0. DOCID:29894 SCORE: 0.00390258738703932
DOCNO: 14738975
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: chemical synthesis
QUALIFIER: metabolism
QUALIFIER: chemical synthesis
QUALIFIER: metabolism
AUTHOR: Natacha Malecki N
AUTHOR: Pascal Carato P
AUTHOR: Benoît Rigo B
AUTHOR: Jean-François Goossens JF
AUTHOR: Raymond Houssin R
AUTHOR: Christian Bailly C
AUTHOR: Jean-Pierre Hénichart JP
AFFILIATION: Institut de Chimie Pharmaceutique Albert Lespagnol, Université de Lille 2, EA 2692, 3 rue du Professeur Laguesse, BP 83, F-59006 Lille, France.
PUBTYPE: Journal Article
JOURNALTITLE: Bioorganic & medicinal chemistry.
COUNTRY: England
TITLE: Synthesis of condensed quinolines and quinazolines as DNA ligands.
PUBDATE: 20040201
Among new condensed quinolines and quinazolines the design of which were inspired by anti-cancer DNA-binding alkaloids such as camptothecin and batracyclin, DNA binding tests identify the 8-methoxy-7-piperazinylpropoxyindeno[1,2-b]quinolin-11-one tetracyclic system as a new motif for DNA recognition.


1. DOCID:28377 SCORE: 0.00328310801417324
DOCNO: 15955688
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Review Literature
QUALIFIER: therapy
AUTHOR: K M Fong KM
AUTHOR: I A Yang IA
AUTHOR: P V Zimmerman PV
AUTHOR: R V Bowman RV
AFFILIATION: Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Australia. Kwun_fong@health.qld.gov.au
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Respiratory medicine.
COUNTRY: England
TITLE: Cochrane systematic reviews of treatments for lung cancer.
PUBDATE: 20050901
Morbidity and mortality from lung cancer is a major burden to global health. The integration of expert clinical experience, patient preference and high-quality evidence, including Cochrane systematic reviews, can only help improve outcomes from this highly lethal condition.


2. DOCID:28373 SCORE: 0.00328310711267359
DOCNO: 12087710
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Nurse-Patient Relations
QUALIFIER: psychology
AUTHOR: Donna Higgins D
AFFILIATION: Frimley Park Hospital NHS Trust, Surrey.
PUBTYPE: Journal Article
JOURNALTITLE: Professional nurse (London, England)
COUNTRY: England
TITLE: Breaking bad news in cancer care.
PUBDATE: 20020601
When a diagnosis of cancer, such as prostate cancer, is made nurses may be involved in presenting the news to the patient. How that news is given can make the experience a distressing or reassuring process. In the first part of this paper, the authors examines the human qualities required by professionals and the barriers to breaking bad news.


3. DOCID:28305 SCORE: 0.00328310563525725
DOCNO: 15996935
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: blood
AUTHOR: Rosanna Ciancia R
AUTHOR: Vincenzo Martinelli V
AUTHOR: Elena Cosentini E
AUTHOR: Marco Picardi M
AUTHOR: Fara Petruzziello F
AUTHOR: Elide Matano E
AUTHOR: Bruno Rotoli B
PUBTYPE: Letter
JOURNALTITLE: Haematologica.
COUNTRY: Italy
TITLE: High number of circulating CD34+ cells in patients with myelophthisis.
PUBDATE: 20050701
Six patients with bone marrow micrometastases from solid cancers presented with increased numbers of circulating CD34+ cells; the CD34+ cell counts were very high in some cases. By contrast, no patient with metastatic cancer without bone marrow involvement showed raised numbers of circulating hemopoietic progenitors.


4. DOCID:28627 SCORE: 0.00324826058141094
DOCNO: 16287993
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: antagonists & inhibitors
AUTHOR: Bradley S Miller BS
AUTHOR: Douglas Yee D
AFFILIATION: Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer research.
COUNTRY: United States
TITLE: Type I insulin-like growth factor receptor as a therapeutic target in cancer.
PUBDATE: 20051101
Data from experimental model systems and population studies have implicated type I insulin-like growth factor receptor (IGF1R) signaling in many different human cancers. Drugs to disrupt IGF1R function have been developed and are now entering clinical trial. This brief review will identify key areas to consider as these clinical trials move forward.


5. DOCID:30691 SCORE: 0.00279016527388989
DOCNO: 15613443
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: R I Nicholson RI
AUTHOR: C Staka C
AUTHOR: F Boyns F
AUTHOR: I R Hutcheson IR
AUTHOR: J M W Gee JM
AFFILIATION: Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Cardiff, UK. nicholsonri@cardiff.ac.uk
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Endocrine-related cancer.
COUNTRY: England
TITLE: Growth factor-driven mechanisms associated with resistance to estrogen deprivation in breast cancer: new opportunities for therapy.
PUBDATE: 20041201
There is an increasing body of evidence demonstrating that elevated growth signaling in breast cancer cells can promote forms of endocrine resistance in either an estrogen receptor-dependent or -independent manner. The current article reviews what is known about such growth factor signaling networks and resistance to estrogen withdrawal and considers the many novel therapeutic opportunities that stem from this knowledge.


6. DOCID:30594 SCORE: 0.00279015629815176
DOCNO: 16204992
OWNER: NLM
STATUS: In-Process
AUTHOR: Atchara Tempeam A
AUTHOR: Nopporn Thasana N
AUTHOR: Chitkavee Pavaro C
AUTHOR: Wongsatit Chuakul W
AUTHOR: Pongpun Siripong P
AUTHOR: Somsak Ruchirawat S
AFFILIATION: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
PUBTYPE: Journal Article
JOURNALTITLE: Chemical & pharmaceutical bulletin.
COUNTRY: Japan
TITLE: A new cytotoxic daphnane diterpenoid, rediocide G, from Trigonostemon reidioides.
PUBDATE: 20051001
Rediocide G (7), a new daphnane diterpenoid, was isolated from the roots of Trigonostemon reidioides (Euphorbiaceae), together with two congeners, rediocide A and rediocide B, (+)-syringaresinol, scopoletin, tomentin and stigmasterol. The structure of the new natural product was elucidated by comparison of its NMR and mass spectral data with those of previously known rediocides and confirmed by extensive 2D NMR spectral analysis. Rediocide G (7) was found to be cytotoxic to various cancer cell lines.


7. DOCID:27075 SCORE: 0.00246432721845022
DOCNO: 10346965
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: isolation & purification
QUALIFIER: chemistry
QUALIFIER: pharmacology
AUTHOR: B S Yun BS
AUTHOR: I J Ryoo IJ
AUTHOR: I K Lee IK
AUTHOR: K H Park KH
AUTHOR: D H Choung DH
AUTHOR: K H Han KH
AUTHOR: I D Yoo ID
AFFILIATION: Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusong, Taejon 305-600, Korea.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of natural products.
COUNTRY: UNITED STATES
TITLE: Two bioactive pentacyclic triterpene esters from the root bark of Hibiscus syriacus.
PUBDATE: 19990501
Two new triterpene caffeates have been isolated from the root bark of Hibiscus syriacus. Their structures were established through various spectral studies as 3beta,23,28-trihydroxy-12-oleanene 23-caffeate (1) and 3beta,23,28-trihydroxy-12-oleanene 3beta-caffeate (2). Compounds 1 and 2 showed lipid peroxidation inhibitory activity and significant cytotoxicity against a panel of human cancer cell lines.


8. DOCID:29381 SCORE: 0.00225857105389565
DOCNO: 12762437
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cluster Analysis
DESCRIPTOR: Data Interpretation, Statistical
DESCRIPTOR: Likelihood Functions
AUTHOR: Catalina Stefanescu C
AUTHOR: Bruce W Turnbull BW
AFFILIATION: London Business School, Regent's Park, London NW1 4SA, UK.
PUBTYPE: Journal Article
JOURNALTITLE: Biometrics.
COUNTRY: United States
TITLE: Likelihood inference for exchangeable binary data with varying cluster sizes.
PUBDATE: 20030301
This article investigates maximum likelihood estimation with saturated and unsaturated models for correlated exchangeable binary data, when a sample of independent clusters of varying sizes is available. We discuss various parameterizations of these models, and propose using the EM algorithm to obtain maximum likelihood estimates. The methodology is illustrated by applications to a study of familial disease aggregation and to the design of a proposed group randomized cancer prevention trial.


9. DOCID:27686 SCORE: 0.00225500706165515
DOCNO: 11007144
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: L Gullo L
AUTHOR: R Golfieri R
AUTHOR: G F Orcioni GF
AUTHOR: S Pileri S
AFFILIATION: Department of Internal Medicine and Gastroenterology, University of Bologna, S. Orsola Hospital, Italy.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: European journal of gastroenterology & hepatology.
COUNTRY: ENGLAND
TITLE: Multivisceral eosinophilic fibrosis: a new clinical presentation.
PUBDATE: 20000901
We describe a patient who was referred to us with the diagnosis of pancreatic cancer but who had eosinophilic fibrosis of the pancreas and other organs, including the sub-mandibular salivary glands, retro-orbital tissue, liver, kidneys, and surrounding the abdominal aorta. He had no pain or other symptoms. After treatment with methylprednisolone, all lesions disappeared and now he seems to be cured of this apparently immune-mediated disorder. To our knowledge, involvement of all these particular organs by eosinophilic fibrosis in the absence of symptoms has never before been described.


10. DOCID:27355 SCORE: 0.0022484585651092
DOCNO: 11091918
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: M B Feinstein MB
AUTHOR: P B Bach PB
AFFILIATION: Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Chest surgery clinics of North America.
COUNTRY: UNITED STATES
TITLE: Epidemiology of lung cancer.
PUBDATE: 20001101
Lung cancer is the leading cause of cancer mortality in the United States, and its incidence is growing throughout the world. The high morbidity and mortality of lung cancer largely results from the fact that most people are diagnosed with advanced disease, when surgical cures are no longer possible. Although many risk factors have been implicated, the most significant risk for developing lung cancer is clearly tobacco exposure. Tobacco use is currently increasing among specific population groups. It is probable that lung cancer will continue as a major medical and social problem for the foreseeable future.


11. DOCID:26199 SCORE: 0.00211454532513489
DOCNO: 11545544
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cancer Vaccines
DESCRIPTOR: Dendritic Cells
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: therapy
AUTHOR: G M Sprinzl GM
AUTHOR: L Kacani L
AUTHOR: A Schrott-Fischer A
AUTHOR: N Romani N
AUTHOR: W F Thumfart WF
AFFILIATION: Department of Otorhinolaryngology, Head and Neck Surgery, University of Innsbruck, Austria. georg.sprinzl@uibk.ac.at
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer treatment reviews.
COUNTRY: England
TITLE: Dendritic cell vaccines for cancer therapy.
PUBDATE: 20010801
Dendritic cells (DC) are professional antigen-presenting cells whose primary function is the initiation of immune response. Based on the finding that the immune system usually fails to identify and kill cancer cells, DC have been recently used as vaccines for stimulation of tumour-specific immunity. This review focuses on pitfalls related to DC-based vaccination against solid tumours and on improvement of this immunotherapeutic approach for routine treatment of cancer disease.


12. DOCID:27845 SCORE: 0.00205488809623382
DOCNO: 9794994
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Quality of Life
QUALIFIER: radiotherapy
AUTHOR: C B Scott CB
AFFILIATION: American College of Radiology, Philadelphia, PA 19107, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in radiation oncology.
COUNTRY: UNITED STATES
TITLE: Issues in quality of life assessment during cancer therapy.
PUBDATE: 19981001
Current treatments for cancer do not differentiate between malignant and normal cells; this limitation results in the adverse effects associated with radiotherapy and chemotherapy. Adverse effects of treatment severely impact the cancer patient's quality of life. Quality of life assessment can help the clinician gauge the efficacy of interventions that reduce the adverse effects of radiotherapy and chemotherapy. Quality of life is an increasingly important outcome measure in the evaluation of cancer treatments, and a variety of tools have been developed for evaluating changes in quality of life. This report reviews several of these measurement tools, focusing primarily on those used in lung cancer trials.


13. DOCID:28776 SCORE: 0.00201813202689325
DOCNO: 12071811
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
AUTHOR: Thomas E Goffman TE
AUTHOR: Eli Glatstein E
AFFILIATION: Department of Radiation Oncology, Eastern Virginia Medical School, Norfolk, Virginia, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Radiation research.
COUNTRY: United States
TITLE: Intensity-modulated radiation therapy.
PUBDATE: 20020701
Intensity-modulated radiation therapy (IMRT) is an increasingly popular technical means of tightly focusing the radiation dose around a cancer. As with stereotactic radiotherapy, IMRT uses multiple fields and angles to converge on the target. The potential for total dose escalation and for escalation of daily fraction size to the gross cancer is exciting. The excitement, however, has greatly overshadowed a range of radiobiological and clinical concerns.


14. DOCID:31029 SCORE: 0.00190798620883676
DOCNO: 16176885
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: methods
AUTHOR: D Corsetti D
AUTHOR: A Bellière A
AUTHOR: P Romestaing P
AFFILIATION: Département d'oncologie radiothérapie, centre hospitalier Lyon-Sud, 69495 Lyon-Pierre-Bénite cedex, France. dominique.corsetti@chu-lyon.fr
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer radiothérapie : journal de la Société française de radiothérapie oncologique.
COUNTRY: France
TITLE: [Radiotherapy optimization in breast cancer: filtration, electronic compensation, intensity modulation]
PUBDATE: 20051101
Purpose of radiation treatment after conservative surgery for breast cancer is improvement of long-term local control rate and reduction of heart and pulmonary toxic events for women with long life expectancy. Breast irradiation with intensity modulation might be promising, as results of treatment planning (dose-volume histogram and normal tissue complication probability) showed. Project of our study is to evaluate the advantage of each following techniques: wedged plans, electronic compensation and intensity modulation.