes. In Part II we analyze the other major causes of men's higher death rates: accidents, suicide, and cirrhosis of the liver. Each of these is related to behaviors which are encouraged or accepted more in men than in women in our society--for example, using guns, being adventurous and acting unafraid, working at hazardous jobs and drinking alcohol. We conclude with suggestions for reducing male mortality; for example, by changing the social conditions which foster in men the behaviors that elevate their mortality.


11. DOCID:3394 SCORE: 0.00175138119442294
DOCNO: 137076
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Carcinogens, Environmental
DESCRIPTOR: Legislation, Medical
QUALIFIER: chemically induced
QUALIFIER: chemically induced
QUALIFIER: prevention & control
AUTHOR: R Montesano R
AUTHOR: L Tomatis L
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Legislation concerning chemical carcinogens in several industrialized countries.
PUBDATE: 19770101
A survey was carried out on legislation in 14 industrialized countries relating to the prevention of occupational cancers. Two types of legislation were considered in particular: that dealing specifically with chemical carcinogens in the working environment, and that relating to compensation for occupational cancers. The survey revealed that legislation prohibiting the manufacture of chemicals known to be carcinogenic in humans or known to represent a possible cancer hazard to humans exists only in a limited number of the 14 countries considered and does not cover the same chemicals in each country. Legislation concerning monetary compensation is more common in these countreis than is legislation providing for primary prevention. There are two fundamental deficiencies in even the more comprehensive legislation. First, some chemicals for which carcinogenicity in humans has been proved are still produced in large quantities and are not covered by legislation. Second, the criteria used to determine which chemicals may be hazardous to humans when only experimental evidence of carcinogenicity exists are overexclusive, while the allowed concentrations of some of the chemicals recognized as possibly hazardous to humans appear to be very high.


12. DOCID:586 SCORE: 0.0017071063251787
DOCNO: 592250
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radionuclide imaging
AUTHOR: J Robillard J
PUBTYPE: Journal Article
JOURNALTITLE: Journal de radiologie, d'électrologie, et de médecine nucléaire.
COUNTRY: FRANCE
TITLE: [Scanning of bone metastases (author's transl)]
PUBDATE: 19771101
The Centers against cancer of Caen, Angers, Montpellier, Strasbourg and "the Curie Foundation" have confronted their experience in detection of bone metastases by total body scanning. From the investigation by this procedure, of 1,467 patients with cancer, it results: --the confrontation between radio and scanning shows a rate of false positive and false negative identical to the literature ones; --the countage scanning allows to reduce the number of false positive; --scanning allows to direct bone biopsy and to improve efficiency of histological examination.


13. DOCID:3691 SCORE: 0.00166441134267366
DOCNO: 300814
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Blood Transfusion
DESCRIPTOR: Postoperative Complications
QUALIFIER: etiology
AUTHOR: K Kuramoto K
AUTHOR: S Matsushita S
AUTHOR: M Murakami M
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Japanese heart journal.
COUNTRY: JAPAN
TITLE: Acute reversible myocardial infarction after blood transfusion in the aged.
PUBDATE: 19770301
Seven elderly cases with reversible electrocardiographic changes simulating acute myocardial infarction in the absence of gross myocardial infarction on postmortem examination were observed following the blood transfusion. The underlying diseases were cancer of gastrointestinal tract or gall bladder in 4, gastric ulcer in 2, and 1 of pseudomembranous enterocolitis. The electrocardiogram revealed the abnormal Q waves with monophasic ST elevation and following coronary T inversion. These findings lasted only for 2 to 7 days and returned to the previous normal tracings. The hematocrit was elevated from 28.9 to 47.7 after the blood transfusion of 800 to 1,800 ml. The disseminated intravascular coagulation was shown in 5 cases. GOT levels were within normal ranges except 1 case. Pathological findings in cases with recent electrocardiographic changes were characterized by the mural thromboses, extending into the myocardium through the Thebesian vein. The focal small necroses of the adjacent myocardium or around the thrombosis of small vessels were also observed. In the later phase the fine interstitial fibrosis took place after the resorption of the thrombi and necrotic foci. From these clinical and pathological findings we proposed a new concept of reversible myocardial infarction induced from the hypercoagulability, disseminated intravascular coagulation, and elevated hematocrit.


14. DOCID:2301 SCORE: 0.00162273170332178
DOCNO: 1001868
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasm Transplantation
DESCRIPTOR: Transplantation, Heterologous
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: S Hirohashi S
AUTHOR: Y Shimosato Y
AUTHOR: K Nagai K
AUTHOR: T Koide T
AUTHOR: T Kameya T
PUBTYPE: Journal Article
JOURNALTITLE: Gann = Gan.
COUNTRY: JAPAN
TITLE: Human breast cancer serially transplantable in nude mice in ascites form.
PUBDATE: 19760601
Cell suspension of a human breast cancer cell line (Hattori line) was injected intraperitoneally into an athymic nude mouse to produce ascites form breast cancer (peritoneal carcinomatosis). Subsequent serail transfers of cancer cells in ascites were also successful in mice. All male and female nude mice injected 1 X 10(7) tumor cells died of accumulation of ascites after a latency period averaging 4 weeks, with one exception which died of a wasting disease. Multiple lung metastases were observed in some mice. The tumor cells retained cytological characteristics of the original cell line, and histology of the infiltrating tumor in the peritoneum and omentum was that of poorly differentiated adenocarcinoma. Differentiation not only toward acinar or duct lining cells but also toward myoepithelial cells was observed by histochemistry, immunohistochemistry, and electron microscopy.