0. DOCID:11585 SCORE: 0.00367389807142081
DOCNO: 4079142
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: surgery
QUALIFIER: etiology
AUTHOR: H Tomoda H
AUTHOR: M Furusawa M
PUBTYPE: Journal Article
JOURNALTITLE: The Japanese journal of surgery.
COUNTRY: JAPAN
TITLE: Sexual and urinary dysfunction following surgery for sigmoid colon cancer.
PUBDATE: 19850901
We investigated sexual and urinary dysfunction following surgery for sigmoid colon cancer. Thirteen (46.4 per cent) of the 28 male patients with a normal sexual life prior to surgery could no longer ejaculate, but all could maintain erection. With the extension of lymph node dissection, the incidence of a disappearance of ejaculation tended to increase. In particular, in patients undergoing an extended lymph node dissection, the incidence was 53.8 per cent. Urinary dysfunction occurred in 7 (10.3 per cent) of the 68 patients (37 men and 31 women), but was slight to mild. There were no significant differences between the extent of lymph node dissection and urinary dysfunction. In surgery for sigmoid colon cancer, care should be taken to preserve the hypogastric nerves.


1. DOCID:22865 SCORE: 0.00306088908170675
DOCNO: 9365848
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: diagnosis
QUALIFIER: blood
QUALIFIER: diagnosis
AUTHOR: N Segawa N
AUTHOR: K Yamamoto K
AUTHOR: T Watsuji T
AUTHOR: T Suzuki T
AUTHOR: H Ueda H
AUTHOR: Y Katsuoka Y
AFFILIATION: Department of the Urology, Osaka Medical College.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Hinyokika kiyo. Acta urologica Japonica.
COUNTRY: JAPAN
TITLE: [Ureteral cancer producing carbohydrate antigen 19-9: report of a case]
PUBDATE: 19970901
A case of a CA19-9-producing ureteral cancer is reported. A 58-year-old man presented with gross hematuria. Retrograde pyelography showed an irregular filling defect in the right ureter. The serum CA19-9 level was 932 U/ml (normal < 37). Right total nephroureterectomy was performed. The histological diagnosis was grade 3 transitional cell carcinoma. Immunohistochemical analysis showed CA19-9 to be expressed not only in the cancer cells but also in the normal transitional cell epithelium of the renal pelvis.


2. DOCID:27008 SCORE: 0.00298578458015471
DOCNO: 11778749
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: V Nwakakwa V
AUTHOR: D Fleischer D
AFFILIATION: Division of Gastroenterology, Georgetown University Medical Center, Washington, DC 20007, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gastrointestinal endoscopy clinics of North America.
COUNTRY: United States
TITLE: Endoscopic mucosal resection of the esophagus: band ligation technique.
PUBDATE: 20010701
Endoscopic mucosal resection (EMR) is a minimally invasive endoscopic technique used in treating superficial cancers of premalignant lesions in the gastrointestinal tract. An attraction of this technique is that it can be curative with low morbidity, often providing the entire lesion for pathologic evaluation. The band ligation technique of EMR uses the existing technology of variceal band ligation to endoscopically place a band on flat mucosal lesions of the gastrointestinal tract to create a "pseudopolyp" before resection with an electrocautery snare. The band ligating technique and two variant band ligating devices are described.


3. DOCID:22120 SCORE: 0.00272615671759745
DOCNO: 8838100
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosomes, Human, Pair 3
DESCRIPTOR: Genes, Tumor Suppressor
QUALIFIER: genetics
AUTHOR: K Hibi K
AUTHOR: T Takahashi T
AFFILIATION: Laboratory of Ultrastructure Research, Nagoya University School of Medicine.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nippon rinsho. Japanese journal of clinical medicine.
COUNTRY: JAPAN
TITLE: [Positional-cloning efforts to identify the tumor suppressor gene at 3p]
PUBDATE: 19960201
Lung cancer is known to carry multiple cytogenetic alterations. Among such chromosomal abnormalities, deletions at the short arm of chromosome 3 has been shown to be the most frequent and can be detected even in hyperplasia of the bronchial epithelium, suggesting its important roles in the pathogenesis of lung cancer. In this chapter, we describe current status of the positional-cloning attempts to identify the target tumor suppressor gene at 3p in our laboratories as well as in other laboratories.


4. DOCID:22172 SCORE: 0.00272615422119305
DOCNO: 7849530
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Brain
DESCRIPTOR: Gene Transfer Techniques
AUTHOR: L J Fisher LJ
AUTHOR: J Ray J
AFFILIATION: Department of Neurosciences, University of California San Diego, La Jolla 92093-0627.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in neurobiology.
COUNTRY: ENGLAND
TITLE: In vivo and ex vivo gene transfer to the brain.
PUBDATE: 19941001
The use of gene transfer techniques to express novel proteins within different cellular populations has provided insights into the function and plasticity of the brain. Recently, this technique has been successfully used to explore physiological processes within the CNS and to intervene in neurodegenerative disease and cancer. Progress in manipulating transgene products in vivo and in achieving cell-specific targeting of genetic material offers promise for enhancing the usefulness of this technique and its therapeutic potential for treating human disorders of the CNS.


5. DOCID:3836 SCORE: 0.00265598236506207
DOCNO: 198130
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: W V Greenhouse WV
AUTHOR: A L Lehninger AL
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Magnitude of malate-aspartate reduced nicotinamide adenine dinucleotide shuttle activity in intact respiring tumor cells.
PUBDATE: 19771101
Measurements of respiration, CO2 and lactate production, and changes in the levels of various key metabolites of the glycolytic sequence and tricarboxylic acid cycle were made on five lines of rodent ascites tumor cells (two strains of Ehrlich ascites tumor cells, Krebs II carcinoma, AS-30D carcinoma, and L1210 cells) incubated aerobically in the presence of uniformly labeled D-[14C]glucose. From these data, as well as earlier evidence demonstrating that the reduced nicotinamide adenine dinucleotide (NADH) shuttle in these cells requires a transaminase step and is thus identified as the malate-aspartate shuttle (W.V.V. Greenhouse and A.L. Lehninger, Cancer Res., 36: 1392-1396, 1976), metabolic flux diagrams were constructed for the five cell lines. These diagrams show the relative rates of glycolysis, the tricarboxylic acid cycle, electron transport, and the malate-aspartate shuttle in these tumors. Large amounts of cytosolic NADH were oxidized by the mitochondrial respiratory chain via the NADH shuttle, comprising anywhere from about 20 to 80% of the total flow of reducing equivalents to oxygen in these tumors. Calculations of the sources of energy for adenosine triphosphate synthesis indicated that on the average about one-third of the respiratory adenosine triphosphate is generated by electron flow originating from cytosolic NADH via the malate-aspartate shuttle.


6. DOCID:3770 SCORE: 0.00254957030504834
DOCNO: 937991
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
AUTHOR: T Salonen T
PUBTYPE: Journal Article
JOURNALTITLE: Annals of clinical research.
COUNTRY: FINLAND
TITLE: Prenatal and perinatal factors in childhood cancer.
PUBDATE: 19760201
The material consists of malignant tumours in childhood notified to the Finnish Cancer Registry in 1959-1968. The maternity health centre cards for these children were collected through the National Board of Health. The immediately preceding parturient of the same maternity health centre was selected as the control. The number of complete pairs obtained for the final analysis was 972. All data concerning the parents, the pregnancy, parturition and the child were extracted from the cards. Information on the cancer patient and the paired control was compared. The results are presented as a comparison of the total tumour series and the controls, but also in smaller sub-groups: leukaemias (373 cases), brain tumours (245 cases) and other tumours (354 cases). Other tumours are further divided into: kidney tumours (96), eye tumours (37) and bone tumours (56). No significant correlations were found between potential aetiologic factors and the cases of cancer. The risk ratio for leukaemia in the group with pelvic radiography was 1.9, and in the group given vaccination against polio 1.8. However, because of the rare occurrence of the exposure mentioned these groups were small and the increase in the risk ratio statistically insignificant. BCG vaccination of children was common (90%) and no differences were established between the tumour and the control groups in this respect.


7. DOCID:23719 SCORE: 0.00254247163310041
DOCNO: 9317183
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Pharmacokinetics
DESCRIPTOR: Pharmacology, Clinical
QUALIFIER: metabolism
AUTHOR: R E Vestal RE
AFFILIATION: Department of Veterans Affairs Medical Center, and Mountain States Medical Research Institute, Boise, Idaho 83702, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Aging and pharmacology.
PUBDATE: 19971001
Research on aging and pharmacology in humans has been termed geriatric clinical pharmacology, which is an established subdiscipline within the broad field of clinical pharmacology. This article reviews information relevant to clinical cancer research and the care of older patients with cancer. Accordingly, the current state of knowledge on drug utilization, pharmacokinetics, pharmacodynamics, adverse drug events, drug interactions, polypharmacy, adherence to treatment, and clinical research considerations are reviewed. Although a review of the literature on aging and cancer chemotherapy is not included in this particular presentation, information is very sparse. Thus, there is significant potential for valuable contributions from clinical research through partnerships between geriatric clinical pharmacologists and medical oncologists.


8. DOCID:26039 SCORE: 0.00251496345421108
DOCNO: 11338019
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
AUTHOR: D S Schrump DS
AUTHOR: D M Nguyen DM
AFFILIATION: Thoracic Oncology Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 2B-07, 10 Center Drive, Bethesda, Maryland 20892-1502, USA. david_schrump@nih.gov
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: World journal of surgery.
COUNTRY: United States
TITLE: Targets for molecular intervention in multistep pulmonary carcinogenesis.
PUBDATE: 20010201
Lung cancers are a leading cause of mortality worldwide, and most of these neoplasms are directly attributable to tobacco abuse. Recent studies have begun to elucidate molecular mechanisms of multistep aero-digestive tract carcinogenesis, revealing novel targets for intervention in lung cancers and their precursor lesions. This review summarizes the molecular biology of lung cancers in relation to the prognosis and treatment of patients with these neoplasms.


9. DOCID:24716 SCORE: 0.00251377796329813
DOCNO: 11343961
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: secondary
QUALIFIER: pathology
AUTHOR: D Carroll D
AUTHOR: P B Rajesh PB
AFFILIATION: Department of Thoracic Surgery, Birmingham Heartlands Hospital, Bordesley Green East, B9 5SS, Birmingham, UK. danderosier@doctors.org.uk
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery.
COUNTRY: England
TITLE: Colonic metastases from primary squamous cell carcinoma of the lung.
PUBDATE: 20010501
Lung cancer is the most common malignancy in the UK. Metastasis to the colon is very rare and only infrequently symptomatic. Here we report a case of squamous cell carcinoma of the lung which presented with symptoms from a colonic metastasis.


10. DOCID:25410 SCORE: 0.00250815244015644
DOCNO: 10751464
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiography
QUALIFIER: methods
AUTHOR: K D Hopper KD
AUTHOR: K Singapuri K
AUTHOR: A Finkel A
AFFILIATION: Department of Radiology, Penn State University, Hershey, PA 17033, USA. khopper@psu.esu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Radiology.
COUNTRY: UNITED STATES
TITLE: Body CT and oncologic imaging.
PUBDATE: 20000401
The most commonly used imaging modality in patients with cancer is computed tomography (CT). Whether to evaluate primary tumor or metastases to the neck, chest, abdomen, or pelvis, oncologic body CT has become invaluable to medical, gynecologic, and radiation oncologists. CT is the principal tool used to stage tumor, assess response, and guide radiation therapy. This review provides a discussion of how we optimize oncologic CT to best meet the needs of the patient with cancer.


11. DOCID:7189 SCORE: 0.00250216136758522
DOCNO: 721322
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: C Marigo C
AUTHOR: P Correa P
AUTHOR: W Haenszel W
PUBTYPE: Journal Article
JOURNALTITLE: International journal of cancer. Journal international du cancer.
COUNTRY: DENMARK
TITLE: Cancer and "cancer related" colorectal lesions in São Paulo, Brazil.
PUBDATE: 19781201
A series of 832 necropsy specimens were studied grossly with a magnifying lens and all lesions identified were studied microscopically. The age and sex-specific prevalence of adenomatous and hyperplastic polyps is reported and results are compared with those of other populations. A correlation was made between polyps and cancer of the colon and rectum (407 cases). The data suggest that São Paulo is a community in a transitional stage between intermediate and high risk of cancer of the colon. The epidemiologic characteristics of lower rectum cancer are peculiar to some populations and appear unrelated to colon cancer. The black population of São Paulo has a higher prevalence than that reported for African negroes. The data also implicate adenomatous polyps, diverticulosis and hemorrhoids as being probably related diseases.


12. DOCID:28930 SCORE: 0.00246438876268239
DOCNO: 15691805
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
AUTHOR: Somkiat Sunpaweravong S
AUTHOR: Patrapim Sunpaweravong P
AFFILIATION: Department of Surgery, Prince of Songkla University, Hat Yai, Songkla 90110, Thailand. susomkia@medicine.psu.ac.th
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Asian journal of surgery / Asian Surgical Association.
COUNTRY: China
TITLE: Recent developments in critical genes in the molecular biology of breast cancer.
PUBDATE: 20050101
The biology of breast cancer is complex, and the increasing knowledge of its molecular biology is having a great impact on the clinical management of this serious condition. This review looks at new findings on the role of various critical genes, including BRCA1, BRCA2, HER2 and p53, in the development of breast cancer and their clinical implications.


13. DOCID:30518 SCORE: 0.00240780100512058
DOCNO: 14763130
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analogs & derivatives
QUALIFIER: therapeutic use
QUALIFIER: antagonists & inhibitors
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: John Lyons J
AUTHOR: Emel Bayar E
AUTHOR: Gil Fine G
AUTHOR: Michael McCullar M
AUTHOR: Randee Rolens R
AUTHOR: Joseph Rubinfeld J
AUTHOR: Craig Rosenfeld C
AFFILIATION: jlyons1@ireland.com
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in investigational drugs (London, England : 2000)
COUNTRY: England
TITLE: Decitabine: development of a DNA methyltransferase inhibitor for hematological malignancies.
PUBDATE: 20031201
Decitabine (DAC) is a small molecule nucleotide analog that is incorporated into DNA and traps human DNA methyltransferases. Although initially developed as a cytotoxic agent, low-dose DAC is enjoying a revival as a specific inhibitor of hypermethylation in cancer. DAC has activity in several hematological diseases, especially myelodysplastic syndrome, chronic myelogenous leukemia and acute myeloid leukemia. Clinical and preclinical advances are presented in this review.


14. DOCID:30602 SCORE: 0.00240779942123737
DOCNO: 15649275
OWNER: NLM
STATUS: In-Data-Review
AUTHOR: Mary J Feeney MJ
AFFILIATION: Los Altos, California, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Clinical and experimental pharmacology & physiology.
COUNTRY: Australia
TITLE: Fruits and the prevention of lifestyle-related diseases.
PUBDATE: 20041201
SUMMARY 1. Fruits contain a variety of compounds that may slow or prevent chronic diseases through a variety of possible mechanisms. Components in fruits thought to be associated with the reduction of these conditions include soluble and insoluble dietary fibre, anti-oxidant nutrients (vitamins C, E, selenium, beta-carotene) and phytonutrients (bioactive plant compounds that impart colour, flavour and other functional properties to foods). 2. The present paper briefly reviews selected studies on the role of some fruits in lifestyle conditions such as cardiovascular disease, some types of cancer and conditions that accompany ageing.