0. DOCID:22865 SCORE: 0.00306088908170675
DOCNO: 9365848
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: diagnosis
QUALIFIER: blood
QUALIFIER: diagnosis
AUTHOR: N Segawa N
AUTHOR: K Yamamoto K
AUTHOR: T Watsuji T
AUTHOR: T Suzuki T
AUTHOR: H Ueda H
AUTHOR: Y Katsuoka Y
AFFILIATION: Department of the Urology, Osaka Medical College.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Hinyokika kiyo. Acta urologica Japonica.
COUNTRY: JAPAN
TITLE: [Ureteral cancer producing carbohydrate antigen 19-9: report of a case]
PUBDATE: 19970901
A case of a CA19-9-producing ureteral cancer is reported. A 58-year-old man presented with gross hematuria. Retrograde pyelography showed an irregular filling defect in the right ureter. The serum CA19-9 level was 932 U/ml (normal < 37). Right total nephroureterectomy was performed. The histological diagnosis was grade 3 transitional cell carcinoma. Immunohistochemical analysis showed CA19-9 to be expressed not only in the cancer cells but also in the normal transitional cell epithelium of the renal pelvis.


1. DOCID:22120 SCORE: 0.00272615671759745
DOCNO: 8838100
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosomes, Human, Pair 3
DESCRIPTOR: Genes, Tumor Suppressor
QUALIFIER: genetics
AUTHOR: K Hibi K
AUTHOR: T Takahashi T
AFFILIATION: Laboratory of Ultrastructure Research, Nagoya University School of Medicine.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine.
COUNTRY: JAPAN
TITLE: [Positional-cloning efforts to identify the tumor suppressor gene at 3p]
PUBDATE: 19960201
Lung cancer is known to carry multiple cytogenetic alterations. Among such chromosomal abnormalities, deletions at the short arm of chromosome 3 has been shown to be the most frequent and can be detected even in hyperplasia of the bronchial epithelium, suggesting its important roles in the pathogenesis of lung cancer. In this chapter, we describe current status of the positional-cloning attempts to identify the target tumor suppressor gene at 3p in our laboratories as well as in other laboratories.


2. DOCID:22172 SCORE: 0.00272615422119305
DOCNO: 7849530
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Brain
DESCRIPTOR: Gene Transfer Techniques
AUTHOR: L J Fisher LJ
AUTHOR: J Ray J
AFFILIATION: Department of Neurosciences, University of California San Diego, La Jolla 92093-0627.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in neurobiology.
COUNTRY: ENGLAND
TITLE: In vivo and ex vivo gene transfer to the brain.
PUBDATE: 19941001
The use of gene transfer techniques to express novel proteins within different cellular populations has provided insights into the function and plasticity of the brain. Recently, this technique has been successfully used to explore physiological processes within the CNS and to intervene in neurodegenerative disease and cancer. Progress in manipulating transgene products in vivo and in achieving cell-specific targeting of genetic material offers promise for enhancing the usefulness of this technique and its therapeutic potential for treating human disorders of the CNS.


3. DOCID:23719 SCORE: 0.00254247163310041
DOCNO: 9317183
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Pharmacokinetics
DESCRIPTOR: Pharmacology, Clinical
QUALIFIER: metabolism
AUTHOR: R E Vestal RE
AFFILIATION: Department of Veterans Affairs Medical Center, and Mountain States Medical Research Institute, Boise, Idaho 83702, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Aging and pharmacology.
PUBDATE: 19971001
Research on aging and pharmacology in humans has been termed geriatric clinical pharmacology, which is an established subdiscipline within the broad field of clinical pharmacology. This article reviews information relevant to clinical cancer research and the care of older patients with cancer. Accordingly, the current state of knowledge on drug utilization, pharmacokinetics, pharmacodynamics, adverse drug events, drug interactions, polypharmacy, adherence to treatment, and clinical research considerations are reviewed. Although a review of the literature on aging and cancer chemotherapy is not included in this particular presentation, information is very sparse. Thus, there is significant potential for valuable contributions from clinical research through partnerships between geriatric clinical pharmacologists and medical oncologists.


4. DOCID:23474 SCORE: 0.0023222548663001
DOCNO: 8015827
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunosuppression
QUALIFIER: etiology
QUALIFIER: adverse effects
QUALIFIER: etiology
QUALIFIER: etiology
AUTHOR: B Nemes B
AUTHOR: N Lázár N
AUTHOR: J Járay J
AFFILIATION: Semmelweis OTE II, Pathologiai Intézet.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Orvosi hetilap.
COUNTRY: HUNGARY
TITLE: [Simultaneous occurrence of transplantation glomerulopathy, malignant Hodgkin lymphoma and lip cancer in a patient under immunosuppressive treatment]
PUBDATE: 19940601
Authors reported on transplantation glomerulopathy (TGP), occurred in a patient's cadaver kidney allograft, as well as on orchitis, lymphogranulomatosis (Hodgkin's lymphoma) and lip cancer detected thereafter in the same patient. While TGP was definitely be verified morphologically, all other observed diseases are commonly and typically met with membranous glomerulopathy (MGP), which is a separate entity. Similar case has not yet been reported in the literature. Since in majority of the cases the MGP is a paraneoplastic phenomenon, and the TGP is a part of chronic rejection in kidney allografts the differential diagnosis may have therapeutic consequences.


5. DOCID:23693 SCORE: 0.00187625165383451
DOCNO: 8127323
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: statistics & numerical data
QUALIFIER: prevention & control
PUBTYPE: Journal Article
JOURNALTITLE: MMWR. Morbidity and mortality weekly report.
COUNTRY: UNITED STATES
TITLE: Examinations for oral cancer--United States, 1992.
PUBDATE: 19940301
During 1992, oral cancer (i.e., cancers of the oral cavity and pharynx) was diagnosed in approximately 30,000 persons in the United States and caused nearly 8000 deaths (1); approximately 70% of deaths from oral cancer are associated with smoking (2) and other forms of tobacco use (3). Although the 5-year survival rate (53%) for persons with oral cancer remains low, survival varies by stage at diagnosis (4). Detection of oral cancers by oral examination can reduce morbidity and death associated with this problem (5). To characterize examinations for oral cancer among U.S. adults, CDC analyzed data from the 1992 National Health Interview Survey-Cancer Control (NHIS-CC) supplement. This report summarizes findings from that analysis.


6. DOCID:22944 SCORE: 0.00187155583974414
DOCNO: 7513895
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: ultrasonography
AUTHOR: P G Hammerer PG
AFFILIATION: Abteilung für Urologie, Stanford Universität.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Der Radiologe.
COUNTRY: GERMANY
TITLE: [Sonographic diagnosis of prostatic cancer]
PUBDATE: 19940301
In 75-80% of all clinically significant prostate cancer, the peripheral zone appears to be hypoechoic on transrectal ultrasound (TRUS). However, examination by TRUS alone in a screening program is not recommended due to its low sensitivity. The combination of prostate-specific antigen, digital rectal examination, and TRUS increases the detection rate of prostate cancer. In prostate cancer arising from the transition zone, TRUS findings are often nonspecific. Even prostate biopsies might be negative due to the location of this tumor. Anterior biopsies of the transition zone will identify these prostate cancers. Color Doppler ultrasound of the prostate has little additional value over TRUS alone in the diagnosis of prostate cancer.


7. DOCID:23292 SCORE: 0.00183632731585083
DOCNO: 8014193
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Expression Regulation, Neoplastic
QUALIFIER: genetics
QUALIFIER: drug therapy
AUTHOR: K W Kohn KW
AUTHOR: J Jackman J
AUTHOR: P M O'Connor PM
AFFILIATION: Laboratory of Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of cellular biochemistry.
COUNTRY: UNITED STATES
TITLE: Cell cycle control and cancer chemotherapy.
PUBDATE: 19940401
As detailed information accumulates about how cell cycle events are regulated, we can expect new opportunities for application to cancer therapy. The altered expression of oncogenes and tumor suppressor genes that commonly occurs in human cancers may impair the ability of the cells to respond to metabolic perturbations of stress. Impaired cell cycle regulation would make cells vulnerable to pharmacologic intervention by drug regimens tailored to the defects existing in particular tumors. Recent findings that may become applicable to therapy are reviewed, and the possible form of new therapeutic stratagems is considered.


8. DOCID:22186 SCORE: 0.00182235514523426
DOCNO: 9201199
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Taxoids
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: secondary
QUALIFIER: pathology
AUTHOR: S J Clarke SJ
AUTHOR: M J Boyer MJ
AFFILIATION: Department of Medical Oncology, Sydney Cancer Centre, Sydney, NSW.
PUBTYPE: Journal Article
JOURNALTITLE: The Medical journal of Australia.
COUNTRY: AUSTRALIA
TITLE: Recent advances in managing non-small-cell lung cancer: 4. Chemotherapy of metastatic cancer.
PUBDATE: 19970601
Chemotherapy has been shown to prolong survival and to be cost effective in the palliative treatment of non-small-cell lung cancer. A meta-analysis of 11 randomised trials has found a small benefit from combination chemotherapy in advanced NSCLC, increasing one-year survival rates from 5% to 15%. New combination regimens, especially carboplatin-paclitaxel, show higher response rates in selected patients, and promise improved survival rates, but this has yet to be confirmed in randomised trials.


9. DOCID:21967 SCORE: 0.00176493771389262
DOCNO: 8066932
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Esophagus
DESCRIPTOR: Foreign Bodies
AUTHOR: L T Hansen LT
AUTHOR: A Grøntved A
AFFILIATION: Odense Universitetshospital, øre-, naese- og halsafdeling F.
PUBTYPE: Journal Article
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: DENMARK
TITLE: [Foreign body in the esophagus]
PUBDATE: 19940701
A ten year retrospective survey of 346 cases of oesophageal foreign bodies is reported. Although coins were the most frequent foreign bodies in the pediatry group, meat was the most common offender in the material taken as a whole. Rigid oesophagoscopy in general anaesthesia was performed on 312 patients. A foreign body was removed in 281 cases (90%). Only one case of oesophageal cancer was discovered. The risk of iatrogenic perforation of the oesophagus was greatest in old patients who had a lump of meat stuck in the distal third of the oesophagus.


10. DOCID:22062 SCORE: 0.00175927246104446
DOCNO: 8800284
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
AUTHOR: K Nakachi K
AUTHOR: K Imai K
AUTHOR: K Suga K
AFFILIATION: Department for Epidemiology, Saitama Cancer Center Research Institute, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of epidemiology / Japan Epidemiological Association.
COUNTRY: JAPAN
TITLE: Some evidences of molecular epidemiology in cancer research.
PUBDATE: 19960801
Molecular epidemiology of cancer has been developed along with rapid advances in molecular carcinogenesis, introducing new approaches to etiology and prevention of cancer. First, research activities in Japan are briefly reviewed in this issue focusing on studies of genetic susceptibility, DNA damages, and immunological defense. Then we make an estimation of age periods of initiation for several cancer on the basis of multistaged carcinogenesis. The results are discussed in relation to strategies of cancer prevention in molecular epidemiology, introducing our trials previous and on-going as examples.


11. DOCID:20893 SCORE: 0.00167199716629059
DOCNO: 9108839
AUTHOR: C J Cold CJ
AUTHOR: M R Storms MR
AUTHOR: R S Van Howe RS
AFFILIATION: Department of Pathology, Marshfield Clinic Lakeland Center, Minocqua, Wisconsin, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Journal of family practice.
COUNTRY: UNITED STATES
TITLE: Carcinoma in situ of the penis in a 76-year-old circumcised man.
PUBDATE: 19970401
The commonly believed notion that circumcised men cannot develop penile cancer can result in delays in diagnosis. Recent medical literature has failed to confirm the protective effect of circumcision on penile neoplasms. Physicians need to be aware that men circumcised after 1 month of age may be at higher risk for penile cancer than those never circumcised.


12. DOCID:21160 SCORE: 0.00166931734140843
DOCNO: 9317186
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Physician-Patient Relations
DESCRIPTOR: Quality of Life
QUALIFIER: psychology
QUALIFIER: therapy
AUTHOR: P A Ganz PA
AFFILIATION: Jonsson Comprehensive Cancer Center, School of Medicine, University of California-Los Angeles, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Interaction between the physician and the older patient: the oncologist's perspective.
PUBDATE: 19971001
This article discusses the oncologist's perspective regarding communication with older cancer patients. Decision-making about the treatment of these patients should be influenced by physiologic and not chronologic age. Patient preferences are very important, and it is critical to consider quality rather than quantity of life. The oncologist should strive to understand the patient's preferences and ensure that they are addressed and reassessed throughout the course of treatment.


13. DOCID:20841 SCORE: 0.00161069812816763
DOCNO: 9017588
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Carcinoma, Small Cell
DESCRIPTOR: Pleural Neoplasms
AUTHOR: P Schinkewitch P
AUTHOR: B Gasser B
AUTHOR: J M Wihlm JM
AUTHOR: G Pauli G
AUTHOR: E Quoix E
AFFILIATION: Service de Pneumologie, Pavillon Laennec, Hôpitaux Universitaires de Strasbourg, France.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Lung cancer (Amsterdam, Netherlands)
COUNTRY: IRELAND
TITLE: Small cell carcinoma of the pleura. A case report.
PUBDATE: 19961201
Small cell carcinoma of the lung (SCLC) represents about 25% of all lung cancers. Extrapulmonary small cell carcinoma is a very uncommon feature, mostly described in the oesophagus. We report here a case of small cell carcinoma of the pleura with histopathological findings, clinical course and response to therapy typical of SCLC.


14. DOCID:20844 SCORE: 0.0016106967341091
DOCNO: 9388516
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: radiotherapy
AUTHOR: Y Koyanagi Y
AUTHOR: K Katoh K
AUTHOR: S Satoh S
AFFILIATION: Department of Surgery, Tokyo Medical College, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Chemoradiation for rectal cancer]
PUBDATE: 19971101
Based on the results of the Study Group for Surgical Adjuvant Radiochemotherapy for Rectal Cancer and the Study Group for Surgical Therapy and Combined Irradiation in Rectal Cancer, we examined the clinical aspects of the relatively new field of chemoradiation for rectal cancer and examined improvements in the therapeutic results. Furthermore, we examined the future outlook with particular regard to selection of therapeutic drugs and autonomic nerve preserving operation.