0. DOCID:3994 SCORE: 0.00774151380593659
DOCNO: 163675
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: analogs & derivatives
AUTHOR: G Falkson G
AUTHOR: J J van Dyk JJ
AUTHOR: E B van Eden EB
AUTHOR: A M van der Merwe AM
AUTHOR: J A van den Bergh JA
AUTHOR: H C Falkson HC
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: A clinical trial of the oral form of 4'-demethyl-epipodophyllotoxin-beta-D ethylidene glucoside (NSC 141540) VP 16-213.
PUBDATE: 19750401
A clinical trial of the oral form of VP 16-213 (NSC-141540), a semisynthetic podophyllotoxin, was undertaken. In 20 patients, treatment was started at 200 mg/day p.o. for 5 days; courses were repeated after a rest period of 16 days. Five patients were treated at the same dose, repeated with only 9-day rest periods. Subsequently, 65 patients were given 300-400 mg/day for 5 days, with rest periods of 9 days between courses. The side effects encountered included anorexia, nausea and vomiting, stomatitis, diarrhea, leukopenia, thrombocytopenia, alopecia, and pruritis. Substernal discomfort with or without palpitations was reported by 18 patients; no explanation for this symptom could be found. No complete remissions (CR) were observed. Parital remissions (PR) and improvement (IMP) were seen as follows: small cell carcinoma, lung (10 patients)--2 PR, 3 IMP; adenocarcinoma, lung (4 patients)--1 PR; alveolar cell carcinoma, lung (1 patient)--1 IMP; mesothelioma (4 patients)--1 IMP; ovarian cancer (12 patients)--3 PR, 3 IMP; breast cancer (20 patients)--4 IMP; colon cancer (8 patients)--2 IMP; bladder cancer (4 patients)--2 IMP; histiocytic lymphoma (7 patients)--2 PR, 3 IMP; chronic myeloid leukemia (1 patient)--1 IMP.


1. DOCID:3547 SCORE: 0.00360985757542251
DOCNO: 326245
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Kidney Transplantation
QUALIFIER: analysis
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: J B Myers JB
AUTHOR: M Frost M
AUTHOR: A S Coates AS
AUTHOR: J D Mathews JD
AUTHOR: P Kincaid-Smith P
PUBTYPE: Journal Article
JOURNALTITLE: Australian and New Zealand journal of medicine.
COUNTRY: AUSTRALIA
TITLE: Carcinoembryonic antigen in renal allograft recipients and immunosuppressed renal patients.
PUBDATE: 19770201
Carcinoembryonic antigen (CEA) was estimated in plasma from 70 patients with a renal transplant, 105 patients with glomerulonephritis who had received immunosuppressive therapy, and 124 healthy controls. There were raised levels in 30% of those with a renal transplant, 10% of those with glomerulonephritis and 2% of controls, and levels were higher in current smokers. CEA levels did not correlate with pre-transplant dialysis time nor with serum creatinine levels, but tended to fall with increasing time after transplantation, especially in non-smokers. CEA levels did not correlate with prednisolone dosage nor with number of rejection episodes, after allowing for time after transplantation and smoking habit. Nine of 70 patients with a renal transplant and three of 105 with glomerulonephritis had cancer, of skin in seven, cervix uteri in four, and colon in one. CEA was raised in all four transplant recipients with a visceral cancer (cervix three and colon one), but in none of the five with cutaneous cancer. Raised CEA levels occurring late after a renal allograft should prompt a careful search for visceral cancer.


2. DOCID:3784 SCORE: 0.00309340757463191
DOCNO: 167949
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: classification
AUTHOR: A L Cubilla AL
AUTHOR: P J Fitzgerald PJ
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Morphological patterns of primary nonendocrine human pancreas carcinoma.
PUBDATE: 19750801
The study of histological sections of 406 cases of nonendocrine pancreas carcinoma at Memorial Hospital indicated that morphological patterns of pancreas carcinoma could be delineated as follows: duct cell adenocarcinoma (76%), giant-cell carcinoma (5%), microadenocarcinoma (4%), adenosquamous cancinoma (4%), mucinous adenocarcinoma (2%), anaplastic carcinoma (2%), cystadenocarcinoma (1%), acinar cell carcinoma (1%), carcinoma in childhood (under 1%), unclassified (7%). In 195 cases of patients with pancreas carcinoma, search was made for changes in the pancreas duct epithelium and these were compared to duct epithelium in a control group of 100 pancreases from autopsies of patients with nonpancreatic cancer. The following incidences were found for pancreas cancer and nonpancreatic cancer, respectively: mucous cell hypertrophy, 39 versus 28%; pyloric gland metaplasia, 28 and 17%; epidermoid metaplasia, 6 and 12%; papillary hyperplasia, 42 and 12%; atypical duct hyperplasia, 14% and none; cancinoma in situ in 19% and none in the control group. Mucin in the majority of pancreas cancers suggested that the cell type of origin of the common pancreas cancer is the mucin-producing duct epithelium. The association of atypias and carcinomas in situ in the patients with pancreas carcinoma implies, by analogy to other organs, that there may be a significant latent period between the appearance of carcinoma in situ and the grossly recognizable pancreas cancer.


3. DOCID:12853 SCORE: 0.00266496811384475
DOCNO: 3668465
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
AUTHOR: J Vioque J
AUTHOR: F Bolumar F
AFFILIATION: Departamento de Salud Comunitaria, Facultad de Medicine, Universidad de Alicante, Spain.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of epidemiology and community health.
COUNTRY: ENGLAND
TITLE: Trends in mortality from lung cancer in Spain, 1951-80.
PUBDATE: 19870301
Lung cancer mortality rates in Spain were calculated for the years 1951 to 1980. Increasing age-standardised rates for men and levelled off ones for women were observed. Available cigarette consumption data suggest that these current trends could change at the beginning of the next century when there may be a levelling off of male rates and an "epidemic" of female lung cancer.


4. DOCID:2364 SCORE: 0.00258990210323123
DOCNO: 1034229
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ethmoid Sinus
QUALIFIER: radiography
QUALIFIER: radiography
QUALIFIER: radiography
AUTHOR: S Naruse S
AUTHOR: G Odake G
AUTHOR: T Yamaki T
AUTHOR: M Toyama M
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: No shinkei geka. Neurological surgery.
COUNTRY: JAPAN
TITLE: [Intracranial invasion of ethmoid cancer --a report of two cases (author's transl)]
PUBDATE: 19761101
Two cases of intracranial invasion of the ethmoid cancer were reported. With additional six cases reported in Japan, the precise clinical course and pathophysiological findings of the disease were reviewed, and the following several points became clear; 1) The incidence of the ethmoid cancer was rare. 2) These were divided into main groups according to the onset of intracranial signs, such as the frontal lobe symptoms and I-VII cranial nerve involvement. The first group showed the intracranial symptoms early, and the second group late. 3) The tumor invaded the cranial cavity along the perineural sheeth of each cranial nerve mainly. 4) It was very difficult to identify the paranasal sinus of origin after invading the cranial cavity. 5) The prognosis was extremely poor. All cases were died within one and half year.


5. DOCID:3814 SCORE: 0.00255900755883545
DOCNO: 406978
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: J D Cox JD
AUTHOR: T J Stoffel TJ
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: The significance of needle biopsy after irradiation for stage C adenocarcinoma of the prostate.
PUBDATE: 19770701
The presence of malignant cells in needle biopsy specimens following irradiation for adenocarcinoma of the prostate has been used to criticize or defend this treatment. At Walter Reed Medical Center, 38 consecutive patients with Stage Cadenocarcinoma underwent definitive irradiation between August 1970 and March 1973. The median dose to the pelvis was 7000 rads in 31 fractions in 43 days (2030 ret). Post treatment examination included palpation of the prostate and transperineal biopsy of the most suspicious areas. Gradual disappearance of the palpable tumor occurred in all patients. Two men have had clinical evidence of re-growth of prostatic cancer. Thirty-three patients have had up to seven biopsies each for a total of 139, an average of four biopsies per patient. There were 49 positive and 90 negative biopsies. Positive biopsy rate correlated only with the interval after irradiation--60% at six months, 37% at one year, 30% at 18 months, and approximately 19% after two and one-half years. There was no correlation of biopsy results with pre-irradiation estrogen or orchiectomy, with time-dose-fractionation relationships, or with prognosis. These biopsies provide interesting data about the regression rate of prostatic adenocarcinoma, but they have no significance for the individual patient. They have, therefore, been eliminated from follow-up studies.


6. DOCID:3301 SCORE: 0.00229333786942349
DOCNO: 911968
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Carcinogens
AUTHOR: K S Crump KS
AUTHOR: H A Guess HA
AUTHOR: K L Deal KL
PUBTYPE: Journal Article
JOURNALTITLE: Biometrics.
COUNTRY: UNITED STATES
TITLE: Confidence intervals and test of hypotheses concerning dose response relations inferred from animal carcinogenicity data.
PUBDATE: 19770901
Confidence intervals and hypothesis tests are developed for dose-response relations based on dichotomous data from animal carcinogenicity experiments. The functional form of the dose-response curve comes from the Armitage-Doll multistage carcinogenesis model and involves a polynomial in the dose-rate, with non-negative coefficients. Asymptotic distributions of the maximum likelihood estimators of these coefficients are used to construct confidence bounds on risk at a given dose and on the dose corresponding to a given risk. Likelihood ratio tests are developed for the presence of a positive dose-related effect and for the existence of a positive slope to the dose-response curve at zero dose. The latter test is of practical importance since a positive slope of the dose-response curve at zero dose rules out any "threshold-like" behavior and would often mean that any concentration low enough to insure a negligibly low cancer risk (e.g., 10(-6)) would be too low to be economically useful for applications such as food additives. Simulation experiments are performed to provide guidelines for applying the theory.


7. DOCID:2841 SCORE: 0.00229035976601653
DOCNO: 871143
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: analysis
QUALIFIER: immunology
AUTHOR: J R van Nagell JR
AUTHOR: E S Donaldson ES
AUTHOR: E G Wood EG
AUTHOR: R M Sharkey RM
AUTHOR: D M Goldenberg DM
PUBTYPE: Journal Article
JOURNALTITLE: American journal of obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: The prognostic significance of carcinoembryonic antigen in the plasma and tumors of patients with endometrial adenocarcinoma.
PUBDATE: 19770601
Carcinoembryonic antigen (CEA) levels in plasma and the immunocytochemical detection of tumor CEA were studied in patients with endometrial adenocarcinoma treated at the University of Kentucky Medical Center from 1973 to 1976. The incidence of CEA elevation in a group of 60 patients varied directly with uterine size, histologic differentiation, and stage of disease. Immunoperoxidase staining for CEA was performed on 42 specimens, and four were positive, indicating a tissue concentration of CEA of at least 5 microng per gram. Following operation, CEA levels returned to normal within eight weeks in all but two patients, both of whom were later shown to have persistent or recurrent cancer. These data suggest that serial plasma CEA determinations may be useful in predicting occult recurrence of endometrial cancer in patients in whom the plasma or tumor initially contains elevated concentrations of this antigen.


8. DOCID:10092 SCORE: 0.00215240201174284
DOCNO: 4016675
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: complications
AUTHOR: R Kuylenstierna R
AUTHOR: E Munck-Wikland E
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Esophagitis and cancer of the esophagus.
PUBDATE: 19850801
Early diagnosis is an important factor in the effort to increase the healing rates of esophageal cancer; another consideration is the establishment of a reliable method of identifying risk groups. Alcohol abuse is known to be associated with a higher risk of esophageal cancer. The current investigation, based on a retrospective study of the records of patients with esophageal cancer, reveals a strong connection between cancer development and chronic esophagitis due mainly to reflux in about 10% of the patients. In the literature this connection has been suspected but never so clearly shown. The clinical implication may be a more rigorous approach to long-standing esophagitis in elderly patients.


9. DOCID:10012 SCORE: 0.00207589131045359
DOCNO: 6876400
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: cytology
QUALIFIER: diagnosis
AUTHOR: S Yamada S
AUTHOR: T Takeda T
AUTHOR: K Takaso K
AUTHOR: H Shinzawa H
AUTHOR: T Matsuda T
AUTHOR: H Saito H
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Prognostic analysis of malignant peritoneal effusions from gastric cancer]
PUBDATE: 19830201
The prognosis of 135 cases with malignant peritoneal effusion from gastric cancer was analyzed clinically and cytologically. The histologic type of the primary gastric cancer or therapeutic differences had no significant influence on the prognosis. Previous gastrectomy or absence of distant metastases had no marked effect on survival. The formation of large clusters of cancer cells on smear preparations of peritoneal effusion was interpreted as a sign of good prognosis. The cancer cell number and the presence of lymphocytes on smear preparations bore no relationship to prognosis.


10. DOCID:3453 SCORE: 0.00195822213580858
DOCNO: 903992
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mining
QUALIFIER: adverse effects
QUALIFIER: etiology
QUALIFIER: etiology
AUTHOR: S Graham S
AUTHOR: M Blanchet M
AUTHOR: T Rohrer T
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Cancer in asbestos-mining and other areas of Quebec.
PUBDATE: 19771001
Employing incidence data from the Quebec Tumor Registry, we examined the relative risks of cancer of all sites for the years 1969-73 in the asbestos-mining, rural, and metropolitan counties of Quebec Province, Canada. Generally, rates for males exceeded those for females, and the relative risks in the asbestos-mining counties for 7-10 different sites of cancer, all of low incidence, were from 1.50 to 8.08 times those of other rural counties of the Province for both sexes. Metropolitan counties exhibited equally high risk for many of these sites. We discovered higher risks among males in asbestos-mining counties for cancer of the pleura, peritoneum, lip, tongue, salivary gland, mouth, and small intestine and higher risks among females for cancer of the pleura, lip, kidney, salivary gland, and for melanoma. Because of the likelihood of a long latent period for asbestos-related cancers, the risks we observed were possibly the product of since-altered occupational and environmental conditions existing 20-30 years ago in the asbestos-mining areas. The similarities in risks for most cancers in asbestos-mining and urban areas were noteworthy.


11. DOCID:11491 SCORE: 0.00179048834596845
DOCNO: 6292076
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cell Division
DESCRIPTOR: Interphase
QUALIFIER: cytology
AUTHOR: C Diatloff-Zito C
AUTHOR: A Macieira-Coelho A
PUBTYPE: Journal Article
JOURNALTITLE: In vitro.
COUNTRY: UNITED STATES
TITLE: Effect of growth arrest on the doubling potential of human fibroblasts in vitro: a possible influence of the donor.
PUBDATE: 19820701
Population doublings versus time in culture were compared in human postnatal skin fibroblasts from normal donors, a cancer patient, and from donors suffering from Cockayne syndrome, Ataxia telangiectasia, and Fanconi's anemia (FA). Confluent cultures were maintained in a nonproliferating state for 14 to 27 d in 0.5% serum medium. The results show that the ability of cells to resume division after a resting stage can be influenced by pathologic conditions. In arrested FA cell populations an increase of the population doublings and of the calendar time were observed. It is possible that in some cell populations the resting stage favors the expression of growth potentialities related to instability of the cells.


12. DOCID:7451 SCORE: 0.00178281072684107
DOCNO: 6970730
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: drug therapy
AUTHOR: E Wold E
AUTHOR: O Kaalhus O
AUTHOR: E S Johansen ES
AUTHOR: A T Ekse AT
PUBTYPE: Journal Article
JOURNALTITLE: International journal of radiation biology and related studies in physics, chemistry, and medicine.
COUNTRY: ENGLAND
TITLE: The electron affinity of some radiotherapeutic agents used in cancer therapy.
PUBDATE: 19801201
In order to evaluate whether chemotherapeutic compounds applied in cancer treatment might interact with radiation as anoxic cell sensitizers, the electron-affinic properties of DTIC, AIC, hydroxyurea, busulfan and cyclophosphamide were studied by pulse radiolysis. Reaction rates with hydrated electrons were determined for all these compounds. With the exception of DTIC, they all reacted much more slowly with electrons than do most electron-affinic sensitizers. One-electron reduction potentials were determined for DTIC, AIC and hydroxyurea. The values were all in the region for the onset of sensitization, with hydroxyurea as the most promising (E71 =- 0.0552V). For busulfan and cyclophosphamide no value could be determined, but these compounds are probably less electron-affinic than hydroxyurea. A possible application of chemotherapeutic agents as radiosensitizers is discussed.


13. DOCID:1289 SCORE: 0.00170527989083332
DOCNO: 1275150
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Emergency Medical Services
DESCRIPTOR: Triage
QUALIFIER: methods
QUALIFIER: pathology
AUTHOR: R W Knapp RW
AUTHOR: J T Mullen JT
PUBTYPE: Journal Article
JOURNALTITLE: American journal of surgery.
COUNTRY: UNITED STATES
TITLE: Triage for the breast biopsy.
PUBDATE: 19760501
A plan is advocated for the management of the dominant breast mass with use of local anesthesia in the outpatient setting as the primary diagnostic tool, but with selection of certain patients for immediate general anesthesia biopsy in the "conventional" manner. Experience with this plan in 2,492 patients during a period of 114 months shows local anesthesia biopsy to be efficient and accurate. Five year survival for all mastectomy-treated patients whose cancers were diagnosed under local anesthesia is 72 per cent. Use of a triage method for selecting biopsy procedures has resulted in a thirteen-fold decrease in the number of patients subjected to general anesthesia.


14. DOCID:6277 SCORE: 0.00160220770969651
DOCNO: 7239711
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: chemically induced
QUALIFIER: administration & dosage
AUTHOR: M Habs M
AUTHOR: H Habs H
AUTHOR: D Schmähi D
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: Effect of the intermittent administration of N-nitrosopyrrolidine (NPYR) on the tumor incidence in Sprague-Dawley rats.
PUBDATE: 19800701
N-Nitrosopyrrolidine (NPYR) was administered orally to 320 Sprague-Dawley rats. An additional group of 80 rats served as an untreated control. There were four experimental groups in which the effects of different periods of dosing and varied intervals without treatment were compared. The total dose for all the groups was constant and was 792 mg/kg body weight. The schedules of carcinogen application had a significant effect on the observed cancer risk. The different tumor indicences in the individual groups could not be attributed to differences in the survival pattern, but were related to the changes in the different treatment schedules.