0. DOCID:27930 SCORE: 0.00250931975675797
DOCNO: 10683075
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: diagnosis
QUALIFIER: etiology
QUALIFIER: diagnosis
AUTHOR: B D Keith BD
AUTHOR: V H Bramwell VH
AFFILIATION: London Regional Cancer Center, Ontario, Canada.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: American journal of clinical oncology : the official publication of the American Radium Society.
COUNTRY: UNITED STATES
TITLE: Pyomyositis after chemotherapy for breast cancer.
PUBDATE: 20000201
Pyomyositis is a rare complication of chemotherapy. A 47-year-old woman with metastatic breast cancer, in whom pyomyositis developed after chemotherapy, is described. It was difficult to differentiate between pyomyositis and deep venous thrombosis early in her admission. Pyomyositis should be considered part of the differential diagnosis of deep venous thrombosis. This infection, after chemotherapy, usually is considered to be caused by neutropenia or immunodeficiency secondary to the cancer, or both. It is postulated that subclinical myopathy, secondary to the malignancy or drugs used in treating the malignancy, or both, may also predispose to pyomyositis.

1. DOCID:26031 SCORE: 0.00243883814228418
DOCNO: 11484991
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
AUTHOR: Y Michiwa Y
AUTHOR: M Earashi M
AUTHOR: H Kobayashi H
AUTHOR: N Matsuki N
AFFILIATION: Dept. of Surgery, Toyama Rosai Hospital, Uozu, Japan. surgery@keiju.co.jp
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of experimental & clinical cancer research : CR.
COUNTRY: Italy
TITLE: Cutaneous metastases from gastric adenocarcinoma treated with combination chemotherapy producing complete response with long survival.
PUBDATE: 20010601
A case of cutaneous metastases from gastric adenocarcinoma was presented. It was treated with combination chemotherapy producing complete response with prolongation of survival. Skin metastasis will indicate early fatal termination, therefore there has not yet been a reported case of cutaneous metastasis from gastric cancer to have complete response with long survival.

2. DOCID:27614 SCORE: 0.00216291124647127
DOCNO: 9721090
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Apoptosis
AUTHOR: G Evan G
AUTHOR: T Littlewood T
AFFILIATION: Imperial Cancer Research Fund Laboratories, 44, Lincoln's Inn Fields, London WC2A 3PX, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Science.
COUNTRY: UNITED STATES
TITLE: A matter of life and cell death.
PUBDATE: 19980801
In multicellular organisms, mutations in somatic cells affecting critical genes that regulate cell proliferation and survival cause fatal cancers. Repair of the damage is one obvious option, although the relative inconsequence of individual cells in metazoans means that it is often a "safer" strategy to ablate the offending cell. Not surprisingly, corruption of the machinery that senses or implements DNA damage greatly predisposes to cancer. Nonetheless, even when oncogenic mutations do occur, there exist potent mechanisms that limit the expansion of affected cells by suppressing their proliferation or triggering their suicide. Growing understanding of these innate mechanisms is suggesting novel therapeutic strategies for cancer.

3. DOCID:27579 SCORE: 0.00204997736300125
DOCNO: 10674986
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: T Kikuchi T
AUTHOR: J Arai J
AUTHOR: H Shibuki H
AUTHOR: H Kawashima H
AUTHOR: N Yoshimura N
AFFILIATION: Department of Ophthalmology, Shinshu University School of Medicine, Matsumoto, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of neuroimmunology.
COUNTRY: NETHERLANDS
TITLE: Tubby-like protein 1 as an autoantigen in cancer-associated retinopathy.
PUBDATE: 20000201
Cancer-associated retinopathy (CAR) is a rare paraneoplastic syndrome that is characterized by retinal degeneration. Two cDNA clones, recoverin and tubby-like protein 1 (TULP1), were isolated from a human retinal cDNA library by using serum from a CAR patient as the probe. Both recoverin and TULP1 are retina-specific protein, and TULP1 is a member of tubby gene family. A determination of the recognized amino acid sequence of TULP1 by the patient serum and immunohistochemical studies on the distribution of TULP1 in the retina were done in this study.

4. DOCID:25011 SCORE: 0.00194932745809621
DOCNO: 11677125
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemistry
QUALIFIER: chemical synthesis
QUALIFIER: analogs & derivatives
QUALIFIER: chemistry
QUALIFIER: chemistry
QUALIFIER: chemistry
AUTHOR: Y Xie Y
AUTHOR: M D Short MD
AUTHOR: P B Cassidy PB
AUTHOR: J C Roberts JC
AFFILIATION: Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Bioorganic & medicinal chemistry letters.
COUNTRY: England
TITLE: Selenazolidines as novel organoselenium delivery agents.
PUBDATE: 20011101
Two new classes of selenazolidine-4(R)-carboxylic acids (2-oxo and 2-methyl-SCAs) were synthesized and characterized. Both were designed as latent forms of selenocysteine, intended to provide a chemically superior delivery form for selenium. The prodrugs may be clinically useful when selenium supplementation at supranutritional levels is indicated, such as in cancer chemoprevention.

5. DOCID:26205 SCORE: 0.00192313492109986
DOCNO: 11355914
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: epidemiology
QUALIFIER: diagnosis
QUALIFIER: epidemiology
AUTHOR: H Messmann H
AFFILIATION: Department of Internal Medicine I, University of Regensburg, Germany.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Best practice & research. Clinical gastroenterology.
COUNTRY: England
TITLE: Squamous cell cancer of the oesophagus.
PUBDATE: 20010401
Squamous cell cancer is the most common neoplasm of the oesophagus worldwide, with an enormous variation in its global incidence. Several risk factors, such as achalasia, Plummer-Vinson syndrome, coeliac disease and nutritional factors, have been identified. The surveillance of patients, especially those with tylosis or caustic ingestion, has been recommended. Vital staining with iodine may improve the diagnosis of early cancer. The endoscopic management of early cancer and dysplasia by minimal invasive techniques such as photodynamic therapy or mucosal resection has become attractive for many of these patients with co-morbidity.

6. DOCID:27560 SCORE: 0.00164562280235257
DOCNO: 11132958
AUTHOR: K Nakae K
AUTHOR: Y Yoshimoto Y
AUTHOR: T Sawa T
AUTHOR: Y Homma Y
AUTHOR: M Hamada M
AUTHOR: T Takeuchi T
AUTHOR: M Imoto M
AFFILIATION: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, Yokohama, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of antibiotics.
COUNTRY: Japan
TITLE: Migrastatin, a new inhibitor of tumor cell migration from Streptomyces sp. MK929-43F1. Taxonomy, fermentation, isolation and biological activities.
PUBDATE: 20001001
A new compound, migrastatin, was isolated from a cultured broth of Streptomyces sp. MK929-43F1, as an inhibitor of tumor cell migration. It was purified by column chromatographies on silica gel and Sephadex LH-20 and HPLC. Migrastatin has the molecular formula of C27H39NO7 consisting of 14-membered macrolide and glutarimide moiety. It inhibited spontaneous migration of human esophageal cancer EC17 cells. Migration inhibitory activity of migrastatin was not dependent on cytotoxicity or inhibition of protein synthesis.

7. DOCID:26256 SCORE: 0.00163829369718143
DOCNO: 9613110
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: enzymology
QUALIFIER: metabolism
AUTHOR: M Oshimura M
AFFILIATION: Department of Molecular & Cell Genetics, School of Life Sciences, Tottori University.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine.
COUNTRY: JAPAN
TITLE: [Telomerase and cancer]
PUBDATE: 19980501
Telomeres progressively shorten with age in somatic cells in culture and in vivo because DNA replication results the loss of sequence at the 5' ends of double-stranded DNA. Whereas normal somatic cells do not express the enzyme, telomerase, which adds repeated telomere sequences to chromosome ends, telomerase activity is detected in immortalized and tumor cells in vitro and in tumor tissues. This represents an important difference between normal cells and cancer cells, indicating that the telomerase activity and/or expression profiles of telomerase components are useful markers for cancer biology and detection.

8. DOCID:26985 SCORE: 0.00152924905173061
DOCNO: 9811028
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Surgical Flaps
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: K Sasaki K
AUTHOR: M Nozaki M
AUTHOR: H Nakazawa H
AUTHOR: Y Kikuchi Y
AUTHOR: T Huang T
AFFILIATION: Department of Plastic and Reconstructive Surgery at Tokyo Women's Medical College, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Plastic and reconstructive surgery.
COUNTRY: UNITED STATES
TITLE: Reconstruction of a large abdominal wall defect using combined free tensor fasciae latae musculocutaneous flap and anterolateral thigh flap.
PUBDATE: 19981101
A large abdominal wall defect was reconstructed with the use of a flap combining the tensor fasciae latae musculocutaneous flap and the anterolateral thigh flap in four individuals who had undergone extensive abdominal wall resection because of cancer. The flap was harvested as a single combined composite flap and was transferred to the recipient site by means of microvascular surgery. Morbidity was minimal and the outcome was satisfactory in all instances.

9. DOCID:26691 SCORE: 0.00151310716689822
DOCNO: 14528707
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Attitude of Health Personnel
DESCRIPTOR: Communication
DESCRIPTOR: Physician-Patient Relations
QUALIFIER: education
QUALIFIER: methods
AUTHOR: G Mackenzie G
AUTHOR: M Parkinson M
AUTHOR: A Lakhani A
AUTHOR: H Pannekoek H
AFFILIATION: British Columbia Cancer Agency, Fraser Valley Cancer Centre, 13750 96th Avenue, Surrey, British Columbia, Canada V3V 1Z2.
PUBTYPE: Journal Article
JOURNALTITLE: Patient education and counseling.
COUNTRY: Ireland
TITLE: Issues that influence patient/physician discussion of complementary therapies.
PUBDATE: 19991001
This article explores what patients expect from physicians when discussing complementary therapies. Counsellors at four cancer centres, under the auspices of the British Columbia Cancer Agency, discuss their clinical observations in working with oncology patients. They present perspectives of factors that influence the patient/physician discussion of complementary therapies. Some of the common themes include desire for collaboration and control, need for understanding treatment information, maintenance of hope, and trust of the physician.

10. DOCID:26047 SCORE: 0.00149987822009805
DOCNO: 11125127
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Databases, Factual
DESCRIPTOR: Disease
DESCRIPTOR: Mutation
QUALIFIER: genetics
AUTHOR: S Minoshima S
AUTHOR: S Mitsuyama S
AUTHOR: M Ohtsubo M
AUTHOR: T Kawamura T
AUTHOR: S Ito S
AUTHOR: S Shibamoto S
AUTHOR: F Ito F
AUTHOR: N Shimizu N
AFFILIATION: Department of Molecular Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Nucleic acids research.
COUNTRY: ENGLAND
TITLE: The KMDB/MutationView: a mutation database for human disease genes.
PUBDATE: 20010101
The KMDB/MutationView is a graphical database of mutations in human disease-causing genes and its current version consists of nine category-based sub-databases including diseases of eye, heart, ear, brain, cancer, syndrome, autoimmunity, muscle and blood. The KMDB/MutationView stores mutation data of 97 genes involved in 87 different disease and is accessible through http://mutview.dmb.med. keio.ac.jp.

11. DOCID:26787 SCORE: 0.00143052353873234
DOCNO: 9771445
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: genetics
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: M Curling M
AUTHOR: S Stenning S
AUTHOR: C N Hudson CN
AUTHOR: J V Watson JV
AFFILIATION: Clinical Oncology Unit, Medical School, Cambridge, UK.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of clinical pathology.
COUNTRY: ENGLAND
TITLE: Multivariate analyses of DNA index, p62c-myc, and clinicopathological status of patients with ovarian cancer.
PUBDATE: 19980601
AIM: To determine if either DNA index or p62c-myc is an independent prognostic variable in ovarian cancer. METHODS: Multivariate and univariate analyses of the relation between DNA index, p62c-myc, FIGO stage, histological type, tumour grade, completeness of surgery, and patient survival in ovarian cancer were examined. RESULTS: Multivariate analysis showed significant association of survival only with stage and grade. There was no relation between survival and DNA index. CONCLUSIONS: DNA index is not an independent prognostic variable in ovarian cancer.

12. DOCID:26623 SCORE: 0.00141937980431717
DOCNO: 9708647
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: complications
QUALIFIER: drug therapy
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: drug therapy
AUTHOR: D B Sokol DB
AUTHOR: G R Hudes GR
AFFILIATION: Department of Medical Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: American journal of clinical oncology : the official publication of the American Radium Society.
COUNTRY: UNITED STATES
TITLE: Cisplatin-based chemotherapy for testicular cancer in a patient with spinal muscular atrophy: a case report.
PUBDATE: 19980801
Metastatic germ-cell tumors of the testis are highly curable with cisplatin-based chemotherapy. Although cisplatin-based chemotherapy is generally well tolerated and rarely causes severe neurotoxicity, there is little information to guide the treatment of patients with neuromuscular disorders. The authors report the successful treatment of a patient with testicular cancer and spinal muscular atrophy, an inherited degenerative neuromuscular disease.

13. DOCID:27655 SCORE: 0.00139826224069619
DOCNO: 11393194
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Lactobacillus
QUALIFIER: therapy
QUALIFIER: therapeutic use
AUTHOR: J A Vanderhoof JA
AFFILIATION: Department of Pediatric Gastroenterology and Nutrition, University of Nebraska/Creighton University, Omaha, USA. jvanderh@unmc.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The American journal of clinical nutrition.
COUNTRY: United States
TITLE: Probiotics: future directions.
PUBDATE: 20010601
Clinical studies have shown that certain probiotics may be useful in treating a variety of diarrheal disorders, including rotavirus diarrhea, antibiotic-associated diarrhea, Clostridium difficile diarrhea, and traveler's diarrhea. New data suggest that probiotics might be useful in controlling inflammatory diseases, treating and preventing allergic diseases, preventing cancer, and stimulating the immune system, which may reduce the incidence of respiratory disease. Different modes of administering probiotics are currently being investigated, which may ultimately lead to the widespread use of probiotics in functional foods. It is important that such practices be directed by carefully controlled clinical studies published in peer-reviewed journals.

14. DOCID:27425 SCORE: 0.00137946959822317
DOCNO: 11769475
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Reimbursement Mechanisms
QUALIFIER: economics
QUALIFIER: economics
QUALIFIER: blood
AUTHOR: T Yamada T
AFFILIATION: Department of Clinical Pathology, Juntendo University School of Medicine, Bunkyo-ku, Tokyo 113-8421.
PUBTYPE: Journal Article
JOURNALTITLE: Rinsho byori. The Japanese journal of clinical pathology.
COUNTRY: Japan
TITLE: [Prostate cancer test and medical reimbursement]
PUBDATE: 20011001
Until now there have been three diagnostic tests, prostate specific antigen (PSA, total PSA), gamma-seminoprotein (gamma-Sm), and prostate acid phosphatase (PAP), for prostate cancer. Recent progresses in utilization of PSA has resulted in two advanced tests, PSA-alpha 1 antichymotrypsin complex (PSA-ACT) and free PSA/total PSA ratio. Payment of each test ranges from 210 to 320 yen. The same as for other cancer tests, three tests is paid 440 yen, and four or more is paid 590 yen. To determine the cost effective choice, it is necessary to consult with appropriate urologists.