0. DOCID:23266 SCORE: 0.00118008984783842
DOCNO: 7668866
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hyperthermia, Induced
DESCRIPTOR: Ultrasonic Therapy
QUALIFIER: therapy
QUALIFIER: methods
AUTHOR: T Okawa T
AUTHOR: M Kita-Okawa M
AFFILIATION: Department of Radiation Oncology, Tokyo Women's Medical College, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [The role and future of radiotherapy in cancer treatment]
PUBDATE: 19950901
The basic principle of radiotherapy for cancer patients is that it has the possibility of a good result (curability), is tolerable and promises a comfortable life thereafter. Radiotherapy is the important tool for early stage cancer by conserving the organ and function and for an advanced or recurrent stage of cancer by helping improve the quality of life. Radiotherapy must be planned on the basis of considering the therapeutic ratio with a 3-dimensional technique. It should be performed with optimum radiation methods in the multimodal treatment of cancer and will undoubtedly prove effective in the future.


1. DOCID:17199 SCORE: 0.00116077786909538
DOCNO: 2169981
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: M Zhu M
PUBTYPE: Journal Article
JOURNALTITLE: Zhonghua yi xue za zhi.
COUNTRY: CHINA
TITLE: [SEM study of invasive characteristics of colorectal cancer]
PUBDATE: 19900601
This paper reports the results of a study on the invasive characteristics of 22 colorectal cancer by scanning electron microscopy (SEM). The results showed that adenocarcinoma cells stretching polymorphic pseudopodia penetrated into peripheral tissue and adhered to or invaded the vessels, but most of the mucoid carcinoma cells migrated separately into the tissue clefts and invaded the vessels. The invasive mode had dominant differentiation in two typical cancer. The author believes that colorectal cancer possesses two invasive factors: ameboid movement and destroying tissues by lysozyme.


2. DOCID:23863 SCORE: 0.00115081855715664
DOCNO: 9241648
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Radioimmunodetection
QUALIFIER: radionuclide imaging
AUTHOR: S M Larson SM
AUTHOR: C Divgi C
AUTHOR: A Scott A
AUTHOR: F Daghighian F
AUTHOR: H Macapinlac H
AUTHOR: S Welt S
AFFILIATION: Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Nuclear medicine and biology.
COUNTRY: ENGLAND
TITLE: Current status of radioimmunodetection.
PUBDATE: 19940701
Radioimmunodetection is a nuclear medicine technique that depends on in vivo detection of localization of antibodies and antibody forms carrying radioactivity for the purpose of diagnosis in patients with cancer. Current methods take advantage of tracers suitable for high resolution gamma-camera imaging, such as 99mTc and 111In, for common tumors, such as colon and lung cancers. In addition, tracers such as 125I have been used for the intraoperative detection of metastatic deposits. These methods detect from 75 to 90% of metastatic deposits with high specificity, and typically contribute important diagnostic information, even in 25-40% of patients with occult disease.


3. DOCID:23890 SCORE: 0.00115081590285785
DOCNO: 8168744
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: diagnosis
AUTHOR: J Helou J
AUTHOR: S Nakhleh S
AUTHOR: E Shalev E
AUTHOR: T Nsseir T
AFFILIATION: Dept. of Obstetrics and Gynecology, St. Vincent de Paul Hospital, Nazareth and Ha'emek Medical Center, Afula.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Harefuah.
COUNTRY: ISRAEL
TITLE: [Colonic carcinoma during pregnancy]
PUBDATE: 19940201
A case of adenocarcinoma of the splenic flexure during pregnancy is reported. A 27-year-old woman was admitted at 34 weeks of pregnancy with abdominal pain and vomiting. 36 hours after normal delivery an emergency exploratory laparotomy was performed for intestinal obstruction. A huge tumor of the splenic flexure with retroperitoneal extension was found. She died 1 year later of metastatic disease. Delay in diagnosis and complications of colonic cancer are more prevalent in pregnancy. While colonic carcinoma during pregnancy is extremely rare, it should be included in the differential diagnosis of colonic symptoms. The 24th case of this type is reported.


4. DOCID:27466 SCORE: 0.000870882142942859
DOCNO: 10858954
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Cycle Proteins
DESCRIPTOR: Enzyme Inhibitors
DESCRIPTOR: Tumor Suppressor Proteins
QUALIFIER: antagonists & inhibitors
QUALIFIER: physiology
AUTHOR: C Desdouets C
AUTHOR: C Bréchot C
AFFILIATION: Inserm U370, Paris, France.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Pathologie-biologie.
COUNTRY: FRANCE
TITLE: p27: a pleiotropic regulator of cellular phenotype and a target for cell cycle dysregulation in cancer.
PUBDATE: 20000401
The eukaryotic cell cycle is regulated by the sequential activation of cyclin-dependent kinases (CDKs). CDK activation is regulated by phosphorylation of the catalytic subunit, by binding to activating (cyclins) and inactivating subunits (cyclin-dependent kinase inhibitor). In this review, we will focus on the role of the cyclin-dependent kinase inhibitor p27 which has been recently the subject of extensive work. This negative regulator of cell growth indeed illustrates the pleiotropic biological effects of such molecules in both normal and cancer cells and the complexity of the regulatory mechanisms involved.


5. DOCID:23935 SCORE: 0.000869443695354803
DOCNO: 8707761
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: chemically induced
AUTHOR: S K Kim SK
AUTHOR: G D Demetri GD
AFFILIATION: Division of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Hematology/oncology clinics of North America.
COUNTRY: UNITED STATES
TITLE: Chemotherapy and neutropenia.
PUBDATE: 19960401
Myelosuppression is the most common toxicity associated with the administration of dose-intensive cytotoxic chemotherapy. The basic understanding of neutrophil biology and the physiology of chemotherapy-induced neutropenia has advanced tremendously in the past 2 decades. Concordantly, the ability to reduce the morbidity associated with neutropenia has improved. Adjunctive cytokine and progenitor cell support of hematologic recovery after myelosuppressive therapy have proved to be models of translational research and have led to novel therapeutic initiatives for patients with cancer and hematologic malignancies. In this article, fundamental aspects of neutrophil production are discussed, and the clinical development of hematopoietic cytokines active on cells of the leukocyte lineages is presented.


6. DOCID:16900 SCORE: 0.000869239102353572
DOCNO: 2269221
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cluster Analysis
QUALIFIER: epidemiology
AUTHOR: T Tango T
AFFILIATION: Department of Epidemiology, Institute of Public Health, Tokyo, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Environmental health perspectives.
COUNTRY: UNITED STATES
TITLE: An index for cancer clustering.
PUBDATE: 19900701
This paper generalizes the index for temporal clustering proposed by Tango in two ways: it allows for nonuniform population distributions across the study period and it is applicable to the detection of disease clustering in space where there are variations in population distribution among categories of the confounding factor such as age and sex. Applications are illustrated with 1833 cases of mortality from uterine cancer in the Tokyo metropolitan area during 1978-1982.


7. DOCID:19220 SCORE: 0.000813850774028454
DOCNO: 1511159
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: cytology
AUTHOR: A G Knudson AG
AFFILIATION: Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, PA 19111.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in cancer biology.
COUNTRY: UNITED STATES
TITLE: Stem cell regulation, tissue ontogeny, and oncogenic events.
PUBDATE: 19920601
The number of necessary oncogenic events is a function of tissue ontogeny. A minimum of two events appears to suffice for certain embryonal tumors, leukemias, and lymphomas for which the target tissues normally show stem cell proliferation. Other tumors, including those featured in the Li-Fraumeni syndrome, arise in target tissues whose stem cells are conditionally stimulated to proliferate, as in response to hormones, and involve more events. The most complex cancers include most carcinomas, which arise in renewal tissues whose stem cells do not normally proliferate. The number of necessary oncogenic events appears to increase with the number of controls on proliferation.


8. DOCID:19974 SCORE: 0.000755986190123774
DOCNO: 1872626
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
QUALIFIER: complications
AUTHOR: M Kurosumi M
AUTHOR: Y Horii Y
AUTHOR: M Aizaki M
AUTHOR: S Kishi S
AUTHOR: T Anzai T
AFFILIATION: Dept. of Surgery, Shibukawa National Hospital, Saitama, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [A case of peritonitis carcinomatosa due to advanced gastric cancer effectively treated by intraperitoneal injection of carboplatin]
PUBDATE: 19910801
The patient was a 72-year-old woman who had advanced carcinoma of the stomach. She presented massive ascites due to peritonitis carcinomatosa. The cytology of ascites was class V and the CEA level of ascites was elevated. Since renal function was low, we injected 300 mg of carboplatin intraperitoneally 2 times in 8 weeks. The amount of ascites was significantly diminished and the CEA level of ascites was decreased. The result suggested the effectiveness of intraperitoneal injection of carboplatin for the therapy of peritoneal metastasis of gastric cancer.


9. DOCID:22573 SCORE: 0.000629285473433908
DOCNO: 10161206
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: diagnosis
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: A S Dias AS
PUBTYPE: Journal Article
JOURNALTITLE: Journal of clinical laser medicine & surgery.
COUNTRY: UNITED STATES
TITLE: Androscopy and treatment of human papillomavirus (HPV) with CO2 laser surgery.
PUBDATE: 19941001
Dysplasia and cancer of the cervix may be related to human papillomavirus infection. To determine the presence of cancer in cases of genital warts we have been using a technique, androscopy, for examining male genitals with magnified lens previously sprayed with white vinegar (5% acetic acid). This paper explores the methods of using colposcopy and androscopy on both sexual partners for a thorough examination of genitals and the anorectal area. It also discusses treatment advantages of the CO2 laser. In our investigation plain, pedunculated warts and a giant condyloma (Buschke-Loewenstein tumor) were found and treated with CO2 laser surgery.


10. DOCID:29859 SCORE: 0.000560658079479883
DOCNO: 16214043
OWNER: NLM
STATUS: In-Process
AUTHOR: George R P Blackledge GR
AFFILIATION: AstraZeneca Pharmaceuticals, Medical Oncology, Alderley House, Alderley Park, Macclesfield, Cheshire SK10 4TF, UK. george.blackledge@astrazeneca.com
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: European journal of cancer (Oxford, England : 1990)
COUNTRY: England
TITLE: The difficulties industry is facing with investigators.
PUBDATE: 20051001
The number of new agents being developed for the treatment of cancer has, over the past 10 years, increased dramatically which has resulted in increased interactions between the pharmaceutical industry that discover and develop most new agents and investigators in academic institutions, hospitals and office practices. This close interaction has inevitably led to a number of issues being identified on both sides and this paper will attempt to identify some of these and propose solutions.


11. DOCID:30836 SCORE: 0.00056062618167447
DOCNO: 14719075
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Apoptosis
QUALIFIER: pathology
AUTHOR: Luca Giannetti L
AUTHOR: Ugo Consolo U
AUTHOR: Cristina Magnoni C
AUTHOR: Lorenzo Lo Muzio L
AFFILIATION: Institute of Dentistry and Surgery, Faculty of Medicine, University of Modena, Modena, Italy.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Oncology reports.
COUNTRY: Greece
TITLE: Apoptosis: escaping strategies in human skin cancer (Review).
PUBDATE: 20040201
Apoptosis must be considered a rescue mechanism that controls the integrity of the cell erasing aberrant clones and it is likely that failure of apoptosis constitutes a key factor responsible for tumour formation, progression and resistance to drugs. Several genes (e.g. survivin, bcl-2 family, p53) are involved in these pathways. Much work still needs to be done to identify the molecular pathway of apoptosis resistance but restoration of the apoptotic response represents a crucial new therapeutic target for cancer treatment.


12. DOCID:31995 SCORE: 0.000560622412442402
DOCNO: 15990438
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: Laura Biganzoli L
AUTHOR: Matti Aapro M
AFFILIATION: Medical Oncology Unit, Department of Oncology, Hospital of Prato, Prato, Italy.
PUBTYPE: Journal Article
JOURNALTITLE: Gynäkologisch-geburtshilfliche Rundschau.
COUNTRY: Switzerland
TITLE: Elderly breast cancer patients: adjuvant chemotherapy and adjuvant endocrine therapy.
PUBDATE: 20050601
Older women have unfortunately been underrepresented in breast cancer clinical trials, with the majority of studies being restricted to patients younger than 70 years. Elderly patients are an inhomogeneous group and frequently suffer from comorbidities and/or impaired organ functions. These facts may often lead to death from causes other than cancer, thus nullifying any possible benefit of adjuvant treatment; furthermore, they render extrapolation of standard treatment recommendations to the elderly potentially hazardous, particularly with respect to chemotherapy. Specific clinical trials are therefore needed to investigate adjuvant treatments tailored for the heterogeneous older population.


13. DOCID:31299 SCORE: 0.000560606432982901
DOCNO: 12648714
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
QUALIFIER: methods
QUALIFIER: radiotherapy
AUTHOR: A Belliere A
AUTHOR: O Chapet O
AUTHOR: R Coquard R
AUTHOR: P Romestaing P
AUTHOR: J M Ardiet JM
AUTHOR: J P Gérard JP
AFFILIATION: Service de radiothérapie, CH Lyon-Sud, 69495 cedex, Pierre-Bénite, France.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer radiothérapie : journal de la Société française de radiothérapie oncologique.
COUNTRY: France
TITLE: [Brachytherapy in carcinomas of anal canal and rectum: techniques and results]
PUBDATE: 20030201
Conservative treatment of small anal canal and low rectal cancers is a valid alternative to radical surgery through combinated strategies including external beam and/or intracavitary irradiation, concomitant chemotherapy and 192 iridium implantation as a booster dose. Feasibility, tolerance and results are effective. Local control of the disease and the quality of the anal functions are good. The treatment requires great care in patient selection and follow-up.


14. DOCID:30271 SCORE: 0.00056057451505548
DOCNO: 15283157
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: antagonists & inhibitors
QUALIFIER: therapeutic use
AUTHOR: Yorifumi Satou Y
AUTHOR: Masao Matsuoka M
AFFILIATION: Institute for Virus Research, Kyoto University.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine.
COUNTRY: Japan
TITLE: [Proteasome inhibitor, bortezomib (Vercade), potently inhibits the growth of adult T-cell leukemia cells]
PUBDATE: 20040701
The proteasome is a multicatalytic proteinase complex responsible for the degradation of most intracellular proteins, including crucial to cell cycle regulation, cell growth, and apoptosis. Bortezomib (Vercade; formerly known as PS-341) is a novel dipeptide boronic acid that is the first proteasome inhibitor to have progressed to clinical trials. Below we discuss the mechanism of bortezomib for cancer therapy, review the clinical data, and introduce the potent effect on ATL cells.