0. DOCID:21934 SCORE: 0.000250017121683647
DOCNO: 8854585
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: pathology
QUALIFIER: diagnosis
QUALIFIER: pathology
QUALIFIER: complications
AUTHOR: E Ichikawa E
AUTHOR: S Asano S
AUTHOR: S Okabe S
AUTHOR: M Itami M
AUTHOR: K Ohara K
AFFILIATION: Department of Dermatology, Doai Memorial Hospital, Tokyo, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of dermatology.
COUNTRY: JAPAN
TITLE: A case of cutaneous malignant fibrous histiocytoma.
PUBDATE: 19960801
A 54-year-old Japanese man with cutaneous malignant fibrous histiocytoma on the back is reported. He not only had a past history of thyroid cancer 1 year prior to the onset of the skin tumor, but also had simultaneous bladder cancer. Despite the early, wide resection, the prognosis was rapid and progressive. Histologically, the primary lesion of the skin tumor was difficult to differentiate from dermatofibrosarcoma protuberans; however, the recurrent and the metastatic lesions changed in appearance.


1. DOCID:22472 SCORE: 0.000250013221190593
DOCNO: 8531380
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Drug Resistance, Neoplasm
QUALIFIER: chemistry
QUALIFIER: physiology
AUTHOR: T Tsuruo T
AFFILIATION: Institute of Molecular and Cellular Biosciences, University of Tokyo.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine.
COUNTRY: JAPAN
TITLE: [Structure and function of P-glycoprotein in antitumor agent resistance; implication for clinical setting]
PUBDATE: 19951001
Resistance of tumors to a variety of chemotherapeutic agents presents a major problem in cancer treatment. The gene responsible for multidrug resistance, termed mdr1, encodes a membrane glycoprotein (P-glycoprotein) that acts as a pump to transport various cytotoxic agents. The P-glycoprotein has been shown to bind anticancer drugs and several resistance-reversing agents including calcium channel blockers, and to be an ATPase. The P-glycoprotein was found to function in blood-brain barrier. The implication of the P-glycoprotein in relation to therapy is discussed.


2. DOCID:20169 SCORE: 0.000250011614300079
DOCNO: 9538660
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: blood
QUALIFIER: enzymology
QUALIFIER: diagnosis
AUTHOR: K Ciechanowski K
AUTHOR: D Cebula D
AFFILIATION: Zakładu Biochemi Klinicznej i Diagnostyki Laboratoryjnej PAM w Szczecinie.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
COUNTRY: POLAND
TITLE: [Two cases of Lambert-Eaton syndrome with an increase of serum cholinesterase activity]
PUBDATE: 19970201
Paraneoplastic Lambert-Eaton myasthenia syndrome is presented in two cases with small cell lung cancer. An increase of serum cholinesterase activity was explained by induced release of biologically active proteins by neoplastic tissue.


3. DOCID:20370 SCORE: 0.000250011593987778
DOCNO: 9363063
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Lung Neoplasms
DESCRIPTOR: Mediastinal Neoplasms
QUALIFIER: secondary
AUTHOR: R S Tharratt RS
AFFILIATION: University of California, Davis, School of Medicine, Sacramento, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in pulmonary medicine.
COUNTRY: UNITED STATES
TITLE: Intrathoracic neoplasms other than bronchogenic carcinoma.
PUBDATE: 19950701
Intrathoracic neoplasms other than lung cancer represent a diverse group of diseases. This review focuses on the recent literature addressing mediastinal neoplasms, unusual primary lung neoplasms, and pulmonary metastases from other locations. Advances in classification, imaging, diagnosis, surgical issues, and treatment issues shown in case series and individual case reports are presented and discussed.


4. DOCID:20032 SCORE: 0.000250011422708205
DOCNO: 9257068
AUTHOR: D Machin D
AFFILIATION: Medical Research Council Cancer Trials Office, Cambridge, United Kingdom.
PUBTYPE: Journal Article
JOURNALTITLE: Controlled clinical trials.
COUNTRY: UNITED STATES
TITLE: Assessing quality of life in comparative cancer clinical trials: does it make a difference?
PUBDATE: 19970801
Many randomized Phase III trials of cancer therapy involve quality of life assessments. This paper argues for graphical presentation of quality of life measures in order to visualize changes over time.


5. DOCID:22456 SCORE: 0.000250010267000773
DOCNO: 8761072
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasm Seeding
DESCRIPTOR: Wound Healing
QUALIFIER: surgery
AUTHOR: P Jacquet P
AUTHOR: D Elias D
AUTHOR: P H Sugarbaker PH
AFFILIATION: Washington Cancer Institute, Washington, DC 20010, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal de chirurgie.
COUNTRY: FRANCE
TITLE: [Tumor implantation in cicatrization sites following surgery for digestive cancers]
PUBDATE: 19960601
The natural history of surgically treated intraabdominal malignancy is such that a large proportion of patients present tumor recurrence at wound sites. Numerous factors operating within the wound environment are important determinants in tumor cells arrest or growth at these sites. This article describes the interactions between the traumatized tissues and tumor cells, and attempts to understand the important factors that may have an impact on implantation of cancer cells in wound sites. Modifications of these biologic factors may represent new perspectives for preventing tumor recurrence in intraabdominal wound sites.


6. DOCID:23876 SCORE: 0.000250010068533966
DOCNO: 7951271
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: methods
QUALIFIER: drug therapy
QUALIFIER: statistics & numerical data
AUTHOR: D Faries D
AFFILIATION: Eli Lilly & Company, Lilly Corporate Center, Indianapolis, Indiana 46285.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of biopharmaceutical statistics.
COUNTRY: UNITED STATES
TITLE: Practical modifications of the continual reassessment method for phase I cancer clinical trials.
PUBDATE: 19940701
The continual reassessment method (1) (CRM) for phase I cancer trials provides improved estimation of the maximum tolerated dose (MTD), and fewer patients receive ineffective dose levels compared to the traditionally used design. However, the CRM has not gained acceptance in practice owing to concerns with administering dose levels that are too toxic. In this article, several conservative modifications of the CRM are introduced. The result is a procedure that improves estimation of the MTD and decreases the use of ineffective doses, without significantly increasing the use of toxic dose levels. The CRM with modification outperforms the traditional method in a simulation study.


7. DOCID:23550 SCORE: 0.000250009984597288
DOCNO: 8653647
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antigens, Nuclear
DESCRIPTOR: DNA Helicases
DESCRIPTOR: Saccharomyces cerevisiae Proteins
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: A Robinson A
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.
COUNTRY: CANADA
TITLE: The Ku autoantigen: cast in a new light.
PUBDATE: 19960601
With his associates at the University of Ottawa, Dr. Robert Haché has demonstrated that the Ku autoantigen, a protein that plays a role in DNA repair and in immunoglobulin gene recombination, also modifies the action of steroid hormones. This finding has potential implications for the treatment of tumours whose growth is influenced by steroid hormones. The researchers suggest that Ku could be involved in the control of gene expression through a mechanism involving protein phosphorylation. They hope that a better understanding of the role Ku plays in many cellular processes may improve our understanding of autoimmune diseases, diseases of immune deficiency and cancer.


8. DOCID:21364 SCORE: 0.000250008711234758
DOCNO: 9294952
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: drug effects
QUALIFIER: ultrasonography
QUALIFIER: adverse effects
QUALIFIER: ultrasonography
AUTHOR: B M Jaeger BM
AUTHOR: K Grumbach K
AFFILIATION: Department of Diagnostic Radiology, University of Maryland Medical Center, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Maryland medical journal (Baltimore, Md. : 1985)
COUNTRY: UNITED STATES
TITLE: Tamoxifen induced endometrial abnormalities: evaluation by saline infusion sonohysterography.
PUBDATE: 19970901
Patients receiving tamoxifen therapy for breast cancer are at an increased risk for endometrial hyperplasia, polyps, and adenocarcinoma. Therefore, any bleeding in the post-menopausal patient on tamoxifen warrants further investigation. Sonohysterography is a new technique for evaluating the uterine cavity and clarifying the location of endometrial and peri-endometrial processes. Differentiating subendometrial cyst formation from endometrial proliferation can save patients from further, invasive investigative diagnostic procedures.


9. DOCID:22311 SCORE: 0.000250008153802716
DOCNO: 7778311
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Nurse-Patient Relations
QUALIFIER: nursing
AUTHOR: B M Artinian BM
AFFILIATION: Azusa Pacific University, Los Angeles, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Western journal of nursing research.
COUNTRY: UNITED STATES
TITLE: Risking involvement with cancer patients.
PUBDATE: 19950601
The helping relationship has been identified by Brammer (1988) as central to the practice of nursing. This study explored the process of developing special relationships with cancer patients. Interviews were conducted with 32 nursing personnel. The grounded theory method of constant comparative analysis was selected for this investigation. An open-ended interview guide explored the difference between the usual relationships nurses had and the special relationships they formed with selected patients. A basic psychosocial process, "risking involvement" in special relationships with cancer patients, was identified. The willingness to risk involvement took the forms of resisting involvement or practicing involvement.


10. DOCID:22336 SCORE: 0.000250008153802716
DOCNO: 8935748
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ambulatory Care
QUALIFIER: therapeutic use
QUALIFIER: complications
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: S Sleijfer S
AUTHOR: H S Koops HS
AUTHOR: W T van der Graaf WT
AFFILIATION: Department of Internal Medicine, University Hospital, Groningen, Netherlands.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Netherlands journal of medicine.
COUNTRY: NETHERLANDS
TITLE: Successful treatment on an out-patient basis of a patient with Down's syndrome and disseminated testicular seminoma.
PUBDATE: 19960301
Due to a high incidence of undescended testicles, patients with Down's syndrome have an increased risk of testicular cancer. The treatment of these patients with the successful cisplatin-containing regimens, which are however toxic and require hospitalization, can cause several problems. We present a patient with Down's syndrome suffering from a disseminated seminomatous tumour of the testis who has been successfully treated with combination chemotherapy on an out-patient basis.


11. DOCID:23450 SCORE: 0.00025000769899467
DOCNO: 7644565
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: B D Curti BD
AUTHOR: J W Smith JW
AFFILIATION: Biological Response Modifiers Program, National Cancer Institute-Frederick Cancer Research and Development Center, MD 21701, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Pharmacology & therapeutics.
COUNTRY: ENGLAND
TITLE: Interleukin-1 in the treatment of cancer.
PUBDATE: 19950301
Interleukin-1 (IL-1) is a cytokine with many activities central to immune function and hematopoiesis. Many IL-1 properties can be potentially exploited in the treatment of malignancy. This review describes the toxicities and antitumor effects observed in Phase I and II trials of IL-1 in cancer patients. The immunophysiology and the induction of cytokines by IL-1 has been examined in many of the Phase I trials and has aided in understanding IL-1 effects in humans. The influence of IL-1 on granulopoiesis and thrombopoiesis when given by different regimes is also reviewed in detail.


12. DOCID:23441 SCORE: 0.000250007450497103
DOCNO: 8539719
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: adverse effects
QUALIFIER: surgery
AUTHOR: T Myrmel T
AUTHOR: S M Almdahl SM
AFFILIATION: Kirurgisk avdeling Regionsykehuset i Tromsø.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Tidsskrift for den Norske laegeforening.
COUNTRY: NORWAY
TITLE: [Omentoplasty in bronchopleural fistulas after pneumonectomy]
PUBDATE: 19951101
A bronchopleural fistula after pneumonectomy is a serious complication, and successful healing is a therapeutic challenge. Increasing evidence indicates that closing of the fistula combined with wrapping the bronchus with omentum (omentoplasty) can secure permanent healing in the majority of cases. The omentum is highly vascularized, and has angiogenetic and anti-inflammatory properties. We describe two patients with bronchopleural fistulas after surgery for lung cancer. The fistulas were diagnosed respectively one and fifteen months after operation. Both were treated successfully with antibiotics, surgical debridement, secondary closure and wrapping of the fistulas with omentum transposed from the abdomen with its attachment to the right gastroepiploic artery preserved.


13. DOCID:20649 SCORE: 0.000250007326092072
DOCNO: 8944207
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Breast Neoplasms
AUTHOR: R Sainsbury R
AFFILIATION: Department of Surgery, Royal Infirmary, Huddersfield, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Postgraduate medical journal.
COUNTRY: ENGLAND
TITLE: Breast cancer.
PUBDATE: 19961101
The management of patients with breast cancer has been changing over the last few years and this article highlights some areas of particular interest. The changes have been brought about against a background of an increasing disease incidence coupled with increasing political aspirations from patients and their relatives. This paper focuses on organisational aspects of breast cancer care, screening, induction and high-dose chemotherapy, clinical trials, genetics, training of surgical and nonsurgical oncologists and future prospects.


14. DOCID:22115 SCORE: 0.000250007302904799
DOCNO: 9095758
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Attitude of Health Personnel
DESCRIPTOR: Attitude to Health
QUALIFIER: diagnosis
QUALIFIER: psychology
QUALIFIER: standards
AUTHOR: L Hay L
AUTHOR: M Farncombe M
AUTHOR: P McKee P
AFFILIATION: Queensway Carleton Hospital, Nepean, Ontano.
PUBTYPE: Journal Article
JOURNALTITLE: The Canadian nurse.
COUNTRY: CANADA
TITLE: Patient, nurse and physician views of dyspnea.
PUBDATE: 19961101
Dyspnea, the subjective sensation of laboured or difficult breathing, is a frequent complaint of patients with terminal disease. Among terminally ill cancer patients, for example, the incidence has been reported to be as high as 74 per cent. Dyspnea is multidimensional, having both physiological and psychological aspects, and, for most people, it worsens as the disease progresses. It is an extremely distressing symptom for both the patient and the family; virtually all dyspneic patients report anxiety or fear of suffocation, a fear that, in turn, exacerbates the dyspnea.