0. DOCID:31507 SCORE: 0.00335905761712167
DOCNO: 15776005
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immune Tolerance
DESCRIPTOR: Tumor Escape
QUALIFIER: immunology
AUTHOR: Weiping Zou W
AFFILIATION: Tulane University Health Sciences Center, Section of Hematology and Medical Oncology, 1430 Tulane Avenue, New Orleans, Louisiana 70112-2699, USA. wzou@tulane.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nature reviews. Cancer.
COUNTRY: England
TITLE: Immunosuppressive networks in the tumour environment and their therapeutic relevance.
PUBDATE: 20050401
It is well known that many tumours are potentially immunogenic, as corroborated by the presence of tumour-specific immune responses in vivo. Nonetheless, spontaneous clearance of established tumours by endogenous immune mechanisms is rare. Therefore, the focus of most cancer immunotherapies is to supplement essential immunogenic elements to boost tumour-specific immunity. Why then has tumour immunotherapy resulted in a generally poor clinical efficiency? The reason might lie in the increasingly documented fact that tumours develop diverse strategies that escape tumour-specific immunity.
1. DOCID:31377 SCORE: 0.00313100106558988
DOCNO: 15770817
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: etiology
QUALIFIER: drug therapy
AUTHOR: A Zouhair A
AUTHOR: P H Wiesel PH
AFFILIATION: Service de radio-oncologie, CHUV, 1011 Lausanne.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Revue médicale suisse.
COUNTRY: Switzerland
TITLE: [Non-surgical treatment of acute and late radiation proctitis]
PUBDATE: 20050101
Pelvic external radiotherapy with or without brachytherapy plays an important role in the management of pelvic cancers. Despite recent technical innovations including conformal three-dimensional (3D) external beam radiotherapy and more recently intensity modulated radiotherapy (IMRT), local side effects can occur secondary to normal tissue damage caused by ionising radiation. Morbidity depends on the anatomic position of the rectum within the pelvis and the fast turnover rate of the mucosa, as well as the characteristics of the radiation treatment and patient co-morbidities. Medical management is sometimes complex and merits herein a short review.
2. DOCID:31864 SCORE: 0.00283835906369146
DOCNO: 16224168
OWNER: NLM
STATUS: In-Process
AUTHOR: Sung Ho Song SH
AUTHOR: Ick Jang I
AUTHOR: Bum Sik Kim BS
AUTHOR: Eun Tak Kim ET
AUTHOR: Seung-Hyo Woo SH
AUTHOR: Mee Ja Park MJ
AUTHOR: Chang Nam Kim CN
AFFILIATION: Department of Urology, Eulji Medical University, Daejeon, Korea.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Journal of Korean medical science.
COUNTRY: Korea (South)
TITLE: A case of primary syphilis in the rectum.
PUBDATE: 20051001
A 30-yr-old man was referred for suspicious rectal cancer because of ulcerated lesions in the rectum and a palpable mass in left inguinal area. Sigmoidoscopy showed two indurated masses and histologic evaluation of biopsy revealed obliterative endarteritis with heavy plasma cell infiltration. Both venereal disease research laboratories (VDRL) and fluorescent treponemal antibody absorption (FTA-ABS) tests were positive. After injection of penicillin G benzathine for 3 weeks, the rectal chancre and the palpable mass disappeared.
3. DOCID:31514 SCORE: 0.00276781669502462
DOCNO: 15517115
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
AUTHOR: J Weitz J
AUTHOR: M Koch M
AUTHOR: J Kleeff J
AUTHOR: M W Müller MW
AUTHOR: J Schmidt J
AUTHOR: H Friess H
AUTHOR: M W Büchler MW
AFFILIATION: Abteilung für Allgemein-, Visceral- und Unfallchirurgie, Chirurgische Universitätsklinik Heidelberg.
PUBTYPE: Journal Article
JOURNALTITLE: Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen.
COUNTRY: Germany
TITLE: [Kausch-Whipple pancreaticoduodenectomy. Technique and results]
PUBDATE: 20041101
The Kausch-Whipple operation is the standard procedure for resection of pancreatic head cancer, distal bile duct cancer, and periampullary cancers. It is also used for some cases of chronic pancreatitis. Traditionally, this operation is associated with high perioperative morbidity and mortality. The aim of our study was to present our current technique for Kausch-Whipple pancreaticoduodenectomy and to demonstrate that acceptable perioperative and long-term outcomes can be achieved by a standardised technique in a high-volume centre.
4. DOCID:30735 SCORE: 0.00275815881213456
DOCNO: 15013720
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Depsipeptides
QUALIFIER: analogs & derivatives
QUALIFIER: drug effects
QUALIFIER: drug effects
QUALIFIER: methods
QUALIFIER: drug therapy
QUALIFIER: genetics
AUTHOR: David S Schrump DS
AFFILIATION: Thoracic Oncology Section, Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland 20892, USA. david_Schrump@nih.gov
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Journal of surgical research.
COUNTRY: United States
TITLE: Genomic surgery for lung cancer.
PUBDATE: 20040301
An emerging body of literature indicates that reversible alterations in chromatin structure modulate gene expression during malignant transformation. Chromatin structure is regulated in part by DNA methylation and histone acetylation; these independent yet highly interrelated epigenetic processes are influenced by a variety of signal transduction pathways. The present review highlights recent advances regarding cancer epigenetics, focusing on the potential utilization of chromatin remodeling agents to induce apoptosis and enhance the immunogenicity of thoracic malignancies.
5. DOCID:30484 SCORE: 0.00264522668878192
DOCNO: 16139035
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapy
AUTHOR: Ricardo J Gonzalez RJ
AUTHOR: Paul F Mansfield PF
AFFILIATION: Department of Surgical Oncology, The University of Texas MD Anderson Cancer Center, Unit 444, 1515 Holcombe Boulevard, Houston, TX 77030-5235, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Surgical clinics of North America.
COUNTRY: United States
TITLE: Adjuvant and neoadjuvant therapy for gastric cancer.
PUBDATE: 20051001
Although the incidence of gastric cancer is decreasing, it remains a significant source of cancer-related mortality. Surgery remains the best chance for cure from gastric cancer. Adjuvant and neoadjuvant therapy have played increasing roles in attempting to reduce the disease-specific mortality and prolong survival. In this article, the authors review the literature and summarize the salient points regarding the roles of adjuvant and neoadjuvant therapy for gastric cancer.
6. DOCID:31802 SCORE: 0.00256576676034488
DOCNO: 12768868
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mammaplasty
DESCRIPTOR: Surgical Flaps
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: methods
AUTHOR: E Vandeweyer E
AFFILIATION: Plastic and Reconstructive Surgery Department, Clinique L. Cathy, Rue Louis Cathy, 136, 7331 Baudour. vandeweyere@skynet.be
PUBTYPE: Journal Article
JOURNALTITLE: Acta chirurgica Belgica.
COUNTRY: Belgium
TITLE: Peri-areolar skin-sparing mastectomy and immediate tram flap reconstruction.
PUBDATE: 20030401
The association of peri-areolar skin-sparing mastectomy with immediate autologous tissue breast reconstruction could be proposed to selected patients necessitating mastectomy to control their breast cancer. A prospective series of 14 consecutive patients were operated using this association and evaluated. Mean age at time of surgery was 52 years. Mean operating time for reconstruction was 163 minutes. There were two minor local complications, one needing secondary adaptation under local anaesthesia. Cosmetic result was judged good to excellent by all the patients with a mean follow-up of 13.2 months.
7. DOCID:29306 SCORE: 0.00253640323867324
DOCNO: 14679175
AUTHOR: Haiwei H Guo HH
AUTHOR: Lawrence A Loeb LA
AFFILIATION: Jospeh Gottstein Research Laboratory, Department of Pathology, University of Washington, Seattle 98195-7705, USA.
PUBTYPE: Comment
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Journal of clinical investigation.
COUNTRY: United States
TITLE: Tumbling down a different pathway to genetic instability.
PUBDATE: 20031201
Ulcerative colitis (UC), a chronic inflammatory condition associated with a predisposition to colon cancer, is frequently characterized by DNA damage in the form of microsatellite instability (MSI). A new report links inflammation in UC with increases in the DNA repair enzymes 3-methyladenine DNA glycosylase and apurinic/apyrimidinic endonuclease, and, paradoxically, with increased MSI. These findings may represent a novel mechanism contributing to MSI in chronic inflammation.
8. DOCID:31889 SCORE: 0.00250182419019691
DOCNO: 15315810
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: virology
QUALIFIER: virology
AUTHOR: Simon J Talbot SJ
AUTHOR: Dorothy H Crawford DH
AFFILIATION: Centre for Infectious Diseases, University of Edinburgh, R(D)SVS, Summerhall, Edinburgh EH9 1QH, UK. stalbot@ed.ac.uk
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: European journal of cancer (Oxford, England : 1990)
COUNTRY: England
TITLE: Viruses and tumours--an update.
PUBDATE: 20040901
In the 40 years since the publication of the article by Harris (Eur J Cancer 1965, 1, 183-188), considerable progress has been made towards the understanding of the contribution of infectious agents to the development of tumours. It is estimated that 15-20% of human malignancies may have an infectious aetiology. This article attempts to summarise the current level of our knowledge with respect to tumour-associated viruses, and to place this in the context of the earlier article by Harris (Eur J Cancer 1965, 1, 183-188).
9. DOCID:31251 SCORE: 0.00222819706760591
DOCNO: 15990060
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: methods
QUALIFIER: trends
QUALIFIER: diagnosis
AUTHOR: Linda S Lee LS
AUTHOR: John M Poneros JM
AFFILIATION: Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, MA 02114, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gastrointestinal endoscopy clinics of North America.
COUNTRY: United States
TITLE: New frontiers in endoscopic imaging.
PUBDATE: 20050701
Gastrointestinal (GI) tract malignancies have a tremendous impact on society. Colorectal cancer is the second leading cause of cancer death in the United States and accounts for 10% of all cancer deaths. Significant research efforts are being directed toward using the interaction of light and tissue to detect pre-cancerous lesions of the GI tract. This article reviews the current status of various experimental optical technologies to detect pre-cancerous changes in the GI tract and focuses on the clinical applications of these technologies for the practicing gastroenterologist.
10. DOCID:31761 SCORE: 0.00215186811580409
DOCNO: 15734683
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: physiology
QUALIFIER: physiology
QUALIFIER: physiology
QUALIFIER: physiology
AUTHOR: Judith Campisi J
AFFILIATION: Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA. jcampisi@lbl.gov
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cell.
COUNTRY: United States
TITLE: Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors.
PUBDATE: 20050201
Cells from organisms with renewable tissues can permanently withdraw from the cell cycle in response to diverse stress, including dysfunctional telomeres, DNA damage, strong mitogenic signals, and disrupted chromatin. This response, termed cellular senescence, is controlled by the p53 and RB tumor suppressor proteins and constitutes a potent anticancer mechanism. Nonetheless, senescent cells acquire phenotypic changes that may contribute to aging and certain age-related diseases, including late-life cancer. Thus, the senescence response may be antagonistically pleiotropic, promoting early-life survival by curtailing the development of cancer but eventually limiting longevity as dysfunctional senescent cells accumulate.
11. DOCID:31254 SCORE: 0.00211791400371439
DOCNO: 15886702
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: adverse effects
QUALIFIER: etiology
QUALIFIER: genetics
AUTHOR: C Lilla C
AUTHOR: T Koehler T
AUTHOR: S Kropp S
AUTHOR: S Wang-Gohrke S
AUTHOR: J Chang-Claude J
AFFILIATION: Division of Clinical Epidemiology, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, Heidelberg 69120, Germany.
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: England
TITLE: Alcohol dehydrogenase 1B (ADH1B) genotype, alcohol consumption and breast cancer risk by age 50 years in a German case-control study.
PUBDATE: 20050601
In a population-based study of 613 cases and 1082 controls, alcohol dehydrogenase 1B (ADH1B) genotype was not an independent risk factor for breast cancer, although the possibility was raised that it modifies risk associated with high levels of alcohol consumption (OR 1.1, 95% confidence interval (CI) 0.8-1.6 for ADH1B*1/*1 genotype vs 0.2, 95% CI 0.1-1.0 for ADH1B*2 carriers).
12. DOCID:31480 SCORE: 0.00210329625160665
DOCNO: 16310670
OWNER: NLM
STATUS: In-Process
AUTHOR: Carolyn Y Muller CY
AUTHOR: Harriet O Smith HO
AFFILIATION: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of New Mexico Health Sciences Center, 1 University of New Mexico, MSC 10 5580, Albuquerque, NM 87131, USA. cmuller@salud.unm.edu
PUBTYPE: Journal Article
JOURNALTITLE: Obstetrics and gynecology clinics of North America.
COUNTRY: United States
TITLE: Cervical neoplasia complicating pregnancy.
PUBDATE: 20051201
This article reviews the key concepts regarding the counseling and management of cervical dysplasia and invasive cervical cancer diagnosed during pregnancy. Emphasis is placed on balancing the maternal and fetal well-being in collaboration with appropriate multidisciplinary teams. Information regarding appropriate diagnosis strategies and the impact of delay in treatment, subsequent prognosis, and treatment algorithms are discussed. Novel fertility-sparing techniques for cervical cancer and their impact on complications of future pregnancies are also discussed.
13. DOCID:31619 SCORE: 0.00210329463864793
DOCNO: 16351679
OWNER: NLM
STATUS: In-Data-Review
AUTHOR: P Nix P
AUTHOR: A Nicolaides A
AUTHOR: A P Coatesworth AP
AFFILIATION: Department of Otolaryngology, Head and Neck Surgery, York, UK.
PUBTYPE: Journal Article
JOURNALTITLE: International journal of clinical practice.
COUNTRY: England
TITLE: Thyroid cancer review 2: management of differentiated thyroid cancers.
PUBDATE: 20051201
Summary This is the second review article on thyroid cancer dealing with the common differentiated types that comprise 90% of thyroid cancers. Despite clinical management guidelines offered by a number of organisations including the British Association of Otolaryngologists and Head and Neck Surgeon, The British Thyroid Association, The American Association Of Endocrinologists, The American Thyroid Association and the National Cancer Centre Network, debate regarding the management of differentiated thyroid cancer continues. This is because of the absence of good quality research evidence as a consequence of the natural history of this disease.
14. DOCID:29119 SCORE: 0.00209467688997907
DOCNO: 15522191
OWNER: NLM
STATUS: OLDMEDLINE
AUTHOR: Zhong-Qi Liu ZQ
AUTHOR: Yong-Quan Tian YQ
AFFILIATION: Department of Otolaryngology, Xiangya Hospital, Central South University, Changsha, Hunan 410 078, P.R. China.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Ai zheng = Aizheng = Chinese journal of cancer.
COUNTRY: China
TITLE: [Application and development of purification in cancer genomics research.]
PUBDATE: 20041101
In the study of cancer genomics, a series of purification methods have been invented to collect homogenous cells from heterogeneous cancerated tissue. Tissue microdissection methods, such as manual microdissection, mechanical microdissection, and laser technology, accelerated cancer genomics research. Each method holds both advantage and disadvantage, the selection of methods depends on the demands of study, and the instruments used in study.