0. DOCID:27466 SCORE: 0.000870882142942859
DOCNO: 10858954
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Cycle Proteins
DESCRIPTOR: Enzyme Inhibitors
DESCRIPTOR: Tumor Suppressor Proteins
QUALIFIER: antagonists & inhibitors
QUALIFIER: physiology
AUTHOR: C Desdouets C
AUTHOR: C Bréchot C
AFFILIATION: Inserm U370, Paris, France.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Pathologie-biologie.
COUNTRY: FRANCE
TITLE: p27: a pleiotropic regulator of cellular phenotype and a target for cell cycle dysregulation in cancer.
PUBDATE: 20000401
The eukaryotic cell cycle is regulated by the sequential activation of cyclin-dependent kinases (CDKs). CDK activation is regulated by phosphorylation of the catalytic subunit, by binding to activating (cyclins) and inactivating subunits (cyclin-dependent kinase inhibitor). In this review, we will focus on the role of the cyclin-dependent kinase inhibitor p27 which has been recently the subject of extensive work. This negative regulator of cell growth indeed illustrates the pleiotropic biological effects of such molecules in both normal and cancer cells and the complexity of the regulatory mechanisms involved.


1. DOCID:25066 SCORE: 0.000559843759518872
DOCNO: 11444184
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: P Laudański P
AUTHOR: T Anchim T
AUTHOR: S Wołczyński S
AFFILIATION: Zakładu Endokrynologii Ginekologicznej AM w Białymstoku.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Ginekologia polska.
COUNTRY: Poland
TITLE: [The role of nitric oxide in carcinogenesis and progression of neoplastic processes]
PUBDATE: 20010401
The aim of the review is to outline the current knowledge about the role of nitric oxide in the processes of proliferation and apoptosis in tumor. Special emphasis has been placed on its direct cytotoxic influence on a cell where as a highly active free radical it may compromise different cellular functions. Nitric oxide literature, regarding its role in the pathogenesis of some gynecological and breast cancer has been briefly reviewed.


2. DOCID:27090 SCORE: 0.000559820612469606
DOCNO: 9781186
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Asbestosis
QUALIFIER: etiology
QUALIFIER: etiology
AUTHOR: C Paris C
AUTHOR: L Chevreau L
AUTHOR: M Letourneux M
AFFILIATION: Service de médecine du travail Hôpital Charles-Nicolle, Rouen.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: La Revue du praticien.
COUNTRY: FRANCE
TITLE: [Asbestos-related diseases]
PUBDATE: 19980601
The growing use of asbestos in France like in other industrialized countries since the beginning of the century is the reason of the increase of asbestos-related diseases, which occur after long latency periods. From asymptomatic benign pleural plaques up to malignant mesothelioma of poor prognosis, the fibrogenic and carcinogenic properties of asbestos mainly concern occupationally exposed subjects. The Institut national de la santé et de la recherche médicale (INSERM) expert committee concluded that about 1,950 deaths due to asbestos-related cancers occurred in France in 1996. Reinforcement of French legislation aims at reducing all kinds of asbestos exposure.


3. DOCID:27106 SCORE: 0.000559820612282977
DOCNO: 11726356
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ethics, Nursing
QUALIFIER: nursing
AUTHOR: J L Neumann JL
AFFILIATION: Department of Blood and Marrow Transplantation, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77478, USA. jneumann@mdanderson.mail.org
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Nursing clinics of North America.
COUNTRY: United States
TITLE: Ethical issues confronting oncology nurses.
PUBDATE: 20011201
The focus of this article is the ethical dilemmas challenging oncology nurses and their patients. The cancer diagnosis itself may present ethical issues related to genetic testing, prevention and early detection, and information sharing. Cancer treatment options may involve considerations related to level of appropriate care, informed consent, patient education, and unproven, but promising, therapies. Finally, the ethical issues related to outcomes of the disease and treatment, such as pain control, advanced directives, do not resuscitate order, discontinuation of medically inappropriate care, euthanasia, and physician assisted suicide are discussed.


4. DOCID:24771 SCORE: 0.000559791894673157
DOCNO: 10655890
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: methods
AUTHOR: J Bancewicz J
AFFILIATION: Department of Surgery, Hope Hospital, Salford, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Annals of the Royal College of Surgeons of England.
COUNTRY: ENGLAND
TITLE: Palliation in oesophageal neoplasia.
PUBDATE: 19991101
Oesophageal cancer is an increasingly common disease in the UK. Sadly, the overall results of treatment remain poor with overall 5 year survival of approximately 10%. More than 50% of patients receive purely palliative care from the outset. Of those having potentially curative treatment, 40% will not survive the first year and 70% will not survive 5 years. Good quality palliation is, therefore, required for the majority of patients.


5. DOCID:26054 SCORE: 0.000559784996217129
DOCNO: 10978897
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: C P Blobel CP
AFFILIATION: Cellular Biochemistry and Biophysics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, Box 368, 1275 York Avenue, New York, New York 10021, USA. c-blobel@ski.mskcc.org
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in cell biology.
COUNTRY: UNITED STATES
TITLE: Remarkable roles of proteolysis on and beyond the cell surface.
PUBDATE: 20001001
Proteolysis on the cell surface and in the extracellular matrix is essential for normal cellular functions during development and in the adult, but it may also have undesirable consequences, such as promoting cancer, arthritis, and Alzheimer's disease. Recent advances highlight the roles of zinc-dependent metalloproteinases (metzincins) in proper skeletal development, in activating EGF-receptor ligands, in Notch-dependent signaling, and in initiating and promoting tumorigenesis.


6. DOCID:27137 SCORE: 0.000559771518440431
DOCNO: 11281249
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: blood
AUTHOR: P J Jones PJ
AUTHOR: M Raeini-Sarjaz M
AFFILIATION: School of Dietetics and Human Nutrition, McGill University, Quebec, Canada.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nutrition reviews.
COUNTRY: United States
TITLE: Plant sterols and their derivatives: the current spread of results.
PUBDATE: 20010101
Whereas the cholesterol-lowering action of plant sterols and their derivatives has been well established, more recent results have produced new information concerning the similar effects of various mixtures and dose-response relationships. Moreover, although these materials have generally been viewed as safe for long-term use in almost all sectors of the population, some concerns remain regarding the impact of phytosterol consumption on other lipid-soluble nutrients, which need to be further addressed. Further work is also required to define the relationship between plant sterol consumption, circulating sterol levels, and risk of certain cancers.


7. DOCID:25611 SCORE: 0.000538701237571249
DOCNO: 10398095
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: P J van Diest PJ
AFFILIATION: Department of Pathology, Free University Hospital, Amsterdam, The Netherlands. pj.vandiest@azvu.nl
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of pathology.
COUNTRY: ENGLAND
TITLE: Ductal carcinoma in situ in breast carcinogenesis.
PUBDATE: 19990301
Evidence is mounting that ductal carcinoma in situ (DCIS) is a direct precursor of invasive breast cancer. Recent molecular biological and cytogenetic studies have revealed chromosomal gains and losses involved in breast carcinogenesis. This editorial discusses how the gains and losses on the different chromosomes fit into previously defined morphological routes of progression from normal cells through DCIS to invasive carcinoma, and the possible uses of these gains and losses in the classification of DCIS and the risk assessment of DCIS patients.


8. DOCID:25631 SCORE: 0.000538700926740875
DOCNO: 9549351
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Magnetics
QUALIFIER: administration & dosage
QUALIFIER: methods
AUTHOR: Y Morimoto Y
AUTHOR: H Natsume H
AFFILIATION: Faculty of Pharmaceutical Sciences, Josai University.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine.
COUNTRY: JAPAN
TITLE: [Targeting technology utilizing magnetic microparticulate system for cancer therapy]
PUBDATE: 19980301
Organ level-targeting of anticancer drugs or other relating stimuli to tumor tissues and their circumstances is important in cancer therapy. The successful targeting results in the greater antitumor effect and the lower numerous side effects. Application of a magnet from the outside of body is a useful tool to increase the targeting efficacy. In this review paper, targeting technology utilizing magnetic microparticulate system for cancer therapy was introduced and the future on the magnetic targeting system was augured.


9. DOCID:27892 SCORE: 0.000538676571611865
DOCNO: 11525058
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cardiopulmonary Resuscitation
DESCRIPTOR: Intensive Care
DESCRIPTOR: Renal Dialysis
DESCRIPTOR: Respiration, Artificial
QUALIFIER: therapy
AUTHOR: J S Groeger JS
AUTHOR: R N Aurora RN
AFFILIATION: Division of Critical Care Medicine, Memorial Sloan-Kettering Cancer Center, Department of Medicine, Weill Medical College of Cornell University, New York, New York, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Critical care clinics.
COUNTRY: United States
TITLE: Intensive care, mechanical ventilation, dialysis, and cardiopulmonary resuscitation. Implications for the patient with cancer.
PUBDATE: 20010701
The broad range in mortality rates seen in the critically ill cancer population reflects the fact that cancer is a heterogeneous disease, affecting a heterogeneous population at different stages of care. Patients, families, and physicians frequently agonize about the utility of CPR and ICU care and whether this care should be offered. Understanding the goals of care, respecting autonomy, and knowing the likelihood of benefits and burdens of these interventions are critical in making these difficult decisions.


10. DOCID:25471 SCORE: 0.000535401282352566
DOCNO: 10853691
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasm Circulating Cells
DESCRIPTOR: Tibial Arteries
QUALIFIER: complications
QUALIFIER: blood supply
QUALIFIER: etiology
QUALIFIER: complications
AUTHOR: N Xiromeritis N
AUTHOR: C Klonaris C
AUTHOR: S Papas S
AUTHOR: M Valsamis M
AUTHOR: E Bastounis E
AFFILIATION: 1st Department of Surgery, University of Athens, Greece.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: International angiology : a journal of the International Union of Angiology.
COUNTRY: ITALY
TITLE: Recurrent peripheral arterial embolism from pulmonary cancer. Case report and review of the literature.
PUBDATE: 20000301
Peripheral arterial embolism arising from a malignant tumour is an infrequent manifestation of neoplastic disease and also a rare cause of acute arterial occlusion. A case of recurrent arterial embolism of the lower extremities due to a primary lung cancer is reported and the literature on this topic is reviewed.


11. DOCID:27687 SCORE: 0.000528799923799632
DOCNO: 10975548
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: R Willemze R
AFFILIATION: Department of Dermatology, Leiden University Medical Center, The Netherlands. willemze.dermatology@lumc.nl
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in oncology.
COUNTRY: UNITED STATES
TITLE: Primary cutaneous lymphomas.
PUBDATE: 20000901
Primary cutaneous lymphomas have a distinct clinical behavior and prognosis, and therefore require a different therapeutic approach, as compared with their primary nodal equivalents. The European Organization for Research and Treatment of Cancer (EORTC) classification for primary cutaneous lymphomas recognizes a limited number of cutaneous T-cell lymphomas and cutaneous B-cell lymphomas and is at present the best guide to optimal management and treatment of these conditions. Herein, the relationship between the EORTC classification and the recently published World Health Organization classification is discussed, and recent developments regarding the main types of cutaneous T-cell lymphomas and cutaneous B-cell lymphomas recognized in the EORTC classification are presented.


12. DOCID:25983 SCORE: 0.000444076772657073
DOCNO: 10192492
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: chemically induced
QUALIFIER: chemically induced
QUALIFIER: chemically induced
QUALIFIER: chemically induced
QUALIFIER: adverse effects
QUALIFIER: chemically induced
AUTHOR: M Friedrich M
AUTHOR: C Villena-Heinsen C
AUTHOR: D Mink D
AUTHOR: H Bonkhoff H
AUTHOR: W Schmidt W
AFFILIATION: Department of Gynecology and Obstetrics, University of Homburg/Saar, Germany.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: European journal of obstetrics, gynecology, and reproductive biology.
COUNTRY: IRELAND
TITLE: Carcinosarcoma, endometrial intraepithelial carcinoma and endometriosis after tamoxifen therapy in breast cancer.
PUBDATE: 19990101
The fourth case of heterologous mesodermal tumour of the uterine corpus, that developed, years following tamoxifen therapy for breast cancer in a postmenopausal woman with no previous pelvic irradiation, is presented with coincidental endometriosis and endometrial intraepithelial carcinoma. This coincidence after tamoxifen treatment appears to be an indication for the possible carcinogenic potency of tamoxifen.


13. DOCID:26781 SCORE: 0.000421017623066512
DOCNO: 10598484
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
AUTHOR: M Sobolewski M
AUTHOR: R Włodarczyk R
AUTHOR: G Wojtas G
AUTHOR: K Jahnz-Rózyk K
AUTHOR: N Hussein N
AUTHOR: P Twarkowski P
AFFILIATION: Wojskowego Szpitala Gruźlicy i Chorób Płuc w Otwocku.
PUBTYPE: Journal Article
JOURNALTITLE: Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego.
COUNTRY: POLAND
TITLE: [Fine needle biopsy in diagnosis of lung tumors]
PUBDATE: 19990901
Fine-needle biopsy is one of the method used in diagnosis of lung tumors. In this study the results of 192 biopsies performed by x-ray apparatus inspection were analysed. There was shown that lung cancer was recognized in over 50% of patients studied. In another cases non-specific inflammation (31%), lung fibrosis (1%), tuberculosis (1%), purulent inflammation (1%), blood (7%) were recognized. These results indicate for usefulness of this method in diagnosis of not only peripheral, but also central localized lung tumors.


14. DOCID:25929 SCORE: 0.000315027324664044
DOCNO: 9726457
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Tomography, X-Ray Computed
QUALIFIER: secondary
QUALIFIER: pathology
QUALIFIER: radiography
QUALIFIER: pathology
AUTHOR: Y Kimura Y
AUTHOR: T Hanazawa T
AUTHOR: T Sano T
AUTHOR: T Okano T
AFFILIATION: Department of Radiology, Showa University Dental Hospital, Tokyo, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: AJNR. American journal of neuroradiology.
COUNTRY: UNITED STATES
TITLE: Lateral retropharyngeal node metastasis from carcinoma of the upper gingiva and maxillary sinus.
PUBDATE: 19980801
Clinically unsuspected metastases to the lateral retropharyngeal nodes from carcinomas of the upper gingiva or maxillary sinus were found in five patients on follow-up CT examinations. Such uncommon metastases may follow the afferent lymphatic channels from the palate or pharyngeal region or arrive by retrograde lymphatics from positive neck nodes. Careful examination of lateral retropharyngeal nodes may be required in cancers of these primary sites.