0. DOCID:7670 SCORE: 0.00614439490305055
DOCNO: 6154531
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: enzymology
QUALIFIER: enzymology
AUTHOR: C H Chang CH
AUTHOR: D Angellis D
AUTHOR: W H Fishman WH
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Presence of the rare D-variant heat-stable, placental-type alkaline phosphatase in normal human testis.
PUBDATE: 19800501
In 11 adult testes studied, about 0.3 to 4.6% of the total alkaline phosphatase activity was heat stable and L-phenylalanine sensitive but L-homoarginine insensitive. The testicular heat-stable enzyme was more susceptible to inhibition by L-leucine and ethylenediaminetetraacetate than were the normal placental and intestinal enzymes. By antibody-directed enzyme inhibition test, the testicular heat-stable enzyme cross-reacted completely with normal placental enzyme but clearly distinguished itself from a heat-stable component of normal intestinal enzyme. Thus, placental alkaline phosphatase D-variant is synthesized in testis, indicating that the gene for elaborating this placental protein is probably already active in the testicular cells. The high incidence of this protein in cancers of testis and ovary is probably due to its increased production by gonadal genes present in the genome of these particular tumors.

1. DOCID:5964 SCORE: 0.0049888752171495
DOCNO: 7436270
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: diagnosis
AUTHOR: J H Cochran JH
AUTHOR: W E Fee WE
PUBTYPE: Journal Article
JOURNALTITLE: Annals of plastic surgery.
COUNTRY: UNITED STATES
TITLE: Metastasis in head and neck cancer, 1979.
PUBDATE: 19800501
Metastatic spread of head and neck cancer signifies a grave change in prognosis for the patient. The presence or absence of detectable metastasis is valuable knowledge both in planning treatment and in predicting prognosis. Knowledge of the metastatic behavior patterns of such tumors, and of the diagnostic means of detecting metastasis, is essential. The available knowledge on this problem is comprehensively reviewed to present, in a single source, the requisite knowledge for any physician treating head and neck cancer. Metastatic spread is reviewed according to incidence, detection methods, anatomical sites, and correlation with characteristics of the primary tumor. Finally, methods of detecting metastasis are reviewed and a practical approach to patient evaluation recommended.

2. DOCID:5608 SCORE: 0.00470381789999918
DOCNO: 7304081
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: secondary
QUALIFIER: deficiency
QUALIFIER: metabolism
AUTHOR: R M Black RM
AUTHOR: G H Daniels GH
AUTHOR: C H Coggins CH
AUTHOR: P R Mueller PR
AUTHOR: R E Data RE
AUTHOR: N Lichtenstein N
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Acta endocrinologica.
COUNTRY: DENMARK
TITLE: Adrenal insufficiency from metastatic colonic carcinoma masquerading as isolated aldosterone deficiency. Report of a case and review of the literature.
PUBDATE: 19811201
A case of adrenal insufficiency secondary to metastatic colonic carcinoma is reported. Because the patient was taking prednisone for an unrelated condition, his initial presentation mimicked isolated aldosterone deficiency with an elevated serum potassium of 8.7 mmol/l. Cortisol deficiency was documented by ACTH testing. The diagnosis of metastatic disease causing adrenal insufficiency was suspected after a computed body scan of the abdomen revealed marked bilateral adrenal enlargement. Adrenal insufficiency secondary to metastatic cancer is reviewed.

3. DOCID:6511 SCORE: 0.00447604056669941
DOCNO: 219746
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: J B Michelson JB
AUTHOR: R F Stephens RF
AUTHOR: J A Shields JA
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Annals of ophthalmology.
COUNTRY: UNITED STATES
TITLE: Clinical conditions mistaken for metastatic cancer to the choroid.
PUBDATE: 19790201
Thirteen patients who were referred to the Oncology Unit with the diagnosis of metastatic cancer to the choroid were studied and found to have other conditions. All of the patients were female. Nine of the 13 had a history of systemic cancer of which 6 were breast cancer. Five patients were currently being treated with chemotherapeutic agents for their systemic cancer. Three of the 13 patients had bilateral fundus lesions. The most common diagnostic entities confused with metastatic disease were either inflammatory or hemorrhagic lesions of the retina. The preceding history of cancer in the patient with a puzzling fundus lesion may predispose the referring ophthalmologist to suggest a diagnosis of metastatic cancer to the choroid.

4. DOCID:5289 SCORE: 0.00421521500559638
DOCNO: 7237303
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Castration
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: analysis
AUTHOR: J H Goldie JH
AUTHOR: N Bruchovsky N
AUTHOR: A J Coldman AJ
AUTHOR: G A Gudauskas GA
PUBTYPE: Journal Article
JOURNALTITLE: Canadian journal of surgery. Journal canadien de chirurgie.
COUNTRY: CANADA
TITLE: Steroid receptors in adjuvant hormonal therapy for breast cancer.
PUBDATE: 19810501
Using a computerized mathematical model the authors found that either a small [5%] or large [50%] hormone-dependent reduction in tumour cell population at the beginning of adjuvant chemotherapy for breast cancer greatly increases the probability fo achieving a cure. The fact that even a minor response to hormonal therapy early in the treatment of the tumor is effective underlines the importance of using estrogen receptors to to select potential responders in whom a cure is at least a strong theoretical possibility.

5. DOCID:6356 SCORE: 0.00403487338167336
DOCNO: 6942812
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: psychology
AUTHOR: C Battersby C
PUBTYPE: Journal Article
JOURNALTITLE: The Australian and New Zealand journal of surgery.
COUNTRY: AUSTRALIA
TITLE: Psychological implications of mastectomy.
PUBDATE: 19810601
Some recent studies on the psychological trauma endured by patients with breast disease are summarized and a number of conclusions are drawn. There appear to be a number of stages through which a patient with a breast lump passes psychologically. Breast cancer attitudes in a community are dependent upon accumulated experience and cannot be changed overnight. Delay in presentation results from unconscious factors which may not be amenable to rational public health appeals. It is possible to identity a group of patients high at risk in breast surgery, although human resilience is such that the outcome if often satisfactory. There is a great need for controlled prospective studies in many areas of breast surgery rehabilitation. Some personal observations are included to stimulate discussion and interest in the area.

6. DOCID:7912 SCORE: 0.0039647486817332
DOCNO: 501862
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiation effects
QUALIFIER: radiation effects
QUALIFIER: epidemiology
QUALIFIER: adverse effects
QUALIFIER: etiology
AUTHOR: P C Royce PC
AUTHOR: B R MacKay BR
AUTHOR: P M DiSabella PM
PUBTYPE: Journal Article
JOURNALTITLE: JAMA : the journal of the American Medical Association.
COUNTRY: UNITED STATES
TITLE: Value of postirradiation screening for thyroid nodules. A controlled study of recalled patients.
PUBDATE: 19791201
We determined the occurrence of palpable thyroid abnormalities in 214 persons with verified history of head and neck irradiation and in 243 concurrently examined, nonirradiated persons (control subjects). Examinations were performed by two physicians, each unaware of the medical history of the examinees and of the findings of the other examiner. Thyroid nodules, either single or multiple, occurred in 6.1% of irradiated persons and in 4.5% of control subjects (95% confidence interval of the difference, -2.6% to +5.7%). Thyroid enlargement without nodules occurred in 5.6% of irradiated persons and in 3.7% of control subjects (95% confidence interval of the difference, -2.0% to +5.8%). Thyroid cancer was detected in one irradiated and in two nonirradiated persons. Our controlled study did not find an excess number of thyroid abnormalities in previously irradiated subjects.

7. DOCID:7067 SCORE: 0.00386756930689025
DOCNO: 433009
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: A Dlhos A
AUTHOR: K J Lennartz KJ
AUTHOR: P Dlhos P
AUTHOR: J Heising J
AUTHOR: C Kaiser C
AUTHOR: R Engelking R
PUBTYPE: Journal Article
JOURNALTITLE: Der Urologe. Ausg. A.
COUNTRY: GERMANY, WEST
TITLE: [In-vitro-technique for autoradiographic investigations of cell proliferation in benign and malignant alterations of the human urinary bladder mucosa from biopsy specimens (author' transl)]
PUBDATE: 19790301
An in-vitro double labelling technique with 3H- AND 14C-Thymidine was applied to biopsy specimens of the human urinary bladder mucosa in order to determine proliferation kinetics of normal bladder epithelium as well as its benign and malignant alterations. Application of above mentioned technique led to evaluable autoradiographs. The mean 3H-Thymidine labelling-index in bladder cancer was remarkably higher than in normal bladder epithelium and in benign papillomas. There was a good correlation between histologic grading of malignancy and increase of the mean 3H-Thymidine labelling index. Addition of 5-Fluorodesoxyuridine to the incubation medium had no influence on the labelling of the incubated tissue.

8. DOCID:4653 SCORE: 0.00361790498572613
DOCNO: 7007222
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Skin Transplantation
QUALIFIER: drug effects
QUALIFIER: drug effects
QUALIFIER: prevention & control
QUALIFIER: pharmacology
AUTHOR: P B Medawar PB
AUTHOR: R Hunt R
PUBTYPE: Journal Article
JOURNALTITLE: Immunology.
COUNTRY: ENGLAND
TITLE: Anti-cancer action of retinoids.
PUBDATE: 19810201
The anti-cancer action of retinyl acetate (Vitamin-A acetate, VAA), chosen as a representative retinoid substance, is attributed to its power to exercise immunopotentiation, though other possibilities are considered. The reasons for forming this opinion were: (1) chronic administration of VAA brought about enlargement of the thymus and peripheral lymph nodes; (2) the administration of VAA curtailed the life of skin allografts though (3) its action could be reversed by the concomitant administration of immunosuppressive agents.

9. DOCID:6927 SCORE: 0.00354310396998434
DOCNO: 6940540
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Occult Blood
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: O Dent O
AUTHOR: K Goulston K
PUBTYPE: Journal Article
JOURNALTITLE: The Australian and New Zealand journal of surgery.
COUNTRY: AUSTRALIA
TITLE: Knowledge of colorectal cancer and attitude to occult blood testing among recent medical graduates in New South Wales.
PUBDATE: 19810401
The extent to which new information on colorectal cancer (C.C.) is being transmitted to medical undergraduates was assessed in a repeated survey of new interns' knowledge of and attitudes on C.C. A probability sample of 214 graduates of the two Sydney medical schools was drawn as they commenced their internships in 1978. A comparable sample of 186 was drawn in 1980. Interns in each sub-sample completed a questionnaire of 54 pre-coded items of knowledge of C.C. epidemiology, early diagnosis, and followup, and on their attitudes towards C.C. On most topics knowledge was not well developed, and 1980 graduates were not significantly better informed than those of 1978. Almost three-quarters of 1980 interns intend using faecal occult blood testing.

10. DOCID:7386 SCORE: 0.00339972335287172
DOCNO: 352329
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
AUTHOR: A E Bray AE
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Australian and New Zealand journal of surgery.
COUNTRY: AUSTRALIA
TITLE: Where is the immunology in cancer?
PUBDATE: 19780201
Whether the common human cancers possess tumour-specific antigens which produce an immune response in the host still remains the crucial question in tumour immunology. Recent reports and discussions at the Third International Congress of Immunology suggested that much of the previously published work was not valid. The reasons for this have been analysed by comparing the well-established experimental data with human cancer. It is suggested that much of the current confusion in tumour immunology stems from the poor models used to study human cancer and the inadequate assessment of in vitro assays which have measured the host response. The present methods require refinement, or new techniques need to be developed, before this question can be answered. The field has been well researched, and there do not appear to be any recent major advances in tumour immunology which can be applied in clinical practice.

11. DOCID:5574 SCORE: 0.00304924874515699
DOCNO: 6791126
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Preoperative Care
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: therapy
QUALIFIER: surgery
AUTHOR: J Belghiti J
AUTHOR: F Langonnet F
AUTHOR: J Y Wessely JY
AUTHOR: F Fekete F
PUBTYPE: Journal Article
JOURNALTITLE: La Nouvelle presse médicale.
COUNTRY: FRANCE
TITLE: [Should undernutrition be corrected prior to surgery in patients with cancer of the oesophagus or cardia? (author's transl)]
PUBDATE: 19810601
A prospective study of 40 patients with cancer of the oesophage or cardia considered for surgery showed that 27 had no evidence of protein or calorie deficiency, while 13 had undernutrition. The 18 patients who benefited from ablative surgery belonged to the group with normal nutritional status; none of the undernourished patients could have benefited from resection. Only controlled studies will show whether or not correcting undernutrition is advantageous, but the number of people with both resectable tumour and corrigible undernutrition is probably very small.

12. DOCID:5788 SCORE: 0.00303453345954379
DOCNO: 6261053
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: secondary
QUALIFIER: surgery
QUALIFIER: secondary
AUTHOR: C T Yarington CT
PUBTYPE: Journal Article
JOURNALTITLE: The Laryngoscope.
COUNTRY: UNITED STATES
TITLE: Metastatic malignant disease to the parotid gland.
PUBDATE: 19810401
A survey of over 250 consecutive parotidectomies performed at The Mason Clinic indicates a surprising incidence of metastatic malignant disease to the parotid gland. Four percent of all parotidectomies performed indicated a metastatic focus of malignancy from an ;unsuspected primary outside areas of the head and neck usually implicated in parotid disease. Twenty-five percent of all cancer discovered at parotidectomy was metastatic malignant disease to the parotid gland. The most common site was the lung. A high index of suspicion, evaluation of pathologic specimens by electron microscopy, and detailed metastatic work-up for patients with malignant disease in parotid lymph nodes are recommendations which should be considered by the surgeon performing parotid procedures.

13. DOCID:7584 SCORE: 0.00274818054409744
DOCNO: 159709
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: E Müller E
AUTHOR: E Kolb E
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: ENGLAND
TITLE: Local responses in primary and secondary human lung cancers. I. Patterns of cellular (eosinophils and macrophages) and extracellular (acid mucopolysaccharide) reactions.
PUBDATE: 19790901
Local free cell (eosinophils and macrophages) and extracellular (acid mucopolysaccharides) reactions were studied by histochemical techniques in 72 primary lung cancers (Group A), 17 pulmonary metastases and 5 lung tumours of unknown origin (Group B). Strong cellular reactions were more frequent in Group A than in Group B, whereas extracellular reactions were more frequent in Group B than in Group A. In both groups the degrees of eosinophilic infiltration and accumulation of acid mucopolysaccharides tended to be negatively correlated. In contrast, macrophages and eosinophils showed a positive correlation in the primary cancers, but none in the other tumours. The extracellular material had physical and chemical properties (solubility, affinity to stains and degradability by enzymes) of the sulphated acid mucopolysaccharides. From its distribution it appeared to be derived from fibroblasts and/or tumour cells.

14. DOCID:7967 SCORE: 0.00266161597397234
DOCNO: 455910
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiography
QUALIFIER: radiography
AUTHOR: J N Bruneton JN
AUTHOR: P Ballanger P
AUTHOR: R Ballanger R
AUTHOR: G Delorme G
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Clinical radiology.
COUNTRY: ENGLAND
TITLE: Renal adenomas.
PUBDATE: 19790501
In presenting five new cases of renal adenomas the authors describe the general nature of these rare tumours. If the small adenoma corresponding to microscopic forms is frequent, the large adenoma is rare and always solitary. Haematuria and pain are the most common signs. The classic criterion of non-malignancy in a solid tumour measuring less than 3 cm has no diagnostic value. From a review of the lieterature on the subject, the authors demonstrate the angio-architecture corresponding to the different types of adenoma: the tubular adenoma which is hypervascularised and well circumscribed; the papillary adenoma, often cortical, hypovascular or avascular with bordering arcade; the alveolar adenoma; the mixed forms. They stress the difficulty of radiological diagnosis and the frequency of transitional forms with cancer. The place of angiography is in the pre-operative diagnostic assessment and in defining localised anomalies in angio-architecture which can guide histological examination in the search for neoplastic foci.