0. DOCID:18236 SCORE: 0.00499693132721413
DOCNO: 8318406
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Lectins
QUALIFIER: pathology
PUBTYPE: Journal Article
PUBTYPE: Multicenter Study
JOURNALTITLE: British journal of cancer.
COUNTRY: ENGLAND
TITLE: Prognostic value of Helix pomatia in breast cancer. International (Ludwig) Breast Cancer Study Group.
PUBDATE: 19930701
Six hundred and eighty-four primary breast cancers from the International (Ludwig) Breast Cancer Study Group (IBCSG) were studied for Helix pomatia lectin (HPA) binding. There was a weak correlation between lymph node-positive and HPA positive (P = 0.04). In our series there was a large advantage in disease-free survival (DFS) and overall survival (OS) for node-negative patients (P < 0.0001 DFS and OS). However, there was no such advantage for HPA-negative patients (P = 0.23 DFS and P = 0.32 OS). We conclude that in this randomised patient group HPA is of no clinical predictive value.


1. DOCID:19231 SCORE: 0.00260220778035004
DOCNO: 1737398
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: X L Han XL
AUTHOR: J G Liehr JG
AFFILIATION: Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston 77550-2782.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Induction of covalent DNA adducts in rodents by tamoxifen.
PUBDATE: 19920301
The antiestrogen tamoxifen, increasingly used as adjuvant treatment for breast cancer, has been found to covalently modify DNA of rodents. For instance, the liver DNA of female Sprague-Dawley rats treated with a single injection of tamoxifen contained two DNA adducts. Four additional DNA adducts were formed and adduct concentrations increased 5- 7- and 10-15-fold after three and six tamoxifen injections, respectively, from levels observed after a single dose. The accumulation of DNA adducts with repeated administrations of tamoxifen to rodents may make this drug a poor choice for the chronic preventative treatment of breast cancer.


2. DOCID:19164 SCORE: 0.00235549651034465
DOCNO: 2202380
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: I F McKenzie IF
AUTHOR: P X Xing PX
AFFILIATION: Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer cells (Cold Spring Harbor, N.Y. : 1989)
COUNTRY: UNITED STATES
TITLE: Mucins in breast cancer: recent immunological advances.
PUBDATE: 19900301
Mucins are heavily glycosylated proteins that are produced in excessive amounts in breast cancers and other adenocarcinomas. These proteins are potent immunogens; indeed, most monoclonal antibodies raised against extracts of breast cancer cells or tumors are directed toward a single family of mucins. The anti-mucin antibodies currently available are valuable diagnostic aids for detecting advanced stages of breast cancer. To improve the sensitivity of these antibodies so that they might be suitable for use in screening and early diagnosis, tumor imaging, and therapy of breast cancer, recent studies have focused on identifying the precise epitopes they recognize.


3. DOCID:19450 SCORE: 0.00227177068246294
DOCNO: 1321398
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Renal Dialysis
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: E Ibrányi E
AUTHOR: I Mihály I
AUTHOR: M Kovács M
AUTHOR: L Telegdy L
AFFILIATION: V. sz. Belosztály, Fóvárosi Szent László Kórház, Budapest.
PUBTYPE: Journal Article
JOURNALTITLE: Orvosi hetilap.
COUNTRY: HUNGARY
TITLE: [Delta virus infection in hemodialyzed kidney patients and patients with chronic liver diseases]
PUBDATE: 19920701
Sera of patients with chronic hepatitis and chronic haemodialysed uraemia were tested for both Hepatitis B virus and Hepatitis Delta virus markers from 1985. Hepatitis Delta virus seroconversion was found in 10 of 88 haemodialysed patients and anti-Delta-IgG sero-positivity in 11 of 108 chronic hepatitis patients. The clinical course of Delta superinfections in haemodialysed patients was as follows: 3 infections were symptomless, 7 patients had acute hepatitis, two of the latter group died because of fulminant hepatitis. Of the 11 HBsAg and anti-Delta-IgG positive chronic hepatitis patients 3 had primary hepatocellular cancer.


4. DOCID:19386 SCORE: 0.00227176408286072
DOCNO: 1420519
AUTHOR: D Trichopoulos D
AUTHOR: R D Lipman RD
AFFILIATION: Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Epidemiology (Cambridge, Mass.)
COUNTRY: UNITED STATES
TITLE: Mammary gland mass and breast cancer risk.
PUBDATE: 19921101
Evidence indicates that early life events and conditions, possibly extending to the intrauterine stages of life, and including energy restriction in early life, affect the risk of breast cancer. The mechanism of this effect is likely to be through a reduction in mammary gland mass and, inferentially, the total number of ductal stem cells. The evidence derives from epidemiologic and animal studies. It can explain certain epidemiologic findings that cannot be accounted for by more established breast cancer risk factors, including the more frequent occurrence of breast cancer in the left breast and the higher incidence of this disease among caucasian women than among Asian women in Asia.


5. DOCID:18666 SCORE: 0.00185526517162603
DOCNO: 2177287
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Pneumonectomy
QUALIFIER: methods
QUALIFIER: immunology
QUALIFIER: surgery
QUALIFIER: immunology
AUTHOR: P Ia Gaus PIa
AUTHOR: A A Veĭsebaev AA
AUTHOR: K Sh Sharipov KSh
AUTHOR: F G An FG
PUBTYPE: Journal Article
JOURNALTITLE: Vestnik khirurgii imeni I. I. Grekova.
COUNTRY: USSR
TITLE: [Dynamics of various indicators of immunity in relation to the type of anesthesia during surgical treatment of patients with lung cancer after irradiation]
PUBDATE: 19900801
Investigation of certain indices of immunity in 52 patients with lung cancer subjected to X-ray irradiation at stages of the surgical treatment under conditions of various kinds of anesthesia have shown that preoperative radiation therapy with the dose of 30 gr resulted in a considerable suppression of immunity indices at the preoperative period and aggravated immune depression following operative procedures. At the same time immune depressive reactions were found to depend on the kind of anesthesia.


6. DOCID:19494 SCORE: 0.00184166413341339
DOCNO: 1666344
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: metabolism
QUALIFIER: blood
AUTHOR: Y Z Wang YZ
AFFILIATION: First Hospital, Lanzhou Medical College.
PUBTYPE: Journal Article
JOURNALTITLE: Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases.
COUNTRY: CHINA
TITLE: [A study of IL-2 activity on lung cancer]
PUBDATE: 19910801
By using thymocytes of mice as target cells in bioassay, IL-2 production activity was investigated in 24 lung cancer patients, 24 noncancerous pulmonary lesions as well as 20 normal individuals. Fourteen cancer patients were reexamined after the first course of chemotherapy. This research demonstrated that: 1. PBL capable of IL-2 production in lung cancer patients were rare in comparison with benign disease or normal control. 2. IL-2 activity was markedly enhanced by chemotherapy. It is suggested that IL-2 is a good indicator for estimating the efficacy of treatment of lung cancer.


7. DOCID:18262 SCORE: 0.00183508976720478
DOCNO: 10115168
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: trends
AUTHOR: G van der Heide-Schoon G
PUBTYPE: Journal Article
JOURNALTITLE: The Canadian journal of medical radiation technology / CAMRT.
COUNTRY: CANADA
TITLE: Radiation therapy--past and future.
PUBDATE: 19911001
Not long ago, cancer was generally looked on as a lethal disease. In the last decades, recovery chances for various forms of cancer have increased spectacularly. And research is still going on. Various new therapeutical techniques have been implemented recently or will be in the near future. In my paper, I will first briefly mention some achievements of the past 25 years. Then I will discuss some methods that have been developed recently, or that are still in an experimental stage. I will also concentrate on aspects that are of interest to the radiographer, and that may influence daily routine and workload.


8. DOCID:19623 SCORE: 0.00181538344504754
DOCNO: 2176735
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: U Metzger U
AFFILIATION: Chirurgische Klinik, Stadtspital Triemli, Zürich.
PUBTYPE: Journal Article
JOURNALTITLE: Schweizerische Rundschau für Medizin Praxis = Revue suisse de médecine Praxis.
COUNTRY: SWITZERLAND
TITLE: [Colon carcinoma--1990]
PUBDATE: 19901201
Colorectal cancer is a major public health problem in Western industrialized countries. It is estimated that more than a quarter of a million people are affected by this disease each year. The population-adjusted yearly incidence rate has remained constant at approximately 40 to 50 cases per 100,000. About 75% of the individuals with these cancers have a primary surgical resection with hope of complete tumor eradication. Despite the high resectability rate and a general improvement in surgical therapy, nearly half of all patients with colorectal cancer still die of metastatic tumor. Major progress has been made in various aspects of colorectal cancer over the last few years, including molecular biology, screening and adjuvant therapy.


9. DOCID:16807 SCORE: 0.00163537372136035
DOCNO: 1393699
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiography
AUTHOR: D Couture D
AFFILIATION: Département de radiologie, Centre hospitalier Ste-Marie, Trois-Rivières, Québec.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes.
COUNTRY: CANADA
TITLE: [Cancer of the breast in radiology]
PUBDATE: 19921001
In this extensive review the author discusses the incidence of breast cancer, screening methods, the theoretic radiation risk, the mammographic signs of suspicious lesions and the value of ultrasonography and stereotactic fine-needle biopsy. The emphasis is on the close relation between radiology, the physical examination, surgery and pathological studies. Up-to-date information about controversial topics is provided, and a therapeutic scheme is suggested.


10. DOCID:18998 SCORE: 0.00136429048322429
DOCNO: 2313895
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Social Environment
DESCRIPTOR: Stress, Psychological
QUALIFIER: epidemiology
AUTHOR: H Ogawa H
AUTHOR: K Tajima K
AFFILIATION: Div. Epidemiol., Aichi Cancer Center Res. Inst.
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [A case-control study of psychosocial stress and cancer]
PUBDATE: 19900201
As psychosocial stress has been suspected as a risk factor for cancer, a case-control study was conducted. A total 106 cases with cancer of the various sites and 106 age-sex matched hospital control with non-cancerous disease or without disease were compared on their responses to the questionnaire which included the items on life event, stress coping behavior, emotional support, and neuroticism. No significant odds ratio was observed for each dimension of the stress and the comprehensive stress index, even after adjusting for smoking and other life style factors. Some methodological problems were discussed.


11. DOCID:16275 SCORE: 0.00135300271079918
DOCNO: 8143623
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
AUTHOR: R W Tennant RW
AFFILIATION: National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Environmental health perspectives.
COUNTRY: UNITED STATES
TITLE: A perspective on nonmutagenic mechanisms in carcinogenesis.
PUBDATE: 19931001
Although there is compelling evidence for multiple mutagenic events in the induction of cancers, there is also substantial evidence in support of nonmutagenic mechanisms. It is proposed that the genetic basis of noninduced or spontaneous tumors, as well as cancers induced by nonmutagens, involves heritable changes in the regulation of gene expression.


12. DOCID:19250 SCORE: 0.00133943823260511
DOCNO: 2069397
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: S Okada S
AUTHOR: N Okazaki N
AFFILIATION: Dept. of Internal Medicine, National Cancer Center Hospital, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Chemotherapy in cancers of the gallbladder and bile ducts]
PUBDATE: 19910701
Chemotherapy for cancers of the biliary tract remains underdeveloped, mainly because of their low incidence. There have been no well-designed chemotherapeutic trials based on a sufficient number of cases in this field. The summarized results from the literature and our experience indicate no standard regimen for chemotherapy of the biliary tract cancers. To improve chemotherapy for these cancers, the development of new active anticancer agents is essential. And, for clinical trials of chemotherapy for this relatively rare cancer, a cooperative group study is considered to be necessary to obtain meaningful results within a reasonable period.


13. DOCID:17374 SCORE: 0.00133663201147997
DOCNO: 2203581
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: administration & dosage
AUTHOR: R Zini R
AUTHOR: P Riant P
AUTHOR: J Barré J
AUTHOR: J P Tillement JP
AFFILIATION: Department Hospital-Universitaire de Pharmacologie, Créteil, France.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Clinical pharmacokinetics.
COUNTRY: NEW ZEALAND
TITLE: Disease-induced variations in plasma protein levels. Implications for drug dosage regimens (Part II).
PUBDATE: 19900901
Part I of this article, which appeared in the previous issue of the Journal, discussed the implications of variations in plasma protein levels in a number of diseases: hepatic and renal disease, acute myocardial infarction, burns, cancer, diabetes mellitus, hyperlipidaemia and inflammatory diseases. In Part II the authors continue their review with a further range of disease states, and consider their import for drug dosages.


14. DOCID:18053 SCORE: 0.00128962161400966
DOCNO: 1450437
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: drug effects
QUALIFIER: drug effects
AUTHOR: S S Daoud SS
AFFILIATION: Department of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Pullman 99164-6510.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Anti-cancer drugs.
COUNTRY: ENGLAND
TITLE: Cell membranes as targets for anti-cancer drug action.
PUBDATE: 19921001
A variety of studies strongly hint that cell membranes can be important targets for new and existing anti-tumor drugs. Traditionally, the search for new anti-cancer agents has focused on compounds designed to act on the biosynthesis, stability or function of DNA; it may be timely, however, to broaden our search horizon and consider targets outside of the nucleus. Thus, the cell membrane as well as membraneous organelles may well play a key role in the future of anti-tumor drug development.