0. DOCID:11402 SCORE: 0.00663826665632343
DOCNO: 6834959
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: F Bagatella F
AUTHOR: L Bignardi L
PUBTYPE: Journal Article
JOURNALTITLE: The Laryngoscope.
COUNTRY: UNITED STATES
TITLE: Behavior of cancer at the anterior commissure of the larynx.
PUBDATE: 19830301
The present research is concerned with the behavior of the vestibular cancer with respect to the portion of the anterior commissure of the larynx which the authors have named the "x-space." The research is based on the analysis of semiseriated vertical sections showing cancers of the vestibule in stages T1 and T2 with histological gradings 1 and 2. The specimens show that, at least in the early stages of the neoplastic spread, the fibrous structures of the x-space act as a fairly effective barrier to deep diffusion of the tumor. This fact enables the surgeon to estimate macroscopically the lower borders of the tumor growth on the basis of the superficial spread of the cancer in the zone of the x-space.

1. DOCID:11739 SCORE: 0.00615957664938829
DOCNO: 2992746
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: etiology
QUALIFIER: secondary
AUTHOR: B I Carr BI
AUTHOR: R Goodkin R
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Breast cancer with osseous metastasis and herniated lumbar disc. A cautionary tale.
PUBDATE: 19851001
A 39-year-old white woman with breast cancer, metastatic to her skeleton, developed low back and left lower extremity pain and lower extremity weakness. A bone scan evidenced increased radioisotope activity in her lumbar spine and a computed tomography (CT) scan showed a lesion of the L4 vertebra. Because of myelographic findings of a extradural defect at the L4-5 disc space and the possibility of a herniated disc causing the patient's pain and neurologic deficit in her lower extremities, the patient underwent surgery and a large herniated L4-5 disc was removed. As a consequence, the patient experienced relief of the lower extremity pain and return of strength in her lower extremities. She died a considerable time later from refractory hypercalcemia.

2. DOCID:7670 SCORE: 0.00614439490305055
DOCNO: 6154531
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: enzymology
QUALIFIER: enzymology
AUTHOR: C H Chang CH
AUTHOR: D Angellis D
AUTHOR: W H Fishman WH
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Presence of the rare D-variant heat-stable, placental-type alkaline phosphatase in normal human testis.
PUBDATE: 19800501
In 11 adult testes studied, about 0.3 to 4.6% of the total alkaline phosphatase activity was heat stable and L-phenylalanine sensitive but L-homoarginine insensitive. The testicular heat-stable enzyme was more susceptible to inhibition by L-leucine and ethylenediaminetetraacetate than were the normal placental and intestinal enzymes. By antibody-directed enzyme inhibition test, the testicular heat-stable enzyme cross-reacted completely with normal placental enzyme but clearly distinguished itself from a heat-stable component of normal intestinal enzyme. Thus, placental alkaline phosphatase D-variant is synthesized in testis, indicating that the gene for elaborating this placental protein is probably already active in the testicular cells. The high incidence of this protein in cancers of testis and ovary is probably due to its increased production by gonadal genes present in the genome of these particular tumors.

3. DOCID:3912 SCORE: 0.00572301893605062
DOCNO: 591172
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Labor Unions
DESCRIPTOR: Mortality
AUTHOR: B Jeune B
PUBTYPE: Journal Article
JOURNALTITLE: International journal of epidemiology.
COUNTRY: ENGLAND
TITLE: Mortality of male members of the Danish Semi-skilled Unskilled Workers' Union in 1973.
PUBDATE: 19770901
The purpose of this cross-sectional study is to evaluate contemporary age and cause specific mortalities of a large group of employed men. The population is the 228,612 male members, aged 20-64, of Denmark's largest trade union, the Semi-skilled and Unskilled Workers' Union (SID). A Standard Mortality Ratio (SMR) of 93.9 compared to all men in Denmark is found. However, the distribution of mortality by age does not resemble that found in many other studies, and is usually said to result from the 'healthy worker effect'. Excess mortality is found in the younger age groups, while the opposite is the case in the older groups, mainly because of a deficit of deaths from chronic illness. Notably higher age and cause specific SMRs are found for violent and unnatural deaths, and higher SMRs for cancer of the lungs and of lymphatic and haemopoietic tissues. Regional variations are found, but no correlation found between mortality and size of union 'local'. However, cancer mortality is higher among members of specialized locals, which are situated in larger urban area. The excess mortality of members of the largest locals in the Copenhagen area is due to deaths by cancer and by violent and unnatural causes. Findings and problems will be examined further in an ongoing cohort study and in other specialized studies under preparation.

4. DOCID:10980 SCORE: 0.00525544630899532
DOCNO: 7044682
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
AUTHOR: J F Cade JF
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Critical care medicine.
COUNTRY: UNITED STATES
TITLE: High risk of the critically ill for venous thromboembolism.
PUBDATE: 19820701
The incidence of deep venous thrombosis of the legs (DVT) was studied in 119 critically ill patients by 125I-labeled fibrinogen scanning; the efficacy of low-dose heparin prophylaxis was assessed in a randomized, double-blind study. DVT occurred in 29% of control patients and in 13% of patients receiving heparin 5000 U subcutaneously twice daily. DVT was found mainly in men and was associated with circulatory impairment, respiratory failure and recent vascular or cancer surgery. In a comparison study of medical patients, DVT occurred in 10% untreated and 2% treated. In conclusion, the critically ill are at high risk of venous thromboembolism and low-dose prophylaxis is warranted in those who have no hemostatic impairment.

5. DOCID:14475 SCORE: 0.0052201517872044
DOCNO: 2586859
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Health Status Indicators
DESCRIPTOR: Housing
QUALIFIER: chemically induced
QUALIFIER: adverse effects
AUTHOR: S Loken S
AUTHOR: T Loken T
AFFILIATION: Salt Lake City Veterans Administration Medical Center, Utah.
PUBTYPE: Journal Article
JOURNALTITLE: The Nurse practitioner.
COUNTRY: UNITED STATES
TITLE: Radon: detection and treatment.
PUBDATE: 19891101
Within the last few years, natural radon exposure in non-industrial settings, primarily homes, has become a health concern. Research has demonstrated that many homes throughout the United States have radon concentrations much higher than the legal federal limits set for miners. Thousands of unsuspecting people are being exposed to high levels of radiation. It is estimated that up to 15 percent of lung cancers are caused from radon. This is a significant health risk. With basic knowledge of the current information on radon, a primary health care provider can address patients' radon concerns and make appropriate referrals.

6. DOCID:13871 SCORE: 0.00499270028767608
DOCNO: 3549189
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Suture Techniques
QUALIFIER: surgery
QUALIFIER: methods
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: mortality
AUTHOR: R Bittner R
AUTHOR: M Butters M
AUTHOR: R Roscher R
AUTHOR: H G Beger HG
PUBTYPE: Journal Article
JOURNALTITLE: Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen.
COUNTRY: GERMANY, WEST
TITLE: [Esophagojejunostomy--how safe is manual suture today?]
PUBDATE: 19870101
Between 1982 and 1986 a total of 137 patients were gastrectomized for cancer of the stomach. The esophago-jejunal anastomosis was always carried out as an end-to-side anastomosis applying the conventional two layer technique. Only in 1 patient (0.7%) an insufficiency of this anastomosis was observed; 9 reoperations (6.6%) were necessary and 3 patients (2.2%) died in the postoperative course. These results confirm that with a precise, standardised conventional suture technique the esophageal anastomosis can be safely performed today.

7. DOCID:5964 SCORE: 0.0049888752171495
DOCNO: 7436270
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: diagnosis
AUTHOR: J H Cochran JH
AUTHOR: W E Fee WE
PUBTYPE: Journal Article
JOURNALTITLE: Annals of plastic surgery.
COUNTRY: UNITED STATES
TITLE: Metastasis in head and neck cancer, 1979.
PUBDATE: 19800501
Metastatic spread of head and neck cancer signifies a grave change in prognosis for the patient. The presence or absence of detectable metastasis is valuable knowledge both in planning treatment and in predicting prognosis. Knowledge of the metastatic behavior patterns of such tumors, and of the diagnostic means of detecting metastasis, is essential. The available knowledge on this problem is comprehensively reviewed to present, in a single source, the requisite knowledge for any physician treating head and neck cancer. Metastatic spread is reviewed according to incidence, detection methods, anatomical sites, and correlation with characteristics of the primary tumor. Finally, methods of detecting metastasis are reviewed and a practical approach to patient evaluation recommended.

8. DOCID:10847 SCORE: 0.00493596331539456
DOCNO: 6805770
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: economics
QUALIFIER: psychology
AUTHOR: P Maguire P
AUTHOR: A Pentol A
AUTHOR: D Allen D
AUTHOR: A Tait A
AUTHOR: M Brooke M
AUTHOR: R Sellwood R
PUBTYPE: Journal Article
JOURNALTITLE: British medical journal (Clinical research ed.)
COUNTRY: ENGLAND
TITLE: Cost of counselling women who undergo mastectomy.
PUBDATE: 19820601
The psychiatric morbidity associated with mastectomy and brest cancer was substantially reduced by a specialist nurse who counselled women before and after surgery and monitored their progress. A controlled study was, therefore, carried out to determine what this cost. National Health Service costs were almost wholly covered by savings made because counselled subjects who developed psychiatric problems were recognised and treated much earlier than control patients. Counselled and control subjects suffered considerable financial losses, but these were offset in the counselled group by their relatives' earlier return to work. Such counselling schemes are necessary and effective and may be implemented at little extra cost.

9. DOCID:5608 SCORE: 0.00470381789999918
DOCNO: 7304081
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: secondary
QUALIFIER: deficiency
QUALIFIER: metabolism
AUTHOR: R M Black RM
AUTHOR: G H Daniels GH
AUTHOR: C H Coggins CH
AUTHOR: P R Mueller PR
AUTHOR: R E Data RE
AUTHOR: N Lichtenstein N
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Acta endocrinologica.
COUNTRY: DENMARK
TITLE: Adrenal insufficiency from metastatic colonic carcinoma masquerading as isolated aldosterone deficiency. Report of a case and review of the literature.
PUBDATE: 19811201
A case of adrenal insufficiency secondary to metastatic colonic carcinoma is reported. Because the patient was taking prednisone for an unrelated condition, his initial presentation mimicked isolated aldosterone deficiency with an elevated serum potassium of 8.7 mmol/l. Cortisol deficiency was documented by ACTH testing. The diagnosis of metastatic disease causing adrenal insufficiency was suspected after a computed body scan of the abdomen revealed marked bilateral adrenal enlargement. Adrenal insufficiency secondary to metastatic cancer is reviewed.

10. DOCID:10646 SCORE: 0.00463843588568093
DOCNO: 6754212
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: prevention & control
QUALIFIER: adverse effects
QUALIFIER: prevention & control
AUTHOR: H H Lucraft HH
AUTHOR: M K Palmer MK
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Clinical radiology.
COUNTRY: ENGLAND
TITLE: Randomised clinical trial of levonantradol and chlorpromazine in the prevention of radiotherapy-induced vomiting.
PUBDATE: 19821101
Levonantradol is a cannabis derivative. Cannabinoid anti-emetics are being assessed in cancer chemotherapy but have been little used in radiotherapy to date. A pilot study and randomised trial compared the anti-emetic effect of a standard drug (Chlorpromazine 26 mg) with Levonantradol at two doses (0.5 and 0.75 mg) in patients receiving palliative single fraction radiotherapy to sites likely to cause nausea and vomiting. Most patients were out-patients. Both drugs were well tolerated. The frequency of vomiting was similar in all three groups in both the pilot study and randomised trial.

11. DOCID:6511 SCORE: 0.00447604056669941
DOCNO: 219746
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: J B Michelson JB
AUTHOR: R F Stephens RF
AUTHOR: J A Shields JA
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Annals of ophthalmology.
COUNTRY: UNITED STATES
TITLE: Clinical conditions mistaken for metastatic cancer to the choroid.
PUBDATE: 19790201
Thirteen patients who were referred to the Oncology Unit with the diagnosis of metastatic cancer to the choroid were studied and found to have other conditions. All of the patients were female. Nine of the 13 had a history of systemic cancer of which 6 were breast cancer. Five patients were currently being treated with chemotherapeutic agents for their systemic cancer. Three of the 13 patients had bilateral fundus lesions. The most common diagnostic entities confused with metastatic disease were either inflammatory or hemorrhagic lesions of the retina. The preceding history of cancer in the patient with a puzzling fundus lesion may predispose the referring ophthalmologist to suggest a diagnosis of metastatic cancer to the choroid.

12. DOCID:11684 SCORE: 0.00437612617714974
DOCNO: 6203754
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: R Wachner R
AUTHOR: C Wittekind C
AUTHOR: S von Kleist S
PUBTYPE: Journal Article
JOURNALTITLE: European journal of cancer & clinical oncology.
COUNTRY: ENGLAND
TITLE: Immunohistological localization of beta-HCG in breast carcinomas.
PUBDATE: 19840501
As reports about HCG positivity in serum or tissue of patients with breast cancer show divergent results, the present investigation was undertaken to study the frequency of positive staining for beta-HCG in breast cancer tissue and to correlate the staining pattern with the histology of the tumor and stage of disease. With the immunoperoxidase technique we studied 129 cases of breast carcinomas. We obtained a positive staining for beta-HCG in 12%. However, in most of the tumors only very few cells contained beta-HCG. Morphologically the positive cells could not be distinguished from beta-HCG-negative cells. We conclude from our data that until now the beta-HCG staining provides no immediate useful information for the management of patients.

13. DOCID:15583 SCORE: 0.0043265144637482
DOCNO: 2801597
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: R F Asbury RF
AUTHOR: J A Blessing JA
AUTHOR: P J DiSaia PJ
AUTHOR: J Malfetano J
AFFILIATION: Department of Medicine in Oncology, University of Rochester School of Medicine, New York.
PUBTYPE: Journal Article
JOURNALTITLE: American journal of clinical oncology : the official publication of the American Radium Society.
COUNTRY: UNITED STATES
TITLE: Aminothiadiazole (NSC 4728) in patients with advanced nonsquamous carcinoma of the cervix. A phase II study of the Gynecologic Oncology Group.
PUBDATE: 19891001
Twenty-six evaluable patients with advanced nonsquamous cell cervical cancer were treated with aminothiadiazole at a dosage of 125 mg/m2 weekly. Sixteen had received prior chemotherapy. Two patients had complete responses neither had received prior chemotherapy; nine had stable disease; 15 had increasing disease. There was a single life-threatening toxic episode. Aminothiadiazole used in this dosage and schedule has minimal activity in previously treated patients with nonsquamous cell carcinoma.

14. DOCID:10048 SCORE: 0.00432540724582389
DOCNO: 6722009
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapeutic use
AUTHOR: A Nethersell A
AUTHOR: H Smedley H
AUTHOR: M Katrak M
AUTHOR: T Wheeler T
AUTHOR: K Sikora K
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: ENGLAND
TITLE: Recombinant interferon in advanced breast cancer.
PUBDATE: 19840501
Fifteen patients with locally advanced refractory breast cancer have been treated with recombinant leucocyte interferon ( rIFN -alpha A) for up to 12 weeks. Toxicity was considerable with the initial dosage schedule employed but became acceptable after reducing the starting dose by 50%. Minor side effects occurred in all patients and major CNS toxicity in six. Nine patients showed some evidence of tumour regression at 4 weeks. Only two of these were still responding at 12 weeks. Response was unrelated to the length of previous history, oestrogen receptor status or previous responsiveness to cytotoxic or hormone therapy.