0. DOCID:18826 SCORE: 0.00754796004068924
DOCNO: 1699401
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: analogs & derivatives
AUTHOR: D D Von Hoff DD
AUTHOR: S Green S
AUTHOR: E A Surwit EA
AUTHOR: E V Hannigan EV
AUTHOR: D S Alberts DS
AFFILIATION: University of Texas Health Science Center, San Antonio 78284-7884.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Multicenter Study
JOURNALTITLE: American journal of clinical oncology : the official publication of the American Radium Society.
COUNTRY: UNITED STATES
TITLE: Phase II study of fludarabine phosphate (NSC 312887) in patients with advanced cervical cancer. A Southwest Oncology Group study.
PUBDATE: 19901001
Twenty evaluable patients with advanced cervical cancer refractory to one prior chemotherapy regimen were treated with a 5-day schedule of fludarabine phosphate. No responses were noted. The major toxicities were anemia and leukopenia. Based on this study, fludarabine phosphate does not appear to be an active agent for patients with chemotherapy refractory cervical cancer.


1. DOCID:23272 SCORE: 0.00702810438039374
DOCNO: 7900710
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: adverse effects
QUALIFIER: therapy
QUALIFIER: etiology
AUTHOR: R Mudad R
AUTHOR: A Hussein A
AUTHOR: W P Peters WP
AFFILIATION: Department of Hematology-Oncology, Duke University Medical Center, Durham, North Carolina 27710.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: American journal of clinical oncology : the official publication of the American Radium Society.
COUNTRY: UNITED STATES
TITLE: Guillain-Barre syndrome following autologous bone marrow transplantation.
PUBDATE: 19950401
The pathogenesis of the Guillain-Barre syndrome (GBS) is felt to involve alterations in cellular and humoral immune responses. We report the case of a 44-year-old female with stage IV breast cancer who developed GBS 2 days after receiving high dose chemotherapy with bone marrow and peripheral progenitor cell support, and granulocyte-macrophage colony stimulating factor (GM-CSF). Her clinical status stabilized with plasmapheresis. This report lends further support to hypotheses regarding cellular immune alterations in the pathogenesis of GBS.


2. DOCID:18634 SCORE: 0.00604349605673443
DOCNO: 1526834
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: M L Jekić ML
AUTHOR: I M Jekić IM
AFFILIATION: Klinisches Krankenhaus, Zemun-Belgrade, Jugoslawien.
PUBTYPE: Journal Article
JOURNALTITLE: Helvetica chirurgica acta.
COUNTRY: SWITZERLAND
TITLE: [Effect of chemotherapy on survival in advanced breast cancer]
PUBDATE: 19920501
Survival time of 119 consecutive patients with metastasizing carcinoma of the breast who had been treated with various chemotherapeutic schedules after radical operation was determined retrospectively. 57 women received chemotherapy and hormones, as well as radiotherapy, while 62 had radiotherapy plus hormone treatment. The mean prolongation of life in the former group over that of the latter was 12 months (p less than 0.01). Although chemotherapy delayed death, the dynamics of cancer were not fundamentally affected. The chemotherapy-induced prolongation (2.5 months to five years) was independent of any risk, primary location of the metastases or age.


3. DOCID:21018 SCORE: 0.0055106568794904
DOCNO: 9262042
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: secondary
QUALIFIER: etiology
QUALIFIER: therapy
QUALIFIER: etiology
QUALIFIER: therapy
AUTHOR: D Oneschuk D
AUTHOR: E Bruera E
AFFILIATION: Palliative Care Program, Grey Nuns Community Health Centre, Edmonton, Canada.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of pain and symptom management.
COUNTRY: UNITED STATES
TITLE: Successful management of multiple enterocutaneous fistulas in a patient with metastatic colon cancer.
PUBDATE: 19970801
Enterocutaneous fistula development is not uncommon in patients with advanced cancer and can be very challenging to manage. The authors present a case study of a patient with multiple enterocutaneous fistulas that developed in the setting of metastatic colon cancer. Assessment methods and interventions that permitted successful management are discussed with emphasis on the value of multidisciplinary care.


4. DOCID:25641 SCORE: 0.00502790731650289
DOCNO: 11894692
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Anus Diseases
DESCRIPTOR: Condylomata Acuminata
AUTHOR: S Sultan S
AFFILIATION: Service de Coloproctologie, Hôpital des Diaconesses, 18, rue du Sergent-Bauchat, F 75012 Paris.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal de chirurgie.
COUNTRY: France
TITLE: [Anal condyloma: its management is still difficult]
PUBDATE: 20011001
Anal condylomas result from papillomavirus infection, the most common sexually transmitted disease. The principal risk is the development of cancer of the anal canal. The risk of contamination is high, even after a single sexual contact. No specific antiviral treatment is available and no consensus has been reached on the appropriate treatment of anal condylomas. Despite the development of various methods (interferon, imiquimod), electrocoagulation remains the treatment of choice. Finally, regular follow-up and treatment of the partner(s) are essential.


5. DOCID:22670 SCORE: 0.00501579769632002
DOCNO: 8037519
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ambulatory Care
DESCRIPTOR: Mediastinoscopy
QUALIFIER: pathology
AUTHOR: I J Cybulsky IJ
AUTHOR: W F Bennett WF
AFFILIATION: Department of Surgery, McMaster University, St. Joseph's Hospital, Hamilton, Ontario, Canada.
PUBTYPE: Journal Article
JOURNALTITLE: The Annals of thoracic surgery.
COUNTRY: UNITED STATES
TITLE: Mediastinoscopy as a routine outpatient procedure.
PUBDATE: 19940701
We reviewed our experience performing mediastinoscopy as an outpatient procedure. From January 1, 1987, to December 31, 1992, 1,015 of 1,062 cervical mediastinoscopies were performed on an outpatient basis. There were no operative deaths. Complications developed in 14 patients, 10 of whom required hospitalization. Two additional patients were hospitalized for social reasons. Supraventricular arrhythmia was the most frequent complication requiring admission to the hospital. This article documents the ability to perform mediastinoscopy safely as an outpatient procedure and discusses why this is our preferred approach in managing patients with lung cancer.


6. DOCID:26228 SCORE: 0.00500703306504518
DOCNO: 10753784
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: J Jiricny J
AUTHOR: M Nyström-Lahti M
AFFILIATION: Institute of Medical Radiobiology of the University of Zürich, Paul Scherrer Institute, Zürich, CH-8008, Switzerland. jiricny@imr.unizh. ch
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in genetics & development.
COUNTRY: ENGLAND
TITLE: Mismatch repair defects in cancer.
PUBDATE: 20000401
Post-replicative mismatch repair in humans utilises the hMSH2, hMSH6, hMSH3, hMLH1 and hPMS2 genes and possibly the newly identified hMLH3 gene. Recently, a link has been established between hMSH6 mutations and 'atypical' hereditary non-polyposis colon cancer (HNPCC) with an increased incidence of endometrial cancers. To satisfy the need for a diagnostic test capable of differentiating between pathogenic mutations and polymorphisms, several functional assays that fulfil these criteria have been described. These should allow for better diagnosis of HNPCC.


7. DOCID:19209 SCORE: 0.00472785667722608
DOCNO: 1306436
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: X M Cui XM
AFFILIATION: School of Stomatology, Beijing Medical University.
PUBTYPE: Journal Article
JOURNALTITLE: Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology.
COUNTRY: CHINA
TITLE: [Effect of connective tissues underlying precancerous lesions combined with epithelia separated from normal mucosa]
PUBDATE: 19920901
The connective tissues underlying the precancerous changes of the epithelia were separated and combined with the epithelia which were separated from the normal mucosa. The combinations were transplanted in nude mice. Specimens were taken at 6 and 10 weeks after transplantation and routinely processed for microscopic examination. The results show that the connective tissue underlying epithelial dysplasia may induce the normal epithelium undergoing epithelial dysplasia changes. The experiment demonstrates the etiological importance of the connective tissue in the development of cancer, and may be applied clinically in the treatment of precancerous lesions.


8. DOCID:31312 SCORE: 0.00463360188472928
DOCNO: 12479113
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Therapy
QUALIFIER: therapy
AUTHOR: Qing-li Li QL
AUTHOR: Zhi-lan Peng ZL
AUTHOR: He Wang H
AFFILIATION: Department of Obstetrics and Gynecology, Second Hospital of West China, Sichuan University, Chengdu 610041, P. R. China.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Ai zheng = Aizheng = Chinese journal of cancer.
COUNTRY: China
TITLE: [Development of research for combined gene therapy and radiotherapy for cancer patients]
PUBDATE: 20020701
Cancer treatment is one of the most important fields in medical research. All strategies such as radiotherapy, chemotherapy, surgery, and gene-based therapy have their own advantage and disadvantages. Nowadays, a novel method which combined traditional therapy with gene therapy plays an important role in the field of cancer research. This review described the current state of combined therapies of gene-based and radiate radiotherapy. Meanwhile, we evaluated the prospect of this combined treatment.


9. DOCID:30163 SCORE: 0.0045241038005073
DOCNO: 15309517
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Aneuploidy
DESCRIPTOR: Chromosomal Instability
QUALIFIER: genetics
AUTHOR: Harith Rajagopalan H
AUTHOR: Christoph Lengauer C
AFFILIATION: Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, 1650 Orleans Street, Baltimore, MD 21231, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer chemotherapy and pharmacology.
COUNTRY: Germany
TITLE: CIN-ful cancers.
PUBDATE: 20040901
Aneuploidy has long been recognized to be a cardinal feature of many neoplasias. However, the role of aneuploidy in tumorigenesis continues to be a matter of debate. We believe that aneuploidy in cancers is the result of chromosomal instability, a process in which dividing cancer cells segregate their chromosomes with decreased fidelity. Here we discuss our definition of chromosomal instability, evidence for its causal role in tumor development, and suggestions regarding the mechanisms that initiate chromosomal instability in cancer cells.


10. DOCID:28362 SCORE: 0.00443575438548907
DOCNO: 15668160
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Models, Biological
QUALIFIER: metabolism
QUALIFIER: physiology
QUALIFIER: physiology
QUALIFIER: physiology
QUALIFIER: physiology
QUALIFIER: physiology
AUTHOR: Mariann Bienz M
AFFILIATION: MRC Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH UK. mb2@mrc-lmb.cam.ac.uk
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current biology : CB.
COUNTRY: England
TITLE: beta-Catenin: a pivot between cell adhesion and Wnt signalling.
PUBDATE: 20050101
Mutual adhesion of animal cells is intimately linked to Wnt signaling through a shared component: beta-catenin, or Armadillo in Drosophila. Recent work indicates how beta-catenin shifts from cell adhesion to Wnt signaling, a switch associated with epithelial-mesenchymal transitions and cancer.


11. DOCID:21409 SCORE: 0.00442374934917349
DOCNO: 8055280
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: D P Kelsen DP
AFFILIATION: Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Chest surgery clinics of North America.
COUNTRY: UNITED STATES
TITLE: The role of chemotherapy in the treatment of esophageal cancer.
PUBDATE: 19940201
Esophageal cancer is a highly virulent malignancy with a poor prognosis. Adenocarcinomas of the proximal stomach and lower esophagus are rapidly increasing in incidence; the reasons for this remain unclear. Both epidermoid and adenocarcinomas have high local and distant failure rates when treated with conventional therapy. New developments in chemotherapy both in the neoadjuvant and advanced disease settings are under intense investigation in an attempt to improve the prognosis of esophageal cancer.


12. DOCID:18780 SCORE: 0.00436995355179419
DOCNO: 12797274
OWNER: NLM
STATUS: PubMed-not-MEDLINE
AUTHOR: B Breyer B
AUTHOR: A Despot A
AUTHOR: M Predanic M
AUTHOR: S Judin S
AFFILIATION: Gynaecological Cancer Centre, Petrova 13, Zagreb, Croatia.
PUBTYPE: Journal Article
JOURNALTITLE: Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology.
COUNTRY: England
TITLE: Characteristics of blood flow in cancer of the uterine cervix.
PUBDATE: 19930701
Blood flow characteristics were measured in patients with histologically proved cervical cancer and compared to normal values. Flow parameters were derived by color and pulsed Doppler ultrasound. The results showed a significant difference in the mean values of resistance index and pulsatility index among the diseased patients and healthy controls. However, the method does not have the required sensitivity for screening purposes, so that its value may mainly be in the follow-up of patients treated conservatively with radiation and chemotherapy.


13. DOCID:25465 SCORE: 0.00435838926009138
DOCNO: 11071453
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: therapy
AUTHOR: T Kakizoe T
AFFILIATION: National Cancer Center Hospital, Tokyo, Japan. tkakizoe@ncc.go.jp
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: World journal of surgery.
COUNTRY: UNITED STATES
TITLE: Urologic oncology in the twenty-first century.
PUBDATE: 20001001
The perspective of urologic oncology in the twenty-first century is presented regarding detection, treatment, and prevention of cancer. There is increasing importance of a cancer information network. Biotechnology and medical engineering based on advances in computer science will be the two key technologies related to such advancement. Ethical, legal, social, and economic issues provoked by the technologic advances will increase in gravity at the same time. Balancing humans in terms of scientific technologic developments and state of mind will be a serious issue.


14. DOCID:23819 SCORE: 0.0043559044978194
DOCNO: 9051130
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: S Ozono S
AUTHOR: E Okajima E
AUTHOR: K Takashima K
AUTHOR: K Yoshida K
AUTHOR: Y Hirao Y
AFFILIATION: Dept. of Urology, Nara Medical University, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Urological emergency for cancer patients]
PUBDATE: 19970201
We summarized here the urological emergency status accompanied by cancer, such as urinary obstruction, bleeding and renal failure. Hydronephrosis occurs due to obstructive change and post-renal failure finally results after complete obstruction of bilateral ureters. Patients with obstructive disease are treated with percutaneous nephrostomy or indwelling double-J catheter. Bladder tamponade develops after bleeding of the urinary tract. Patients with bleeding are treated by bladder irrigation or transcatheter arterial embolization. Acute renal failure (ARF) includes pre-renal ARF, renal ARF and post-renal ARF, necessitating emergency hemodialysis. The emergency status can be often observed simultaneously, so careful examination and rapid treatment are necessary.