0. DOCID:27466 SCORE: 0.000870882142942859
DOCNO: 10858954
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Cycle Proteins
DESCRIPTOR: Enzyme Inhibitors
DESCRIPTOR: Tumor Suppressor Proteins
QUALIFIER: antagonists & inhibitors
QUALIFIER: physiology
AUTHOR: C Desdouets C
AUTHOR: C Bréchot C
AFFILIATION: Inserm U370, Paris, France.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Pathologie-biologie.
COUNTRY: FRANCE
TITLE: p27: a pleiotropic regulator of cellular phenotype and a target for cell cycle dysregulation in cancer.
PUBDATE: 20000401
The eukaryotic cell cycle is regulated by the sequential activation of cyclin-dependent kinases (CDKs). CDK activation is regulated by phosphorylation of the catalytic subunit, by binding to activating (cyclins) and inactivating subunits (cyclin-dependent kinase inhibitor). In this review, we will focus on the role of the cyclin-dependent kinase inhibitor p27 which has been recently the subject of extensive work. This negative regulator of cell growth indeed illustrates the pleiotropic biological effects of such molecules in both normal and cancer cells and the complexity of the regulatory mechanisms involved.


1. DOCID:29859 SCORE: 0.000560658079479883
DOCNO: 16214043
OWNER: NLM
STATUS: In-Process
AUTHOR: George R P Blackledge GR
AFFILIATION: AstraZeneca Pharmaceuticals, Medical Oncology, Alderley House, Alderley Park, Macclesfield, Cheshire SK10 4TF, UK. george.blackledge@astrazeneca.com
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: European journal of cancer (Oxford, England : 1990)
COUNTRY: England
TITLE: The difficulties industry is facing with investigators.
PUBDATE: 20051001
The number of new agents being developed for the treatment of cancer has, over the past 10 years, increased dramatically which has resulted in increased interactions between the pharmaceutical industry that discover and develop most new agents and investigators in academic institutions, hospitals and office practices. This close interaction has inevitably led to a number of issues being identified on both sides and this paper will attempt to identify some of these and propose solutions.


2. DOCID:30836 SCORE: 0.00056062618167447
DOCNO: 14719075
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Apoptosis
QUALIFIER: pathology
AUTHOR: Luca Giannetti L
AUTHOR: Ugo Consolo U
AUTHOR: Cristina Magnoni C
AUTHOR: Lorenzo Lo Muzio L
AFFILIATION: Institute of Dentistry and Surgery, Faculty of Medicine, University of Modena, Modena, Italy.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oncology reports.
COUNTRY: Greece
TITLE: Apoptosis: escaping strategies in human skin cancer (Review).
PUBDATE: 20040201
Apoptosis must be considered a rescue mechanism that controls the integrity of the cell erasing aberrant clones and it is likely that failure of apoptosis constitutes a key factor responsible for tumour formation, progression and resistance to drugs. Several genes (e.g. survivin, bcl-2 family, p53) are involved in these pathways. Much work still needs to be done to identify the molecular pathway of apoptosis resistance but restoration of the apoptotic response represents a crucial new therapeutic target for cancer treatment.


3. DOCID:31995 SCORE: 0.000560622412442402
DOCNO: 15990438
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: Laura Biganzoli L
AUTHOR: Matti Aapro M
AFFILIATION: Medical Oncology Unit, Department of Oncology, Hospital of Prato, Prato, Italy.
PUBTYPE: Journal Article
JOURNALTITLE: Gynäkologisch-geburtshilfliche Rundschau.
COUNTRY: Switzerland
TITLE: Elderly breast cancer patients: adjuvant chemotherapy and adjuvant endocrine therapy.
PUBDATE: 20050601
Older women have unfortunately been underrepresented in breast cancer clinical trials, with the majority of studies being restricted to patients younger than 70 years. Elderly patients are an inhomogeneous group and frequently suffer from comorbidities and/or impaired organ functions. These facts may often lead to death from causes other than cancer, thus nullifying any possible benefit of adjuvant treatment; furthermore, they render extrapolation of standard treatment recommendations to the elderly potentially hazardous, particularly with respect to chemotherapy. Specific clinical trials are therefore needed to investigate adjuvant treatments tailored for the heterogeneous older population.


4. DOCID:31299 SCORE: 0.000560606432982901
DOCNO: 12648714
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
QUALIFIER: methods
QUALIFIER: radiotherapy
AUTHOR: A Belliere A
AUTHOR: O Chapet O
AUTHOR: R Coquard R
AUTHOR: P Romestaing P
AUTHOR: J M Ardiet JM
AUTHOR: J P Gérard JP
AFFILIATION: Service de radiothérapie, CH Lyon-Sud, 69495 cedex, Pierre-Bénite, France.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer radiothérapie : journal de la Société française de radiothérapie oncologique.
COUNTRY: France
TITLE: [Brachytherapy in carcinomas of anal canal and rectum: techniques and results]
PUBDATE: 20030201
Conservative treatment of small anal canal and low rectal cancers is a valid alternative to radical surgery through combinated strategies including external beam and/or intracavitary irradiation, concomitant chemotherapy and 192 iridium implantation as a booster dose. Feasibility, tolerance and results are effective. Local control of the disease and the quality of the anal functions are good. The treatment requires great care in patient selection and follow-up.


5. DOCID:30271 SCORE: 0.00056057451505548
DOCNO: 15283157
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: antagonists & inhibitors
QUALIFIER: therapeutic use
AUTHOR: Yorifumi Satou Y
AUTHOR: Masao Matsuoka M
AFFILIATION: Institute for Virus Research, Kyoto University.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine.
COUNTRY: Japan
TITLE: [Proteasome inhibitor, bortezomib (Vercade), potently inhibits the growth of adult T-cell leukemia cells]
PUBDATE: 20040701
The proteasome is a multicatalytic proteinase complex responsible for the degradation of most intracellular proteins, including crucial to cell cycle regulation, cell growth, and apoptosis. Bortezomib (Vercade; formerly known as PS-341) is a novel dipeptide boronic acid that is the first proteasome inhibitor to have progressed to clinical trials. Below we discuss the mechanism of bortezomib for cancer therapy, review the clinical data, and introduce the potent effect on ATL cells.


6. DOCID:25066 SCORE: 0.000559843759518872
DOCNO: 11444184
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: P Laudański P
AUTHOR: T Anchim T
AUTHOR: S Wołczyński S
AFFILIATION: Zakładu Endokrynologii Ginekologicznej AM w Białymstoku.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Ginekologia polska.
COUNTRY: Poland
TITLE: [The role of nitric oxide in carcinogenesis and progression of neoplastic processes]
PUBDATE: 20010401
The aim of the review is to outline the current knowledge about the role of nitric oxide in the processes of proliferation and apoptosis in tumor. Special emphasis has been placed on its direct cytotoxic influence on a cell where as a highly active free radical it may compromise different cellular functions. Nitric oxide literature, regarding its role in the pathogenesis of some gynecological and breast cancer has been briefly reviewed.


7. DOCID:27090 SCORE: 0.000559820612469606
DOCNO: 9781186
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Asbestosis
QUALIFIER: etiology
QUALIFIER: etiology
AUTHOR: C Paris C
AUTHOR: L Chevreau L
AUTHOR: M Letourneux M
AFFILIATION: Service de médecine du travail Hôpital Charles-Nicolle, Rouen.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: La Revue du praticien.
COUNTRY: FRANCE
TITLE: [Asbestos-related diseases]
PUBDATE: 19980601
The growing use of asbestos in France like in other industrialized countries since the beginning of the century is the reason of the increase of asbestos-related diseases, which occur after long latency periods. From asymptomatic benign pleural plaques up to malignant mesothelioma of poor prognosis, the fibrogenic and carcinogenic properties of asbestos mainly concern occupationally exposed subjects. The Institut national de la santé et de la recherche médicale (INSERM) expert committee concluded that about 1,950 deaths due to asbestos-related cancers occurred in France in 1996. Reinforcement of French legislation aims at reducing all kinds of asbestos exposure.


8. DOCID:27106 SCORE: 0.000559820612282977
DOCNO: 11726356
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ethics, Nursing
QUALIFIER: nursing
AUTHOR: J L Neumann JL
AFFILIATION: Department of Blood and Marrow Transplantation, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77478, USA. jneumann@mdanderson.mail.org
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Nursing clinics of North America.
COUNTRY: United States
TITLE: Ethical issues confronting oncology nurses.
PUBDATE: 20011201
The focus of this article is the ethical dilemmas challenging oncology nurses and their patients. The cancer diagnosis itself may present ethical issues related to genetic testing, prevention and early detection, and information sharing. Cancer treatment options may involve considerations related to level of appropriate care, informed consent, patient education, and unproven, but promising, therapies. Finally, the ethical issues related to outcomes of the disease and treatment, such as pain control, advanced directives, do not resuscitate order, discontinuation of medically inappropriate care, euthanasia, and physician assisted suicide are discussed.


9. DOCID:24771 SCORE: 0.000559791894673157
DOCNO: 10655890
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: methods
AUTHOR: J Bancewicz J
AFFILIATION: Department of Surgery, Hope Hospital, Salford, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Annals of the Royal College of Surgeons of England.
COUNTRY: ENGLAND
TITLE: Palliation in oesophageal neoplasia.
PUBDATE: 19991101
Oesophageal cancer is an increasingly common disease in the UK. Sadly, the overall results of treatment remain poor with overall 5 year survival of approximately 10%. More than 50% of patients receive purely palliative care from the outset. Of those having potentially curative treatment, 40% will not survive the first year and 70% will not survive 5 years. Good quality palliation is, therefore, required for the majority of patients.


10. DOCID:26054 SCORE: 0.000559784996217129
DOCNO: 10978897
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: C P Blobel CP
AFFILIATION: Cellular Biochemistry and Biophysics Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, Box 368, 1275 York Avenue, New York, New York 10021, USA. c-blobel@ski.mskcc.org
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in cell biology.
COUNTRY: UNITED STATES
TITLE: Remarkable roles of proteolysis on and beyond the cell surface.
PUBDATE: 20001001
Proteolysis on the cell surface and in the extracellular matrix is essential for normal cellular functions during development and in the adult, but it may also have undesirable consequences, such as promoting cancer, arthritis, and Alzheimer's disease. Recent advances highlight the roles of zinc-dependent metalloproteinases (metzincins) in proper skeletal development, in activating EGF-receptor ligands, in Notch-dependent signaling, and in initiating and promoting tumorigenesis.


11. DOCID:27137 SCORE: 0.000559771518440431
DOCNO: 11281249
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: blood
AUTHOR: P J Jones PJ
AUTHOR: M Raeini-Sarjaz M
AFFILIATION: School of Dietetics and Human Nutrition, McGill University, Quebec, Canada.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nutrition reviews.
COUNTRY: United States
TITLE: Plant sterols and their derivatives: the current spread of results.
PUBDATE: 20010101
Whereas the cholesterol-lowering action of plant sterols and their derivatives has been well established, more recent results have produced new information concerning the similar effects of various mixtures and dose-response relationships. Moreover, although these materials have generally been viewed as safe for long-term use in almost all sectors of the population, some concerns remain regarding the impact of phytosterol consumption on other lipid-soluble nutrients, which need to be further addressed. Further work is also required to define the relationship between plant sterol consumption, circulating sterol levels, and risk of certain cancers.


12. DOCID:31391 SCORE: 0.000554510446091678
DOCNO: 15389379
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: U Lehmann U
AUTHOR: F Länger F
AUTHOR: G Celikkaya G
AUTHOR: H J Lück HJ
AUTHOR: H Kreipe H
AFFILIATION: Institut für Pathologie, Medizinische Hochschule Hannover.
PUBTYPE: Journal Article
JOURNALTITLE: Zentralblatt für Gynäkologie.
COUNTRY: Germany
TITLE: [Epigenetic changes in breast cancer shown by aberrant promoter methylation]
PUBDATE: 20040801
The aberrant methylation of cytosine residues in the promoter region of growth-regulatory genes is now recognized as an important inactivation mechanism in addition to deletion and mutation in the development and progression of cancer. Principally all pathways regulating proliferation and differentiation, which are perturbed in cancer cells, can be affected. In breast cancer epigenetic inactivation is a frequent and early event displaying great quantitative gene-specific differences during progression. The occurrence of specific aberrant methylation patterns is associated with the histological grade and subtype of mammary carcinoma biopsies.


13. DOCID:31442 SCORE: 0.000538892216188372
DOCNO: 12242108
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Nuclear Proteins
DESCRIPTOR: Saccharomyces cerevisiae Proteins
QUALIFIER: chemistry
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: Kristen E Neely KE
AUTHOR: Jerry L Workman JL
AFFILIATION: Howard Hughes Medical Institute and Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 306 Althouse Laboratory, University Park, PA 16802, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Biochimica et biophysica acta.
COUNTRY: Netherlands
TITLE: The complexity of chromatin remodeling and its links to cancer.
PUBDATE: 20021001
The relief of chromatin-mediated repression by ATP-dependent chromatin-remodeling complexes is an important step in the proper transcriptional regulation of many genes. This review gives an organized summary of this large group of complexes that exist in yeast, flies, and humans. Their subunit composition and brief overview of their functional properties will be discussed. Also, current links between human chromatin-remodeling complexes and cell growth and cancer will be presented.


14. DOCID:25611 SCORE: 0.000538701237571249
DOCNO: 10398095
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: P J van Diest PJ
AFFILIATION: Department of Pathology, Free University Hospital, Amsterdam, The Netherlands. pj.vandiest@azvu.nl
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of pathology.
COUNTRY: ENGLAND
TITLE: Ductal carcinoma in situ in breast carcinogenesis.
PUBDATE: 19990301
Evidence is mounting that ductal carcinoma in situ (DCIS) is a direct precursor of invasive breast cancer. Recent molecular biological and cytogenetic studies have revealed chromosomal gains and losses involved in breast carcinogenesis. This editorial discusses how the gains and losses on the different chromosomes fit into previously defined morphological routes of progression from normal cells through DCIS to invasive carcinoma, and the possible uses of these gains and losses in the classification of DCIS and the risk assessment of DCIS patients.