0. DOCID:23266 SCORE: 0.00118008984783842
DOCNO: 7668866
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hyperthermia, Induced
DESCRIPTOR: Ultrasonic Therapy
QUALIFIER: therapy
QUALIFIER: methods
AUTHOR: T Okawa T
AUTHOR: M Kita-Okawa M
AFFILIATION: Department of Radiation Oncology, Tokyo Women's Medical College, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [The role and future of radiotherapy in cancer treatment]
PUBDATE: 19950901
The basic principle of radiotherapy for cancer patients is that it has the possibility of a good result (curability), is tolerable and promises a comfortable life thereafter. Radiotherapy is the important tool for early stage cancer by conserving the organ and function and for an advanced or recurrent stage of cancer by helping improve the quality of life. Radiotherapy must be planned on the basis of considering the therapeutic ratio with a 3-dimensional technique. It should be performed with optimum radiation methods in the multimodal treatment of cancer and will undoubtedly prove effective in the future.
1. DOCID:23863 SCORE: 0.00115081855715664
DOCNO: 9241648
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Radioimmunodetection
QUALIFIER: radionuclide imaging
AUTHOR: S M Larson SM
AUTHOR: C Divgi C
AUTHOR: A Scott A
AUTHOR: F Daghighian F
AUTHOR: H Macapinlac H
AUTHOR: S Welt S
AFFILIATION: Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Nuclear medicine and biology.
COUNTRY: ENGLAND
TITLE: Current status of radioimmunodetection.
PUBDATE: 19940701
Radioimmunodetection is a nuclear medicine technique that depends on in vivo detection of localization of antibodies and antibody forms carrying radioactivity for the purpose of diagnosis in patients with cancer. Current methods take advantage of tracers suitable for high resolution gamma-camera imaging, such as 99mTc and 111In, for common tumors, such as colon and lung cancers. In addition, tracers such as 125I have been used for the intraoperative detection of metastatic deposits. These methods detect from 75 to 90% of metastatic deposits with high specificity, and typically contribute important diagnostic information, even in 25-40% of patients with occult disease.
2. DOCID:23890 SCORE: 0.00115081590285785
DOCNO: 8168744
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: diagnosis
AUTHOR: J Helou J
AUTHOR: S Nakhleh S
AUTHOR: E Shalev E
AUTHOR: T Nsseir T
AFFILIATION: Dept. of Obstetrics and Gynecology, St. Vincent de Paul Hospital, Nazareth and Ha'emek Medical Center, Afula.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Harefuah.
COUNTRY: ISRAEL
TITLE: [Colonic carcinoma during pregnancy]
PUBDATE: 19940201
A case of adenocarcinoma of the splenic flexure during pregnancy is reported. A 27-year-old woman was admitted at 34 weeks of pregnancy with abdominal pain and vomiting. 36 hours after normal delivery an emergency exploratory laparotomy was performed for intestinal obstruction. A huge tumor of the splenic flexure with retroperitoneal extension was found. She died 1 year later of metastatic disease. Delay in diagnosis and complications of colonic cancer are more prevalent in pregnancy. While colonic carcinoma during pregnancy is extremely rare, it should be included in the differential diagnosis of colonic symptoms. The 24th case of this type is reported.
3. DOCID:23935 SCORE: 0.000869443695354803
DOCNO: 8707761
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: chemically induced
AUTHOR: S K Kim SK
AUTHOR: G D Demetri GD
AFFILIATION: Division of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Hematology/oncology clinics of North America.
COUNTRY: UNITED STATES
TITLE: Chemotherapy and neutropenia.
PUBDATE: 19960401
Myelosuppression is the most common toxicity associated with the administration of dose-intensive cytotoxic chemotherapy. The basic understanding of neutrophil biology and the physiology of chemotherapy-induced neutropenia has advanced tremendously in the past 2 decades. Concordantly, the ability to reduce the morbidity associated with neutropenia has improved. Adjunctive cytokine and progenitor cell support of hematologic recovery after myelosuppressive therapy have proved to be models of translational research and have led to novel therapeutic initiatives for patients with cancer and hematologic malignancies. In this article, fundamental aspects of neutrophil production are discussed, and the clinical development of hematopoietic cytokines active on cells of the leukocyte lineages is presented.
4. DOCID:22573 SCORE: 0.000629285473433908
DOCNO: 10161206
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: diagnosis
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: A S Dias AS
PUBTYPE: Journal Article
JOURNALTITLE: Journal of clinical laser medicine & surgery.
COUNTRY: UNITED STATES
TITLE: Androscopy and treatment of human papillomavirus (HPV) with CO2 laser surgery.
PUBDATE: 19941001
Dysplasia and cancer of the cervix may be related to human papillomavirus infection. To determine the presence of cancer in cases of genital warts we have been using a technique, androscopy, for examining male genitals with magnified lens previously sprayed with white vinegar (5% acetic acid). This paper explores the methods of using colposcopy and androscopy on both sexual partners for a thorough examination of genitals and the anorectal area. It also discusses treatment advantages of the CO2 laser. In our investigation plain, pedunculated warts and a giant condyloma (Buschke-Loewenstein tumor) were found and treated with CO2 laser surgery.
5. DOCID:23546 SCORE: 0.000559007074798064
DOCNO: 8767098
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Laparoscopes
QUALIFIER: surgery
QUALIFIER: instrumentation
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: B Ablassmaier B
AUTHOR: K Gellert K
AUTHOR: S Said S
AUTHOR: U Tanzella U
AUTHOR: J M Müller JM
AFFILIATION: Klinik für Chirurgie der Charité, Humboldt Universität Berlin.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen.
COUNTRY: GERMANY
TITLE: [Laparoscopic gastrectomy. A case report]
PUBDATE: 19960601
Although laparoscopic techniques in gastric surgery have become an important part of upper gastrointestinal surgery, they are mainly utilized for organ preserving procedures. A standardized technique for laparoscopic gastrectomy has not yet been described in detail. The purpose of this study was to develop a standardized technique for laparoscopic gastrectomy with reconstruction by a stapled termino-lateral esophago-je-junostomy and Roux-en-Y-anastomosis in a cadaver model. The resected stomach was removed through an enlarged trocar incision. The described technique has been successfully performed in one patient with early gastric cancer.
6. DOCID:22918 SCORE: 0.000558947192308101
DOCNO: 7675283
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Breast Diseases
QUALIFIER: secretion
AUTHOR: P Cottu P
AUTHOR: M L Cossu ML
AUTHOR: A M Scanu AM
AUTHOR: A Gadeddu A
AUTHOR: G Noya G
AUTHOR: G Dettori G
AFFILIATION: Istituto di Clinica Chirurgica Generale e Terapia Chirurgica, Università degli Studi, Sassari.
PUBTYPE: Journal Article
JOURNALTITLE: Minerva chirurgica.
COUNTRY: ITALY
TITLE: [Mammary secretion: retrospective study of diagnostic and therapeutic problems]
PUBDATE: 19950401
Nipple secretion is an important clinical symptom in the context of breast pathology second only, in terms of incidence and diagnostic role, to the presence of a mammary nodule. Its importance derives from its possible association with cancer (from 3% to 47%) of which it may be the earliest sign, even if it is most often in relation to a benign pathology. The authors report their experience from 1988 to the present in 60 cases of mammary secretion out of 1200 patients attending the clinic.
7. DOCID:22765 SCORE: 0.00055888240971518
DOCNO: 8014531
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: therapy
QUALIFIER: complications
AUTHOR: C Ripamonti C
AFFILIATION: Pain Therapy and Palliative Care Division, National Cancer Institute, Milan, Italy.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of pain and symptom management.
COUNTRY: UNITED STATES
TITLE: Management of bowel obstruction in advanced cancer patients.
PUBDATE: 19940401
Bowel obstruction is a common and distressing outcome in patients with abdominal or pelvic cancer. While surgery must remain the primary treatment for malignant obstruction, it is now recognized that there is a group of patients with advanced disease or poor general condition who are unfit for surgery and require alternative management to relieve distressing symptoms. A number of treatment options are now available for the patient with advanced cancer who develops intestinal obstruction. This review examines the indications for surgery, the use of nasogastric tube and percutaneous gastrostomy, and the place of drugs for symptom control.
8. DOCID:22695 SCORE: 0.00055888240558458
DOCNO: 9101541
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mass Screening
QUALIFIER: prevention & control
AUTHOR: H Saito H
AFFILIATION: First Department of Internal Medicine, Hirosaki University School of Medicine, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Nippon Geka Gakkai zasshi.
COUNTRY: JAPAN
TITLE: [Colorectal cancer: Japanese screening program today]
PUBDATE: 19970301
Colorectal cancer screening using immunochemical fecal occult blood tests has been performed supported by legislation since 1992 in Japan. Approximately 3.6 million persons were screened and 5,400 cases of colorectal cancer were found in 1993. The effectiveness of the screening program has been evaluated by several observational studies. It has been strongly suggested that risk of dying of colorectal cancer would be reduced by 60% for those screened annually by the program. Japanese screening program today seems to be promising in terms of the mortality reduction, however, issues such as limitation of capacity for diagnostic work-ups should be resolved.
9. DOCID:22572 SCORE: 0.000552971757209839
DOCNO: 7489308
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Contrast Media
DESCRIPTOR: Image Enhancement
DESCRIPTOR: Magnetic Resonance Imaging
QUALIFIER: diagnosis
AUTHOR: C W Piccoli CW
AFFILIATION: Department of Radiology, Jefferson Medical College, Philadelphia, Pennsylvania, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Magnetic resonance imaging clinics of North America.
COUNTRY: UNITED STATES
TITLE: The specificity of contrast-enhanced breast MR imaging.
PUBDATE: 19941101
The sensitivity of contrast-enhanced breast MR imaging for malignancy is close to 100%, an improvement over traditional methods of cancer detection. The reported specificity of breast MR imaging, however, ranges from approximately 37% to 97%. This range of values is the result of differences in technique and diagnostic criteria. The variation in biologic activity and vascularity of benign and malignant lesions, as well as normal tissue, also complicates MR imaging diagnosis. A review of breast MR imaging research with an emphasis on specificity issues is also presented.
10. DOCID:23839 SCORE: 0.000540652032933171
DOCNO: 8689012
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemistry
QUALIFIER: chemistry
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: P Alemany Monraval P
AUTHOR: M Martorell Cebollada M
AUTHOR: I Salvador Villalba I
AUTHOR: E Martínez Leandro E
AFFILIATION: Servicio de Anatomía Patológica, Hospital General Universitario de Valencia.
PUBTYPE: Journal Article
JOURNALTITLE: Archivos de bronconeumología.
COUNTRY: SPAIN
TITLE: [Study of the expression of proliferating cell nuclear antigen and p185 in non-small cell lung carcinoma]
PUBDATE: 19960401
We assessed immunohistochemical expression of p185 and the proliferating cell nuclear antigen (PCNA) in 68 patients undergoing surgery for non-small cell lung cancer. Adenocarcinoma of the lung was the histological type whose expression of p185 at levels exceeding 10% was greater to a statistically significant degree. Epidermoid carcinoma, on the other hand, was associated with the highest PCNA indices. Although these 2 markers had no prognostic value in the survival study, it must be pointed out that the longest survivors were patients with p185 expression less than 10% in neoplastic cells.
11. DOCID:22507 SCORE: 0.000519817928862533
DOCNO: 8040144
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: analogs & derivatives
QUALIFIER: antagonists & inhibitors
AUTHOR: H A Burris HA
AUTHOR: S M Fields SM
AFFILIATION: Institute for Drug Development, Cancer Therapy and Research Center, San Antonio, Texas.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Hematology/oncology clinics of North America.
COUNTRY: UNITED STATES
TITLE: Topoisomerase I inhibitors. An overview of the camptothecin analogs.
PUBDATE: 19940401
The topoisomerase I inhibitors are an exciting new class of antineoplastic agents currently under clinical development. Analogues of camptothecin with improved toxicity profiles and antitumor activity included CPT-11 and topotecan. CPT-11 has demonstrated activity against a variety of tumor types, particularly colon and lung cancer. Early results with topotecan against ovarian and lung cancer are also encouraging. Combination trials with other antineoplastic agents including cisplatin and etoposide, and early clinical trials with new topoisomerase I inhibitors, such as 9-aminocamptothecin, are underway.
12. DOCID:23817 SCORE: 0.000436394224924803
DOCNO: 9126241
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: blood
QUALIFIER: drug therapy
AUTHOR: D C Smith DC
AUTHOR: K J Pienta KJ
AFFILIATION: Department of Internal Medicine, University of Michigan, Ann Arbor, USA.
PUBTYPE: Journal Article
JOURNALTITLE: The Urologic clinics of North America.
COUNTRY: UNITED STATES
TITLE: The use of prostate-specific antigen as a surrogate end point in the treatment of patients with hormone refractory prostate cancer.
PUBDATE: 19970501
Prostate-specific antigen increasingly is being used as a surrogate end point in trials of new agents in patients with hormone refractory prostate cancer. This article reviews data that support this marker as a surrogate end point and the contradictory data reported recently for trials of suramin. These contrasting views may originate in the different mechanisms of actions of the agents studied. These data suggest that a decline in prostate-specific antigen of at least 50% from baseline may be an important predictor of survival for patients receiving cytotoxic therapy.
13. DOCID:23408 SCORE: 0.000289357635939424
DOCNO: 9384705
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Therapy
DESCRIPTOR: Genes, Tumor Suppressor
QUALIFIER: therapy
QUALIFIER: metabolism
QUALIFIER: biosynthesis
QUALIFIER: genetics
AUTHOR: B A Sullenger BA
AFFILIATION: Department of Experimental Surgery, Duke University Medical Center, Durham, NC, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cytokines and molecular therapy.
COUNTRY: ENGLAND
TITLE: Ribozyme-mediated repair of RNAs encoding mutant tumor suppressors.
PUBDATE: 19960901
The observation that a number of genetic mutations can result in neoplastic transformation has led many investigators to speculate that gene therapy may represent a useful approach to treat cancer. Conceptually, this application of gene therapy seems quite simple: to treat cancer, restore the correctly regulated expression of the needed tumor suppressor genes inside tumor cells and revert the transformed phenotype of such cells. However, such regulated expression has been difficult to achieve in practice. Here we describe recent efforts at such restoration via a novel approach to gene therapy that involves ribozyme-mediated repair of mutant RNA transcripts.
14. DOCID:20952 SCORE: 0.000278321199951792
DOCNO: 8767501
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Penile Neoplasms
AUTHOR: V De Luca V
AUTHOR: G Cancarini G
AUTHOR: R Fortis R
AUTHOR: G Pezzotti G
AUTHOR: B Taher B
AUTHOR: T Zanotelli T
AUTHOR: S Cosciani Cunico S
AFFILIATION: Divisione Clinicizzata di Urologia, Spedali Civili, Brescia.
PUBTYPE: Journal Article
PUBTYPE: Multicenter Study
JOURNALTITLE: Archivio italiano di urologia, andrologia : organo ufficiale [di] Società italiana di ecografia urologica e nefrologica / Associazione ricerche in urologia.
COUNTRY: ITALY
TITLE: [Multicenter study of penile cancer]
PUBDATE: 19960601
The authors report the experience about diagnosis, treatment, results and follow-up on penile cancer of 15 department of urology of Lombardia region. The aim of the study is to find, through the historical experience, the better way to menage this rare cancer.