0. DOCID:18826 SCORE: 0.00754796004068924
DOCNO: 1699401
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: analogs & derivatives
AUTHOR: D D Von Hoff DD
AUTHOR: S Green S
AUTHOR: E A Surwit EA
AUTHOR: E V Hannigan EV
AUTHOR: D S Alberts DS
AFFILIATION: University of Texas Health Science Center, San Antonio 78284-7884.
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Multicenter Study
JOURNALTITLE: American journal of clinical oncology : the official publication of the American Radium Society.
COUNTRY: UNITED STATES
TITLE: Phase II study of fludarabine phosphate (NSC 312887) in patients with advanced cervical cancer. A Southwest Oncology Group study.
PUBDATE: 19901001
Twenty evaluable patients with advanced cervical cancer refractory to one prior chemotherapy regimen were treated with a 5-day schedule of fludarabine phosphate. No responses were noted. The major toxicities were anemia and leukopenia. Based on this study, fludarabine phosphate does not appear to be an active agent for patients with chemotherapy refractory cervical cancer.

1. DOCID:23272 SCORE: 0.00702810438039374
DOCNO: 7900710
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: adverse effects
QUALIFIER: therapy
QUALIFIER: etiology
AUTHOR: R Mudad R
AUTHOR: A Hussein A
AUTHOR: W P Peters WP
AFFILIATION: Department of Hematology-Oncology, Duke University Medical Center, Durham, North Carolina 27710.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: American journal of clinical oncology : the official publication of the American Radium Society.
COUNTRY: UNITED STATES
TITLE: Guillain-Barre syndrome following autologous bone marrow transplantation.
PUBDATE: 19950401
The pathogenesis of the Guillain-Barre syndrome (GBS) is felt to involve alterations in cellular and humoral immune responses. We report the case of a 44-year-old female with stage IV breast cancer who developed GBS 2 days after receiving high dose chemotherapy with bone marrow and peripheral progenitor cell support, and granulocyte-macrophage colony stimulating factor (GM-CSF). Her clinical status stabilized with plasmapheresis. This report lends further support to hypotheses regarding cellular immune alterations in the pathogenesis of GBS.

2. DOCID:11402 SCORE: 0.00663826665632343
DOCNO: 6834959
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: F Bagatella F
AUTHOR: L Bignardi L
PUBTYPE: Journal Article
JOURNALTITLE: The Laryngoscope.
COUNTRY: UNITED STATES
TITLE: Behavior of cancer at the anterior commissure of the larynx.
PUBDATE: 19830301
The present research is concerned with the behavior of the vestibular cancer with respect to the portion of the anterior commissure of the larynx which the authors have named the "x-space." The research is based on the analysis of semiseriated vertical sections showing cancers of the vestibule in stages T1 and T2 with histological gradings 1 and 2. The specimens show that, at least in the early stages of the neoplastic spread, the fibrous structures of the x-space act as a fairly effective barrier to deep diffusion of the tumor. This fact enables the surgeon to estimate macroscopically the lower borders of the tumor growth on the basis of the superficial spread of the cancer in the zone of the x-space.

3. DOCID:11739 SCORE: 0.00615957664938829
DOCNO: 2992746
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: complications
QUALIFIER: etiology
QUALIFIER: secondary
AUTHOR: B I Carr BI
AUTHOR: R Goodkin R
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Breast cancer with osseous metastasis and herniated lumbar disc. A cautionary tale.
PUBDATE: 19851001
A 39-year-old white woman with breast cancer, metastatic to her skeleton, developed low back and left lower extremity pain and lower extremity weakness. A bone scan evidenced increased radioisotope activity in her lumbar spine and a computed tomography (CT) scan showed a lesion of the L4 vertebra. Because of myelographic findings of a extradural defect at the L4-5 disc space and the possibility of a herniated disc causing the patient's pain and neurologic deficit in her lower extremities, the patient underwent surgery and a large herniated L4-5 disc was removed. As a consequence, the patient experienced relief of the lower extremity pain and return of strength in her lower extremities. She died a considerable time later from refractory hypercalcemia.

4. DOCID:7670 SCORE: 0.00614439490305055
DOCNO: 6154531
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: enzymology
QUALIFIER: enzymology
AUTHOR: C H Chang CH
AUTHOR: D Angellis D
AUTHOR: W H Fishman WH
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Presence of the rare D-variant heat-stable, placental-type alkaline phosphatase in normal human testis.
PUBDATE: 19800501
In 11 adult testes studied, about 0.3 to 4.6% of the total alkaline phosphatase activity was heat stable and L-phenylalanine sensitive but L-homoarginine insensitive. The testicular heat-stable enzyme was more susceptible to inhibition by L-leucine and ethylenediaminetetraacetate than were the normal placental and intestinal enzymes. By antibody-directed enzyme inhibition test, the testicular heat-stable enzyme cross-reacted completely with normal placental enzyme but clearly distinguished itself from a heat-stable component of normal intestinal enzyme. Thus, placental alkaline phosphatase D-variant is synthesized in testis, indicating that the gene for elaborating this placental protein is probably already active in the testicular cells. The high incidence of this protein in cancers of testis and ovary is probably due to its increased production by gonadal genes present in the genome of these particular tumors.

5. DOCID:18634 SCORE: 0.00604349605673443
DOCNO: 1526834
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: M L Jekić ML
AUTHOR: I M Jekić IM
AFFILIATION: Klinisches Krankenhaus, Zemun-Belgrade, Jugoslawien.
PUBTYPE: Journal Article
JOURNALTITLE: Helvetica chirurgica acta.
COUNTRY: SWITZERLAND
TITLE: [Effect of chemotherapy on survival in advanced breast cancer]
PUBDATE: 19920501
Survival time of 119 consecutive patients with metastasizing carcinoma of the breast who had been treated with various chemotherapeutic schedules after radical operation was determined retrospectively. 57 women received chemotherapy and hormones, as well as radiotherapy, while 62 had radiotherapy plus hormone treatment. The mean prolongation of life in the former group over that of the latter was 12 months (p less than 0.01). Although chemotherapy delayed death, the dynamics of cancer were not fundamentally affected. The chemotherapy-induced prolongation (2.5 months to five years) was independent of any risk, primary location of the metastases or age.

6. DOCID:3912 SCORE: 0.00572301893605062
DOCNO: 591172
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Labor Unions
DESCRIPTOR: Mortality
AUTHOR: B Jeune B
PUBTYPE: Journal Article
JOURNALTITLE: International journal of epidemiology.
COUNTRY: ENGLAND
TITLE: Mortality of male members of the Danish Semi-skilled Unskilled Workers' Union in 1973.
PUBDATE: 19770901
The purpose of this cross-sectional study is to evaluate contemporary age and cause specific mortalities of a large group of employed men. The population is the 228,612 male members, aged 20-64, of Denmark's largest trade union, the Semi-skilled and Unskilled Workers' Union (SID). A Standard Mortality Ratio (SMR) of 93.9 compared to all men in Denmark is found. However, the distribution of mortality by age does not resemble that found in many other studies, and is usually said to result from the 'healthy worker effect'. Excess mortality is found in the younger age groups, while the opposite is the case in the older groups, mainly because of a deficit of deaths from chronic illness. Notably higher age and cause specific SMRs are found for violent and unnatural deaths, and higher SMRs for cancer of the lungs and of lymphatic and haemopoietic tissues. Regional variations are found, but no correlation found between mortality and size of union 'local'. However, cancer mortality is higher among members of specialized locals, which are situated in larger urban area. The excess mortality of members of the largest locals in the Copenhagen area is due to deaths by cancer and by violent and unnatural causes. Findings and problems will be examined further in an ongoing cohort study and in other specialized studies under preparation.

7. DOCID:21018 SCORE: 0.0055106568794904
DOCNO: 9262042
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: secondary
QUALIFIER: etiology
QUALIFIER: therapy
QUALIFIER: etiology
QUALIFIER: therapy
AUTHOR: D Oneschuk D
AUTHOR: E Bruera E
AFFILIATION: Palliative Care Program, Grey Nuns Community Health Centre, Edmonton, Canada.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of pain and symptom management.
COUNTRY: UNITED STATES
TITLE: Successful management of multiple enterocutaneous fistulas in a patient with metastatic colon cancer.
PUBDATE: 19970801
Enterocutaneous fistula development is not uncommon in patients with advanced cancer and can be very challenging to manage. The authors present a case study of a patient with multiple enterocutaneous fistulas that developed in the setting of metastatic colon cancer. Assessment methods and interventions that permitted successful management are discussed with emphasis on the value of multidisciplinary care.

8. DOCID:10980 SCORE: 0.00525544630899532
DOCNO: 7044682
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
AUTHOR: J F Cade JF
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Critical care medicine.
COUNTRY: UNITED STATES
TITLE: High risk of the critically ill for venous thromboembolism.
PUBDATE: 19820701
The incidence of deep venous thrombosis of the legs (DVT) was studied in 119 critically ill patients by 125I-labeled fibrinogen scanning; the efficacy of low-dose heparin prophylaxis was assessed in a randomized, double-blind study. DVT occurred in 29% of control patients and in 13% of patients receiving heparin 5000 U subcutaneously twice daily. DVT was found mainly in men and was associated with circulatory impairment, respiratory failure and recent vascular or cancer surgery. In a comparison study of medical patients, DVT occurred in 10% untreated and 2% treated. In conclusion, the critically ill are at high risk of venous thromboembolism and low-dose prophylaxis is warranted in those who have no hemostatic impairment.

9. DOCID:14475 SCORE: 0.0052201517872044
DOCNO: 2586859
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Health Status Indicators
DESCRIPTOR: Housing
QUALIFIER: chemically induced
QUALIFIER: adverse effects
AUTHOR: S Loken S
AUTHOR: T Loken T
AFFILIATION: Salt Lake City Veterans Administration Medical Center, Utah.
PUBTYPE: Journal Article
JOURNALTITLE: The Nurse practitioner.
COUNTRY: UNITED STATES
TITLE: Radon: detection and treatment.
PUBDATE: 19891101
Within the last few years, natural radon exposure in non-industrial settings, primarily homes, has become a health concern. Research has demonstrated that many homes throughout the United States have radon concentrations much higher than the legal federal limits set for miners. Thousands of unsuspecting people are being exposed to high levels of radiation. It is estimated that up to 15 percent of lung cancers are caused from radon. This is a significant health risk. With basic knowledge of the current information on radon, a primary health care provider can address patients' radon concerns and make appropriate referrals.

10. DOCID:25641 SCORE: 0.00502790731650289
DOCNO: 11894692
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Anus Diseases
DESCRIPTOR: Condylomata Acuminata
AUTHOR: S Sultan S
AFFILIATION: Service de Coloproctologie, Hôpital des Diaconesses, 18, rue du Sergent-Bauchat, F 75012 Paris.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal de chirurgie.
COUNTRY: France
TITLE: [Anal condyloma: its management is still difficult]
PUBDATE: 20011001
Anal condylomas result from papillomavirus infection, the most common sexually transmitted disease. The principal risk is the development of cancer of the anal canal. The risk of contamination is high, even after a single sexual contact. No specific antiviral treatment is available and no consensus has been reached on the appropriate treatment of anal condylomas. Despite the development of various methods (interferon, imiquimod), electrocoagulation remains the treatment of choice. Finally, regular follow-up and treatment of the partner(s) are essential.

11. DOCID:22670 SCORE: 0.00501579769632002
DOCNO: 8037519
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Ambulatory Care
DESCRIPTOR: Mediastinoscopy
QUALIFIER: pathology
AUTHOR: I J Cybulsky IJ
AUTHOR: W F Bennett WF
AFFILIATION: Department of Surgery, McMaster University, St. Joseph's Hospital, Hamilton, Ontario, Canada.
PUBTYPE: Journal Article
JOURNALTITLE: The Annals of thoracic surgery.
COUNTRY: UNITED STATES
TITLE: Mediastinoscopy as a routine outpatient procedure.
PUBDATE: 19940701
We reviewed our experience performing mediastinoscopy as an outpatient procedure. From January 1, 1987, to December 31, 1992, 1,015 of 1,062 cervical mediastinoscopies were performed on an outpatient basis. There were no operative deaths. Complications developed in 14 patients, 10 of whom required hospitalization. Two additional patients were hospitalized for social reasons. Supraventricular arrhythmia was the most frequent complication requiring admission to the hospital. This article documents the ability to perform mediastinoscopy safely as an outpatient procedure and discusses why this is our preferred approach in managing patients with lung cancer.

12. DOCID:26228 SCORE: 0.00500703306504518
DOCNO: 10753784
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: J Jiricny J
AUTHOR: M Nyström-Lahti M
AFFILIATION: Institute of Medical Radiobiology of the University of Zürich, Paul Scherrer Institute, Zürich, CH-8008, Switzerland. jiricny@imr.unizh. ch
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in genetics & development.
COUNTRY: ENGLAND
TITLE: Mismatch repair defects in cancer.
PUBDATE: 20000401
Post-replicative mismatch repair in humans utilises the hMSH2, hMSH6, hMSH3, hMLH1 and hPMS2 genes and possibly the newly identified hMLH3 gene. Recently, a link has been established between hMSH6 mutations and 'atypical' hereditary non-polyposis colon cancer (HNPCC) with an increased incidence of endometrial cancers. To satisfy the need for a diagnostic test capable of differentiating between pathogenic mutations and polymorphisms, several functional assays that fulfil these criteria have been described. These should allow for better diagnosis of HNPCC.

13. DOCID:13871 SCORE: 0.00499270028767608
DOCNO: 3549189
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Suture Techniques
QUALIFIER: surgery
QUALIFIER: methods
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: mortality
AUTHOR: R Bittner R
AUTHOR: M Butters M
AUTHOR: R Roscher R
AUTHOR: H G Beger HG
PUBTYPE: Journal Article
JOURNALTITLE: Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen.
COUNTRY: GERMANY, WEST
TITLE: [Esophagojejunostomy--how safe is manual suture today?]
PUBDATE: 19870101
Between 1982 and 1986 a total of 137 patients were gastrectomized for cancer of the stomach. The esophago-jejunal anastomosis was always carried out as an end-to-side anastomosis applying the conventional two layer technique. Only in 1 patient (0.7%) an insufficiency of this anastomosis was observed; 9 reoperations (6.6%) were necessary and 3 patients (2.2%) died in the postoperative course. These results confirm that with a precise, standardised conventional suture technique the esophageal anastomosis can be safely performed today.

14. DOCID:5964 SCORE: 0.0049888752171495
DOCNO: 7436270
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: diagnosis
AUTHOR: J H Cochran JH
AUTHOR: W E Fee WE
PUBTYPE: Journal Article
JOURNALTITLE: Annals of plastic surgery.
COUNTRY: UNITED STATES
TITLE: Metastasis in head and neck cancer, 1979.
PUBDATE: 19800501
Metastatic spread of head and neck cancer signifies a grave change in prognosis for the patient. The presence or absence of detectable metastasis is valuable knowledge both in planning treatment and in predicting prognosis. Knowledge of the metastatic behavior patterns of such tumors, and of the diagnostic means of detecting metastasis, is essential. The available knowledge on this problem is comprehensively reviewed to present, in a single source, the requisite knowledge for any physician treating head and neck cancer. Metastatic spread is reviewed according to incidence, detection methods, anatomical sites, and correlation with characteristics of the primary tumor. Finally, methods of detecting metastasis are reviewed and a practical approach to patient evaluation recommended.