0. DOCID:16003 SCORE: 0.000250023976473358
DOCNO: 1826844
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: R Karel-Brant R
PUBTYPE: Journal Article
JOURNALTITLE: Dermatology nursing / Dermatology Nurses' Association.
COUNTRY: UNITED STATES
TITLE: Periorbital skin cancers.
PUBDATE: 19910401
Mohs surgery is an excellent treatment for removal of periorbital skin cancers. Important structures and surrounding tissue may be preserved with this technique.

1. DOCID:24004 SCORE: 0.000250023934138709
DOCNO: 11682928
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Survival Rate
QUALIFIER: standards
QUALIFIER: standards
QUALIFIER: nursing
PUBTYPE: Journal Article
JOURNALTITLE: Clinical resource management.
COUNTRY: United States
TITLE: More educated nurses prove cost-effective for the sickest patients.
PUBDATE: 20011001
Follow-up by advanced practice nurses--as opposed to traditionally trained RNs--is associated with better outcomes among cancer patients.

2. DOCID:19587 SCORE: 0.000250023821599849
DOCNO: 1736473
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genital Neoplasms, Male
DESCRIPTOR: Penile Neoplasms
DESCRIPTOR: Precancerous Conditions
DESCRIPTOR: Scrotum
AUTHOR: P F Schellhammer PF
AUTHOR: G H Jordan GH
AUTHOR: E L Robey EL
AUTHOR: J T Spaulding JT
AFFILIATION: Department of Urology, Eastern Virginia Medical School, Norfolk.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Urologic clinics of North America.
COUNTRY: UNITED STATES
TITLE: Premalignant lesions and nonsquamous malignancy of the penis and carcinoma of the scrotum.
PUBDATE: 19920201
Premalignant lesions of the penis include cutaneous horn, balanitis xerotica obliterans, and leukoplakia. The true incidence of progression of each of these to squamous-cell carcinoma is unknown. Bowenoid papulosis, erythroplasia of Queyrat, and Bowen's disease are histologically identical to in situ carcinoma. Although the first is consistently benign, the latter two regularly evolve into invasive cancer. Malignant scrotal lesions include squamous-cell carcinoma, liposarcoma, leiomyosarcoma, basal-cell carcinoma, extramammary Paget's disease, erythroplasia of Queyrat, malignant melanoma, and metastases. Hemangioma can be confused with carcinoma.

3. DOCID:19300 SCORE: 0.000250021759025964
DOCNO: 8094712
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Amplification
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: therapeutic use
AUTHOR: U Lönn U
AUTHOR: S Lönn S
AUTHOR: B Stenkvist B
AFFILIATION: Radiumhemmet, Karolinska Hospital, Stockholm, Sweden.
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: UNITED STATES
TITLE: Reduced occurrence of mdr-1 amplification in stage-IV breast-cancer patients treated with tamoxifen compared with other endocrine treatments.
PUBDATE: 19930201
Amplification of mdr-1 occurs in breast cancer patients receiving endocrine treatment. We have compared a group of patients receiving tamoxifen and a group receiving second-line endocrine treatment after failure of tamoxifen treatment. Chronological tumor samples were obtained by fine-needle biopsies from the same tumor lesion of each patient and PCR was used to detect the appearance of gene amplification. Three of 20 patients receiving tamoxifen developed amplified mdr-1 whereas 7 of 17 patients receiving second-line endocrine treatment developed mdr-1 amplification.

4. DOCID:16005 SCORE: 0.00025002009188577
DOCNO: 8487233
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemically induced
QUALIFIER: adverse effects
QUALIFIER: adverse effects
AUTHOR: P J Maguire PJ
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Journal of reproductive medicine.
COUNTRY: UNITED STATES
TITLE: Estrogen replacement therapy and breast cancer.
PUBDATE: 19930301
The safety of estrogen use in breast cancer patients is discussed. Most reports indicate there is no risk.

5. DOCID:27728 SCORE: 0.000250018193756397
DOCNO: 9848370
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: blood supply
QUALIFIER: physiopathology
AUTHOR: H M Pinedo HM
AUTHOR: H M Verheul HM
AUTHOR: R J D'Amato RJ
AUTHOR: J Folkman J
AFFILIATION: Department of Medical Oncology, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands.
PUBTYPE: Journal Article
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: Involvement of platelets in tumour angiogenesis?
PUBDATE: 19981101
Preclinical and clinical research show that tumour growth is dependent on angiogenesis. Activation of the coagulation cascade is commonly found in patients with cancer. We propose that platelets contribute to tumour-induced angiogenesis. The basis of our hypothesis is that platelets are a rich source of stimulators and inhibitors of angiogenesis and their interaction with the endothelium. Presumably, the antithrombotic state of normal endothelium is disturbed by endothelial stimuli derived from tumour cells. This hypothesis may explain the suggested clinical benefits of anticoagulants in cancer and implies that targeting of platelet interaction with tumour vasculature will inhibit angiogenesis.

6. DOCID:21934 SCORE: 0.000250017121683647
DOCNO: 8854585
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: pathology
QUALIFIER: diagnosis
QUALIFIER: pathology
QUALIFIER: complications
AUTHOR: E Ichikawa E
AUTHOR: S Asano S
AUTHOR: S Okabe S
AUTHOR: M Itami M
AUTHOR: K Ohara K
AFFILIATION: Department of Dermatology, Doai Memorial Hospital, Tokyo, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of dermatology.
COUNTRY: JAPAN
TITLE: A case of cutaneous malignant fibrous histiocytoma.
PUBDATE: 19960801
A 54-year-old Japanese man with cutaneous malignant fibrous histiocytoma on the back is reported. He not only had a past history of thyroid cancer 1 year prior to the onset of the skin tumor, but also had simultaneous bladder cancer. Despite the early, wide resection, the prognosis was rapid and progressive. Histologically, the primary lesion of the skin tumor was difficult to differentiate from dermatofibrosarcoma protuberans; however, the recurrent and the metastatic lesions changed in appearance.

7. DOCID:24034 SCORE: 0.000250016407711069
DOCNO: 10101465
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: surgery
AUTHOR: W I Krasnodebski WI
AUTHOR: D Kopeć D
AFFILIATION: Katedry i Kliniki Chirurgii Gastroenterologicznej AM w Warszawie.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
COUNTRY: POLAND
TITLE: [Results of treatment of the cancer of the large intestine in elderly patients]
PUBDATE: 19980801
In the surgical management of colorectal cancer was disscussed and clinico-pathological features of prognostic significance were undelined.

8. DOCID:18816 SCORE: 0.000250015772396121
DOCNO: 2043699
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: C Naftzger C
AUTHOR: A N Houghton AN
AFFILIATION: Memorial Sloan-Kettering Cancer Center, New York, New York.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in oncology.
COUNTRY: UNITED STATES
TITLE: Tumor immunology.
PUBDATE: 19910201
The underlying premise of tumor immunology is that the immune system is capable of recognizing cancer cells and that immune recognition can lead to rejection of tumors by the host. We focus on recent advances in tumor immunology in experimental systems, including the molecular identification of tumor antigens, studies of recognition of tumor cells by the immune system, and the development of new strategies for treatment of cancer. Identifying potential target antigens on tumors and defining effector arms of the immune system that mediate tumor rejection (including T cells, natural killer cells, antibodies, complement cells, and cytokines) remain crucial problems for the field.

9. DOCID:24215 SCORE: 0.000250015251097188
DOCNO: 9616560
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Critical Pathways
QUALIFIER: surgery
AUTHOR: R A Tucci RA
AUTHOR: K L Bartels KL
AFFILIATION: Lankenau Hospital, Main Health Systems, Wynnewood, PA, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Clinical journal of oncology nursing.
COUNTRY: UNITED STATES
TITLE: Ovarian cancer surgery: a clinical pathway.
PUBDATE: 19980401
Clinical pathways are useful tools in providing quality care while decreasing the cost of that care. Pathways help to facilitate managed care, identify patient and family educational needs, encourage multidisciplinary communication, and expedite patient discharge. This article discusses a clinical pathway for ovarian cancer surgery.

10. DOCID:22472 SCORE: 0.000250013221190593
DOCNO: 8531380
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Drug Resistance, Neoplasm
QUALIFIER: chemistry
QUALIFIER: physiology
AUTHOR: T Tsuruo T
AFFILIATION: Institute of Molecular and Cellular Biosciences, University of Tokyo.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine.
COUNTRY: JAPAN
TITLE: [Structure and function of P-glycoprotein in antitumor agent resistance; implication for clinical setting]
PUBDATE: 19951001
Resistance of tumors to a variety of chemotherapeutic agents presents a major problem in cancer treatment. The gene responsible for multidrug resistance, termed mdr1, encodes a membrane glycoprotein (P-glycoprotein) that acts as a pump to transport various cytotoxic agents. The P-glycoprotein has been shown to bind anticancer drugs and several resistance-reversing agents including calcium channel blockers, and to be an ATPase. The P-glycoprotein was found to function in blood-brain barrier. The implication of the P-glycoprotein in relation to therapy is discussed.

11. DOCID:28058 SCORE: 0.000250012882140227
DOCNO: 12565007
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: trends
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
AUTHOR: Andrew D Westwell AD
AFFILIATION: School of Pharmaceutical Sciences, University of Nottingham, University Park, Nottingham, UK NG7 2RD. Andrew.Westwell@nottingham.ac.uk
PUBTYPE: Journal Article
JOURNALTITLE: Drug discovery today.
COUNTRY: England
TITLE: A new era in cancer therapeutics?
PUBDATE: 20030101
Highlights from the 14th EORTC-NCI-AACR Symposium Molecular Targets and Cancer Therapeutics, 19-22 November 2002, in Frankfurt, Germany.

12. DOCID:28555 SCORE: 0.000250012714172963
DOCNO: 16121704
OWNER: NLM
STATUS: In-Process
AUTHOR: Tomasz Switaj T
AUTHOR: Witold Lasek W
AFFILIATION: Center of Oncology--Institute Soft Tissue/Bone Sarcoma and Melanoma Department, Roentgena 5, Warsaw 02-781, Poland. tswitaj@ib.amwaw.edu.pl
PUBTYPE: Journal Article
JOURNALTITLE: Current opinion in molecular therapeutics.
COUNTRY: England
TITLE: Technology evaluation: HYB-2055, Hybridon.
PUBDATE: 20050801
Hybridon is developing immunomodulatory oligonucleotides. including injectable HYB-2055 (IMOxine) which acts as an agonist of toll-like receptor 9, for the potential treatment of cancer. HYB-2055 is currently undergoing phase II clinical trials. The immunomodulatory oligonucleotides are also being investigated for the potential treatment of infectious diseases and immune disorders.

13. DOCID:17351 SCORE: 0.000250012437959484
DOCNO: 1919352
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: pathology
QUALIFIER: secondary
AUTHOR: S Elango S
AUTHOR: B A Kareem BA
AUTHOR: S Chandrasekaran S
AUTHOR: N Azman N
AFFILIATION: School of Medical Sciences (USM), Kota Bharu, Malaysia.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of laryngology and otology.
COUNTRY: ENGLAND
TITLE: Nasopharyngeal carcinoma with spinal secondaries.
PUBDATE: 19910901
Nasopharyngeal carcinoma has been reported to have a higher incidence of distant metastases as compared to other head and neck cancers. Distant metastases of nasopharyngeal carcinoma has been reported in the bones, lungs, liver, distant lymph nodes, brain and porta hepatis. This report presents a case of nasopharyngeal carcinoma with secondaries in the extradural space at the thoracic level of the spinal cord which hitherto has been an unreported site.

14. DOCID:26484 SCORE: 0.000250012404187059
DOCNO: 11063129
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: pathology
QUALIFIER: physiopathology
AUTHOR: M Molinari M
AFFILIATION: European Institute of Oncology, Milan, Italy. mmolinari@ieo.it
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cell proliferation.
COUNTRY: ENGLAND
TITLE: Cell cycle checkpoints and their inactivation in human cancer.
PUBDATE: 20001001
Checkpoints are mechanisms that regulate progression through the cell cycle insuring that each step takes place only once and in the right sequence. Mutations of checkpoint proteins are frequent in all types of cancer as defects in cell cycle control can lead to genetic instability. This review will focus on three major areas of cell cycle transition control, with particular attention to the alterations found in human cancer. These areas include the G1/S transition, where most cancer-related defects occur, the G2/M checkpoint and its activation in response to DNA damage, and the spindle checkpoint.