0. DOCID:18236 SCORE: 0.00499693132721413
DOCNO: 8318406
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Lectins
QUALIFIER: pathology
PUBTYPE: Journal Article
PUBTYPE: Multicenter Study
JOURNALTITLE: British journal of cancer.
COUNTRY: ENGLAND
TITLE: Prognostic value of Helix pomatia in breast cancer. International (Ludwig) Breast Cancer Study Group.
PUBDATE: 19930701
Six hundred and eighty-four primary breast cancers from the International (Ludwig) Breast Cancer Study Group (IBCSG) were studied for Helix pomatia lectin (HPA) binding. There was a weak correlation between lymph node-positive and HPA positive (P = 0.04). In our series there was a large advantage in disease-free survival (DFS) and overall survival (OS) for node-negative patients (P < 0.0001 DFS and OS). However, there was no such advantage for HPA-negative patients (P = 0.23 DFS and P = 0.32 OS). We conclude that in this randomised patient group HPA is of no clinical predictive value.


1. DOCID:29337 SCORE: 0.0030955967561268
DOCNO: 16474761
OWNER: NLM
STATUS: In-Data-Review
AUTHOR: Michael W Kattan MW
AFFILIATION: MW Kattan is Chairman of the Department of Quantitative Health Sciences at the Cleveland Clinic Foundation, OH, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Nature clinical practice. Urology.
COUNTRY: United States
TITLE: When and how to use informatics tools in caring for urologic patients.
PUBDATE: 20050401
Making predictions is an essential part of any medical decision. It is particularly crucial when considering treatment of clinically localized prostate cancer. Nomograms and prediction model software typically provide the most accurate predictions. Many nomograms have been developed, for all prostate cancer clinical states. Some of these are discussed in this review, as is their utility in facilitating decision making and informed consent.


2. DOCID:28879 SCORE: 0.00309557839384329
DOCNO: 16354327
OWNER: NLM
STATUS: In-Process
AUTHOR: Luciano Wannesson L
AUTHOR: Franco Cavalli F
AUTHOR: Emmanuele Zucca E
AFFILIATION: Department of Medical Oncology, Institute of Southern Switzerland, Bellinzona, Switzerland.
PUBTYPE: Journal Article
JOURNALTITLE: Clinical lymphoma & myeloma.
COUNTRY: United States
TITLE: Primary pulmonary lymphoma: current status.
PUBDATE: 20051101
Primary pulmonary lymphoma (PPL) is a rare disease with a favorable prognosis compared with lung cancer. Although a number of histologic variables of B- and T-cell lymphoma were reported as PPL, marginal zone lymphoma of the mucosa-associated lymphoid tissue type is by far the most frequent diagnosis. This review summarizes the present knowledge of histopathology, molecular biology, diagnosis, prognosis, and treatment of this heterogeneous entity.


3. DOCID:19231 SCORE: 0.00260220778035004
DOCNO: 1737398
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: X L Han XL
AUTHOR: J G Liehr JG
AFFILIATION: Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston 77550-2782.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Induction of covalent DNA adducts in rodents by tamoxifen.
PUBDATE: 19920301
The antiestrogen tamoxifen, increasingly used as adjuvant treatment for breast cancer, has been found to covalently modify DNA of rodents. For instance, the liver DNA of female Sprague-Dawley rats treated with a single injection of tamoxifen contained two DNA adducts. Four additional DNA adducts were formed and adduct concentrations increased 5- 7- and 10-15-fold after three and six tamoxifen injections, respectively, from levels observed after a single dose. The accumulation of DNA adducts with repeated administrations of tamoxifen to rodents may make this drug a poor choice for the chronic preventative treatment of breast cancer.


4. DOCID:27930 SCORE: 0.00250931975675797
DOCNO: 10683075
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: diagnosis
QUALIFIER: etiology
QUALIFIER: diagnosis
AUTHOR: B D Keith BD
AUTHOR: V H Bramwell VH
AFFILIATION: London Regional Cancer Center, Ontario, Canada.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: American journal of clinical oncology : the official publication of the American Radium Society.
COUNTRY: UNITED STATES
TITLE: Pyomyositis after chemotherapy for breast cancer.
PUBDATE: 20000201
Pyomyositis is a rare complication of chemotherapy. A 47-year-old woman with metastatic breast cancer, in whom pyomyositis developed after chemotherapy, is described. It was difficult to differentiate between pyomyositis and deep venous thrombosis early in her admission. Pyomyositis should be considered part of the differential diagnosis of deep venous thrombosis. This infection, after chemotherapy, usually is considered to be caused by neutropenia or immunodeficiency secondary to the cancer, or both. It is postulated that subclinical myopathy, secondary to the malignancy or drugs used in treating the malignancy, or both, may also predispose to pyomyositis.


5. DOCID:26031 SCORE: 0.00243883814228418
DOCNO: 11484991
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
AUTHOR: Y Michiwa Y
AUTHOR: M Earashi M
AUTHOR: H Kobayashi H
AUTHOR: N Matsuki N
AFFILIATION: Dept. of Surgery, Toyama Rosai Hospital, Uozu, Japan. surgery@keiju.co.jp
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of experimental & clinical cancer research : CR.
COUNTRY: Italy
TITLE: Cutaneous metastases from gastric adenocarcinoma treated with combination chemotherapy producing complete response with long survival.
PUBDATE: 20010601
A case of cutaneous metastases from gastric adenocarcinoma was presented. It was treated with combination chemotherapy producing complete response with prolongation of survival. Skin metastasis will indicate early fatal termination, therefore there has not yet been a reported case of cutaneous metastasis from gastric cancer to have complete response with long survival.


6. DOCID:23051 SCORE: 0.0023982085524768
DOCNO: 9067076
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mammography
DESCRIPTOR: Mass Screening
DESCRIPTOR: Physical Examination
QUALIFIER: prevention & control
AUTHOR: M E Costanza ME
AUTHOR: K L Edmiston KL
AFFILIATION: University of Massachusetts Medical Center, Department of Medicine, Worcester 01655, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Comprehensive therapy.
COUNTRY: UNITED STATES
TITLE: Breast cancer screening: early recognition.
PUBDATE: 19970101
The epidemic of breast cancer and the availability of tools to increase early detection and decrease mortality require care and diligence on the part of every physician directly caring for patients. With the widespread implementation of managed care, primary care physicians are in the best position to recommend breast cancer screening. Educational programs to emphasize the primary care physician's role in breast cancer prevention and detection, to improve physical examination skills, and to implement office systems to facilitate screening should be available to primary care physicians, and may have a major impact on breast cancer mortality in the future.


7. DOCID:19164 SCORE: 0.00235549651034465
DOCNO: 2202380
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: I F McKenzie IF
AUTHOR: P X Xing PX
AFFILIATION: Department of Pathology, University of Melbourne, Parkville, Victoria, Australia.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer cells (Cold Spring Harbor, N.Y. : 1989)
COUNTRY: UNITED STATES
TITLE: Mucins in breast cancer: recent immunological advances.
PUBDATE: 19900301
Mucins are heavily glycosylated proteins that are produced in excessive amounts in breast cancers and other adenocarcinomas. These proteins are potent immunogens; indeed, most monoclonal antibodies raised against extracts of breast cancer cells or tumors are directed toward a single family of mucins. The anti-mucin antibodies currently available are valuable diagnostic aids for detecting advanced stages of breast cancer. To improve the sensitivity of these antibodies so that they might be suitable for use in screening and early diagnosis, tumor imaging, and therapy of breast cancer, recent studies have focused on identifying the precise epitopes they recognize.


8. DOCID:22305 SCORE: 0.00233394995452921
DOCNO: 7552793
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Parenteral Nutrition, Total
QUALIFIER: therapy
AUTHOR: A D Hill AD
AUTHOR: J M Daly JM
AFFILIATION: Department of Surgery, New York Hospital/Cornell University Medical Center, New York, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Surgical oncology clinics of North America.
COUNTRY: UNITED STATES
TITLE: Current indications for intravenous nutritional support in oncology patients.
PUBDATE: 19950701
No clear role has yet been defined for the role of total parenteral nutrition in the management of the cancer patient, and this subject remains an area of controversy. Peri-operative nutritional support, if given for at least 10 days, may reduce morbidity and mortality in some patients, although this subgroup has not been fully characterized. There is no evidence that parenteral nutritional support benefits patients undergoing chemotherapy or radiotherapy in terms of an increased tumor response rate or prolongation of survival.


9. DOCID:19450 SCORE: 0.00227177068246294
DOCNO: 1321398
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Renal Dialysis
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: E Ibrányi E
AUTHOR: I Mihály I
AUTHOR: M Kovács M
AUTHOR: L Telegdy L
AFFILIATION: V. sz. Belosztály, Fóvárosi Szent László Kórház, Budapest.
PUBTYPE: Journal Article
JOURNALTITLE: Orvosi hetilap.
COUNTRY: HUNGARY
TITLE: [Delta virus infection in hemodialyzed kidney patients and patients with chronic liver diseases]
PUBDATE: 19920701
Sera of patients with chronic hepatitis and chronic haemodialysed uraemia were tested for both Hepatitis B virus and Hepatitis Delta virus markers from 1985. Hepatitis Delta virus seroconversion was found in 10 of 88 haemodialysed patients and anti-Delta-IgG sero-positivity in 11 of 108 chronic hepatitis patients. The clinical course of Delta superinfections in haemodialysed patients was as follows: 3 infections were symptomless, 7 patients had acute hepatitis, two of the latter group died because of fulminant hepatitis. Of the 11 HBsAg and anti-Delta-IgG positive chronic hepatitis patients 3 had primary hepatocellular cancer.


10. DOCID:19386 SCORE: 0.00227176408286072
DOCNO: 1420519
AUTHOR: D Trichopoulos D
AUTHOR: R D Lipman RD
AFFILIATION: Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Epidemiology (Cambridge, Mass.)
COUNTRY: UNITED STATES
TITLE: Mammary gland mass and breast cancer risk.
PUBDATE: 19921101
Evidence indicates that early life events and conditions, possibly extending to the intrauterine stages of life, and including energy restriction in early life, affect the risk of breast cancer. The mechanism of this effect is likely to be through a reduction in mammary gland mass and, inferentially, the total number of ductal stem cells. The evidence derives from epidemiologic and animal studies. It can explain certain epidemiologic findings that cannot be accounted for by more established breast cancer risk factors, including the more frequent occurrence of breast cancer in the left breast and the higher incidence of this disease among caucasian women than among Asian women in Asia.


11. DOCID:27614 SCORE: 0.00216291124647127
DOCNO: 9721090
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Apoptosis
AUTHOR: G Evan G
AUTHOR: T Littlewood T
AFFILIATION: Imperial Cancer Research Fund Laboratories, 44, Lincoln's Inn Fields, London WC2A 3PX, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Science.
COUNTRY: UNITED STATES
TITLE: A matter of life and cell death.
PUBDATE: 19980801
In multicellular organisms, mutations in somatic cells affecting critical genes that regulate cell proliferation and survival cause fatal cancers. Repair of the damage is one obvious option, although the relative inconsequence of individual cells in metazoans means that it is often a "safer" strategy to ablate the offending cell. Not surprisingly, corruption of the machinery that senses or implements DNA damage greatly predisposes to cancer. Nonetheless, even when oncogenic mutations do occur, there exist potent mechanisms that limit the expansion of affected cells by suppressing their proliferation or triggering their suicide. Growing understanding of these innate mechanisms is suggesting novel therapeutic strategies for cancer.


12. DOCID:29784 SCORE: 0.00208402315740498
DOCNO: 15841168
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: therapy
QUALIFIER: genetics
QUALIFIER: therapy
AUTHOR: Yakov Chudnovsky Y
AUTHOR: Paul A Khavari PA
AUTHOR: Amy E Adams AE
AFFILIATION: Veterans Affairs Palo Alto Healthcare System, Palo Alto, California, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Journal of clinical investigation.
COUNTRY: United States
TITLE: Melanoma genetics and the development of rational therapeutics.
PUBDATE: 20050401
Melanoma is a cancer of the neural crest-derived cells that provide pigmentation to skin and other tissues. Over the past 4 decades, the incidence of melanoma has increased more rapidly than that of any other malignancy in the United States. No current treatments substantially enhance patient survival once metastasis has occurred. This review focuses on recent insights into melanoma genetics and new therapeutic approaches being developed based on these advances.


13. DOCID:27579 SCORE: 0.00204997736300125
DOCNO: 10674986
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: T Kikuchi T
AUTHOR: J Arai J
AUTHOR: H Shibuki H
AUTHOR: H Kawashima H
AUTHOR: N Yoshimura N
AFFILIATION: Department of Ophthalmology, Shinshu University School of Medicine, Matsumoto, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of neuroimmunology.
COUNTRY: NETHERLANDS
TITLE: Tubby-like protein 1 as an autoantigen in cancer-associated retinopathy.
PUBDATE: 20000201
Cancer-associated retinopathy (CAR) is a rare paraneoplastic syndrome that is characterized by retinal degeneration. Two cDNA clones, recoverin and tubby-like protein 1 (TULP1), were isolated from a human retinal cDNA library by using serum from a CAR patient as the probe. Both recoverin and TULP1 are retina-specific protein, and TULP1 is a member of tubby gene family. A determination of the recognized amino acid sequence of TULP1 by the patient serum and immunohistochemical studies on the distribution of TULP1 in the retina were done in this study.


14. DOCID:25011 SCORE: 0.00194932745809621
DOCNO: 11677125
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemistry
QUALIFIER: chemical synthesis
QUALIFIER: analogs & derivatives
QUALIFIER: chemistry
QUALIFIER: chemistry
QUALIFIER: chemistry
AUTHOR: Y Xie Y
AUTHOR: M D Short MD
AUTHOR: P B Cassidy PB
AUTHOR: J C Roberts JC
AFFILIATION: Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Bioorganic & medicinal chemistry letters.
COUNTRY: England
TITLE: Selenazolidines as novel organoselenium delivery agents.
PUBDATE: 20011101
Two new classes of selenazolidine-4(R)-carboxylic acids (2-oxo and 2-methyl-SCAs) were synthesized and characterized. Both were designed as latent forms of selenocysteine, intended to provide a chemically superior delivery form for selenium. The prodrugs may be clinically useful when selenium supplementation at supranutritional levels is indicated, such as in cancer chemoprevention.