0. DOCID:29337 SCORE: 0.0030955967561268
DOCNO: 16474761
OWNER: NLM
STATUS: In-Data-Review
AUTHOR: Michael W Kattan MW
AFFILIATION: MW Kattan is Chairman of the Department of Quantitative Health Sciences at the Cleveland Clinic Foundation, OH, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Nature clinical practice. Urology.
COUNTRY: United States
TITLE: When and how to use informatics tools in caring for urologic patients.
PUBDATE: 20050401
Making predictions is an essential part of any medical decision. It is particularly crucial when considering treatment of clinically localized prostate cancer. Nomograms and prediction model software typically provide the most accurate predictions. Many nomograms have been developed, for all prostate cancer clinical states. Some of these are discussed in this review, as is their utility in facilitating decision making and informed consent.

1. DOCID:28879 SCORE: 0.00309557839384329
DOCNO: 16354327
OWNER: NLM
STATUS: In-Process
AUTHOR: Luciano Wannesson L
AUTHOR: Franco Cavalli F
AUTHOR: Emmanuele Zucca E
AFFILIATION: Department of Medical Oncology, Institute of Southern Switzerland, Bellinzona, Switzerland.
PUBTYPE: Journal Article
JOURNALTITLE: Clinical lymphoma & myeloma.
COUNTRY: United States
TITLE: Primary pulmonary lymphoma: current status.
PUBDATE: 20051101
Primary pulmonary lymphoma (PPL) is a rare disease with a favorable prognosis compared with lung cancer. Although a number of histologic variables of B- and T-cell lymphoma were reported as PPL, marginal zone lymphoma of the mucosa-associated lymphoid tissue type is by far the most frequent diagnosis. This review summarizes the present knowledge of histopathology, molecular biology, diagnosis, prognosis, and treatment of this heterogeneous entity.

2. DOCID:29784 SCORE: 0.00208402315740498
DOCNO: 15841168
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: therapy
QUALIFIER: genetics
QUALIFIER: therapy
AUTHOR: Yakov Chudnovsky Y
AUTHOR: Paul A Khavari PA
AUTHOR: Amy E Adams AE
AFFILIATION: Veterans Affairs Palo Alto Healthcare System, Palo Alto, California, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Journal of clinical investigation.
COUNTRY: United States
TITLE: Melanoma genetics and the development of rational therapeutics.
PUBDATE: 20050401
Melanoma is a cancer of the neural crest-derived cells that provide pigmentation to skin and other tissues. Over the past 4 decades, the incidence of melanoma has increased more rapidly than that of any other malignancy in the United States. No current treatments substantially enhance patient survival once metastasis has occurred. This review focuses on recent insights into melanoma genetics and new therapeutic approaches being developed based on these advances.

3. DOCID:31496 SCORE: 0.0017791893615121
DOCNO: 15991629
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: Khalil Zaman K
AUTHOR: Nicholas Ketterer N
AUTHOR: Diane Vulliémoz D
AUTHOR: Roger Stupp R
AUTHOR: Serge Leyvraz S
AFFILIATION: Fondation du Centre pluridisciplinaire d'oncologie, CHUV, 1011 Lausanne. Khalil.Zaman@hospvd.ch
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Revue médicale suisse.
COUNTRY: Switzerland
TITLE: [New systemic therapies in oncology]
PUBDATE: 20050501
These last decades showed important progress in cancer systemic therapies. A better understanding of the differences between cancer cells and normal cells lead to the emergence of targeted therapies. These treatments interfere with different specific molecules playing a critical role in tumour growth or progression. On the other side, thanks to the development of new therapeutic substances, new modes of administration and to the improvement of supportive care, conventional chemotherapy is more effective and less toxic. The following review summarizes current progress with clinical impact observed these last years.

4. DOCID:28891 SCORE: 0.00174204263990916
DOCNO: 15211821
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: metabolism
QUALIFIER: epidemiology
AUTHOR: Junfang Wang J
AUTHOR: Chengyu Huang C
AUTHOR: Sihan Li S
AFFILIATION: Huaxi School of Public Health, Sichuan University, Chengdu 610041, China.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Wei sheng yan jiu = Journal of hygiene research.
COUNTRY: China
TITLE: [Research progress on dietary fat and the development of lung cancer]
PUBDATE: 20040501
The epidemiological studies showed close relations between dietary fat and lung cancer, but large gaps still exist in understanding. There were no mechanical indications to confirm some conclusions. In this paper, the possible mechanisms including imbalance of fatty acid ratios, insulin resistance, lipids peroxidation, endocrine mechanism, cytokine abnormality and membrane fluidity changes were reviewed.

5. DOCID:30579 SCORE: 0.00171709121623254
DOCNO: 16266579
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: trends
AUTHOR: Ole Kronborg O
AFFILIATION: Odense Universitetshospital, Kirurgisk Afdeling A. ole.kronborg@dadlnet.dk
PUBTYPE: Journal Article
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: Denmark
TITLE: [Future perspectives in screening for colorectal cancer]
PUBDATE: 20051001
Based on international experience, pilot studies with fecal occult blood tests and colonoscopy in those with blood in the stools are now to be performed in Scandinavia in limited geographic areas before introducing countrywide screening. The Danish State has offered to pay for feasibility studies in two counties. Provided that the results of randomised clinical trials are reproduced according to acceptability and stage of the cancer found and the organisation is feasible, it will then be possible to evaluate newer technologies as well as other methods which have not previously been evaluated in a satisfactory way.

6. DOCID:30481 SCORE: 0.00171708828661897
DOCNO: 16266579
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: trends
AUTHOR: Ole Kronborg O
AFFILIATION: Odense Universitetshospital, Kirurgisk Afdeling A. ole.kronborg@dadlnet.dk
PUBTYPE: Journal Article
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: Denmark
TITLE: [Future perspectives in screening for colorectal cancer]
PUBDATE: 20051001
Based on international experience, pilot studies with fecal occult blood tests and colonoscopy in those with blood in the stools are now to be performed in Scandinavia in limited geographic areas before introducing countrywide screening. The Danish State has offered to pay for feasibility studies in two counties. Provided that the results of randomised clinical trials are reproduced according to acceptability and stage of the cancer found and the organisation is feasible, it will then be possible to evaluate newer technologies as well as other methods which have not previously been evaluated in a satisfactory way.

7. DOCID:31505 SCORE: 0.00171427972498326
DOCNO: 15830466
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemical synthesis
QUALIFIER: pharmacology
QUALIFIER: chemistry
QUALIFIER: pharmacology
QUALIFIER: chemistry
QUALIFIER: pharmacology
QUALIFIER: chemistry
AUTHOR: M Laronze M
AUTHOR: M Boisbrun M
AUTHOR: S Léonce S
AUTHOR: B Pfeiffer B
AUTHOR: P Renard P
AUTHOR: O Lozach O
AUTHOR: L Meijer L
AUTHOR: A Lansiaux A
AUTHOR: C Bailly C
AUTHOR: J Sapi J
AUTHOR: J-Y Laronze JY
AFFILIATION: CNRS FRE 2715 'Isolement, Structure, Transformations et Synthèse de Produits Naturels', IFR 53, Faculté de Pharmacie, 51 Rue Cognacq Jay, 51096 Reims cedex, France. marie.laronze@univ-reims.fr
PUBTYPE: Journal Article
JOURNALTITLE: Bioorganic & medicinal chemistry.
COUNTRY: England
TITLE: Synthesis and anticancer activity of new pyrrolocarbazoles and pyrrolo-beta-carbolines.
PUBDATE: 20050301
'Bended' 1, 3 or 'linear' 2 pyrrolidino-fused (aza)carbazoles were prepared and screened towards a few cancer-related targets. Whereas 'bended' derivatives 1 and 3 proved to be weakly toxic, several members of the 'linear' family strongly interact with DNA, especially derivative 28a.

8. DOCID:28819 SCORE: 0.00170965940475076
DOCNO: 12070461
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: secondary
QUALIFIER: secondary
AUTHOR: V Gentile V
AUTHOR: G Mariotti G
AUTHOR: F Fattore F
AUTHOR: A Cardi A
AUTHOR: F Di Silverio F
AFFILIATION: Dipartimento di Urologia U. Bracci, Università degli Studi di Roma La Sapienza, Rome, Italy.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Minerva urologica e nefrologica = The Italian journal of urology and nephrology.
COUNTRY: Italy
TITLE: [Penile metastasis from bladder cancer. A case report]
PUBDATE: 20020601
Penile metastases from bladder cancer are unusual. A case of a man, 50 years old, with undifferentiated bladder carcinoma submitted to radical cystoprostatectomy and ileal conduit is presented. Twelve months after the primary diagnosis the patient presented metastases of the penis.

9. DOCID:30957 SCORE: 0.00161032636623584
DOCNO: 15086060
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: therapy
AUTHOR: Philippe Rougier P
AUTHOR: Marie-Christine Clavero-Fabri MC
AUTHOR: Emmanuel Mitry E
AFFILIATION: Hépato-gastro-entérologie, oncologie digestive, hôpital Ambroise Paré, 92104 Boulogne. philippe.rougier@apr.ap-hop-paris.fr
PUBTYPE: Journal Article
JOURNALTITLE: La Revue du praticien.
COUNTRY: France
TITLE: [Colorectal cancer management]
PUBDATE: 20040101
Colorectal cancer is a frequent disease with an increasing incidence. Its prognosis improved recently because of progress in diagnostic and therapeutic procedures. Rationale and guidelines for colorectal cancer screening using the faecal occult blood test in the average risk population and screening recommendations for high risk groups are presented, as well as diagnostic and therapeutic principles. Because of the efficacy of the new chemotherapy regimens, the availability of biotherapies and the fact that surgery can potentially cure more and more patients, colorectal cancer management needs to be multidisciplinary.

10. DOCID:31503 SCORE: 0.00158355977505418
DOCNO: 15850673
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Base Pair Mismatch
QUALIFIER: physiology
QUALIFIER: genetics
AUTHOR: Simona Francisconi S
AUTHOR: Mara Codenotti M
AUTHOR: Giulia Ferrari-Toninelli G
AUTHOR: Daniela Uberti D
AUTHOR: Maurizio Memo M
AFFILIATION: Department of Biomedical Sciences and Biotechnologies, University of Brescia, Medical School, Italy.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Brain research. Brain research reviews.
COUNTRY: Netherlands
TITLE: Preservation of DNA integrity and neuronal degeneration.
PUBDATE: 20050401
The mismatch repair system (MMR) is an important member of the DNA checkpoint, that includes a number of protein deputed to control genomic stability through cell cycle arrest, DNA repair, and apoptosis. Here we summarize some recent data from our and other groups underlining the contribution to neurodegeneration of MSH2, perhaps the most relevant component of the MMR system. These data suggest that this protein participates not only in the cancer prevention machinery for the body but also in neurodegenerative processes.

11. DOCID:31313 SCORE: 0.0015797503510837
DOCNO: 12440163
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Maxillofacial Prosthesis Implantation
DESCRIPTOR: Palatal Obturators
DESCRIPTOR: Reconstructive Surgical Procedures
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: Kengo Nishimoto K
AUTHOR: Mituaki Iwamoto M
AUTHOR: Atuko Karaki A
AUTHOR: Yasuhiro Nishi Y
AUTHOR: Yasuhiko Morita Y
AUTHOR: Yuichi Kurono Y
AFFILIATION: Department of Otolaryngology, Faculty of Medicine, Kagoshima University, Kagoshima.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Nippon Jibiinkoka Gakkai kaiho.
COUNTRY: Japan
TITLE: [Application of prosthetic replacement for bilateral maxillectomy defect]
PUBDATE: 20021001
A 59-year-old woman with large hard palate cancer underwent surgical resection. We constructed a maxillary prosthesis to be connected to the patient's mandibular denture. Bilateral maxillectomy resulted in total loss of the hard palate and bilateral alveolar and partial loss of the soft palate. A obturator prosthesis was prepared beforehand to fit the surgical cavity. The patient recovered functional speech and swallowing at a relatively early stage, achieving satisfactory cosmetic results.

12. DOCID:30716 SCORE: 0.00145720629812924
DOCNO: 15638768
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: Arya Biragyn A
AFFILIATION: Laboratory of Immunology, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21224, USA. biragyna@grc.nia.nih.gov
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current protein & peptide science.
COUNTRY: Netherlands
TITLE: Defensins--non-antibiotic use for vaccine development.
PUBDATE: 20050201
Vaccines should elicit protective and long lasting immune memory, which depends on well choreographed responses between innate and acquired immunity. Defensins are small host defense peptides of innate immunity hitherto reported to have antimicrobial activity, which also orchestrate chemotaxis and activation of effector immune cells, including immature dendritic cells. This review analyzes the biological meaning of the immunomodulatory and immunoenhancing features of defensins and their use for the development of novel vaccines to combat cancer and clinically relevant diseases.

13. DOCID:29251 SCORE: 0.00145170425096819
DOCNO: 14755895
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Angiogenesis Inhibitors
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: metabolism
AUTHOR: Stanley A Vinores SA
AFFILIATION: Johns Hopkins Hospital, Wilmer Ophthalmological Institute, 825 Maumenee, 600 N Wolfe Street, Baltimore, MD 21287-9289, USA. svinores@jhmi.edu
PUBTYPE: Evaluation Studies
PUBTYPE: Journal Article
JOURNALTITLE: Current opinion in molecular therapeutics.
COUNTRY: England
TITLE: Technology evaluation: pegaptanib, Eyetech/Pfizer.
PUBDATE: 20031201
Eyetech Pharmaceuticals and Pfizer are co-developing the anti-vascular endothelial growth factor aptamer, pegaptanib, as an angiogenesis inhibitor for the potential treatment of age-related macular degeneration and diabetic macular edema, in addition to other ocular diseases. Gilead was previously investigating the aptamer for the potential treatment of cancer, however, no data have been published for this indication since 1999.

14. DOCID:28949 SCORE: 0.00137193217220895
DOCNO: 12910364
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: secondary
QUALIFIER: pathology
QUALIFIER: radiotherapy
QUALIFIER: methods
AUTHOR: Edward Chow E
AUTHOR: Jackson Wu J
AUTHOR: Andrew Loblaw A
AUTHOR: Carlos A Perez CA
AFFILIATION: Department of Radiation Oncology, Toronto Sunnybrook Regional Cancer Centre, 2075 Bayview Avenue, ON M4 N 3M5, Toronto, Canada. Edward.Chow@tsrcc.on.ca
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: World journal of urology.
COUNTRY: Germany
TITLE: Radiotherapeutic approaches to metastatic disease.
PUBDATE: 20030901
Bone metastases in patients with prostate cancer are common. Prostate cancer patients also have a relatively long survival. Palliative radiation can provide effective symptom control in many clinical settings. This article focuses on the management of bone pain and its complications (pathological fractures and spinal cord compression) with radiation treatment.