0. DOCID:29894 SCORE: 0.00390258738703932
DOCNO: 14738975
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: chemical synthesis
QUALIFIER: metabolism
QUALIFIER: chemical synthesis
QUALIFIER: metabolism
AUTHOR: Natacha Malecki N
AUTHOR: Pascal Carato P
AUTHOR: Benoît Rigo B
AUTHOR: Jean-François Goossens JF
AUTHOR: Raymond Houssin R
AUTHOR: Christian Bailly C
AUTHOR: Jean-Pierre Hénichart JP
AFFILIATION: Institut de Chimie Pharmaceutique Albert Lespagnol, Université de Lille 2, EA 2692, 3 rue du Professeur Laguesse, BP 83, F-59006 Lille, France.
PUBTYPE: Journal Article
JOURNALTITLE: Bioorganic & medicinal chemistry.
COUNTRY: England
TITLE: Synthesis of condensed quinolines and quinazolines as DNA ligands.
PUBDATE: 20040201
Among new condensed quinolines and quinazolines the design of which were inspired by anti-cancer DNA-binding alkaloids such as camptothecin and batracyclin, DNA binding tests identify the 8-methoxy-7-piperazinylpropoxyindeno[1,2-b]quinolin-11-one tetracyclic system as a new motif for DNA recognition.

1. DOCID:28377 SCORE: 0.00328310801417324
DOCNO: 15955688
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Review Literature
QUALIFIER: therapy
AUTHOR: K M Fong KM
AUTHOR: I A Yang IA
AUTHOR: P V Zimmerman PV
AUTHOR: R V Bowman RV
AFFILIATION: Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Australia. Kwun_fong@health.qld.gov.au
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Respiratory medicine.
COUNTRY: England
TITLE: Cochrane systematic reviews of treatments for lung cancer.
PUBDATE: 20050901
Morbidity and mortality from lung cancer is a major burden to global health. The integration of expert clinical experience, patient preference and high-quality evidence, including Cochrane systematic reviews, can only help improve outcomes from this highly lethal condition.

2. DOCID:28373 SCORE: 0.00328310711267359
DOCNO: 12087710
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Nurse-Patient Relations
QUALIFIER: psychology
AUTHOR: Donna Higgins D
AFFILIATION: Frimley Park Hospital NHS Trust, Surrey.
PUBTYPE: Journal Article
JOURNALTITLE: Professional nurse (London, England)
COUNTRY: England
TITLE: Breaking bad news in cancer care.
PUBDATE: 20020601
When a diagnosis of cancer, such as prostate cancer, is made nurses may be involved in presenting the news to the patient. How that news is given can make the experience a distressing or reassuring process. In the first part of this paper, the authors examines the human qualities required by professionals and the barriers to breaking bad news.

3. DOCID:28305 SCORE: 0.00328310563525725
DOCNO: 15996935
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: blood
AUTHOR: Rosanna Ciancia R
AUTHOR: Vincenzo Martinelli V
AUTHOR: Elena Cosentini E
AUTHOR: Marco Picardi M
AUTHOR: Fara Petruzziello F
AUTHOR: Elide Matano E
AUTHOR: Bruno Rotoli B
PUBTYPE: Letter
JOURNALTITLE: Haematologica.
COUNTRY: Italy
TITLE: High number of circulating CD34+ cells in patients with myelophthisis.
PUBDATE: 20050701
Six patients with bone marrow micrometastases from solid cancers presented with increased numbers of circulating CD34+ cells; the CD34+ cell counts were very high in some cases. By contrast, no patient with metastatic cancer without bone marrow involvement showed raised numbers of circulating hemopoietic progenitors.

4. DOCID:28627 SCORE: 0.00324826058141094
DOCNO: 16287993
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: antagonists & inhibitors
AUTHOR: Bradley S Miller BS
AUTHOR: Douglas Yee D
AFFILIATION: Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer research.
COUNTRY: United States
TITLE: Type I insulin-like growth factor receptor as a therapeutic target in cancer.
PUBDATE: 20051101
Data from experimental model systems and population studies have implicated type I insulin-like growth factor receptor (IGF1R) signaling in many different human cancers. Drugs to disrupt IGF1R function have been developed and are now entering clinical trial. This brief review will identify key areas to consider as these clinical trials move forward.

5. DOCID:22826 SCORE: 0.00313246548125337
DOCNO: 7773901
AUTHOR: A Mullens A
PUBTYPE: Journal Article
JOURNALTITLE: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.
COUNTRY: CANADA
TITLE: The Dutch experience with euthanasia: lessons for Canada?
PUBDATE: 19950601
Anne Mullens used a recent fellowship provided by the Atkinson Foundation to take an in-depth look at euthanasia in the Netherlands. During her time in Holland, she discussed the issue with doctors who support and oppose euthanasia. She accompanied a doctor as he visited a patient who was dying of cancer and was beginning to consider the possibility of euthanasia. She talked to a nonphysician who is adamantly opposed to euthanasia and carries a card stating that. She visited a hospital in Amsterdam that has received requests from foreigners seeking euthansia. Mullens offers a comprehensive look at an issue that continues to provoke strong feelings among Canadian physicians and patients.

6. DOCID:21463 SCORE: 0.00301199782222056
DOCNO: 7998012
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: H J Haga HJ
AUTHOR: J H Magnus JH
AFFILIATION: Revmatologisk avdeling, Regionsykehuset i Tromsø.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Tidsskrift for den Norske laegeforening.
COUNTRY: NORWAY
TITLE: [Polymyalgia rheumatica and temporal arteritis. New aspects of diagnosis, treatment, prognosis and risk of cancer]
PUBDATE: 19940901
The incidence of polymyalgia rheumatica and temporal arteritis is increasing, mainly in elderly people. The risk of cancer during a lifetime is high in patients with positive biopsy of the temporal artery, but polymyalgia rheumatica and temporal arteritis are not to be considered as paraneoplastic syndromes. Temporal arteritis can appear in patients under treatment for polymyalgia rheumatica, and polymyalgia rheumatica can be accompanied by arthritis. Various new aspects of diagnoses and treatment are discussed.

7. DOCID:19352 SCORE: 0.00290527512407835
DOCNO: 2157081
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: S Uetsuji S
AUTHOR: M Yamamura M
AUTHOR: Y Okuda Y
AUTHOR: K Yamamichi K
AUTHOR: M Yamamoto M
AFFILIATION: Dept. of Surgery, Kansai Medical Univ.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Primary liver cancer coincident with schistosomiasis japonica]
PUBDATE: 19900301
The etiologic relationship of a parasitic liver disease to primary liver cancer has long been debated, and reported is a case that has been encountered of a primary liver cancer coincident with Schistosomiasis japonica. A fifty-nine year-old-man was diagnosed as having a primary liver cancer complicated with liver cirrhosis. A posterior segmentectomy was performed and a microscopic examination revealed a primary liver cancer with multiple ovae of Schistosoma japonicum in the fibrous stroma of the portal spaces. Discussed is the etiologic relationship of Schistosomiasis japonica to the primary liver cancer.

8. DOCID:30691 SCORE: 0.00279016527388989
DOCNO: 15613443
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: R I Nicholson RI
AUTHOR: C Staka C
AUTHOR: F Boyns F
AUTHOR: I R Hutcheson IR
AUTHOR: J M W Gee JM
AFFILIATION: Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Cardiff, UK. nicholsonri@cardiff.ac.uk
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Endocrine-related cancer.
COUNTRY: England
TITLE: Growth factor-driven mechanisms associated with resistance to estrogen deprivation in breast cancer: new opportunities for therapy.
PUBDATE: 20041201
There is an increasing body of evidence demonstrating that elevated growth signaling in breast cancer cells can promote forms of endocrine resistance in either an estrogen receptor-dependent or -independent manner. The current article reviews what is known about such growth factor signaling networks and resistance to estrogen withdrawal and considers the many novel therapeutic opportunities that stem from this knowledge.

9. DOCID:30594 SCORE: 0.00279015629815176
DOCNO: 16204992
OWNER: NLM
STATUS: In-Process
AUTHOR: Atchara Tempeam A
AUTHOR: Nopporn Thasana N
AUTHOR: Chitkavee Pavaro C
AUTHOR: Wongsatit Chuakul W
AUTHOR: Pongpun Siripong P
AUTHOR: Somsak Ruchirawat S
AFFILIATION: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
PUBTYPE: Journal Article
JOURNALTITLE: Chemical & pharmaceutical bulletin.
COUNTRY: Japan
TITLE: A new cytotoxic daphnane diterpenoid, rediocide G, from Trigonostemon reidioides.
PUBDATE: 20051001
Rediocide G (7), a new daphnane diterpenoid, was isolated from the roots of Trigonostemon reidioides (Euphorbiaceae), together with two congeners, rediocide A and rediocide B, (+)-syringaresinol, scopoletin, tomentin and stigmasterol. The structure of the new natural product was elucidated by comparison of its NMR and mass spectral data with those of previously known rediocides and confirmed by extensive 2D NMR spectral analysis. Rediocide G (7) was found to be cytotoxic to various cancer cell lines.

10. DOCID:23018 SCORE: 0.00262136741733637
DOCNO: 8000210
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Nursing Assessment
DESCRIPTOR: Pain Measurement
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: nursing
AUTHOR: M McCaffery M
AUTHOR: B R Ferrell BR
PUBTYPE: Journal Article
JOURNALTITLE: Contemporary nurse : a journal for the Australian nursing profession.
COUNTRY: AUSTRALIA
TITLE: Nurses' assessment of pain intensity and choice of analgesic dose.
PUBDATE: 19940601
Under-treatment of all types of pain has been identified in many countries throughout the world. For example, the World Health Organization states that unrelieved cancer pain is an international problem. Lack of education of health care professionals, including nurses, is frequently cited as a major reason for under-treatment of pain. This survey of 517 Australian nurses suggests that they have some of the same educational needs as nurses in North America, such as how to assess pain intensity and how to select a dose of an opioid analgesic that is appropriate for the individual patient.

11. DOCID:19226 SCORE: 0.00254696228979911
DOCNO: 1593004
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Magnetic Resonance Imaging
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: A Zemtsov A
AUTHOR: J Reed J
AUTHOR: L Dixon L
AFFILIATION: Department of Dermatology and Biochemistry, Texas Tech University School of Medicine, Lubbock 79430.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of dermatologic surgery and oncology.
COUNTRY: UNITED STATES
TITLE: Magnetic resonance imaging evaluation helps to delineate a recurrent skin cancer present under the skin flap.
PUBDATE: 19920601
A case of recurrent squamous cell carcinoma under a skin flap as confirmed and delineated by magnetic resonance imaging (MRI) is described. This report illustrates a potentially new indication for MRI in clinical dermatology, namely, to define skin cancer recurrences under skin flaps and grafts and to determine the extent of underlying tissue involvement. The cost-effectiveness of MRI and the use of gadolinium, an MRI contrast agent, in the evaluation of skin tumors are also addressed.

12. DOCID:27075 SCORE: 0.00246432721845022
DOCNO: 10346965
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: isolation & purification
QUALIFIER: chemistry
QUALIFIER: pharmacology
AUTHOR: B S Yun BS
AUTHOR: I J Ryoo IJ
AUTHOR: I K Lee IK
AUTHOR: K H Park KH
AUTHOR: D H Choung DH
AUTHOR: K H Han KH
AUTHOR: I D Yoo ID
AFFILIATION: Korea Research Institute of Bioscience and Biotechnology, P.O. Box 115, Yusong, Taejon 305-600, Korea.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of natural products.
COUNTRY: UNITED STATES
TITLE: Two bioactive pentacyclic triterpene esters from the root bark of Hibiscus syriacus.
PUBDATE: 19990501
Two new triterpene caffeates have been isolated from the root bark of Hibiscus syriacus. Their structures were established through various spectral studies as 3beta,23,28-trihydroxy-12-oleanene 23-caffeate (1) and 3beta,23,28-trihydroxy-12-oleanene 3beta-caffeate (2). Compounds 1 and 2 showed lipid peroxidation inhibitory activity and significant cytotoxicity against a panel of human cancer cell lines.

13. DOCID:23462 SCORE: 0.00245430065688027
DOCNO: 9371276
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Blood Substitutes
DESCRIPTOR: Erythrocytes
QUALIFIER: methods
AUTHOR: R P Goodrich RP
AUTHOR: S O Sowemino-Coker SO
AUTHOR: R Weinstein R
AFFILIATION: Cryopharm Corporation, Pasadena, California, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in hematology.
COUNTRY: UNITED STATES
TITLE: Advances in erythrocyte preservation and hemoglobin substitutes.
PUBDATE: 19940301
The desirability of extending the therapeutic benefits of erythrocyte transfusions beyond the currently available options is well established. Extended frozen storage of rare blood types, hemoglobin-based or artificial blood substitutes for treatment of short-term deficits in oxygen-carrying capacity, novel approaches to tissue oxygenation for cancer therapy, and efficient storage and availability of erythrocytes in military field installations are all potential applications of ongoing research and development efforts. This review explains the need for improvement in erythrocyte storage and development of blood substitutes, the current problems in the field, and the progress made toward solving these problems in the past year.

14. DOCID:20190 SCORE: 0.00233682564935899
DOCNO: 9238814
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: L Juncker L
AUTHOR: J Blondon J
AUTHOR: A de Gayffier A
AFFILIATION: Service chirurgical et gynécologique, Groupe hospitalier Pitié-Salpêtrière, Paris.
PUBTYPE: Journal Article
JOURNALTITLE: La Revue du praticien.
COUNTRY: FRANCE
TITLE: [Diagnosis of cancers of the ovary]
PUBDATE: 19970601
Early diagnosis of ovarian cancer is difficult and is still a matter of chance. Diagnosis rests on pelvic examination, ultrasonography and serum CA125 levels. Surgery establishes a definitive diagnosis and allows accurate staging and primary cytoreduction. No technique suitable for routine screening is currently available.