0. DOCID:3912 SCORE: 0.00572301893605062
DOCNO: 591172
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Labor Unions
DESCRIPTOR: Mortality
AUTHOR: B Jeune B
PUBTYPE: Journal Article
JOURNALTITLE: International journal of epidemiology.
COUNTRY: ENGLAND
TITLE: Mortality of male members of the Danish Semi-skilled Unskilled Workers' Union in 1973.
PUBDATE: 19770901
The purpose of this cross-sectional study is to evaluate contemporary age and cause specific mortalities of a large group of employed men. The population is the 228,612 male members, aged 20-64, of Denmark's largest trade union, the Semi-skilled and Unskilled Workers' Union (SID). A Standard Mortality Ratio (SMR) of 93.9 compared to all men in Denmark is found. However, the distribution of mortality by age does not resemble that found in many other studies, and is usually said to result from the 'healthy worker effect'. Excess mortality is found in the younger age groups, while the opposite is the case in the older groups, mainly because of a deficit of deaths from chronic illness. Notably higher age and cause specific SMRs are found for violent and unnatural deaths, and higher SMRs for cancer of the lungs and of lymphatic and haemopoietic tissues. Regional variations are found, but no correlation found between mortality and size of union 'local'. However, cancer mortality is higher among members of specialized locals, which are situated in larger urban area. The excess mortality of members of the largest locals in the Copenhagen area is due to deaths by cancer and by violent and unnatural causes. Findings and problems will be examined further in an ongoing cohort study and in other specialized studies under preparation.

1. DOCID:1302 SCORE: 0.0041913149809737
DOCNO: 579447
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Environment
QUALIFIER: epidemiology
AUTHOR: H P Friedl HP
PUBTYPE: Journal Article
JOURNALTITLE: Österreichische Zeitschrift für Onkologie. Austrian journal of oncology.
COUNTRY: AUSTRIA
TITLE: [Epidemiology of cancer and the environment]
PUBDATE: 19771001
Results of epidemiological investigations point out that environmental factors have an influence on the development of at least 80% of cancer diseases. The cancer mortality rates in Austria are analyzed with regard to this point. Austrian mortality trends of the most common malignancies are similar to those of other western industrialized countries. The relationship between cancer risk and the size of the Austrian communities is shown. As opposed to other common cancer sites, cancer of the stomach is most common in small communities with mainly an agricultural population. Etiological hypotheses about the origin of stomach cancer are discussed with regard to its epidemiological findings as well as the dietary habits of the population.

2. DOCID:2299 SCORE: 0.00394341890959264
DOCNO: 326397
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Bladder Neoplasms
AUTHOR: D F Paulson DF
AUTHOR: K R Stone KR
AUTHOR: D D Mickey DD
AUTHOR: R A Bonar RA
AUTHOR: H Wunderli H
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Development and application of basic research techniques in bladder cancer research.
PUBDATE: 19770801
The growth of transitional epithelial cells with different growth media and growth supports was examined. Sephadex G-10, Bio-Gel P-20, Bio-Glas-1000, DEAE-Sephadex A-50, DEAE-cellulose, CM-Sephadex C-50, acid-soluble collagen, and immobilized collagen fibers were used to enhance plating efficiency. Acid-soluble collagen layers optimally increased the plating efficiency of primary cultures of bladder carcinoma. Media alterations with serial combinations of fetal calf, newborn calf, calf, bovine, and bull serum with minimum essential medium, Roswell Park Memorial Institute Tissue Culture Medium 1640, Connaught Medical Research Laboratories Medium 1066, Medium 199, Grand Island Biological, National Cancer Tissue Culture 135, 1415, McCoy's 5A, and National Cancer Institute medium were established. No promotion of cell division was noted with any one of these basic medium formulations.

3. DOCID:2805 SCORE: 0.00380485368766451
DOCNO: 170673
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: T Berge T
AUTHOR: N G Toremalm NG
PUBTYPE: Journal Article
JOURNALTITLE: Scandinavian journal of respiratory diseases.
COUNTRY: DENMARK
TITLE: Bronchial cancer - a clinical and pathological study. I. Histopathology and metastases.
PUBDATE: 19750801
Among 16,394 necropsies during the 12-year period, 1958-1969 (representing about 60% of all persons who died in Malmö during this period, 747 cases of bronchial cancer were found in 744 individuals. There were considerable differences in frequency of different histologic types with regard to sex. Two main classes have therefore been distinguished: Group I, comprising squamous epithelial cancer and anaplastic cancer (including oat-cell cancer), which was predominant among men; and Group II, comprising adenocarcinoma, bronchiolar carcinoma, carcinoid and bronchial gland tumour, which was of more or less equal frequency in both sexes. Compared with other malignant tumours, bronchial carcinoma had a strong tendency to metastasise to the adrenals, brain, kidneys and skeleton. Bronchial cancer did not differ from other tumours with regard to lymphogenous spread but had a stronger tendency to spread via the blood stream. Squamous epithelial cancer showed the strongest tendency to remain confined to the thoracic cavity.

4. DOCID:1516 SCORE: 0.0037051267788836
DOCNO: 979796
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapy
AUTHOR: W Woods W
AUTHOR: G A Coupland GA
AUTHOR: A G Poole AG
PUBTYPE: Journal Article
JOURNALTITLE: The Medical journal of Australia.
COUNTRY: AUSTRALIA
TITLE: Sequential multidrug chemotherapy and radiotherapy with possible surgery for locally advanced cancer.
PUBDATE: 19760701
A preliminary report describes the use of both a single and a combined chemotherapeutic drug regime before radiotherapy for locally advanced and radioresistant cancers. Some tumours have been rendered operable with safety by this sequence. This method is suggested to replace the current practice of following surgery with radiotherapy and finally chemotherapy. In our experience, chemotherapy before radiotherapy is assisting in the effective control of locally advanced and hitherto radioresistant cancers of many types, and in converting inoperable cancers into cancers that can be resected sometimes with safety. Also, when chemotherapeutic drugs are given before radiotherapy, damage to normal adjacent tissue is less than that seen after radiotherapy alone.

5. DOCID:3516 SCORE: 0.0036007810689533
DOCNO: 974988
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Carcinoma, Squamous Cell
DESCRIPTOR: Uterine Cervical Neoplasms
AUTHOR: W M Christopherson WM
AUTHOR: L A Gray LA
AUTHOR: J E Parker JE
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Microinvasive carcinoma of the uterine cervix: A long-term followup study of eighty cases.
PUBDATE: 19760801
One hundred and eleven patients with microinvasive carcinoma of the uterine cervix were studied over a 21-year period. Thirty-five cases of carcinoma in situ with questionable stromal invasion were excluded. Cases with pathologic examination of less than a cervical cone or the entire cervix were not accepted. The sole pathologic criterion for inclusion was unequivocal invasion to a depth of no more than 5.0 mm. Ninety-one patients were followed for 5 years or until death, and 80 patients for 10 years or until death. One patient was lost to follow-up at 5.5 years. The two deaths officially attributed to cervix cancer prior to 10 years were signed out by nonphysician assistant coroners. Available clinical evidence indicates that at least one of these patients, and probably both, did not die of cervix cancer. From these data, simple hysterectomy would seem to be the maximal treatment indicated. Since the prognosis of microinvasive carcinoma is similar to that of carcinoma in situ, it is suggested that such cases not be included when considering the end results of Stage I cervix cancer.

6. DOCID:1776 SCORE: 0.00359026770724761
DOCNO: 1147755
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Brachial Plexus
DESCRIPTOR: Radiation Injuries
QUALIFIER: etiology
AUTHOR: R M Match RM
PUBTYPE: Journal Article
JOURNALTITLE: Archives of surgery (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Radiation-induced brachial plexus paralysis.
PUBDATE: 19750401
Fifteen patients with radiation-induced brachial plexus paralysis were studied. Thirteen women had been treated for breast cancer. Two men developed symptoms and signs following radiation therapy for lung cancer. The brachial plexus paralysis initially was not static and progressed, but spontaneous arrest with permanent residual paralysis was seen in three patients. Three were noted to have intractable pain, but the major complaint of the remaining 12 was the inability to use their hand. The ten patients on whom an earlier operation directed at the brachial plexus had been performed were not relieved. Two of these were later considered excellent candidates for a tendon transfer in the hand. One did not desire surgery. The other underwent operation and showed marked improvement of her grasp and general hand function.

7. DOCID:2825 SCORE: 0.00345744842025267
DOCNO: 1247998
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
AUTHOR: W B Dunham WB
AUTHOR: C Waymouth C
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Intradermal transplantation in mice of small numbers of sarcoma cells followed by tumor growth and regression.
PUBDATE: 19760101
Relatively small numbers of Sarcoma 1 cells were transplanted intradermally in A/WySn mice to study the course of growth when the size of the transplant is comparable to an early stage of spontaneous cancer. Transplants of 31 to 32,000 cells took one of three courses: no apparent growth; development of tumor followed by regression; or progressive growth. Transplants of 8,000 cells were the most evenly divided among these three courses and were selected for further study. Bilateral tumors took the same course to regression or to continued growth with significant frequency. There was complete correlation between regression of a tumor and immunity to a challenge made 1 to 5 weeks after the original transplant. Persistent tumors had a similar relationship, but the immunity was less complete. Limited, inapparent growth, followed by regression, was indicated in some mice, simulating immunological surveillance. Serum from such mice, when administered systemically in other mice, apparently induced enhancement of intradermal transplants.

8. DOCID:3535 SCORE: 0.003314817129115
DOCNO: 946155
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: M E Harper ME
AUTHOR: W B Peeling WB
AUTHOR: T Cowley T
AUTHOR: B G Brownsey BG
AUTHOR: M E Phillips ME
AUTHOR: G Groom G
AUTHOR: D R Fahmy DR
AUTHOR: K Griffiths K
PUBTYPE: Journal Article
JOURNALTITLE: Acta endocrinologica.
COUNTRY: DENMARK
TITLE: Plasma steroid and protein hormone concentrations in patients with prostatic carcinoma, before and during oestrogen therapy.
PUBDATE: 19760201
Plasma testosterone, androstenedione, oestradiol-17beta, follicle stimulating hormone (FSH) and luteinizing hormone (LH) were not significantly different in patients with prostatic cancer, with benign prostatic hyperplasia or in patients without prostatic disease. Plasma prolactin concentrations were significantly lower in the patients with benign disease than those with prostatic carcinoma. Endocrine therapy in the form of stilboestrol administration significantly decreased plasma levels of testosterone, oestradiol-17beta, FSH and LH within 7 days of the treatment. After 7 days therapy prolactin levels increased significantly in all patients studied. Changes in growth hormone concentrations were more varied in response to stilboestrol, being elevated in several patients and remaining unchanged in others. Treatment of a few prostatic carcinoma patients who were receiving stilboestrol therapy with CB154, an inhibitor of prolactin secretion, brought an immediate decrease in prolactin levels which was was sustained. Plasma testosterone, androstenedione and growth hormone were unchanged in these patients but a significant decrease in plasma oestradiol-17beta was noted in two patients during CB154 administration.

9. DOCID:3619 SCORE: 0.0031831157654445
DOCNO: 1089036
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: A Richters A
AUTHOR: C L Kaspersky CL
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Surface immunoglobulin positive lymphocytes in human breast cancer tissue and homolateral axillary lymph nodes.
PUBDATE: 19750101
Surface immunoglobulins were determined on human lymph node lymphocytes by the use of immunofluorescence technique in 59 breast cancer patients undergoing radical mastectomy. In 10 of these cases, lymphocyte surface immunoglobulins were also studied on lymphocytes infiltrating the primary cancer mass. The most outstanding finding was a difference between the IgM lymphocyte populations in the lymph nodes of patients with and without lymph node metastases. When cancer tissue was present in one or more lymph nodes, the tumor-free as well as the tumor-positive nodes showed a higher percentage of IgM positive lymphocytes than did lymph nodes from patients without nodal metastases. The greatest difference was found when IgM lymphocytes from tumor-bearing lymph nodes were compared with those from the lymph nodes of patients without nodal metastases (p is less than .005). The lymphocyte populations infiltrating 5 of the 10 primary cancer masses studied showed no surface immunoglobulins; in the remainder, both IgG and IgM positive lymphocytes were found but in variable proportions. While the findings are not definitive, this is the first study dealing with the quantitation of immunoglobulin specific lymphocytes in the lymph nodes and tumor tissue of patients with breast cancer.

10. DOCID:944 SCORE: 0.00302907853962456
DOCNO: 904951
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasm Circulating Cells
QUALIFIER: physiology
QUALIFIER: complications
QUALIFIER: pathology
QUALIFIER: complications
AUTHOR: K J Donald KJ
AUTHOR: S Chalk S
AUTHOR: J J Sullivan JJ
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Pathology.
COUNTRY: AUSTRALIA
TITLE: Fibrin-bound tumour cells on a sclerosed mitral valve.
PUBDATE: 19770701
The association of fibrin and tumour cells on a sclerosed mitral valve in a 62-year-old woman is described. This was the first indication of malignant disease but bilateral ovarian cancer was proved two months later. ino further tumour deposits have been found in fifteen months. The tumour deposit on the valve was most likely a metastasis but primary heart valve sarcoma has not been positively excluded. If the lesion was a secondary deposit this has possible implications for the role of fibrin in metastasis in humans.

11. DOCID:782 SCORE: 0.0030175610788906
DOCNO: 1030780
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasm Regression, Spontaneous
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: P H Wiernik PH
PUBTYPE: Journal Article
JOURNALTITLE: National Cancer Institute monograph.
COUNTRY: UNITED STATES
TITLE: Spontaneous regression of hematologic cancers.
PUBDATE: 19761101
Spontaneous regression of hematologic cancer is extremely rare. Data gleaned from the literature and from previously unreported cases allow certain interesting general conclusions. Spontaneous remission of acute leukemia is associated with bacterial infection and is of short duration, weeks to months. Spontaneous regression of lymphoma or plasma cell dyscrasia is often of substantial duration, months or years, and frequently is associated with viral infections. Spontaneous regression of chronic lymphocytic leukemia is also of significant duration and has been associated with the occurence of a new primary carcinoma in one-third of the cases.

12. DOCID:334 SCORE: 0.00292292190073414
DOCNO: 142218
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: analogs & derivatives
QUALIFIER: therapeutic use
AUTHOR: A de Matteis A
AUTHOR: V Perrone V
AUTHOR: A Marone A
PUBTYPE: Journal Article
JOURNALTITLE: Minerva medica.
COUNTRY: ITALY
TITLE: [Clinical considerations on the use of a new synthetic androgen, Calusterone, in the treatment of advanced breast cancer]
PUBDATE: 19770701
Results with a new synthetic androgen (Calusterone) in the management of 22 cases of advanced breast cancer are presented. Reference is made to the doses employed, the therapeutic results observed, and the side-effects caused by the drug. By comparison with the literature data, a partial response to treatment was observed in 47% of the series.

13. DOCID:123 SCORE: 0.00291037594103899
DOCNO: 336907
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Skin Transplantation
QUALIFIER: surgery
QUALIFIER: transplantation
QUALIFIER: surgery
AUTHOR: L A Huot LA
AUTHOR: D Larochelle D
AUTHOR: N B Gagnon NB
AUTHOR: S S Dupont SS
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of otolaryngology.
COUNTRY: CANADA
TITLE: Reconstruction of the floor of the mouth following surgery for cancer.
PUBDATE: 19771001
The authors, members of a very active service of Head and Neck Surgery, tell of their experience with the reconstruction of the floor of the mouth following surgery for cancer. They feel that the simplest methods of reconstruction are the best.

14. DOCID:2922 SCORE: 0.00285427179303094
DOCNO: 779949
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
AUTHOR: L H Baker LH
AUTHOR: R W Talley RW
AUTHOR: R Matter R
AUTHOR: D E Lehane DE
AUTHOR: B W Ruffner BW
AUTHOR: S E Jones SE
AUTHOR: F S Morrison FS
AUTHOR: R L Stephens RL
AUTHOR: E A Gehan EA
AUTHOR: V K Vaitkevicius VK
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Phase III comparison of the treatment of advanced gastrointestinal cancer with bolus weekly 5-FU vs. methyl-CCNU plus bolus weekly 5-FU. A Southwest Oncology Group study.
PUBDATE: 19760701
In a randomized and stratified study, 294 patients with advanced gastrointestinal cancer were treated either with 5-fluorouracil (5-FU) 400 mg/m2 weekly intravenously (i.v.) or 5-FU 400 mg/m2 i.v. weekly plus methyl-CCNU 175 mg/m2 orally (p.o.) every 6 weeks. The response rate in colorectal cancer with 5-FU was 9.5% while the two-drug treatment produced a response of 31.8% (p=.009). The response in all gastrointestinal cancers to 5-FU was 10.6% as compared with29.3% for the combination (p=.012). All responses were partial. The two-drug regimen is more effective and more toxic than weekly 5-FU therapy.