0. DOCID:9405 SCORE: 0.000250017894299735
DOCNO: 6233779
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: J B deKernion JB
AUTHOR: A Lindner A
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Urologic clinics of North America.
COUNTRY: UNITED STATES
TITLE: Chemotherapy of hormonally unresponsive prostatic carcinoma.
PUBDATE: 19840501
The national Prostatic Cancer Project has evaluated single and combination chemotherapeutic agents for the treatment of patients with advanced prostatic cancer that has been unresponsive to hormonal therapy. Although regression rates have been modest, a number of drugs have shown some efficacy and are now undergoing testing in combination. Current trials of the LH-RH agonists and the antiandrogen flutamide are in progress. These trials have demonstrated a role for chemotherapy in the treatment of the patient who has failed hormonal therapy.

1. DOCID:1938 SCORE: 0.000250017277049139
DOCNO: 865202
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: C Gebhardt C
AUTHOR: D Moschinski D
AUTHOR: J Usmiani J
PUBTYPE: Journal Article
JOURNALTITLE: Langenbecks Archiv für Chirurgie.
COUNTRY: GERMANY, WEST
TITLE: [The treatment to the high gastric ulcer (author's transl)]
PUBDATE: 19770401
This is a report on 64 patients, who were operated on because of gastric ulcer situated near the cardia. We found the best results after the so-called step-like resection, which is preferable to selective vagotomy with excision of the ulcer and pyloroplasty because of the special conditions of the secretion of gastric juice in the case of high ulcers. Because of the danger of the development of a cancer in a B-II-stomach we prefer the B-I-anastomosis. For ulcers with stenosis of the esophagus a cardiofundectomy should be performed. Ulcers high on the greater curvature and in the fundus should be excised and a distal gastrectomy (B-I) should follow. The sole excision of the ulcer or the operation according to Kelling-Madlener are not recommended.

2. DOCID:2974 SCORE: 0.000250016153875806
DOCNO: 169865
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: biosynthesis
QUALIFIER: metabolism
AUTHOR: M S Al-Adnani MS
AUTHOR: J A Kirrane JA
AUTHOR: J O McGee JO
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: ENGLAND
TITLE: Inappropriate production of collagen and prolyl hydroxylase by human breast cancer cells in vivo.
PUBDATE: 19750601
Thirty-two scirrhous cancers of breast have been examined to determine the origin of the collagen stroma in these tumours. Employing two immunohistochemical techniques it has been shown that the malignant epithelial cells in 30 of these tumours contain not only collagen but also prolyl hydroxylase, a key enzyme in collagen biosynthesis. Neither this enzyme nor collagen was detectable in the spindle cells in the stroma of these tumours. Neither the epithelium in normal breast, that in fibrocystic disease and in fibroadenomata, nor the malignant epithelium in two medullary cancers of breast contained either collagen or prolyl hydroxylase. These results strongly suggest that the malignant epithelium of scirrhous breast cancers produces its own collagen stroma and that the scirrhous reaction in these tumours is not a host response to tumour invasion. The production of collagen and prolyl hydroxylase by breast cancer cells (of the scirrhous type) therefore represents another example of inappropriate protein production by a human tumour.

3. DOCID:10297 SCORE: 0.000250015972505974
DOCNO: 6582324
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasms, Radiation-Induced
DESCRIPTOR: Ultraviolet Rays
QUALIFIER: chemically induced
QUALIFIER: pharmacology
QUALIFIER: chemically induced
AUTHOR: J H Epstein JH
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Effects of mechlorethamine (HN2, nitrogen mustard) on UV-induced carcinogenesis in hairless mouse skin.
PUBDATE: 19840201
The influence of mechlorethamine (HN2, nitrogen mustard) on UV-induced carcinogenesis was examined in the hairless mouse skin in vivo. Noncarcinogenic amounts of topically applied HN2 and carcinogenic levels of UVB energy were used in the study. The HN2 applications significantly accelerated the appearance and growth of cutaneous tumors in this study. Thus HN2 acted as either a promoter or cocarcinogen for UV-induced cancer formation. Although the mechanism of this effect was not established, combinations of UVB radiation and HN2 topical therapy pointed to an increased incidence of cutaneous tumors in human skin.

4. DOCID:229 SCORE: 0.000250015505290237
DOCNO: 1154620
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: M A Zybina MA
AUTHOR: N N Nabatich NN
PUBTYPE: Journal Article
JOURNALTITLE: Vestnik khirurgii imeni I. I. Grekova.
COUNTRY: USSR
TITLE: [Results of combination therapy of rectal cancer]
PUBDATE: 19750601
A comparative study of the results of treatment in 264 patients treated surgically and in 236 patients subjected to a combination treatment, using an intensive concentration gammatherapy (500 rad daily up to 3000 rad), has demonstrated that preoperative irradiation does not result in a higher postoperative mortality. In the combination therapy all kinds of surgery performed for rectal cancer seem to be feasible.

5. DOCID:15434 SCORE: 0.000250014321887307
DOCNO: 2824111
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: immunology
AUTHOR: J L Vila JL
AUTHOR: C Juarez C
AUTHOR: I Illa I
AUTHOR: M Agusti M
AUTHOR: C Gelpi C
AUTHOR: M J Amengual MJ
AUTHOR: J L Rodriguez JL
AFFILIATION: Department of Immunology, Hospital de Sant Pau, Universitat Autonoma de Barcelona, Spain.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Clinical immunology and immunopathology.
COUNTRY: UNITED STATES
TITLE: Autoantibodies against the H1(0) subtype of histone H1.
PUBDATE: 19871201
The specificity of antinuclear autoantibodies in a patient with a sensory neuropathy associated with cancer has been analyzed. The autoantibodies recognize the histone H1(0) as shown by its dissociation from DNA, perchloric solubility, electrophoretic mobility in SDS or urea/acid polyacrylamide gels, and by the capacity of purified H1(0) to block the reactivity of these autoantibodies. Almost no reactivity was observed with other subtypes of H1. To our knowledge, this is the first autoantibody described with such specific reactivity for the H1(0) subtype.

6. DOCID:545 SCORE: 0.000250014297336724
DOCNO: 1241712
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: C Damele C
AUTHOR: L Lancellotti L
PUBTYPE: Journal Article
JOURNALTITLE: Minerva chirurgica.
COUNTRY: ITALY
TITLE: [Statistical notes and long-term results in 178 patients operated for benign breast diseases]
PUBDATE: 19751101
178 patients of both sexes operated on for benign conditions of the mamilla between 1957 and 1967 were reviewed and the results are reported. The most frequent condition was sclerocystic mastosis, followed by benign cancer and forms with chronic inflammatory aetiology. The most affected sex, obviously, was the female. At follow-up, on average 9 yrs after operation, 19 female patients reported the reappearance of benign neoformations of the mamilla while carcinoma had occurred in a further 7 patients.

7. DOCID:4629 SCORE: 0.000250014135604226
DOCNO: 6269721
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: etiology
QUALIFIER: complications
AUTHOR: M L Hayward ML
AUTHOR: D A Howell DA
AUTHOR: J F O'Donnell JF
AUTHOR: L H Maurer LH
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Hypercalcemia complicating small-cell carcinoma.
PUBDATE: 19811001
Hypercalcemia is a common paraneoplastic syndrome complicating some varieties of lung cancer. It has rarely been reported with small-cell carcinoma of the lung. Seven cases of hypercalcemia complicating small-cell carcinoma of the lung are described; clinical features indicate that significant bone or bone marrow involvement is present in all cases. Parathormone assays were found to be generally in the normal range, though inappropriate for the levels of hypercalcemia.

8. DOCID:5830 SCORE: 0.000250014099792117
DOCNO: 7272931
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: administration & dosage
AUTHOR: A Manni A
AUTHOR: B M Arafah BM
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Tamoxifen-induced remission in breast cancer by escalating the dose to 40 mg daily after progression on 20 mg daily: a case report and review of the literature.
PUBDATE: 19810801
An 80-year-old woman with metastatic breast cancer to the lungs and bones was treated with tamoxifen, 10 mg twice daily, with arrest of disease of six month's duration. At the time of progression, increasing the dosage to 20 mg twice daily resulted in an objective remission now lasting 8+ months. This finding indicates that in this patient, the tamoxifen dosage of 40 mg/daily had a significantly higher anti-tumor effect than 20 mg/daily. Pertinent literature on the correlation of response with tamoxifen dosage is reviewed.

9. DOCID:12987 SCORE: 0.000250013702361754
DOCNO: 3818819
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antineoplastic Agents
DESCRIPTOR: Drug Evaluation, Preclinical
DESCRIPTOR: Drug Information Services
AUTHOR: M T Zehnacker MT
AUTHOR: R H Brennan RH
AUTHOR: G W Milne GW
AUTHOR: J A Miller JA
PUBTYPE: Journal Article
JOURNALTITLE: Journal of chemical information and computer sciences.
COUNTRY: UNITED STATES
TITLE: The NCI Drug Information System. 5. DIS Biology Module.
PUBDATE: 19861101
The NCI drug screening program tests over 10,000 chemicals per year for activity against cancer. The associated Drug Information System (DIS) captures all the raw testing data and provides for its validation. The large quantity of numeric data gathered during testing is maintained within the DIS in a database that is interactively searchable and automatically updated at regular intervals.

10. DOCID:1342 SCORE: 0.000250012465203583
DOCNO: 330975
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Blood Transfusion
DESCRIPTOR: Platelet Transfusion
QUALIFIER: therapy
AUTHOR: J Aisner J
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Medical clinics of North America.
COUNTRY: UNITED STATES
TITLE: Platelet transfusion therapy.
PUBDATE: 19770901
Platelet transfusions are of unquestionably proven benefit for the correction of thrombocytopenia or functional platelet disorders, and they have allowed for more intensive antineoplastic therapy. With the advent of blood component therapy most modern blood banks now have the capabilities for supplying at least limited quantities of platelets. Refinements in procurement methods will inevitably lead to a greater supply of platelets and the establishment of larger transfusion programs. These programs will need to incorporate facilities for platelet storage, recruitment of suitable donors, selection of special donors for refractory patients, and methods for quality control. As antineoplastic therapy becomes more aggressive, such transfusion programs will become an integral part of the operation of cancer treatment centers.

11. DOCID:12765 SCORE: 0.000250012291780973
DOCNO: 2769539
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: N S Adzick NS
AUTHOR: J H Fisher JH
AUTHOR: H S Winter HS
AUTHOR: R H Sandler RH
AUTHOR: W H Hendren WH
AFFILIATION: Department of Surgery, Children's Hospital, Boston, MA 02115.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of pediatric surgery.
COUNTRY: UNITED STATES
TITLE: Esophageal adenocarcinoma 20 years after esophageal atresia repair.
PUBDATE: 19890801
We report a case of esophageal adenocarcinoma 20 years after esophageal atresia repair. From one case report it is premature to recommend cancer surveillance for all esophageal atresia patients. However, the first survivors are now reaching an age when esophageal cancer related to chronic esophagitis may become more prevalent.

12. DOCID:6614 SCORE: 0.000250011867691465
DOCNO: 361145
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hyperbaric Oxygenation
QUALIFIER: radiotherapy
AUTHOR: S Dische S
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of radiology.
COUNTRY: ENGLAND
TITLE: Hyperbaric oxygen: the Medical Research Council trials and their clinical significance.
PUBDATE: 19781101
The clinical trials of the use of hyperbaric oxygen in radiotherapy conducted by the Medical Research Council's working party have shown that local cure and survival can be improved in head and neck and cervical cancer. Evidence for benefit has been presented in carcinoma of bronchus, but none has so far been found in carcinoma of the bladder. Although hyperbaric oxygen has produced increased effect upon normal tissues as well as upon tumour, a real improvement in therapeutic ratio appears to be present. The future use of hyperbaric oxygen in radiotherapy will depend upon a comparison of effectiveness with other methods now being tested to improve radiotherapy. The trials have yielded much fundamental and clinical data of general relevance in the radiotherapy of malignant disease.

13. DOCID:2805 SCORE: 0.000250011654057564
DOCNO: 170673
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: T Berge T
AUTHOR: N G Toremalm NG
PUBTYPE: Journal Article
JOURNALTITLE: Scandinavian journal of respiratory diseases.
COUNTRY: DENMARK
TITLE: Bronchial cancer - a clinical and pathological study. I. Histopathology and metastases.
PUBDATE: 19750801
Among 16,394 necropsies during the 12-year period, 1958-1969 (representing about 60% of all persons who died in Malmö during this period, 747 cases of bronchial cancer were found in 744 individuals. There were considerable differences in frequency of different histologic types with regard to sex. Two main classes have therefore been distinguished: Group I, comprising squamous epithelial cancer and anaplastic cancer (including oat-cell cancer), which was predominant among men; and Group II, comprising adenocarcinoma, bronchiolar carcinoma, carcinoid and bronchial gland tumour, which was of more or less equal frequency in both sexes. Compared with other malignant tumours, bronchial carcinoma had a strong tendency to metastasise to the adrenals, brain, kidneys and skeleton. Bronchial cancer did not differ from other tumours with regard to lymphogenous spread but had a stronger tendency to spread via the blood stream. Squamous epithelial cancer showed the strongest tendency to remain confined to the thoracic cavity.

14. DOCID:4411 SCORE: 0.000250011575194656
DOCNO: 6272398
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: T W Moody TW
AUTHOR: C B Pert CB
AUTHOR: A F Gazdar AF
AUTHOR: D N Carney DN
AUTHOR: J D Minna JD
PUBTYPE: Journal Article
JOURNALTITLE: Science.
COUNTRY: UNITED STATES
TITLE: High levels of intracellular bombesin characterize human small-cell lung carcinoma.
PUBDATE: 19811201
"Small cells" or "oat cells" characterize a virulent form of lung cancer and share many biochemical properties with peptide-secreting neurones. The neuropeptide bombesin is present in all small-cell lines examined, but not in other lung cancer cell lines, suggesting that bombesinergic precursor cells in lung may give rise to this disease.