0. DOCID:3994 SCORE: 0.00774151380593659
DOCNO: 163675
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: analogs & derivatives
AUTHOR: G Falkson G
AUTHOR: J J van Dyk JJ
AUTHOR: E B van Eden EB
AUTHOR: A M van der Merwe AM
AUTHOR: J A van den Bergh JA
AUTHOR: H C Falkson HC
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: A clinical trial of the oral form of 4'-demethyl-epipodophyllotoxin-beta-D ethylidene glucoside (NSC 141540) VP 16-213.
PUBDATE: 19750401
A clinical trial of the oral form of VP 16-213 (NSC-141540), a semisynthetic podophyllotoxin, was undertaken. In 20 patients, treatment was started at 200 mg/day p.o. for 5 days; courses were repeated after a rest period of 16 days. Five patients were treated at the same dose, repeated with only 9-day rest periods. Subsequently, 65 patients were given 300-400 mg/day for 5 days, with rest periods of 9 days between courses. The side effects encountered included anorexia, nausea and vomiting, stomatitis, diarrhea, leukopenia, thrombocytopenia, alopecia, and pruritis. Substernal discomfort with or without palpitations was reported by 18 patients; no explanation for this symptom could be found. No complete remissions (CR) were observed. Parital remissions (PR) and improvement (IMP) were seen as follows: small cell carcinoma, lung (10 patients)--2 PR, 3 IMP; adenocarcinoma, lung (4 patients)--1 PR; alveolar cell carcinoma, lung (1 patient)--1 IMP; mesothelioma (4 patients)--1 IMP; ovarian cancer (12 patients)--3 PR, 3 IMP; breast cancer (20 patients)--4 IMP; colon cancer (8 patients)--2 IMP; bladder cancer (4 patients)--2 IMP; histiocytic lymphoma (7 patients)--2 PR, 3 IMP; chronic myeloid leukemia (1 patient)--1 IMP.


1. DOCID:3547 SCORE: 0.00360985757542251
DOCNO: 326245
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Kidney Transplantation
QUALIFIER: analysis
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: J B Myers JB
AUTHOR: M Frost M
AUTHOR: A S Coates AS
AUTHOR: J D Mathews JD
AUTHOR: P Kincaid-Smith P
PUBTYPE: Journal Article
JOURNALTITLE: Australian and New Zealand journal of medicine.
COUNTRY: AUSTRALIA
TITLE: Carcinoembryonic antigen in renal allograft recipients and immunosuppressed renal patients.
PUBDATE: 19770201
Carcinoembryonic antigen (CEA) was estimated in plasma from 70 patients with a renal transplant, 105 patients with glomerulonephritis who had received immunosuppressive therapy, and 124 healthy controls. There were raised levels in 30% of those with a renal transplant, 10% of those with glomerulonephritis and 2% of controls, and levels were higher in current smokers. CEA levels did not correlate with pre-transplant dialysis time nor with serum creatinine levels, but tended to fall with increasing time after transplantation, especially in non-smokers. CEA levels did not correlate with prednisolone dosage nor with number of rejection episodes, after allowing for time after transplantation and smoking habit. Nine of 70 patients with a renal transplant and three of 105 with glomerulonephritis had cancer, of skin in seven, cervix uteri in four, and colon in one. CEA was raised in all four transplant recipients with a visceral cancer (cervix three and colon one), but in none of the five with cutaneous cancer. Raised CEA levels occurring late after a renal allograft should prompt a careful search for visceral cancer.


2. DOCID:3784 SCORE: 0.00309340757463191
DOCNO: 167949
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: classification
AUTHOR: A L Cubilla AL
AUTHOR: P J Fitzgerald PJ
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Morphological patterns of primary nonendocrine human pancreas carcinoma.
PUBDATE: 19750801
The study of histological sections of 406 cases of nonendocrine pancreas carcinoma at Memorial Hospital indicated that morphological patterns of pancreas carcinoma could be delineated as follows: duct cell adenocarcinoma (76%), giant-cell carcinoma (5%), microadenocarcinoma (4%), adenosquamous cancinoma (4%), mucinous adenocarcinoma (2%), anaplastic carcinoma (2%), cystadenocarcinoma (1%), acinar cell carcinoma (1%), carcinoma in childhood (under 1%), unclassified (7%). In 195 cases of patients with pancreas carcinoma, search was made for changes in the pancreas duct epithelium and these were compared to duct epithelium in a control group of 100 pancreases from autopsies of patients with nonpancreatic cancer. The following incidences were found for pancreas cancer and nonpancreatic cancer, respectively: mucous cell hypertrophy, 39 versus 28%; pyloric gland metaplasia, 28 and 17%; epidermoid metaplasia, 6 and 12%; papillary hyperplasia, 42 and 12%; atypical duct hyperplasia, 14% and none; cancinoma in situ in 19% and none in the control group. Mucin in the majority of pancreas cancers suggested that the cell type of origin of the common pancreas cancer is the mucin-producing duct epithelium. The association of atypias and carcinomas in situ in the patients with pancreas carcinoma implies, by analogy to other organs, that there may be a significant latent period between the appearance of carcinoma in situ and the grossly recognizable pancreas cancer.


3. DOCID:2364 SCORE: 0.00258990210323123
DOCNO: 1034229
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ethmoid Sinus
QUALIFIER: radiography
QUALIFIER: radiography
QUALIFIER: radiography
AUTHOR: S Naruse S
AUTHOR: G Odake G
AUTHOR: T Yamaki T
AUTHOR: M Toyama M
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: No shinkei geka. Neurological surgery.
COUNTRY: JAPAN
TITLE: [Intracranial invasion of ethmoid cancer --a report of two cases (author's transl)]
PUBDATE: 19761101
Two cases of intracranial invasion of the ethmoid cancer were reported. With additional six cases reported in Japan, the precise clinical course and pathophysiological findings of the disease were reviewed, and the following several points became clear; 1) The incidence of the ethmoid cancer was rare. 2) These were divided into main groups according to the onset of intracranial signs, such as the frontal lobe symptoms and I-VII cranial nerve involvement. The first group showed the intracranial symptoms early, and the second group late. 3) The tumor invaded the cranial cavity along the perineural sheeth of each cranial nerve mainly. 4) It was very difficult to identify the paranasal sinus of origin after invading the cranial cavity. 5) The prognosis was extremely poor. All cases were died within one and half year.


4. DOCID:3814 SCORE: 0.00255900755883545
DOCNO: 406978
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: J D Cox JD
AUTHOR: T J Stoffel TJ
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: The significance of needle biopsy after irradiation for stage C adenocarcinoma of the prostate.
PUBDATE: 19770701
The presence of malignant cells in needle biopsy specimens following irradiation for adenocarcinoma of the prostate has been used to criticize or defend this treatment. At Walter Reed Medical Center, 38 consecutive patients with Stage Cadenocarcinoma underwent definitive irradiation between August 1970 and March 1973. The median dose to the pelvis was 7000 rads in 31 fractions in 43 days (2030 ret). Post treatment examination included palpation of the prostate and transperineal biopsy of the most suspicious areas. Gradual disappearance of the palpable tumor occurred in all patients. Two men have had clinical evidence of re-growth of prostatic cancer. Thirty-three patients have had up to seven biopsies each for a total of 139, an average of four biopsies per patient. There were 49 positive and 90 negative biopsies. Positive biopsy rate correlated only with the interval after irradiation--60% at six months, 37% at one year, 30% at 18 months, and approximately 19% after two and one-half years. There was no correlation of biopsy results with pre-irradiation estrogen or orchiectomy, with time-dose-fractionation relationships, or with prognosis. These biopsies provide interesting data about the regression rate of prostatic adenocarcinoma, but they have no significance for the individual patient. They have, therefore, been eliminated from follow-up studies.


5. DOCID:3301 SCORE: 0.00229333786942349
DOCNO: 911968
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Carcinogens
AUTHOR: K S Crump KS
AUTHOR: H A Guess HA
AUTHOR: K L Deal KL
PUBTYPE: Journal Article
JOURNALTITLE: Biometrics.
COUNTRY: UNITED STATES
TITLE: Confidence intervals and test of hypotheses concerning dose response relations inferred from animal carcinogenicity data.
PUBDATE: 19770901
Confidence intervals and hypothesis tests are developed for dose-response relations based on dichotomous data from animal carcinogenicity experiments. The functional form of the dose-response curve comes from the Armitage-Doll multistage carcinogenesis model and involves a polynomial in the dose-rate, with non-negative coefficients. Asymptotic distributions of the maximum likelihood estimators of these coefficients are used to construct confidence bounds on risk at a given dose and on the dose corresponding to a given risk. Likelihood ratio tests are developed for the presence of a positive dose-related effect and for the existence of a positive slope to the dose-response curve at zero dose. The latter test is of practical importance since a positive slope of the dose-response curve at zero dose rules out any "threshold-like" behavior and would often mean that any concentration low enough to insure a negligibly low cancer risk (e.g., 10(-6)) would be too low to be economically useful for applications such as food additives. Simulation experiments are performed to provide guidelines for applying the theory.


6. DOCID:2841 SCORE: 0.00229035976601653
DOCNO: 871143
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: analysis
QUALIFIER: immunology
AUTHOR: J R van Nagell JR
AUTHOR: E S Donaldson ES
AUTHOR: E G Wood EG
AUTHOR: R M Sharkey RM
AUTHOR: D M Goldenberg DM
PUBTYPE: Journal Article
JOURNALTITLE: American journal of obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: The prognostic significance of carcinoembryonic antigen in the plasma and tumors of patients with endometrial adenocarcinoma.
PUBDATE: 19770601
Carcinoembryonic antigen (CEA) levels in plasma and the immunocytochemical detection of tumor CEA were studied in patients with endometrial adenocarcinoma treated at the University of Kentucky Medical Center from 1973 to 1976. The incidence of CEA elevation in a group of 60 patients varied directly with uterine size, histologic differentiation, and stage of disease. Immunoperoxidase staining for CEA was performed on 42 specimens, and four were positive, indicating a tissue concentration of CEA of at least 5 microng per gram. Following operation, CEA levels returned to normal within eight weeks in all but two patients, both of whom were later shown to have persistent or recurrent cancer. These data suggest that serial plasma CEA determinations may be useful in predicting occult recurrence of endometrial cancer in patients in whom the plasma or tumor initially contains elevated concentrations of this antigen.


7. DOCID:3453 SCORE: 0.00195822213580858
DOCNO: 903992
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mining
QUALIFIER: adverse effects
QUALIFIER: etiology
QUALIFIER: etiology
AUTHOR: S Graham S
AUTHOR: M Blanchet M
AUTHOR: T Rohrer T
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Cancer in asbestos-mining and other areas of Quebec.
PUBDATE: 19771001
Employing incidence data from the Quebec Tumor Registry, we examined the relative risks of cancer of all sites for the years 1969-73 in the asbestos-mining, rural, and metropolitan counties of Quebec Province, Canada. Generally, rates for males exceeded those for females, and the relative risks in the asbestos-mining counties for 7-10 different sites of cancer, all of low incidence, were from 1.50 to 8.08 times those of other rural counties of the Province for both sexes. Metropolitan counties exhibited equally high risk for many of these sites. We discovered higher risks among males in asbestos-mining counties for cancer of the pleura, peritoneum, lip, tongue, salivary gland, mouth, and small intestine and higher risks among females for cancer of the pleura, lip, kidney, salivary gland, and for melanoma. Because of the likelihood of a long latent period for asbestos-related cancers, the risks we observed were possibly the product of since-altered occupational and environmental conditions existing 20-30 years ago in the asbestos-mining areas. The similarities in risks for most cancers in asbestos-mining and urban areas were noteworthy.


8. DOCID:1289 SCORE: 0.00170527989083332
DOCNO: 1275150
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Emergency Medical Services
DESCRIPTOR: Triage
QUALIFIER: methods
QUALIFIER: pathology
AUTHOR: R W Knapp RW
AUTHOR: J T Mullen JT
PUBTYPE: Journal Article
JOURNALTITLE: American journal of surgery.
COUNTRY: UNITED STATES
TITLE: Triage for the breast biopsy.
PUBDATE: 19760501
A plan is advocated for the management of the dominant breast mass with use of local anesthesia in the outpatient setting as the primary diagnostic tool, but with selection of certain patients for immediate general anesthesia biopsy in the "conventional" manner. Experience with this plan in 2,492 patients during a period of 114 months shows local anesthesia biopsy to be efficient and accurate. Five year survival for all mastectomy-treated patients whose cancers were diagnosed under local anesthesia is 72 per cent. Use of a triage method for selecting biopsy procedures has resulted in a thirteen-fold decrease in the number of patients subjected to general anesthesia.


9. DOCID:2089 SCORE: 0.00159470489233808
DOCNO: 187160
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Oncogenic Viruses
QUALIFIER: etiology
AUTHOR: N F Stanley NF
PUBTYPE: Journal Article
JOURNALTITLE: Australian family physician.
COUNTRY: AUSTRALIA
TITLE: The placement of viruses in the aetiology of cancer.
PUBDATE: 19760701
The role of viruses as causative agents of cancer in man has been examined for more than 50 years. These studies have recently been intensified by employing newly developed, more sensitive techniques in virology and immunology. In spite of proof that viruses cause cancer in animals and that about one-quarter of the known 600 viruses possess oncogenic potential, definite proof of their aetiology in human cancer remains elusive even though cancer research is a highly respectable and costly pursuit. Nevertheless, the probabilities are high that human cancer viruses have been and will be identified and that their induced diseases can be prevented or controlled. It is accepted that some benign tumours of man (such as warts) are induced by a virus infection. This article examines the current situation and highlights the difficulties, hopes and usefulness of research in this field.


10. DOCID:2326 SCORE: 0.00141128130873265
DOCNO: 264592
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: H Chan H
AUTHOR: C B Pratt CB
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: A new familial cancer syndrome? A spectrum of malignant and benign tumors including retinoblastoma, carcinoma of the bladder and other genitourinary tumors, thyroid adenoma, and a probable case of multifocal osteosarcoma.
PUBDATE: 19770201
An 11-year-old Caucasian girl who had been cured of bilateral retinoblastoma developed non-radiation-induced osteosarcoma in multiple sites of the extremities. Investigation of the medical histories of 36 of her family members through six generations revealed that 8 relatives on the maternal side (22%) had malignant tumors, predominately genitourinary carcinomas, 2(6%) had benign tumors only, and 2(6%) had both benign and malignant neoplasms. The histologic variety of these tumors, the predominance of genitourinary carcinoma, the higher than expected frequency of tumor appearance over six generations, and the occurrence of malignant tumors in direct lineage suggest that the case of retinoblastoma followed by osteosarcoma is part of a familial cancer syndrome.


11. DOCID:1218 SCORE: 0.00141125982855802
DOCNO: 1191940
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: P C England PC
AUTHOR: L G Skinner LG
AUTHOR: K M Cottrell KM
AUTHOR: R A Sellwood RA
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of surgery.
COUNTRY: ENGLAND
TITLE: Sex hormones in breast disease.
PUBDATE: 19751001
Serum concentrations of oestradiol 17beta and progesterone were measured daily throughout one menstrual cycle in 32 normal women, 32 women with benign disease of the breast and 10 women with cancer of the breast. In normal women concentrations varied with age. Women with cysts had concentrations of oestradiol 17beta which were significantly higher than normal. In women with cancer the concentrations of oestradiol 17beta and progesterone were significantly higher than normal, but the difference was very small and much larger numbers of patients need to be studied. Concentrations of oestradiol 17beta and progesterone in postmenopausal women were consistently very low.


12. DOCID:1789 SCORE: 0.0014112133188108
DOCNO: 320405
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: L J Resseguie LJ
AUTHOR: S J Marks SJ
AUTHOR: R K Winkelmann RK
AUTHOR: L T Kurland LT
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Mayo Clinic proceedings. Mayo Clinic.
COUNTRY: UNITED STATES
TITLE: Malignant melanoma in the resident population of Rochester, Minnesota.
PUBDATE: 19770301
The incidence of malignant melanoma in the population of Rochester, Minnesota, was studied through use of the countywide diagnostic indexing system at the Mayo Clinic. The average annual incidence of cutaneous melanoma (4.0/100,000 creude, 4.2 adjusted to the age structure of the US 1950 population) was similar to that reported by the Third National Cancer Survey for 1969 through 1971 for locations in the United States at the approximate latitude of Rochester. Unlike reports from other studies, no change in incidence rate during the 25 years 1950 through 1974 was detjected in Rochester. The crude annual incidence of malignant melanoma of the eye, also determined for the same period, was 1.3/100,000.


13. DOCID:2829 SCORE: 0.001192190619334
DOCNO: 1146724
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: J G Bieri JG
AUTHOR: R P Evarts RP
PUBTYPE: Journal Article
JOURNALTITLE: The American journal of clinical nutrition.
COUNTRY: UNITED STATES
TITLE: Tocopherols and polyunsaturated fatty acids in human tissues.
PUBDATE: 19750701
Five tissues from three adults who died suddenly and three adult cancer victims were analyzed for alpha- and gamma-tocopherols and fatty acids. When compared with two reports in 1949 and 1958, the three presumably normal subjects had alpha-tocopherol concentrations in liver, muscle and adipose tissue in about the same range as earlier, but heart was twice as high and lung was three times higher than earlier. The content of gamma-tocopherol in all tissues was considerably higher than in 1949 or 1958. Tissues from cancer patients were no lower in alpha-tocopherol than tissues from normal subjects. Adipose tissue from three of the six subjects contained linoleic acid exceeding 15 per cent of total fatty acids. Tocopherols in these subjects, expressed on a tissue weight or tissue lipid basis, were not remarkable. The molar ratio of polyunsaturated fatty acids to alpha-tocopherol in heart and lung was calculated and its possible use in evaluating vitamin E status is discussed.


14. DOCID:3704 SCORE: 0.00112063839953867
DOCNO: 1121634
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: analysis
AUTHOR: A Unger A
AUTHOR: G S Panayi GS
AUTHOR: M H Lessof MH
PUBTYPE: Journal Article
JOURNALTITLE: Rheumatology and rehabilitation.
COUNTRY: ENGLAND
TITLE: Carcinoembryonic antigen in rheumatic diseases.
PUBDATE: 19750201
In an earlier study, the mean plasma carcinoembryonic antigen (CEA) level of patients with seropositive rheumatoid arthritis (RA) was found to be significantly higher than that of normal, control subjects. Levels of CEA in patients with seronegative RA and ankylosing spondylitis, however, did not differ from normal. In this study it was shown that the mean CEA level of 16 patients with Sjögren's syndrome was also significantly higher than normal (P equals 0.001), whereas in a group of 23 children with Still's disease the mean level fell within the normal adult range. Despite the apparent association between rheumatoid factor and raised plasma CEA, no correlation was found between titre of rheumatoid factor and CEA levels. Gel filtration studies indicated that the CEA in rheumatoid arthritis was of a similar molecular weight to that found in cancer of the colon and that there was minimal contribution by the known cross-reacting antigen CCEA2. The mean CEA level in rheumatoid synovial fluids was found to be significantly higher than in osteoarthrotic fluids. A preliminary study has also shown that CEA can be extracted from rheumatoid synovial membranes but was not detected in a normal synovium, further indicating that the source of this antigen in RA may be the inflamed synovium.