0. DOCID:3379 SCORE: 0.00339032569469796
DOCNO: 782652
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: biosynthesis
AUTHOR: J O Drife JO
AUTHOR: D B McClelland DB
AUTHOR: A Pryde A
AUTHOR: M M Roberts MM
AUTHOR: I I Smith II
PUBTYPE: Journal Article
JOURNALTITLE: British medical journal.
COUNTRY: ENGLAND
TITLE: Immunoglobulin synthesis in the "resting" breast.
PUBDATE: 19760801
Nulliparous women have a greater risk of developing breast cancer than women who have borne children, but so far no functional differences in breast tissue have been reported between parous women and nulliparae. Macroscopically and histologically normal breast tissue was obtained from 74 women of reproductive age during biopsy of benign breast lesions and was examined for the presence of plasma cells by immunfluorescence. Immunoglobulin synthesis was detected by an in-vitro culture technique. Synthesis of IgA was detected in 81% of specimans of IgG in 45%, and of IgM in 3%. IgA synthesis much more intense than IgG or IgM synthesis. Plasma cells containing IgA were seen in 71% of the specimens examined, and 88% of specimens had deposits of IgA in the ductules. The findings were not significantly incluenced by the nature of the condition necessitating biopsy or by oral contraception. Nulliparous women showed no cyclical changes, but among parous women IgA synthesis was more intense during luteal phase of the menstrual cycle. This suggests that after the first pregnancy the breast is more sensitive to progesterone.


1. DOCID:7072 SCORE: 0.00287408838690663
DOCNO: 760187
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: R Killer-Walser R
AUTHOR: H Hess H
AUTHOR: T G Würsch TG
AUTHOR: K Stuby K
AUTHOR: A Sonnenberg A
AUTHOR: W Brühlmann W
AUTHOR: A L Blum AL
PUBTYPE: Journal Article
JOURNALTITLE: Schweizerische medizinische Wochenschrift.
COUNTRY: SWITZERLAND
TITLE: [Fiber endoscopy and radiology in stomach ulcer, stomach neoplasms and hiatal hernia: questions, timing and value]
PUBDATE: 19790101
In 306 patients, fiberpanendoscopy and radiology were performed within a time interval of 7 days or less. In 196 cases, radiology was performed before endoscopy and in 110 cases after endoscopy. In cases with histologically unproven divergent findings, follow-up studies were performed. In the diagnosis of gastric ulcer and gastric cancer, endoscopy with biopsy was more accurate than radiology. In the diagnosis of hiatal hernia, radiology was more accurate. Important additional findings difficult or impossible to observe with endoscopy were present in 36% of the radiological examinations. Thus, the first examination should be endoscopy when ulcer or carcinoma is suspected. In patients with uncharacteristic epigastric symptoms, radiology should be performed first.


2. DOCID:3437 SCORE: 0.00281805847615284
DOCNO: 4457397
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Endometrium
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: J E Dunn JE
PUBTYPE: Journal Article
JOURNALTITLE: Gynecologic oncology.
COUNTRY: UNITED STATES
TITLE: Geographic considerations of endometrial cancer.
PUBDATE: 19740801
There are certain problems associated with investigation of the geographic variation in the occurrence of cancer of the uterine corpus. Mortality rates are especially unsuitable for this because of the large proportion of deaths from uterine cancer which are not specified as to whether they originated in the cervix or the corpus. Incidence rates may be somewhat inflated if cytology screening is being extensively used in a population of women, but the designation between corpus and cervix is nearly complete. Incidence rates compiled by the International Union Against Cancer indicate much variation in the frequency of this cancer and that of the ovary and breast, but not with cervical cancer. In the United States southern white women tend to have cancers of the uterine corpus, breast, and ovary less frequently and of the cervix more frequently than women of the north and west. American born Japanese women are developing breast cancer nearly as frequently in California as white women, which may also be true for ovarian cancer. Uterine corpus cancer may be increasing but the population is still too young, since this cancer reaches its highest rates at older ages. All these cancers are less frequent in Japan.


3. DOCID:7855 SCORE: 0.00278334834466423
DOCNO: 582494
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Food Habits
DESCRIPTOR: Vitamin A
QUALIFIER: etiology
AUTHOR: C Mettlin C
AUTHOR: S Graham S
PUBTYPE: Journal Article
JOURNALTITLE: American journal of epidemiology.
COUNTRY: UNITED STATES
TITLE: Dietary risk factors in human bladder cancer.
PUBDATE: 19790901
Retrospective data on dietary habits, employment history and tobacco use were obtained from 569 bladder cancer patients and 1025 age-matched controls admitted to Roswell Park Memorial Institute. Sex-adjusted relative risks revealed increases in risk for lower levels of an index of vitamin A intake. A similar pattern of risk elevation was associated with infrequent milk and carrot intake. Some elevation of risk was found for heavy coffee drinking but the apparent protective effect for milk consumption was not found to be a spurious result of lower coffee intake. Neither was the role of vitamin A explained by its relationship with smoking or employment in high risk occupations. Some association of bladder cancer with infrequent consumption of cruciferous vegetables was also observed. The findings of this investigation are consistent with tumor inhibition by retinoids in animal studies and the low risk associated with vitamin A in epidemiologic studies of lung cancer.


4. DOCID:7724 SCORE: 0.0025962249776749
DOCNO: 464805
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ultrasonography
QUALIFIER: prevention & control
QUALIFIER: analysis
QUALIFIER: prevention & control
AUTHOR: C R Mackie CR
AUTHOR: J Bowie J
AUTHOR: M J Cooper MJ
AUTHOR: M H Lewis MH
AUTHOR: A R Moossa AR
PUBTYPE: Journal Article
JOURNALTITLE: Archives of surgery (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Ultrasonography and tumor-associated antigens. The concept of combining noninvasive tests in the screening for pancreatic cancer.
PUBDATE: 19790801
A total of 134 patients suspected of having pancreatic cancer were given preoperative ultrasonic examinations. A total of 54 cases had a final diagnosis of pancreatic cancer histologically confirmed. The diagnostic sensitivity and specificity of the ultrasonographies were 76% and 91% or 87% and 74%, depending on whether doubtful results were called abnormal or normal. "Doubtful" results were defined as those that stated that pancreatic cancer was "possible" or "could not be excluded." When these results were divided into abnormal and normal groups on the basis of the patients' preoperative serum carcinoembryonic antigen and pancreatic oncofetal antigen levels, the sensitivity and specificity of the combined tests may prove to be a more accurate means of screening patients for pancreatic cancer than ultrasonography alone.


5. DOCID:5265 SCORE: 0.00247049859280808
DOCNO: 7379661
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Age Factors
QUALIFIER: epidemiology
AUTHOR: I L Horovitz IL
AUTHOR: M Huber M
PUBTYPE: Journal Article
JOURNALTITLE: Diseases of the colon and rectum.
COUNTRY: UNITED STATES
TITLE: Cancer of the colon: a study of age-related incidence.
PUBDATE: 19800301
Incidence of colorectal cancer in Israel was studied in 1035 patients who were divided by ethno-geography into a Euro-American group and an Afro-Asian group. The majority of patients were in the age groups over 50 years, with a markedly higher incidence rate of disease in the Euro-American group. In the younger age group the incidence rate of the disease was significantly higher in the Afro-Asian group. These findings, if verified by others, must lead to revision of our present concepts of epidemiology of colorectal cancer.


6. DOCID:4464 SCORE: 0.00228738509547606
DOCNO: 417987
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: R Schrage R
PUBTYPE: Journal Article
JOURNALTITLE: Fortschritte der Medizin.
COUNTRY: GERMANY, WEST
TITLE: [Problems of current diagnosis of neoplasms in women]
PUBDATE: 19780501
The value of early cancer detection in women is limited by the screening methods and their minor reliability in "mass-screening". The effect of detection programs is difficult to demonstrate. The interest in cancer detection is low, especially in elderly high risk patients. A more suitable application of screening tests with widespread indication of further methods together with exact demonstration could be the basis for better results in early cancer detection programs in women.


7. DOCID:3508 SCORE: 0.00222676758080196
DOCNO: 865367
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Blood Transfusion
DESCRIPTOR: Leukocyte Transfusion
QUALIFIER: complications
QUALIFIER: therapeutic use
QUALIFIER: therapy
QUALIFIER: transplantation
QUALIFIER: therapy
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: J F Bishop JF
AUTHOR: R McLennan R
AUTHOR: M G Whiteside MG
PUBTYPE: Journal Article
JOURNALTITLE: The Medical journal of Australia.
COUNTRY: AUSTRALIA
TITLE: The management of febrile episodes in-neutropenic cancer.
PUBDATE: 19770401
The management of 33 febrile episodes in neutropenic patients suffering from acute leukaemia and other cancers is described. In 32 out of 33 episodes, the fever subsided. One patient died of cerebral haemorrhage while infected. The most common clinical sites of infection were, in order of frequency, the chest, the throat and the skin. Positive cultures were obtained in about half the episodes, the most common site being the throat followed by blood and sputum. The most common organisms isolated were Gram negative. Eighty-four per cent of febrile episodes occurred with neutrophil counts of less than 500/mm3, and in the majority of these, less than 100 neutrophils per cubic millmetre. All patients were reverse barrier nursed and on becoming febrile were given 48 hours of parenteral antibiotic therapy. The most common antibiotic combination used was gentamicin and cephalothin. At 48 hours, granulocyte transfusion and a third antibiotic were added to the regimen of patients not responding. The percentage response to antibiotics alone, in this series, at 58% was similar to that of other series, but the mortality experienced was lower.


8. DOCID:2851 SCORE: 0.00218989166244034
DOCNO: 1177638
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Glottis
DESCRIPTOR: Laryngectomy
DESCRIPTOR: Radioisotope Teletherapy
QUALIFIER: therapeutic use
QUALIFIER: therapy
AUTHOR: A Ennuyer A
AUTHOR: P Bataini P
PUBTYPE: Journal Article
JOURNALTITLE: The Laryngoscope.
COUNTRY: UNITED STATES
TITLE: Laryngeal carcinomas.
PUBDATE: 19750901
This study is based upon 214 cases of laryngeal carcinoma treated at the Foundation Curie, Paris, France, from January, 1958, to 1968. The results in terms of five-year survival have been: (see article). A statistical study of these results was made by Professor Daudel and demonstrated the absence of significant difference for the groups of tumors classed T1 and in Stage I and II treated either by radiocobalt or by surgery, whether followed or not by radiotherapy. By contrast there was a clearly significant difference in favor of surgery for the group of tumors classified as T2, T3, T4, or in Stage III. This significant difference in favor of primary surgery disappeared if we excluded the patients who died of intercurrent illnesses or of a second cancer not involving the larynx, and when we took into account those cures obtained by surgery in the event of failure of radiation and inversely, of those cures having been obtained by radiation therapy in the event of failure of surgery.


9. DOCID:3689 SCORE: 0.00214338518232816
DOCNO: 142934
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hypophysectomy
QUALIFIER: metabolism
AUTHOR: G C Lachelin GC
AUTHOR: S C Yen SC
AUTHOR: J F Alksne JF
PUBTYPE: Journal Article
JOURNALTITLE: Obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Hormonal changes following hypophysectomy in humans.
PUBDATE: 19770901
Pituitary function was studied before and after surgery in 1 patient who underwent chryohypophysectomy and 5 patients who underwent transsphenoidal excision hypophysectomy for metastatic breast cancer ablation therapy. Changes in serum luteinizing hormone, follicle stimulating hormone, growth hormone, thyrotropin stimulating hormone, pituitary prolactin (PRL), and steroid hormone levels of estrone, estradiol, testosterone, and rostenedione, and dehydroepiandrosterone levels were determined. All of the above were assessed before and from 6 weeks to 10 months after hypophysectomy. Pituitary hormone release in response to sequential stimuli of arginine infusion, thyrotropic releasing factor (TRF), and luteinizing hormone-releaseing factor was analyzed. In 3 patients, hypophysectomy was considered incomplete because of the presence of measurable amounts of circulating pituitary hormones and their release in response to stimuli, although all levels except PRL were markedly reduced. In 3 patients, hypophysectomy was considered nearly complete. Basal PRL levels remained unchanged whether the procedure was considered complete or not. PRL release was absent in response to TRF or arginine stimulation in 4 patients with substantial residual pituitary function. Hypophysectomy was followed by a marked reduction in circulating levels of estrogens and androgens. The assessment of quantitative release of pituitary hormones in response to stimuli is an improved direct measure of residual functioning pituitary tissue.


10. DOCID:3565 SCORE: 0.00209918074329607
DOCNO: 942247
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Sterilization, Reproductive
AUTHOR: S D Court SD
AUTHOR: J K Lloyd JK
PUBTYPE: Journal Article
JOURNALTITLE: Archives of disease in childhood.
COUNTRY: ENGLAND
TITLE: Letter: Sterilization of children under 16 years of age.
PUBDATE: 19760601
This is an official response by the British Paediatric Association t o a discussion paper prepared by the Dept. of Health and Social Security . Sterilization in children falls into 2 groups: 1) those for whom ster ilization is unavoidable in the course of treatment of a serious medical condition, and (2) sterilization of children with a severe mental handicap to avoid pregnancy. In the 1st case a 2nd opinion should be sought if at all possible, but in some cases of cancer when the decision must be made at operation, this is not always feasible. In genetic conditions the presence of the condition alone cannot justify sterilization. A full consultation involving medical social workers, psychologists, and others should be sought. In no case should a parent be able to secure a daughter's sterilization because it is feared she may become promiscuous. Whenever possible sterilization should be postponed until age of consent. In cases of severe mental handicap there should be procedures which safeguard the interest of the person regardless of age. The Association opposes a central registry, as well as ethical committees. If consensus cannot be reached a Ward of the Court Procedure should be followed.


11. DOCID:3552 SCORE: 0.00207404408051049
DOCNO: 960093
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Proctoscopy
DESCRIPTOR: Sigmoidoscopy
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: H Watanabe H
AUTHOR: M Numazawa M
AUTHOR: S Yamagata S
PUBTYPE: Journal Article
JOURNALTITLE: The Tohoku journal of experimental medicine.
COUNTRY: JAPAN
TITLE: Analysis of 6,293 routine proctosigmoidoscopies.
PUBDATE: 19760701
7,679 proctosigmoidoscopies were performed on 6,293 patients during a period from 1962 to 1974 at the Third Department of Internal Medicine, Tohoku University Hospital. Results were summarized as follows: Polyps were observed in 470 patients (7.5%) and cancer was found in 178 patients (2.8%). 129 patients (2.0%) were observed to have ulcerative colitis. There were 57 patients with melanosis coli, 12 radiation proctitis, 7 amebic colitis, 5 granulomatous colitis, 2 endometriosis coli, 2 carcinoid and 2 intestinal tuberculosis. Thus, 879 out of 6,293 patients examined had some forms of disease, an over-all incidence being 14.0%. Biopsies were performed under the proctosigmoidoscopic observation in 82.4% out of 273 patients with polyps during the 6-year period from 1969 to 1974 and 105 patients (46.7%) were observed to have adenomatous polyps. The age-specific distribution pattern and incidences of these patients with adenomatous polyps were mostly consistent with those of 178 patients with cancer of the large bowel, which were observed by proctosigmoidoscopy during the 13-year period from 1962 to 1974. Thus, it is suggested that etiological correlation exists between polyps of adenomatous type and cancer of the large bowel.


12. DOCID:3820 SCORE: 0.00199423247155558
DOCNO: 998552
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cellulose
DESCRIPTOR: Colonic Neoplasms
DESCRIPTOR: Diet
DESCRIPTOR: Dietary Fiber
AUTHOR: A R Walker AR
PUBTYPE: Journal Article
JOURNALTITLE: The American journal of clinical nutrition.
COUNTRY: UNITED STATES
TITLE: Colon cancer and diet, with special reference to intakes of fat and fiber.
PUBDATE: 19761201
Colon cancer, rare in the past, and in developing populations, currently accounts for 2 to 4% of all deaths in Western populations. Evidence suggests the primary cause to be changes in diet, which affect the bowel milieu intérieur. It is possible that in sophisticated populations, the higher concentrations of fecal bile acids and sterols, and longer transit time, favor the production of potentially carcinogenic metabolites. Of secular changes in diet, evidence suggests that the following may have etiological importance: 1) the fall in intake of fiber-containing foods with its effects on bowel physiology, and 2) the decreased fiber but increased fat intakes, in their respective capacities to raise concentrations of fecal bile acids, sterols, and other noxious substances. For possible prophylaxis against colon cancer, recommendations for a lower fat intake, or a higher intake of fiber-containing foods (apart from fiber ingestion from bran) are extremely unlikely to be adopted. For future research, western populations with considerably lower than average mortality rates, e.g., Seventh Day Adventists, Mormons, the rural Finnish population, as well as developing populations, demand intensive study. Also requiring elucidation are the respective roles of diet and of genetic constitution on concentrations of fecal bile acids, etc., and on transit time, in prone and nonprone populations.


13. DOCID:7689 SCORE: 0.00193782245887808
DOCNO: 746104
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Adaptation, Psychological
DESCRIPTOR: Ego
QUALIFIER: psychology
AUTHOR: J W Worden JW
AUTHOR: H J Sobel HJ
PUBTYPE: Journal Article
JOURNALTITLE: Psychosomatic medicine.
COUNTRY: UNITED STATES
TITLE: Ego strength and psychosocial adaptation to cancer.
PUBDATE: 19781201
This study investigated a patient's ego strength (Es) at the time of an initial cancer diagnosis and its relationship, over time, to mood disturbance, vulnerability, self-reported physical symptom totals, current concerns, coping strategies, and effectiveness in the resolution of problems. The subjects were 163 newly diagnosed male and female cancer patients representing five primary tumor sites. All patients were seen for an initial evaluation, at which time they completed Barron's Es scale, the Profile of Mood States, the Inventory of Current Concerns, and a semistructured interview. Ratings on patient vulnerability, coping strategies, and problem resolutions were made at each of the five follow-ups. Results showed that psychosocial adaptation to cancer was related to a patient's ego strength. Es correlated positively with a patient's use of effective coping strategies. The concept of Es and problems with Es assessment were discussed within a cognitive-ego analytic frame of reference.


14. DOCID:7808 SCORE: 0.00187010365853572
DOCNO: 6447114
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Lymphocyte Activation
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: G B Cannon GB
AUTHOR: J H Dean JH
AUTHOR: R B Herberman RB
AUTHOR: E Perlin E
AUTHOR: J Reid J
AUTHOR: C Miller C
AUTHOR: N P Lang NP
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: Association of depressed postoperative lymphoproliferative responses to alloantigens with poor prognosis in patients with stage I lung cancer.
PUBDATE: 19800101
Thirty-five patients with Stage I carcinoma of the lung were tested postoperatively to assess lymphoproliferative responses. Depressed lymphocyte proliferation (LP) responses to alloantaigen in the mixed leukocyte culture (MLC) as measured by thee relative proliferation index (RPI) were associated with a significantly shorter disease-free interval. In this group of patients, the immunologic responses predicted subsequent clinical course better than the TNM classification or the histological type of the tumor, and therefore this procedure appears promising for improved staging of patients with early stages of lung cancer (stage I lung cancer and T1N0M0). The depressed response to alloantaigen was a more sensitive discriminator of disease recurrence than PHA alone or even conbined with PHA.