0. DOCID:12853 SCORE: 0.00266496811384475
DOCNO: 3668465
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
AUTHOR: J Vioque J
AUTHOR: F Bolumar F
AFFILIATION: Departamento de Salud Comunitaria, Facultad de Medicine, Universidad de Alicante, Spain.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of epidemiology and community health.
COUNTRY: ENGLAND
TITLE: Trends in mortality from lung cancer in Spain, 1951-80.
PUBDATE: 19870301
Lung cancer mortality rates in Spain were calculated for the years 1951 to 1980. Increasing age-standardised rates for men and levelled off ones for women were observed. Available cigarette consumption data suggest that these current trends could change at the beginning of the next century when there may be a levelling off of male rates and an "epidemic" of female lung cancer.


1. DOCID:10092 SCORE: 0.00215240201174284
DOCNO: 4016675
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: complications
AUTHOR: R Kuylenstierna R
AUTHOR: E Munck-Wikland E
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Esophagitis and cancer of the esophagus.
PUBDATE: 19850801
Early diagnosis is an important factor in the effort to increase the healing rates of esophageal cancer; another consideration is the establishment of a reliable method of identifying risk groups. Alcohol abuse is known to be associated with a higher risk of esophageal cancer. The current investigation, based on a retrospective study of the records of patients with esophageal cancer, reveals a strong connection between cancer development and chronic esophagitis due mainly to reflux in about 10% of the patients. In the literature this connection has been suspected but never so clearly shown. The clinical implication may be a more rigorous approach to long-standing esophagitis in elderly patients.


2. DOCID:10012 SCORE: 0.00207589131045359
DOCNO: 6876400
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: cytology
QUALIFIER: diagnosis
AUTHOR: S Yamada S
AUTHOR: T Takeda T
AUTHOR: K Takaso K
AUTHOR: H Shinzawa H
AUTHOR: T Matsuda T
AUTHOR: H Saito H
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Prognostic analysis of malignant peritoneal effusions from gastric cancer]
PUBDATE: 19830201
The prognosis of 135 cases with malignant peritoneal effusion from gastric cancer was analyzed clinically and cytologically. The histologic type of the primary gastric cancer or therapeutic differences had no significant influence on the prognosis. Previous gastrectomy or absence of distant metastases had no marked effect on survival. The formation of large clusters of cancer cells on smear preparations of peritoneal effusion was interpreted as a sign of good prognosis. The cancer cell number and the presence of lymphocytes on smear preparations bore no relationship to prognosis.


3. DOCID:11491 SCORE: 0.00179048834596845
DOCNO: 6292076
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Division
DESCRIPTOR: Interphase
QUALIFIER: cytology
AUTHOR: C Diatloff-Zito C
AUTHOR: A Macieira-Coelho A
PUBTYPE: Journal Article
JOURNALTITLE: In vitro.
COUNTRY: UNITED STATES
TITLE: Effect of growth arrest on the doubling potential of human fibroblasts in vitro: a possible influence of the donor.
PUBDATE: 19820701
Population doublings versus time in culture were compared in human postnatal skin fibroblasts from normal donors, a cancer patient, and from donors suffering from Cockayne syndrome, Ataxia telangiectasia, and Fanconi's anemia (FA). Confluent cultures were maintained in a nonproliferating state for 14 to 27 d in 0.5% serum medium. The results show that the ability of cells to resume division after a resting stage can be influenced by pathologic conditions. In arrested FA cell populations an increase of the population doublings and of the calendar time were observed. It is possible that in some cell populations the resting stage favors the expression of growth potentialities related to instability of the cells.


4. DOCID:15858 SCORE: 0.00117497572331762
DOCNO: 2701419
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: S G Urba SG
AUTHOR: A A Forastiere AA
AFFILIATION: Division of Hematology/Oncology, U of Michigan Medical Center.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oncology (Williston Park, N.Y.)
COUNTRY: UNITED STATES
TITLE: Systemic therapy of head and neck cancer: most effective agents, areas of promise.
PUBDATE: 19890401
The management of squamous cell cancer of the head and neck is a challenging problem. However, "induction" chemotherapy administered prior to surgery and radiation therapy in newly diagnosed patients is showing encouraging results for the preservation of organ function and is the focus of multi-institutional trials. Concurrent chemotherapy and radiation therapy is another approach with promise for unresectable disease. Recent studies combining cisplatin with radiation therapy have reported minimal enhancement of mucocutaneous toxicity and promising survival data. Other strategies which are just beginning to receive attention in clinical research trials include adjuvant chemotherapy in the disease-free patient and biologic response modifiers.


5. DOCID:9765 SCORE: 0.00117208429544088
DOCNO: 2983952
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
AUTHOR: G C Roviaro GC
AUTHOR: F Varoli F
AUTHOR: P Zannini P
AUTHOR: A Fascianella A
AUTHOR: G Pezzuoli G
PUBTYPE: Journal Article
JOURNALTITLE: Chest.
COUNTRY: UNITED STATES
TITLE: Lung cancer in the young.
PUBDATE: 19850401
A long-term retrospective study was carried out on 1,514 cases of lung cancer to assess whether the disease presents substantial differences in young as compared to older patients. Clinical, epidemiologic, surgical, and survival data were evaluated in all cases. A young group under 45 years of age was studied separately and compared with the remaining older patients. In contrast with the literature, our results showed no percentage increase or variation in the male/female ratio of lung cancer in the young group. No significant difference was found regarding clinical picture, operability, histotype, and prognosis.


6. DOCID:10883 SCORE: 0.0011457720360492
DOCNO: 6538239
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: W E Dougherty WE
AUTHOR: J H Lynch JH
AUTHOR: W C Maxted WC
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: Case report: complete response of metastatic transitional cell carcinoma of the bladder with chemotherapy alone.
PUBDATE: 19840201
Transitional cell carcinoma of the bladder has remained to date basically a surgical disease with the addition of preoperative radiation therapy to increase survival. Chemotherapy for bladder cancer is administered either in an adjuvant setting or in patients with metastatic disease, most of whom have been treated already with cystectomy and/or radiation. We report a complete response at 54 months in a patient with clinical stage D2 and pathologic stage D1 carcinoma using cisplatin, doxorubicin and cyclophosphamide. The patient was treated with urinary diversion and chemotherapy alone, and no attempt was made to remove the primary lesion.


7. DOCID:15425 SCORE: 0.00102844423017594
DOCNO: 3285477
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: M J O'Connell MJ
AUTHOR: L L Gunderson LL
AUTHOR: T R Fleming TR
AFFILIATION: Division of Medical and Radiation Oncology, Mayo Clinic, Rochester, MN 55905.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in oncology.
COUNTRY: UNITED STATES
TITLE: Surgical adjuvant therapy of rectal cancer.
PUBDATE: 19880401
Surgery is the preferred method of curative therapy for carcinoma of the rectum. However, in spite of complete gross tumor resection, many patients with locally advanced tumors will experience recurrence of malignant disease in the pelvis and/or distant metastases. This article summarizes the roles of radiotherapy and chemotherapy, administered alone and in combination, as surgical adjuvant treatment for patients with resectable rectal cancer. A biostatistical overview is presented. It is concluded that strong evidence exists supporting the efficacy of combined postoperative radiotherapy and chemotherapy. Further clinical trials are indicated to determine the optimum chemotherapy regimen, sequence, and duration of the therapy.


8. DOCID:15031 SCORE: 0.00100597895888226
DOCNO: 3602810
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: D Dargent D
AUTHOR: H Barletta H
AUTHOR: P Adeleine P
PUBTYPE: Journal Article
JOURNALTITLE: Revue française de gynécologie et d'obstétrique.
COUNTRY: FRANCE
TITLE: [Prognostic elements of cancer of the endometrium. Therapeutic deductions]
PUBDATE: 19870501
The authors report a series of 120 cancers of the endometrium treated between 1970 and 1985 included. Of all "morphological" factors, the degree of tumor differentiation is the one which has the greatest predictive value for the prognosis. The general condition of the patient have, stricto sensu, a very significant influence on the prognosis of cancer. The Wertheim's procedure offer results which are far superior to those of a simple hysterectomy. It must be favored in all patients who can withstand it. In patients with poor general condition, perform a simple total vaginal hysterectomy. This will be performed with all the less reserve as the tumor was well differentiated.


9. DOCID:10148 SCORE: 0.000863558691288996
DOCNO: 6723926
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Models, Biological
QUALIFIER: pharmacology
QUALIFIER: pharmacology
QUALIFIER: pharmacology
QUALIFIER: pharmacology
AUTHOR: I A Macdonald IA
AUTHOR: J A Mader JA
AUTHOR: B G Rao BG
AUTHOR: D A Malatjalian DA
PUBTYPE: Journal Article
JOURNALTITLE: Experientia.
COUNTRY: SWITZERLAND
TITLE: Model systems demonstrating the volatile mutagenicity and carcinogenicity of sodium nitrite in rats.
PUBDATE: 19840601
Volatile mutagens derived from sodium nitrite buffered at various pH values or in the presence of human feces were detected using Ames Salmonella tester strain TA 1535 on petrie plates inverted over samples. Volatile mutagenicity increased as the pH decreased and was primarily a function of the nitrous acid produced from sodium nitrite and hydrogen ions. Sodium nitrite administered intracecally to 3 Wistar rats through surgically implanted cannula caused tumors (fibrosarcoma: 1/3 and squamous cell, 2/3). The possible role of nitrite-derived mutagens in GI cancer is discussed.


10. DOCID:11661 SCORE: 0.000863555485040717
DOCNO: 3923296
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Electrocardiography
QUALIFIER: radiation effects
QUALIFIER: radiotherapy
AUTHOR: T V Blokhina TV
AUTHOR: B A Berdov BA
AUTHOR: V I Byrikhin VI
PUBTYPE: Journal Article
JOURNALTITLE: Meditsinskaia radiologiia.
COUNTRY: USSR
TITLE: [ECG changes during radiotherapy of stomach cancer]
PUBDATE: 19850501
Myocardial diffuse dystrophic changes were recorded on the ECG of patients with stomach cancer of different site. After a preoperative course of radiation therapy in the summary focal dose up to 24 Gy these changes were aggravated in 63% of cases: changes in the voltage of the QRS complex waves, amplitudes of P and T waves, S-T intervals and the heart rate were noted. The most pronounced ECG changes developed in patients with tumors in the proximal part of the stomach when radiation exposure of the heart corresponded to 100% of a focal dose. The voltage of the QRS complex waves decreased, the amplitude of P waves increased, a rise of the S-T interval was noted, the amplitude of T waves decreased.


11. DOCID:10169 SCORE: 0.000863525414226633
DOCNO: 7118615
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
AUTHOR: L L Doss LL
AUTHOR: N Memula N
PUBTYPE: Journal Article
JOURNALTITLE: International journal of radiation oncology, biology, physics.
COUNTRY: UNITED STATES
TITLE: The radioresponsiveness of melanoma.
PUBDATE: 19820701
The variability of malignant melanoma in its response to irradiation is well documented. Recent radiobiological studies suggest that high individual dose and low total fraction regimens will enhance the responsiveness of this tumor to irradiation. The experience of the Ellis Fischel State Cancer Hospital and the Cancer Research Center, Columbia, Missouri was reviewed with particular attention to such radiotherapeutic regimens. Of 41 lesions in 27 patients, the overall response rate to irradiation was 37%. When regimens using more than 400 cGy per fraction were analyzed, a 67% response rate was noted. Complete response and small volume of tumor correlated significantly (p = 0.008) with long-term survival.


12. DOCID:15977 SCORE: 0.000859536126826473
DOCNO: 2884183
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: A Giwercman A
AUTHOR: J G Berthelsen JG
AUTHOR: J Müller J
AUTHOR: H von der Maase H
AUTHOR: N E Skakkebaek NE
PUBTYPE: Journal Article
JOURNALTITLE: International journal of andrology.
COUNTRY: DENMARK
TITLE: Screening for carcinoma-in-situ of the testis.
PUBDATE: 19870201
Germ cell neoplasia detected at the preinvasive stage of carcinoma-in-situ (CIS) can be cured by orchidectomy or by localized irradiation of the testis. Therefore, screening for carcinoma-in-situ of the testis has been applied to groups of individuals known to have an increased risk of testicular cancer. A high (5.5%) incidence of CIS was found in the contralateral testis of men with a unilateral cancer of the testis. An increased incidence of CIS was also found among men with a history of cryptorchidism. We recommend routine screening for CIS of the testis in both groups of men. The role of screening for CIS among subfertile men remains to be elucidated.


13. DOCID:11273 SCORE: 0.000816194573486731
DOCNO: 6518451
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: A M Watrach AM
AUTHOR: J A Milner JA
AUTHOR: M A Watrach MA
AUTHOR: K A Poirier KA
PUBTYPE: Journal Article
JOURNALTITLE: Cancer letters.
COUNTRY: NETHERLANDS
TITLE: Inhibition of human breast cancer cells by selenium.
PUBDATE: 19841101
The viability of human breast cancer cells (cell lines MCF-7 and MDA-MB 231) was inhibited in vitro in a dose-dependent manner by selenium supplementation. However, a normal diploid human cell line (MRC-5) was relatively resistant to selenium supplementation. The presence of selenium as Na2SeO3 at 1.1 X 10(-6) M reduced cancer cell viability by approximately 50%, whereas non-cancerous cells were not affected. Parenteral administration of sodium selenite also significantly inhibited the growth of the cancerous cell lines transplanted into nude mice. Selenium administration at 0.8 micrograms/g body wt resulted in an 80-93% reduction in the rate of tumor growth without apparent ill effects on the host.


14. DOCID:15378 SCORE: 0.000730265779716005
DOCNO: 2945307
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: surgery
AUTHOR: Iu A Volokh IuA
AUTHOR: V P Pak VP
PUBTYPE: Journal Article
JOURNALTITLE: Vestnik khirurgii imeni I. I. Grekova.
COUNTRY: USSR
TITLE: [Thyroid cancer in an endemic goiter region]
PUBDATE: 19860801
On the basis of an analysis of 1062 operations on the thyroid gland the authors make a conclusion that incidence of cancer of the thyroid gland in the focus of the moderate goiter endemia is 9,6%. Three stages of the development of cancer of the thyroid gland are established: a) precancer, b) latent stage of cancer (histological findings), c) stage of manifest cancer. Complex methods of treatment were used such as radical operation followed by the obligatory radiation therapy (in patients having no contraindications) and permanent treatment by thyroidine in combination with chemotherapy (on indications). Remote results followed in 92 patients during 9 years were quite satisfactory. Recurrences were found in 2 patients.