0. DOCID:29894 SCORE: 0.00390258738703932
DOCNO: 14738975
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: chemical synthesis
QUALIFIER: metabolism
QUALIFIER: chemical synthesis
QUALIFIER: metabolism
AUTHOR: Natacha Malecki N
AUTHOR: Pascal Carato P
AUTHOR: Benoît Rigo B
AUTHOR: Jean-François Goossens JF
AUTHOR: Raymond Houssin R
AUTHOR: Christian Bailly C
AUTHOR: Jean-Pierre Hénichart JP
AFFILIATION: Institut de Chimie Pharmaceutique Albert Lespagnol, Université de Lille 2, EA 2692, 3 rue du Professeur Laguesse, BP 83, F-59006 Lille, France.
PUBTYPE: Journal Article
JOURNALTITLE: Bioorganic & medicinal chemistry.
COUNTRY: England
TITLE: Synthesis of condensed quinolines and quinazolines as DNA ligands.
PUBDATE: 20040201
Among new condensed quinolines and quinazolines the design of which were inspired by anti-cancer DNA-binding alkaloids such as camptothecin and batracyclin, DNA binding tests identify the 8-methoxy-7-piperazinylpropoxyindeno[1,2-b]quinolin-11-one tetracyclic system as a new motif for DNA recognition.

1. DOCID:3379 SCORE: 0.00339032569469796
DOCNO: 782652
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: biosynthesis
AUTHOR: J O Drife JO
AUTHOR: D B McClelland DB
AUTHOR: A Pryde A
AUTHOR: M M Roberts MM
AUTHOR: I I Smith II
PUBTYPE: Journal Article
JOURNALTITLE: British medical journal.
COUNTRY: ENGLAND
TITLE: Immunoglobulin synthesis in the "resting" breast.
PUBDATE: 19760801
Nulliparous women have a greater risk of developing breast cancer than women who have borne children, but so far no functional differences in breast tissue have been reported between parous women and nulliparae. Macroscopically and histologically normal breast tissue was obtained from 74 women of reproductive age during biopsy of benign breast lesions and was examined for the presence of plasma cells by immunfluorescence. Immunoglobulin synthesis was detected by an in-vitro culture technique. Synthesis of IgA was detected in 81% of specimans of IgG in 45%, and of IgM in 3%. IgA synthesis much more intense than IgG or IgM synthesis. Plasma cells containing IgA were seen in 71% of the specimens examined, and 88% of specimens had deposits of IgA in the ductules. The findings were not significantly incluenced by the nature of the condition necessitating biopsy or by oral contraception. Nulliparous women showed no cyclical changes, but among parous women IgA synthesis was more intense during luteal phase of the menstrual cycle. This suggests that after the first pregnancy the breast is more sensitive to progesterone.

2. DOCID:28377 SCORE: 0.00328310801417324
DOCNO: 15955688
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Review Literature
QUALIFIER: therapy
AUTHOR: K M Fong KM
AUTHOR: I A Yang IA
AUTHOR: P V Zimmerman PV
AUTHOR: R V Bowman RV
AFFILIATION: Department of Thoracic Medicine, The Prince Charles Hospital, Brisbane, Australia. Kwun_fong@health.qld.gov.au
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Respiratory medicine.
COUNTRY: England
TITLE: Cochrane systematic reviews of treatments for lung cancer.
PUBDATE: 20050901
Morbidity and mortality from lung cancer is a major burden to global health. The integration of expert clinical experience, patient preference and high-quality evidence, including Cochrane systematic reviews, can only help improve outcomes from this highly lethal condition.

3. DOCID:28373 SCORE: 0.00328310711267359
DOCNO: 12087710
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Nurse-Patient Relations
QUALIFIER: psychology
AUTHOR: Donna Higgins D
AFFILIATION: Frimley Park Hospital NHS Trust, Surrey.
PUBTYPE: Journal Article
JOURNALTITLE: Professional nurse (London, England)
COUNTRY: England
TITLE: Breaking bad news in cancer care.
PUBDATE: 20020601
When a diagnosis of cancer, such as prostate cancer, is made nurses may be involved in presenting the news to the patient. How that news is given can make the experience a distressing or reassuring process. In the first part of this paper, the authors examines the human qualities required by professionals and the barriers to breaking bad news.

4. DOCID:28305 SCORE: 0.00328310563525725
DOCNO: 15996935
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: blood
AUTHOR: Rosanna Ciancia R
AUTHOR: Vincenzo Martinelli V
AUTHOR: Elena Cosentini E
AUTHOR: Marco Picardi M
AUTHOR: Fara Petruzziello F
AUTHOR: Elide Matano E
AUTHOR: Bruno Rotoli B
PUBTYPE: Letter
JOURNALTITLE: Haematologica.
COUNTRY: Italy
TITLE: High number of circulating CD34+ cells in patients with myelophthisis.
PUBDATE: 20050701
Six patients with bone marrow micrometastases from solid cancers presented with increased numbers of circulating CD34+ cells; the CD34+ cell counts were very high in some cases. By contrast, no patient with metastatic cancer without bone marrow involvement showed raised numbers of circulating hemopoietic progenitors.

5. DOCID:28627 SCORE: 0.00324826058141094
DOCNO: 16287993
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: antagonists & inhibitors
AUTHOR: Bradley S Miller BS
AUTHOR: Douglas Yee D
AFFILIATION: Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer research.
COUNTRY: United States
TITLE: Type I insulin-like growth factor receptor as a therapeutic target in cancer.
PUBDATE: 20051101
Data from experimental model systems and population studies have implicated type I insulin-like growth factor receptor (IGF1R) signaling in many different human cancers. Drugs to disrupt IGF1R function have been developed and are now entering clinical trial. This brief review will identify key areas to consider as these clinical trials move forward.

6. DOCID:22826 SCORE: 0.00313246548125337
DOCNO: 7773901
AUTHOR: A Mullens A
PUBTYPE: Journal Article
JOURNALTITLE: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.
COUNTRY: CANADA
TITLE: The Dutch experience with euthanasia: lessons for Canada?
PUBDATE: 19950601
Anne Mullens used a recent fellowship provided by the Atkinson Foundation to take an in-depth look at euthanasia in the Netherlands. During her time in Holland, she discussed the issue with doctors who support and oppose euthanasia. She accompanied a doctor as he visited a patient who was dying of cancer and was beginning to consider the possibility of euthanasia. She talked to a nonphysician who is adamantly opposed to euthanasia and carries a card stating that. She visited a hospital in Amsterdam that has received requests from foreigners seeking euthansia. Mullens offers a comprehensive look at an issue that continues to provoke strong feelings among Canadian physicians and patients.

7. DOCID:10579 SCORE: 0.00307752590194078
DOCNO: 6297705
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosome Deletion
DESCRIPTOR: Chromosomes, Human, 13-15
QUALIFIER: complications
QUALIFIER: genetics
AUTHOR: T E Goffman TE
AUTHOR: J J Mulvihill JJ
AUTHOR: D N Carney DN
AUTHOR: T J Triche TJ
AUTHOR: J Whang-Peng J
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer genetics and cytogenetics.
COUNTRY: UNITED STATES
TITLE: Fatal hypereosinophilia with chromosome 15q- in a patient with multiple primary and familial neoplasms.
PUBDATE: 19830301
A man with large-cell carcinoma of the lung, cerebral meningioma, occult adenocarcinoma of the prostate, and follicular adenoma of the thyroid developed symptomatic, rapidly progressive hypereosinophilia with abnormalities of eosinophil ultrastructure and bone marrow karyotype (45,X,15q22-). Although the patient's eosinophilia defied strict classification as idiopathic hypereosinophilic syndrome (HES), simple tumor-associated eosinophilia, or eosinophilic leukemia, it appeared to be incited by the lung cancer and quickly acquired malignant independence. The family had an excess of prostate cancer and lymphoproliferative neoplasms.

8. DOCID:21463 SCORE: 0.00301199782222056
DOCNO: 7998012
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: H J Haga HJ
AUTHOR: J H Magnus JH
AFFILIATION: Revmatologisk avdeling, Regionsykehuset i Tromsø.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Tidsskrift for den Norske laegeforening.
COUNTRY: NORWAY
TITLE: [Polymyalgia rheumatica and temporal arteritis. New aspects of diagnosis, treatment, prognosis and risk of cancer]
PUBDATE: 19940901
The incidence of polymyalgia rheumatica and temporal arteritis is increasing, mainly in elderly people. The risk of cancer during a lifetime is high in patients with positive biopsy of the temporal artery, but polymyalgia rheumatica and temporal arteritis are not to be considered as paraneoplastic syndromes. Temporal arteritis can appear in patients under treatment for polymyalgia rheumatica, and polymyalgia rheumatica can be accompanied by arthritis. Various new aspects of diagnoses and treatment are discussed.

9. DOCID:13743 SCORE: 0.00296358838907438
DOCNO: 2444099
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: ultrastructure
QUALIFIER: pathology
QUALIFIER: ultrastructure
AUTHOR: D M Jacobs DM
AUTHOR: M A Weiss MA
AFFILIATION: Department of Pathology, University of Cincinnati Medical Center, Ohio 45267.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: American journal of clinical pathology.
COUNTRY: UNITED STATES
TITLE: Basal cells of prostate in fine-needle aspiration.
PUBDATE: 19871001
Fine-needle aspiration in conjunction with a transrectal core biopsy was performed on a 58-year-old man who presented with a prostate nodule. The aspirate contained many cell clusters that were negative for prostatic acid phosphatase and cytologically appeared to be basal cells. The entity of basal cell hyperplasia of the prostate is discussed with reference to its appearance in aspiration cytologic examination. Emphasis is placed upon the possibility that these cells may be mistaken for cancer cells.

10. DOCID:19352 SCORE: 0.00290527512407835
DOCNO: 2157081
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
AUTHOR: S Uetsuji S
AUTHOR: M Yamamura M
AUTHOR: Y Okuda Y
AUTHOR: K Yamamichi K
AUTHOR: M Yamamoto M
AFFILIATION: Dept. of Surgery, Kansai Medical Univ.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Primary liver cancer coincident with schistosomiasis japonica]
PUBDATE: 19900301
The etiologic relationship of a parasitic liver disease to primary liver cancer has long been debated, and reported is a case that has been encountered of a primary liver cancer coincident with Schistosomiasis japonica. A fifty-nine year-old-man was diagnosed as having a primary liver cancer complicated with liver cirrhosis. A posterior segmentectomy was performed and a microscopic examination revealed a primary liver cancer with multiple ovae of Schistosoma japonicum in the fibrous stroma of the portal spaces. Discussed is the etiologic relationship of Schistosomiasis japonica to the primary liver cancer.

11. DOCID:7072 SCORE: 0.00287408838690663
DOCNO: 760187
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: R Killer-Walser R
AUTHOR: H Hess H
AUTHOR: T G Würsch TG
AUTHOR: K Stuby K
AUTHOR: A Sonnenberg A
AUTHOR: W Brühlmann W
AUTHOR: A L Blum AL
PUBTYPE: Journal Article
JOURNALTITLE: Schweizerische medizinische Wochenschrift.
COUNTRY: SWITZERLAND
TITLE: [Fiber endoscopy and radiology in stomach ulcer, stomach neoplasms and hiatal hernia: questions, timing and value]
PUBDATE: 19790101
In 306 patients, fiberpanendoscopy and radiology were performed within a time interval of 7 days or less. In 196 cases, radiology was performed before endoscopy and in 110 cases after endoscopy. In cases with histologically unproven divergent findings, follow-up studies were performed. In the diagnosis of gastric ulcer and gastric cancer, endoscopy with biopsy was more accurate than radiology. In the diagnosis of hiatal hernia, radiology was more accurate. Important additional findings difficult or impossible to observe with endoscopy were present in 36% of the radiological examinations. Thus, the first examination should be endoscopy when ulcer or carcinoma is suspected. In patients with uncharacteristic epigastric symptoms, radiology should be performed first.

12. DOCID:3437 SCORE: 0.00281805847615284
DOCNO: 4457397
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Endometrium
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: J E Dunn JE
PUBTYPE: Journal Article
JOURNALTITLE: Gynecologic oncology.
COUNTRY: UNITED STATES
TITLE: Geographic considerations of endometrial cancer.
PUBDATE: 19740801
There are certain problems associated with investigation of the geographic variation in the occurrence of cancer of the uterine corpus. Mortality rates are especially unsuitable for this because of the large proportion of deaths from uterine cancer which are not specified as to whether they originated in the cervix or the corpus. Incidence rates may be somewhat inflated if cytology screening is being extensively used in a population of women, but the designation between corpus and cervix is nearly complete. Incidence rates compiled by the International Union Against Cancer indicate much variation in the frequency of this cancer and that of the ovary and breast, but not with cervical cancer. In the United States southern white women tend to have cancers of the uterine corpus, breast, and ovary less frequently and of the cervix more frequently than women of the north and west. American born Japanese women are developing breast cancer nearly as frequently in California as white women, which may also be true for ovarian cancer. Uterine corpus cancer may be increasing but the population is still too young, since this cancer reaches its highest rates at older ages. All these cancers are less frequent in Japan.

13. DOCID:30691 SCORE: 0.00279016527388989
DOCNO: 15613443
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: R I Nicholson RI
AUTHOR: C Staka C
AUTHOR: F Boyns F
AUTHOR: I R Hutcheson IR
AUTHOR: J M W Gee JM
AFFILIATION: Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Cardiff, UK. nicholsonri@cardiff.ac.uk
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Endocrine-related cancer.
COUNTRY: England
TITLE: Growth factor-driven mechanisms associated with resistance to estrogen deprivation in breast cancer: new opportunities for therapy.
PUBDATE: 20041201
There is an increasing body of evidence demonstrating that elevated growth signaling in breast cancer cells can promote forms of endocrine resistance in either an estrogen receptor-dependent or -independent manner. The current article reviews what is known about such growth factor signaling networks and resistance to estrogen withdrawal and considers the many novel therapeutic opportunities that stem from this knowledge.

14. DOCID:30594 SCORE: 0.00279015629815176
DOCNO: 16204992
OWNER: NLM
STATUS: In-Process
AUTHOR: Atchara Tempeam A
AUTHOR: Nopporn Thasana N
AUTHOR: Chitkavee Pavaro C
AUTHOR: Wongsatit Chuakul W
AUTHOR: Pongpun Siripong P
AUTHOR: Somsak Ruchirawat S
AFFILIATION: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Mahidol University, Bangkok, Thailand.
PUBTYPE: Journal Article
JOURNALTITLE: Chemical & pharmaceutical bulletin.
COUNTRY: Japan
TITLE: A new cytotoxic daphnane diterpenoid, rediocide G, from Trigonostemon reidioides.
PUBDATE: 20051001
Rediocide G (7), a new daphnane diterpenoid, was isolated from the roots of Trigonostemon reidioides (Euphorbiaceae), together with two congeners, rediocide A and rediocide B, (+)-syringaresinol, scopoletin, tomentin and stigmasterol. The structure of the new natural product was elucidated by comparison of its NMR and mass spectral data with those of previously known rediocides and confirmed by extensive 2D NMR spectral analysis. Rediocide G (7) was found to be cytotoxic to various cancer cell lines.