0. DOCID:3379 SCORE: 0.00339032569469796
DOCNO: 782652
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: biosynthesis
AUTHOR: J O Drife JO
AUTHOR: D B McClelland DB
AUTHOR: A Pryde A
AUTHOR: M M Roberts MM
AUTHOR: I I Smith II
PUBTYPE: Journal Article
JOURNALTITLE: British medical journal.
COUNTRY: ENGLAND
TITLE: Immunoglobulin synthesis in the "resting" breast.
PUBDATE: 19760801
Nulliparous women have a greater risk of developing breast cancer than women who have borne children, but so far no functional differences in breast tissue have been reported between parous women and nulliparae. Macroscopically and histologically normal breast tissue was obtained from 74 women of reproductive age during biopsy of benign breast lesions and was examined for the presence of plasma cells by immunfluorescence. Immunoglobulin synthesis was detected by an in-vitro culture technique. Synthesis of IgA was detected in 81% of specimans of IgG in 45%, and of IgM in 3%. IgA synthesis much more intense than IgG or IgM synthesis. Plasma cells containing IgA were seen in 71% of the specimens examined, and 88% of specimens had deposits of IgA in the ductules. The findings were not significantly incluenced by the nature of the condition necessitating biopsy or by oral contraception. Nulliparous women showed no cyclical changes, but among parous women IgA synthesis was more intense during luteal phase of the menstrual cycle. This suggests that after the first pregnancy the breast is more sensitive to progesterone.

1. DOCID:10579 SCORE: 0.00307752590194078
DOCNO: 6297705
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosome Deletion
DESCRIPTOR: Chromosomes, Human, 13-15
QUALIFIER: complications
QUALIFIER: genetics
AUTHOR: T E Goffman TE
AUTHOR: J J Mulvihill JJ
AUTHOR: D N Carney DN
AUTHOR: T J Triche TJ
AUTHOR: J Whang-Peng J
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer genetics and cytogenetics.
COUNTRY: UNITED STATES
TITLE: Fatal hypereosinophilia with chromosome 15q- in a patient with multiple primary and familial neoplasms.
PUBDATE: 19830301
A man with large-cell carcinoma of the lung, cerebral meningioma, occult adenocarcinoma of the prostate, and follicular adenoma of the thyroid developed symptomatic, rapidly progressive hypereosinophilia with abnormalities of eosinophil ultrastructure and bone marrow karyotype (45,X,15q22-). Although the patient's eosinophilia defied strict classification as idiopathic hypereosinophilic syndrome (HES), simple tumor-associated eosinophilia, or eosinophilic leukemia, it appeared to be incited by the lung cancer and quickly acquired malignant independence. The family had an excess of prostate cancer and lymphoproliferative neoplasms.

2. DOCID:13743 SCORE: 0.00296358838907438
DOCNO: 2444099
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: ultrastructure
QUALIFIER: pathology
QUALIFIER: ultrastructure
AUTHOR: D M Jacobs DM
AUTHOR: M A Weiss MA
AFFILIATION: Department of Pathology, University of Cincinnati Medical Center, Ohio 45267.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: American journal of clinical pathology.
COUNTRY: UNITED STATES
TITLE: Basal cells of prostate in fine-needle aspiration.
PUBDATE: 19871001
Fine-needle aspiration in conjunction with a transrectal core biopsy was performed on a 58-year-old man who presented with a prostate nodule. The aspirate contained many cell clusters that were negative for prostatic acid phosphatase and cytologically appeared to be basal cells. The entity of basal cell hyperplasia of the prostate is discussed with reference to its appearance in aspiration cytologic examination. Emphasis is placed upon the possibility that these cells may be mistaken for cancer cells.

3. DOCID:7072 SCORE: 0.00287408838690663
DOCNO: 760187
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: R Killer-Walser R
AUTHOR: H Hess H
AUTHOR: T G Würsch TG
AUTHOR: K Stuby K
AUTHOR: A Sonnenberg A
AUTHOR: W Brühlmann W
AUTHOR: A L Blum AL
PUBTYPE: Journal Article
JOURNALTITLE: Schweizerische medizinische Wochenschrift.
COUNTRY: SWITZERLAND
TITLE: [Fiber endoscopy and radiology in stomach ulcer, stomach neoplasms and hiatal hernia: questions, timing and value]
PUBDATE: 19790101
In 306 patients, fiberpanendoscopy and radiology were performed within a time interval of 7 days or less. In 196 cases, radiology was performed before endoscopy and in 110 cases after endoscopy. In cases with histologically unproven divergent findings, follow-up studies were performed. In the diagnosis of gastric ulcer and gastric cancer, endoscopy with biopsy was more accurate than radiology. In the diagnosis of hiatal hernia, radiology was more accurate. Important additional findings difficult or impossible to observe with endoscopy were present in 36% of the radiological examinations. Thus, the first examination should be endoscopy when ulcer or carcinoma is suspected. In patients with uncharacteristic epigastric symptoms, radiology should be performed first.

4. DOCID:3437 SCORE: 0.00281805847615284
DOCNO: 4457397
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Endometrium
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: J E Dunn JE
PUBTYPE: Journal Article
JOURNALTITLE: Gynecologic oncology.
COUNTRY: UNITED STATES
TITLE: Geographic considerations of endometrial cancer.
PUBDATE: 19740801
There are certain problems associated with investigation of the geographic variation in the occurrence of cancer of the uterine corpus. Mortality rates are especially unsuitable for this because of the large proportion of deaths from uterine cancer which are not specified as to whether they originated in the cervix or the corpus. Incidence rates may be somewhat inflated if cytology screening is being extensively used in a population of women, but the designation between corpus and cervix is nearly complete. Incidence rates compiled by the International Union Against Cancer indicate much variation in the frequency of this cancer and that of the ovary and breast, but not with cervical cancer. In the United States southern white women tend to have cancers of the uterine corpus, breast, and ovary less frequently and of the cervix more frequently than women of the north and west. American born Japanese women are developing breast cancer nearly as frequently in California as white women, which may also be true for ovarian cancer. Uterine corpus cancer may be increasing but the population is still too young, since this cancer reaches its highest rates at older ages. All these cancers are less frequent in Japan.

5. DOCID:7855 SCORE: 0.00278334834466423
DOCNO: 582494
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Food Habits
DESCRIPTOR: Vitamin A
QUALIFIER: etiology
AUTHOR: C Mettlin C
AUTHOR: S Graham S
PUBTYPE: Journal Article
JOURNALTITLE: American journal of epidemiology.
COUNTRY: UNITED STATES
TITLE: Dietary risk factors in human bladder cancer.
PUBDATE: 19790901
Retrospective data on dietary habits, employment history and tobacco use were obtained from 569 bladder cancer patients and 1025 age-matched controls admitted to Roswell Park Memorial Institute. Sex-adjusted relative risks revealed increases in risk for lower levels of an index of vitamin A intake. A similar pattern of risk elevation was associated with infrequent milk and carrot intake. Some elevation of risk was found for heavy coffee drinking but the apparent protective effect for milk consumption was not found to be a spurious result of lower coffee intake. Neither was the role of vitamin A explained by its relationship with smoking or employment in high risk occupations. Some association of bladder cancer with infrequent consumption of cruciferous vegetables was also observed. The findings of this investigation are consistent with tumor inhibition by retinoids in animal studies and the low risk associated with vitamin A in epidemiologic studies of lung cancer.

6. DOCID:11065 SCORE: 0.00270413365919373
DOCNO: 4054832
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: J T Emerman JT
AUTHOR: M Leahy M
AUTHOR: P W Gout PW
AUTHOR: N Bruchovsky N
PUBTYPE: Journal Article
JOURNALTITLE: Hormone and metabolic research. Hormon- und Stoffwechselforschung. Hormones et métabolisme.
COUNTRY: GERMANY, WEST
TITLE: Elevated growth hormone levels in sera from breast cancer patients.
PUBDATE: 19850801
The concentrations of growth hormone (GH) and prolactin (PRL) in the serum of 42 breast cancer patients were determined by radioimmunoassay (RIA). Forty percent of the patients had elevated GH levels while only 17% had elevated PRL levels. These findings suggest a relationship between GH and breast cancer; a weaker correlation exists between PRL and this malignancy. In addition, total lactogens in the serum were measured by a bioassay (BA). The BA/RIA (GH + PRL) ratio was greater in the breast cancer patients than the controls, indicating that variant forms of the hormones with higher than normal biological activity might be present.

7. DOCID:7724 SCORE: 0.0025962249776749
DOCNO: 464805
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ultrasonography
QUALIFIER: prevention & control
QUALIFIER: analysis
QUALIFIER: prevention & control
AUTHOR: C R Mackie CR
AUTHOR: J Bowie J
AUTHOR: M J Cooper MJ
AUTHOR: M H Lewis MH
AUTHOR: A R Moossa AR
PUBTYPE: Journal Article
JOURNALTITLE: Archives of surgery (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Ultrasonography and tumor-associated antigens. The concept of combining noninvasive tests in the screening for pancreatic cancer.
PUBDATE: 19790801
A total of 134 patients suspected of having pancreatic cancer were given preoperative ultrasonic examinations. A total of 54 cases had a final diagnosis of pancreatic cancer histologically confirmed. The diagnostic sensitivity and specificity of the ultrasonographies were 76% and 91% or 87% and 74%, depending on whether doubtful results were called abnormal or normal. "Doubtful" results were defined as those that stated that pancreatic cancer was "possible" or "could not be excluded." When these results were divided into abnormal and normal groups on the basis of the patients' preoperative serum carcinoembryonic antigen and pancreatic oncofetal antigen levels, the sensitivity and specificity of the combined tests may prove to be a more accurate means of screening patients for pancreatic cancer than ultrasonography alone.

8. DOCID:5265 SCORE: 0.00247049859280808
DOCNO: 7379661
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Age Factors
QUALIFIER: epidemiology
AUTHOR: I L Horovitz IL
AUTHOR: M Huber M
PUBTYPE: Journal Article
JOURNALTITLE: Diseases of the colon and rectum.
COUNTRY: UNITED STATES
TITLE: Cancer of the colon: a study of age-related incidence.
PUBDATE: 19800301
Incidence of colorectal cancer in Israel was studied in 1035 patients who were divided by ethno-geography into a Euro-American group and an Afro-Asian group. The majority of patients were in the age groups over 50 years, with a markedly higher incidence rate of disease in the Euro-American group. In the younger age group the incidence rate of the disease was significantly higher in the Afro-Asian group. These findings, if verified by others, must lead to revision of our present concepts of epidemiology of colorectal cancer.

9. DOCID:14383 SCORE: 0.00238870829590125
DOCNO: 3471994
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: S R Alberts SR
AUTHOR: A P Lanier AP
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Leukemia, lymphoma, and multiple myeloma in Alaskan natives.
PUBDATE: 19870501
All Alaskan Native patients diagnosed with leukemia, lymphoma, multiple myeloma, and related cancers during the time period 1969-83 were identified. Of 72 biopsy-confirmed cases, lymphoma was diagnosed in 37 (including mycosis fungoides in 5), leukemia in 22, multiple myeloma in 11, and other lymphoreticular cancers in 2. Compared to the rates for U.S. whites, incidence rates were low for leukemia and lymphoma (especially Hodgkin's disease), but not for multiple myeloma in males. There was an apparent increase over time in lymphomas in males, while no increase occurred in females, nor for leukemia or multiple myeloma in either sex.

10. DOCID:15930 SCORE: 0.00236411138884898
DOCNO: 3012138
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: N Sakai N
AUTHOR: S Tanaka S
AUTHOR: T Ito T
AUTHOR: K Matsumura K
AUTHOR: T Takekoshi T
AUTHOR: H Ohshita H
AUTHOR: O Nonomura O
AUTHOR: M Kato M
AUTHOR: H Kachi H
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Primary diffused infiltrating (linitis plastica) type of colonic cancer--case report]
PUBDATE: 19860301
The primary diffused infiltrating type of colonic cancer is characteristically rare, and has a high rate of malignancy. A 54-year-old Japanese man was admitted to our hospital complaining of abdominal pain and decreased stools. Sigmoid colonic cancer was suspected as a result of the Ba-enema and colonic fiberscopy examination, but the biopsy results were negative. The sigmoid colon was resected extensively. Histopathologically, the cancer was diagnosed as being a signet ring-cell carcinoma of the sigmoid colon. Although the patient received postoperative chemotherapy, he died of carcinomata peritonitis 175 days after surgery.

11. DOCID:15773 SCORE: 0.00231965374587917
DOCNO: 2511322
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: R A Smith RA
AUTHOR: M W Lockey MW
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the Mississippi State Medical Association.
COUNTRY: UNITED STATES
TITLE: Carcinoma in situ and T-1 squamous cell carcinoma of the glottis: the Mississippi Baptist Medical Center experience.
PUBDATE: 19891101
This report is a retrospective analysis of 62 patients treated for early glottic carcinoma during the six-year period of January 1982 through December 1987. The authors report that the cancer has been controlled in 100% of patients. For invasive stage 1 tumors the radiation cure rate is 42 of 45 patients or 93%, and voice quality after treatment was usually normal. Surgically treated tumors are usually confined to one vocal cord. Primary surgery with laser or cord stripping ultimately led to tumor control and voice preservation in all eleven patients treated although two required salvage with radiotherapy and mild but acceptable hoarseness was a usual sequel.

12. DOCID:9726 SCORE: 0.00230137749579058
DOCNO: 6142253
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: J Cuzick J
AUTHOR: R Harris R
AUTHOR: P S Mortimer PS
PUBTYPE: Journal Article
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: Palmar keratoses and cancers of the bladder and lung.
PUBDATE: 19840301
In a case control study of the prevalence of palmar keratoses in 69 bladder cancer patients, 66 lung cancer patients, and 218 hospital controls palmar keratoses were more common in the cases, especially among those with cancer of the bladder. Above the age of 50 years, 87% of bladder cancer patients and 71% of lung cancer patients but only 36% of the controls had one or more keratoses. The prevalence increased with age and keratoses were more common in males. No features could be found which distinguished the keratoses in cases from those in controls.

13. DOCID:4464 SCORE: 0.00228738509547606
DOCNO: 417987
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: R Schrage R
PUBTYPE: Journal Article
JOURNALTITLE: Fortschritte der Medizin.
COUNTRY: GERMANY, WEST
TITLE: [Problems of current diagnosis of neoplasms in women]
PUBDATE: 19780501
The value of early cancer detection in women is limited by the screening methods and their minor reliability in "mass-screening". The effect of detection programs is difficult to demonstrate. The interest in cancer detection is low, especially in elderly high risk patients. A more suitable application of screening tests with widespread indication of further methods together with exact demonstration could be the basis for better results in early cancer detection programs in women.

14. DOCID:3508 SCORE: 0.00222676758080196
DOCNO: 865367
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Blood Transfusion
DESCRIPTOR: Leukocyte Transfusion
QUALIFIER: complications
QUALIFIER: therapeutic use
QUALIFIER: therapy
QUALIFIER: transplantation
QUALIFIER: therapy
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: J F Bishop JF
AUTHOR: R McLennan R
AUTHOR: M G Whiteside MG
PUBTYPE: Journal Article
JOURNALTITLE: The Medical journal of Australia.
COUNTRY: AUSTRALIA
TITLE: The management of febrile episodes in-neutropenic cancer.
PUBDATE: 19770401
The management of 33 febrile episodes in neutropenic patients suffering from acute leukaemia and other cancers is described. In 32 out of 33 episodes, the fever subsided. One patient died of cerebral haemorrhage while infected. The most common clinical sites of infection were, in order of frequency, the chest, the throat and the skin. Positive cultures were obtained in about half the episodes, the most common site being the throat followed by blood and sputum. The most common organisms isolated were Gram negative. Eighty-four per cent of febrile episodes occurred with neutrophil counts of less than 500/mm3, and in the majority of these, less than 100 neutrophils per cubic millmetre. All patients were reverse barrier nursed and on becoming febrile were given 48 hours of parenteral antibiotic therapy. The most common antibiotic combination used was gentamicin and cephalothin. At 48 hours, granulocyte transfusion and a third antibiotic were added to the regimen of patients not responding. The percentage response to antibiotics alone, in this series, at 58% was similar to that of other series, but the mortality experienced was lower.