0. DOCID:23051 SCORE: 0.0023982085524768
DOCNO: 9067076
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mammography
DESCRIPTOR: Mass Screening
DESCRIPTOR: Physical Examination
QUALIFIER: prevention & control
AUTHOR: M E Costanza ME
AUTHOR: K L Edmiston KL
AFFILIATION: University of Massachusetts Medical Center, Department of Medicine, Worcester 01655, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Comprehensive therapy.
COUNTRY: UNITED STATES
TITLE: Breast cancer screening: early recognition.
PUBDATE: 19970101
The epidemic of breast cancer and the availability of tools to increase early detection and decrease mortality require care and diligence on the part of every physician directly caring for patients. With the widespread implementation of managed care, primary care physicians are in the best position to recommend breast cancer screening. Educational programs to emphasize the primary care physician's role in breast cancer prevention and detection, to improve physical examination skills, and to implement office systems to facilitate screening should be available to primary care physicians, and may have a major impact on breast cancer mortality in the future.

1. DOCID:22305 SCORE: 0.00233394995452921
DOCNO: 7552793
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Parenteral Nutrition, Total
QUALIFIER: therapy
AUTHOR: A D Hill AD
AUTHOR: J M Daly JM
AFFILIATION: Department of Surgery, New York Hospital/Cornell University Medical Center, New York, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Surgical oncology clinics of North America.
COUNTRY: UNITED STATES
TITLE: Current indications for intravenous nutritional support in oncology patients.
PUBDATE: 19950701
No clear role has yet been defined for the role of total parenteral nutrition in the management of the cancer patient, and this subject remains an area of controversy. Peri-operative nutritional support, if given for at least 10 days, may reduce morbidity and mortality in some patients, although this subgroup has not been fully characterized. There is no evidence that parenteral nutritional support benefits patients undergoing chemotherapy or radiotherapy in terms of an increased tumor response rate or prolongation of survival.

2. DOCID:22972 SCORE: 0.00185244031435012
DOCNO: 9117272
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: F J Rescorla FJ
AFFILIATION: Department of Surgery, Indiana University School of Medicine, Indianapolis, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in pediatric surgery.
COUNTRY: UNITED STATES
TITLE: Germ cell tumors.
PUBDATE: 19970201
Germ cell tumors are relatively uncommon childhood tumors. Several interesting characteristics distinguish them from other tumors. (1) Abnormal migration of primordial germ cells results in the frequent occurrence of extragonadal germ cell tumors in children. (2) Serum markers exist to allow evaluation of extent of resection and development of recurrent tumor. (3) The introduction of modern chemotherapy including cisplatin, etoposide, and bleomycin has significantly improved survival of these children. Optimal therapy includes complete surgical resection, accurate histological examination, and selective use of chemotherapy. Mature and immature teratomas at any site and stage I testicular cancers are managed by observation alone, whereas all other tumors require chemotherapy.

3. DOCID:22209 SCORE: 0.00168503401753515
DOCNO: 8547404
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genes, p53
QUALIFIER: genetics
QUALIFIER: therapy
AUTHOR: S W Lowe SW
AFFILIATION: Cold Springs Harbor Laboratory, New York, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in oncology.
COUNTRY: UNITED STATES
TITLE: Cancer therapy and p53.
PUBDATE: 19951101
Apoptosis is now recognized as an important process in tissue homeostasis. In malignancy, mutations in apoptotic programs may promote tumor progression as well as reduce the efficacy of cancer therapy. Recent studies identify the product of the p53 tumor-suppressor gene as an important regulator of apoptosis in tumor cells. At the same time, clinical studies implicate p53 mutations in pleiotropic resistance to cytotoxic cancer therapy. Together, these observations suggest that inactivation of p53 promotes resistance to anticancer agents by attenuating apoptosis. This view identifies p53 as a potential drug target and suggests several strategies for therapeutic intervention.

4. DOCID:23999 SCORE: 0.00164060026140056
DOCNO: 7935315
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
PUBTYPE: Journal Article
JOURNALTITLE: MMWR. Morbidity and mortality weekly report.
COUNTRY: UNITED STATES
TITLE: Cigarette smoking among women of reproductive age--United States, 1987-1992.
PUBDATE: 19941101
Women who smoke cigarettes are at increased risk for lung cancer, chronic obstructive pulmonary disease, and complications of oral contraceptive use. During pregnancy, cigarette smoking increases the risks for a low birthweight infant and infant mortality. A national health objective for the year 2000 is to reduce cigarette smoking among women of reproductive age (i.e., 18-44 years) to a prevalence of no more than 12% (objective 3.4h)(1). This goal is substantially lower than the estimated baseline prevalence of 29% measured by CDC's 1987 National Health Interview Survey (NHIS). To characterize recent trends in cigarette smoking and monitor progress toward the year 2000 objective, data from the NHIS for 1987 through 1992 were analyzed for women aged 18-44 years.

5. DOCID:21258 SCORE: 0.00161916683361414
DOCNO: 7519786
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: methods
AUTHOR: H Gräter H
AFFILIATION: Medizinische Klinik, Fachbereich Gastroenterologie, Städtische Krankenanstalten Esslingen am Neckar.
PUBTYPE: Journal Article
JOURNALTITLE: Schweizerische Rundschau für Medizin Praxis = Revue suisse de médecine Praxis.
COUNTRY: SWITZERLAND
TITLE: [Palliative therapy of inoperable esophageal carcinoma]
PUBDATE: 19940701
The life expectancy of patients with inoperable esophageal neoplasms is very limited. Therefore, palliative strategies should be immediately effective in relieving dysphagia. The efficiency of different methods so far available for palliation is discussed. In inoperable localized cancers, combined chemotherapy and radiation therapy are more effective than irradiation alone. Patients with more advanced carcinomas will benefit from the development of self-expanding metal stents. These stents can be placed quickly, are safe and show low morbidity rates.

6. DOCID:21111 SCORE: 0.00159805822251697
DOCNO: 9301718
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: C R deVries CR
AUTHOR: G W Kaplan GW
AFFILIATION: Section of Urology, Medical College of Georgia, Augusta 30912-4050, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Urology.
COUNTRY: UNITED STATES
TITLE: An unusual case of urinary incontinence, ataxia-telangiectasia, and metastatic dysgerminoma: case report and review of the literature.
PUBDATE: 19970901
Ataxia-telangiectasia (A-T) is a rare autosomal recessive disease notable for neurodegeneration, chromosomal instability, and a predisposition to cancer. It presents in childhood with a variable phenotype. We report the first case of an A-T related tumor presenting as urinary incontinence, and the first case of 2-year survival in an A-T patient with metastatic dysgerminoma.

7. DOCID:20743 SCORE: 0.00147206045027532
DOCNO: 7852218
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: complications
AUTHOR: D H Henry DH
AFFILIATION: Department of Medicine, University of Pennsylvania School of Medicine, Graduate Hospital Division of Hematology/Oncology, Philadelphia.
PUBTYPE: Journal Article
JOURNALTITLE: Hematology/oncology clinics of North America.
COUNTRY: UNITED STATES
TITLE: Clinical application of recombinant erythropoietin in anemic cancer patients.
PUBDATE: 19941001
Anemia is common in cancer patients and may require treatment for symptomatic palliation. Transfusion has been the mainstay of therapy, but is not without risk. Because erythropoietin levels in cancer-related anemia are inadequate for the degree of anemia, recombinant human erythropoietin has been studied to treat the anemia. Results from these studies are encouraging.

8. DOCID:22098 SCORE: 0.00146082386554865
DOCNO: 7839547
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Attitude of Health Personnel
DESCRIPTOR: Attitude to Health
DESCRIPTOR: Truth Disclosure
QUALIFIER: psychology
QUALIFIER: psychology
QUALIFIER: psychology
AUTHOR: P Gjersøe P
AUTHOR: O O Thomsen OO
AUTHOR: J H Larsen JH
AUTHOR: H A Holmsgaard HA
AUTHOR: K M Lønborg KM
AUTHOR: H R Wulff HR
AFFILIATION: Medicinsk afdeling C. Amtssygehuset i Herlev.
PUBTYPE: Journal Article
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: DENMARK
TITLE: [Attitude of Danish patients and physicians to information on cancer. A questionnaire study]
PUBDATE: 19950101
This survey reports the attitude towards information of cancer patients as regards diagnosis and prognosis among gastroenterologists and patients (not suffering from cancer). The questions were based on a case history (a patient with colonic cancer). Most doctors informed their patients openly, and most patients expected that. Younger doctors in particular were more restrictive than patients as regards information of the spouse.

9. DOCID:21943 SCORE: 0.00146081949463787
DOCNO: 9206461
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: adverse effects
QUALIFIER: etiology
AUTHOR: S Iida S
AUTHOR: K Shirasuna K
AUTHOR: M Kogo M
AUTHOR: T Matsuya T
AFFILIATION: First Department of Oral and Maxillofacial Surgery, Osaka University Faculty of Dentistry, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of Osaka University Dental School.
COUNTRY: JAPAN
TITLE: Amputation neuroma following radical neck dissection--report of 3 cases.
PUBDATE: 19951201
Amputation neuroma occurred in three cases among 111 cases of oral cancer patients after radical neck dissection. All of three cases appeared as a small nodule at superior neck around the carotid artery with accompanying tenderness. The lesions were located in continuity with the proximal end of nerve at excision. Although the incidence of amputation neuroma is low, critical examination is required to distinguish this from recurrent tumor after cancer surgery.

10. DOCID:23273 SCORE: 0.00145982537663243
DOCNO: 7893103
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: W M Cocke WM
AFFILIATION: Department of Surgery, Marshall University School of Medicine, Huntington, West Virginia 25755-9450.
PUBTYPE: Journal Article
JOURNALTITLE: The American surgeon.
COUNTRY: UNITED STATES
TITLE: Radial composite chondrocutaneous flap for ear reconstruction.
PUBDATE: 19950401
Moderate sized cancers of the upper third of the ear can be widely excised, including cartilage, leaving the posterior skin intact. This avoids a large wedge excision and primary closure which leaves a significant defect. The unsupported soft tissue of the upper ear following excision of the cancer can be reconstructed by rotating into position a composite flap of skin and cartilage from the middle third of the ear. This composite flap supports the superior helix. The tissue defects of the flap donor site and the area superior to the flap inset can be closed with thick split grafts from the post-auricular area.

11. DOCID:20952 SCORE: 0.00145916932253998
DOCNO: 8767501
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Penile Neoplasms
AUTHOR: V De Luca V
AUTHOR: G Cancarini G
AUTHOR: R Fortis R
AUTHOR: G Pezzotti G
AUTHOR: B Taher B
AUTHOR: T Zanotelli T
AUTHOR: S Cosciani Cunico S
AFFILIATION: Divisione Clinicizzata di Urologia, Spedali Civili, Brescia.
PUBTYPE: Journal Article
PUBTYPE: Multicenter Study
JOURNALTITLE: Archivio italiano di urologia, andrologia : organo ufficiale [di] Società italiana di ecografia urologica e nefrologica / Associazione ricerche in urologia.
COUNTRY: ITALY
TITLE: [Multicenter study of penile cancer]
PUBDATE: 19960601
The authors report the experience about diagnosis, treatment, results and follow-up on penile cancer of 15 department of urology of Lombardia region. The aim of the study is to find, through the historical experience, the better way to menage this rare cancer.

12. DOCID:23338 SCORE: 0.0013921646570379
DOCNO: 8710788
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: C Poremba C
AUTHOR: A Bankfalvi A
AUTHOR: B Dockhorn-Dworniczak B
AFFILIATION: Gerhard-Domagk-Institut für Pathologie, Westfälische Wilhelms-Universität, Münster.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Der Pathologe.
COUNTRY: GERMANY
TITLE: [Tumor suppressor gene p53. Theoretical principles and their significance for pathology]
PUBDATE: 19960501
Mutations of the p53 tumor-suppressor gene are the most common genetic alterations in human cancer, found in approximately 50% of all tumors. The importance of p53 in human cancer attracts attention in molecular studies dealing with the pathogenesis, diagnosis and prognosis in tumor pathology. This review summarizes the current understanding of p53 both on the genetic and protein level. Frequency and spectrum of somatic p53 mutations in the carcinogenesis of breast cancer, colorectal cancer, gastric cancer, hepatocellular carcinoma, squamous-cell carcinoma of the skin and malignant melanoma are discussed including our own investigations and studies published in the literature.

13. DOCID:23615 SCORE: 0.00138145427856073
DOCNO: 9114524
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: B Lobel B
AUTHOR: F Guillé F
AFFILIATION: Service d'urologie, CHRU Hôpital Pontchaillou, Rennes.
PUBTYPE: Journal Article
JOURNALTITLE: La Revue du praticien.
COUNTRY: FRANCE
TITLE: [Surgery of infiltrating bladder tumors]
PUBDATE: 19970201
Surgical treatment of transitional bladder tumours is based on liberal resection of the bladder. After cystectomy, reconstitution of the urinary tract is required for urinary excretion and patient comfort. The bladder can be replaced by a segment of intestine detached from the digestive tract. Another mean is urinary diversion at the abdominal wall by a direct or continent fistula. The patient should be seen 6 weeks after surgery to assess the quality of the surgical assemblage, the absence of distension of the upper urinary tract and the degree of patient comfort. Subsequently, the patient should be seen every 6 months. Early treatment of bladder cancer leads to cure at 5 years in 50 to 75% of cases.

14. DOCID:23073 SCORE: 0.00138029406518752
DOCNO: 8821094
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: pathology
AUTHOR: M Grégoire M
AUTHOR: B Lieubeau B
AFFILIATION: Institut de Biologie, INSERM U419, Nantes, France.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer metastasis reviews.
COUNTRY: UNITED STATES
TITLE: The role of fibroblasts in tumor behavior.
PUBDATE: 19951201
The prominent desmoplastic or stromal reaction seen in many invasive carcinomas suggests that stromal cells play a role in cancer pathogenesis. Investigations based on cell typing, using antibodies to cytoskeletal constituents, have revealed that most tumors contain various types of fibroblasts. Stromal cells with myofibroblastic differentiation features are the predominant cell type at the periphery of epithelial tumors. These tumor-activated fibroblasts play a major role in tumor development and spread, affecting the proliferation, differentiation, invasion or regression of cancer cells. This review considers the events inducing the different fibroblastic responses and the role of tumor-activated fibroblasts in both tumor development and anti-cancer treatments.