0. DOCID:7189 SCORE: 0.00250216136758522
DOCNO: 721322
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: C Marigo C
AUTHOR: P Correa P
AUTHOR: W Haenszel W
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: Cancer and "cancer related" colorectal lesions in São Paulo, Brazil.
PUBDATE: 19781201
A series of 832 necropsy specimens were studied grossly with a magnifying lens and all lesions identified were studied microscopically. The age and sex-specific prevalence of adenomatous and hyperplastic polyps is reported and results are compared with those of other populations. A correlation was made between polyps and cancer of the colon and rectum (407 cases). The data suggest that São Paulo is a community in a transitional stage between intermediate and high risk of cancer of the colon. The epidemiologic characteristics of lower rectum cancer are peculiar to some populations and appear unrelated to colon cancer. The black population of São Paulo has a higher prevalence than that reported for African negroes. The data also implicate adenomatous polyps, diverticulosis and hemorrhoids as being probably related diseases.


1. DOCID:7663 SCORE: 0.00238064798500903
DOCNO: 6256057
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: J L Wittliff JL
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Steroid receptor interactions in human breast carcinoma.
PUBDATE: 19801201
Sucrose gradient centrifugation of estrogen and progestin receptors in cytosol preparations revealed that the majority of human breast tumors contained two molecular forms sedimenting at either 8S or 4S. Few tumors exhibited profiles containing predominately the 8S form or the 4S form alone. Molecular heterogeneity of the estrogen receptors in cytosol was demonstrated with regard to surface charge using ion-exchange chromatography and isoelectric focusing. The molecular properties of estrogen receptors in breast tumor biopsy specimens appear to be related to clinical responsiveness of patients given hormonal manipulations. These data and other findings related to the clinical utility of steroid receptor quantification impose a requirement for rigid quality control of analyses by the laboratory. The composition, evaluation, and distribution of tissue reference powders for establishing uniformity and quality control of steroid receptor analyses used in cooperative clinical trials of breast cancer treatment are described. This approach ensures meaningful correlations between laboratory results and clinical response.


2. DOCID:6267 SCORE: 0.00219567686668009
DOCNO: 7333704
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: etiology
AUTHOR: D Trichopoulos D
AUTHOR: M Papapostolou M
AUTHOR: A Polychronopoulou A
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: Coffee and ovarian cancer.
PUBDATE: 19811201
Ninety-two women with common epithelial tumors of the ovary and 105 comparison women admitted for various orthopedic conditions were interviewed regarding demographic, socio-economic and biomedical characteristics, including their use of coffee and tobacco. There was no association between tobacco smoking and ovarian cancer. However a statistically significant trend association was noted between coffee drinking and ovarian cancer (p approximately 0.03). The association could not be explained in terms of any other variable included in the present study. The relative risk for women drinking two or more cups of coffee per day was 2.2 with 95% confidence limits 1.0-4.8. Several descriptive epidemiologic data are compatible with a causal association between coffee and ovarian cancer.


3. DOCID:5812 SCORE: 0.00218158092758226
DOCNO: 376107
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Postoperative Complications
QUALIFIER: metabolism
QUALIFIER: etiology
AUTHOR: M F Brennan MF
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Metabolic response to surgery in the cancer patient: consequences of aggressive multimodality therapy.
PUBDATE: 19790501
The metabolic response to uncomplicated surgery in the patient undergoing primary therapy for malignancy is no different than the response to surgery of similar magnitude for benign disease. Hemodynamic, nutritional-endocrine, and convalescent changes are similar. However, with current aggressive approaches to the management of cancer, the patient often comes to surgery with evidence of major debilitating side effects from his progressive malignancy or from aggressive multimodality therapy. The surgeon must be aware of the consequences of the use of combination therapies on the expected metabolic response to surgery. Awareness of such problems such as the nutritional deficit will allow preventive methods to supercede metabolic salvage procedures.


4. DOCID:6503 SCORE: 0.00217066619127923
DOCNO: 6244077
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antigens, Viral
DESCRIPTOR: Cell Transformation, Neoplastic
DESCRIPTOR: Cell Transformation, Viral
QUALIFIER: genetics
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: L Kopelovich L
AUTHOR: S Sirlin S
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Human skin fibroblasts from individuals genetically predisposed to cancer are sensitive to an SV40-induced T antigen display and transformation.
PUBDATE: 19800301
In the present study we have used a viral probe to determine the genetic susceptibility of fibroblastic cell strains derived from individuals with hereditary adenomatosis of the colon and rectum (ACR), an autosomal dominant trait. This report shows an increased sensitivity of apparently karyologically-normal diploid skin fibroblasts from ACR individuals to an SV40-induced T antigen display and transformation. None of the SV40-transformed cells grew as tumors in athymic mice and they all appeared to have a finite life span. The results suggest that the induction of T antigen positive cells by SV40 may be used as a marker of cancer risk in this cell system.


5. DOCID:7102 SCORE: 0.00211901757080376
DOCNO: 6154429
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: L L Gunderson LL
AUTHOR: A M Cohen AM
AUTHOR: C E Welch CE
PUBTYPE: Journal Article
JOURNALTITLE: American journal of surgery.
COUNTRY: UNITED STATES
TITLE: Residual, inoperable or recurrent colorectal cancer. Interaction of surgery and radiotherapy.
PUBDATE: 19800401
For irradiation of inoperable, residual or recurrent colorectal cancers, doses of 4,500 to 5,000 rads can achieve short-term palliation; doses must be increased to 6,000 to 7,000 rads or more, however, if long-term control of disease or possible cure is desired. The ability to achieve those dose levels safely depends on close interaction between the surgeon, the radiation oncologist and the diagnostic radiologist in defining and displacing normal and tumor tissues. Methods used at Massachusetts General Hospital from March 1976 to August 1979 are defined. They include the use of operative clips and pelvic reconstruction, diagnostic computed tomography and ultrasound, radiotherapy optimization including shrinking field techniques, radiation with bladder distention and single intraoperative boost doses given in combination with external beam.


6. DOCID:7292 SCORE: 0.00206705643110889
DOCNO: 7333239
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Vinyl Compounds
QUALIFIER: chemically induced
QUALIFIER: chemically induced
QUALIFIER: adverse effects
QUALIFIER: analogs & derivatives
QUALIFIER: adverse effects
AUTHOR: R Apfeldorf R
AUTHOR: P F Infante PF
PUBTYPE: Journal Article
JOURNALTITLE: Environmental health perspectives.
COUNTRY: UNITED STATES
TITLE: Review of epidemiologic study results of vinyl chloride-related compounds.
PUBDATE: 19811001
Epidemiologic study results addressing the carcinogenicity of six compounds related to vinyl chloride (vinylidene chloride, trichloroethylene, perchloroethylene, carbon tetrachloride, ethylene dibromide and epichlorohydrin) are reviewed. The study results suggest an increased carcinogenic risk among workers exposed to epichlorohydrin and to dry cleaning and degreasing solvents. Although several studies report no significant excess of cancer mortality, an evaluation of the design of these investigations demonstrates that these negative cohort studies consisted of populations of insufficient sample size and latency to permit any meaningful conclusions regarding carcinogenic risk. Therefore, experimental studies must be relied upon to determine whether several of these substances pose a potential carcinogenic risk to humans. Available evidence indicates that all of these substances have demonstrated a carcinogenic response in experimental animals and most are mutagenic in experimental test systems.


7. DOCID:5623 SCORE: 0.00204359536794401
DOCNO: 7417951
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasm Regression, Spontaneous
QUALIFIER: secondary
QUALIFIER: secondary
AUTHOR: J A Smith JA
AUTHOR: H W Herr HW
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Spontaneous regression of pulmonary metastases from transitional cell carcinoma.
PUBDATE: 19800901
Spontaneous regression of metastatic cancers occurs rarely and has been reported only once for pulmonary metastases from transitional cell carcinoma. Two cases of spontaneous complete regression of lung metastases from transitional cell carcinoma are presented. In one case, regression occurred after a course of radiation to the primary bladder cancer, but in the other patient, lung lesions disappeared without treatment to the primary or metastatic cancers. The factors that alter the tumor-host relationship to allow spontaneous regression of cancers are unknown, but observation of these phenomena may help reveal parameters that influence tumor progression in the majority of cancer patients.


8. DOCID:6717 SCORE: 0.00200292060078734
DOCNO: 6247990
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: J A Wijnen JA
AUTHOR: N B Rosenshein NB
PUBTYPE: Journal Article
JOURNALTITLE: Archives of surgery (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Surgery in ovarian cancer.
PUBDATE: 19800701
Ovarian cancer has the highest mortality of the cancers of the female genital tract. The signs and symptoms of ovarian cancer are either nonexistent or nonspecific. Women who are to undergo exploratory laparotomy without a definite diagnosis should have ovarian cancer considered as part of the differential diagnosis. Therefore, it is important that each surgeon know the current concepts of surgery for ovarian cancer. Documenting true extent of disease in those cases with limited ovarian cancer prevents the need for reexploration before adjuvant therapy. In those cases of disseminated disease, an attempt at tumor reduction should be undertaken, as reduction of tumor aggregates to less than 1.6 cm in greatest diameter improves prognosis. Surgery is the mainstay of therapy for ovarian cancer. Optimal initial surgery prevents the need for reexploration.


9. DOCID:6870 SCORE: 0.0018909874791052
DOCNO: 7256542
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemically induced
QUALIFIER: chemically induced
QUALIFIER: adverse effects
AUTHOR: J P Minton JP
AUTHOR: H Abou-Issa H
AUTHOR: N Reiches N
AUTHOR: J M Roseman JM
PUBTYPE: Journal Article
JOURNALTITLE: Surgery.
COUNTRY: UNITED STATES
TITLE: Clinical and biochemical studies on methylxanthine-related fibrocystic breast disease.
PUBDATE: 19810801
The results of this study show that the consumption of methylxanthines through dietary sources appears to be associated with the etiologic development of benign fibrocystic disease in the American woman. Complete abstention from methylxanthine consumption resulted in complete resolution of the disease in 82.5% and significant improvement in 15% of those studied. Thus 97.5% showed clinical benefit from total methylxanthine abstention. The results of a clinical questionnaire answered by 500 women consuming methylxanthines, one half of whom had fibrocystic breast disease, suggest that women with fibrocystic disease may have a genetic predisposition for both benign breast disease and cancer. Biochemical studies implicate increased sensitivity of the adenylate cyclase system to catecholamines in patients with fibrocystic disease. Methylxanthines are known to increase circulating catecholamines.


10. DOCID:6916 SCORE: 0.00189097946887604
DOCNO: 203726
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: toxicity
QUALIFIER: chemically induced
QUALIFIER: poisoning
QUALIFIER: toxicity
AUTHOR: E S Schmidt ES
AUTHOR: G W Newton GW
AUTHOR: S M Sanders SM
AUTHOR: J P Lewis JP
AUTHOR: E E Conn EE
PUBTYPE: Journal Article
JOURNALTITLE: JAMA : the journal of the American Medical Association.
COUNTRY: UNITED STATES
TITLE: Laetrile toxicity studies in dogs.
PUBDATE: 19780301
Dogs were fed laetrile and fresh, sweet almonds under various conditions. The doses of laetrile were similar to those prescribed for patients with cancer and ranged on a basis of gram to square meter from an equivalent of the oral dose for man to five times this dose. Six of the ten dogs died of cyanide poisoning. One dog recovered, and three dogs, at the time of sacrifice, demonstrated various levels of neurologic impairment, ranging from difficulty in walking to coma. These studies demonstrate that oral laetrile is highly toxic when taken with some common table foods. We predict that there will be an increased incidence of cyanide poisoning in man as laetrile becomes more readily available.


11. DOCID:7371 SCORE: 0.00188679708320156
DOCNO: 88732
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
AUTHOR: V Schulz V
AUTHOR: S Busch S
AUTHOR: P Endres P
AUTHOR: R Rubin R
AUTHOR: M Schönen M
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Praxis und Klinik der Pneumologie.
COUNTRY: GERMANY, WEST
TITLE: [Polychemotherapy of inoperable bronchogenic carcinoma: preliminary results (author's transl)]
PUBDATE: 19790401
Preliminary results indicate that BACO and SAKK are capable of inducing remission in 80-90% of cases of small-cell bronchogenic carcinoma; these remissions last for about 6 months and not only prolong, but improve the quality of, life. In view of the small number of cases so far observed no assessment can as yet be made of the superiority of one or the other method concerning the incidence and duration of remissions and survival time. In cases of squamous cell cancer the two therapeutic methods succeeded in only 30-40% of the patients in inducing partical remissions and they did not appear to improve the quality of life. The question whether the treatment actually prolongs life as compared with the natural course of the disease remains open.


12. DOCID:6483 SCORE: 0.0018526553971775
DOCNO: 6790651
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Medical Record Linkage
DESCRIPTOR: Medical Records
QUALIFIER: adverse effects
AUTHOR: D C Skegg DC
AUTHOR: S M Richards SM
AUTHOR: R Doll R
PUBTYPE: Journal Article
JOURNALTITLE: Journal of epidemiology and community health.
COUNTRY: ENGLAND
TITLE: Assessment of the "E' book as a tool for drug monitoring.
PUBDATE: 19810301
For two years, the following records were linked for 10 453 people: (1) basic attributes; (2) details of prescriptions; and (3) information about illnesses recorded by general practitioners (GPs) in an "E' book. Analyses were performed to reveal association between drugs and diagnoses. Although the "E' book has certain disadvantages for drug monitoring, the methods proved to be capable of detecting adverse effects of drugs. Unfortunately the number of practitioners using "E' books would be too small for detection of most serious hazards such as the induction of cancer. Hence it is concluded that the first priority should be to establish a record linkage scheme covering hospital admissions, obstetric deliveries, and deaths.


13. DOCID:7728 SCORE: 0.00175147461927028
DOCNO: 453110
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: cytology
AUTHOR: B Frist B
AUTHOR: A V Kahan AV
AUTHOR: L G Koss LG
PUBTYPE: Journal Article
JOURNALTITLE: American journal of clinical pathology.
COUNTRY: UNITED STATES
TITLE: Comparison of the diagnostic values of biopsies of the pleura and cytologic evaluation of pleural fluids.
PUBDATE: 19790701
Results of a comparison of the diagnostic efficacy of percutaneous needle biopsy of the parietal pleura with that of cytologic examination of pleural fluid sediment obtained concurrently from 166 patients with benign or cancerous pleural disorders are reported. Of 44 patients with confirmatory evidence of cancer involving the pleural surfaces, 43 had positive cytologic findings, whereas pleural biopsies were diagnostic in only 16 cases. Of a total of 122 patients with benign pleural diseases, cytology provided the diagnosis in two cases of eosinophilic pleurisy, and pleural biopsy contributed the diagnosis in four of ten cases of tuberculosis. The data indicate that percutaneous needle biopsy of the parietal pleura is less efficacious in the diagnosis of malignant pleural disease than is cytologic evaluation of the fluid sediment, whereas in the diagnosis of tuberculous pleurisy, pleural biopsy proved superior.


14. DOCID:6109 SCORE: 0.00173343917931292
DOCNO: 748773
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: diagnosis
AUTHOR: P D Guinan PD
AUTHOR: C McKiel C
AUTHOR: B Sundar B
AUTHOR: R Veith R
AUTHOR: A Dubin A
AUTHOR: R J Ablin RJ
PUBTYPE: Journal Article
JOURNALTITLE: National Cancer Institute monograph.
COUNTRY: UNITED STATES
TITLE: The carcinoembryonic antigen test in urologic cancer.
PUBDATE: 19781201
The diagnostic value of the CEA test was evaluated in 2,029 blood and urine samples from 308 patients with urologic cancer, 13 with nonurologic cancer, 20 urologic patients with nonmalignant disease, and in 30 controls. The blood CEA test was positive in 50% of the patients with active urologic cancer and in 35% of those with inactive cancer. The urine CEA test was elevated only in patients with active bladder cancer, but most of these had concurrently infected urines. At the present time, the CEA test does not reflect the accuracy necessary for an acceptable diagnostic test for the detection of urologic cancer.