0. DOCID:19009 SCORE: 0.00308829815111136
DOCNO: 8405372
AUTHOR: J Knowland J
AUTHOR: E A McKenzie EA
AUTHOR: P J McHugh PJ
AUTHOR: N A Cridland NA
AFFILIATION: Department of Biochemistry, South Parks Road, Oxford OX1 3QU, UK.
PUBTYPE: Journal Article
JOURNALTITLE: FEBS letters.
COUNTRY: NETHERLANDS
TITLE: Sunlight-induced mutagenicity of a common sunscreen ingredient.
PUBDATE: 19930601
We have tested the mutagenicity of a UV-B sunscreen ingredient called Padimate-O or octyl dimethyl PABA, which, chemically speaking, is identical to an industrial chemical that generates free radicals when illuminated. It is harmless in the dark but mutagenic in sunlight, attacking DNA directly. A commercial sunscreen containing Padimate-O behaves in the same way. UV-A in sunlight also excites Padimate-O, although less than UV-B. Some related compounds, including a known carcinogen, behave similarly. As mutagens may be carcinogenic, our results suggest that some sunscreens could, while preventing sunburn, contribute to sunlight-related cancers.

1. DOCID:16731 SCORE: 0.00297523861186542
DOCNO: 1967109
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: administration & dosage
QUALIFIER: administration & dosage
QUALIFIER: methods
QUALIFIER: administration & dosage
QUALIFIER: therapy
AUTHOR: J Brahm J
AUTHOR: J Chesta J
AUTHOR: V Gaínza V
AUTHOR: V Arriagada V
AFFILIATION: Centro de Gastroenterología, Universidad de Chile, Santiago.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Revista médica de Chile.
COUNTRY: CHILE
TITLE: [Selective chemoembolization with adriamycin-Urografin-Lipiodol in the treatment of hepatocarcinoma]
PUBDATE: 19901001
Various methods of regional chemotherapy have been used in patients with non resectable heptic carcinoma. We report our preliminary experience with embolization using adriamycin-urographin-lipiodol in 2 patients with this cancer in whom a considerable reduction of tumoral mass was observed. The pertinent literature is briefly commented.

2. DOCID:19326 SCORE: 0.0028004105711638
DOCNO: 1894956
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: W Lange W
AUTHOR: W Brugger W
AUTHOR: F M Rosenthal FM
AUTHOR: L Kanz L
AUTHOR: A Lindemann A
AFFILIATION: Albert-Ludwigs University Medical Center, Department of Hematology and Oncology, Freiburg, Germany.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: International journal of cell cloning.
COUNTRY: UNITED STATES
TITLE: The role of cytokines in oncology.
PUBDATE: 19910701
The availability of sufficient quantities of recombinant human cytokines and promising preclinical data have led to their introduction into clinical trials. Cytokines have potential as new therapeutic agents in a variety of hematological disorders as well as in solid tumors. Only a few of the still increasing number of these glycoprotein hormones have been studied in humans so far, either as single agents or in combination with chemotherapy and other cytokines. Their clinical effects, beneficial role in supportive care, and use in the treatment of certain cancer patients are reviewed.

3. DOCID:18178 SCORE: 0.00272973494382464
DOCNO: 7681998
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Palliative Care
DESCRIPTOR: Radiotherapy, High-Energy
QUALIFIER: complications
QUALIFIER: radiation effects
QUALIFIER: etiology
QUALIFIER: radiotherapy
QUALIFIER: complications
AUTHOR: E G Russi EG
AUTHOR: S Pergolizzi S
AUTHOR: M Gaeta M
AUTHOR: M Mesiti M
AUTHOR: A D'Aquino A
AUTHOR: P Delia P
AFFILIATION: Department of Biomedical Technology (Radiobiomedical Research), IST, Genova, Italy.
PUBTYPE: Journal Article
JOURNALTITLE: Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
COUNTRY: IRELAND
TITLE: Palliative-radiotherapy in lumbosacral carcinomatous neuropathy.
PUBDATE: 19930201
The authors report their own experience in obtaining pain relief in 13 recurrent or disseminated cancer patients affected by lumbosacral carcinomatous neuropathy (LCN). The site, where the disease involved the lumbosacral plexus or its branches, was palliatively irradiated with a few large fractions. The average duration of response was 196 days. Median survival (uncensored) was 185 days (range 47-636 days).

4. DOCID:19208 SCORE: 0.00268309570465666
DOCNO: 10171339
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: economics
QUALIFIER: economics
QUALIFIER: economics
AUTHOR: H D Banta HD
AFFILIATION: The Netherlands Organization for Applied Scientific Research (TNO), Leiden.
PUBTYPE: Journal Article
JOURNALTITLE: Health policy (Amsterdam, Netherlands)
COUNTRY: NETHERLANDS
TITLE: The cost-effectiveness of 10 selected applications in minimally invasive therapy.
PUBDATE: 19930101
In this article, evidence of effectiveness and cost-effectiveness of the following procedures is reviewed: (1) laser treatment of bladder tumors; (2) extracorporeal shock-wave lithotripsy and percutaneous nephrolithotomy; (3) laparoscopic treatment of endometriosis; (4) laparoscopic removal of ovarian cysts; (5) laparoscopic cholecystectomy; (6) laparoscopic appendectomy; (7) catheter treatment of coronary artery disease; (8) palliation of colon cancer by endoscopic intervention; (9) treatment of upper gastrointestinal (UGI) bleeding by endoscopic intervention; and (10) arthroscopic knee surgery. Despite considerable potential to be effective and cost-effective, evidence is disappointingly limited in these cases. The lack of evidence hampers decision-making in this new field.

5. DOCID:18836 SCORE: 0.00259436225248058
DOCNO: 2341731
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
AUTHOR: S Gururangan S
AUTHOR: R F Stevens RF
AUTHOR: D J Morris DJ
AFFILIATION: Department of Paediatric Oncology, Royal Manchester Children's Hospital, U.K.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of infection.
COUNTRY: ENGLAND
TITLE: Ribavirin response in measles pneumonia.
PUBDATE: 19900501
A 9-year-old boy with Hodgkin's disease developed measles 1 month after completing eight courses of intensive anti-cancer chemotherapy. The atypical nature of the rash and the absence of Koplik's spots indicated a high risk of progression to fatal giant cell pneumonia. Seven days nebulised and intravenous ribavirin therapy produced apparent recovery. Two weeks later the child presented with measles giant cell pneumonia diagnosed on open lung biopsy. Ribavirin therapy was again successful. The role of ribavirin in the treatment of measles in immunocompromised children is discussed.

6. DOCID:18509 SCORE: 0.00258165415765031
DOCNO: 1651685
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: analogs & derivatives
QUALIFIER: antagonists & inhibitors
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: T Taguchi T
AFFILIATION: Hospital Attached to Research Institute for Microbial Diseases, Osaka University, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [DNA topoisomerase inhibitor as chemotherapeutic drug--clinical point of view]
PUBDATE: 19910801
CPT-11 is a semisynthesized derivative of camptothecin that has a potent antitumor activity by inhibiting DNA topoisomerase I. Leukopenia (mainly neutropenia) is DLF (dose limiting factor) and MTD (maximum tolerated dose) is higher than 250 mg/m2 in CPT-11 from the results of clinical phase I study. Now we are going on phase II study of CPT-11. We are seeing the cases responded to the drug in cancer of the lung, ovary, uterus, stomach, colorectum, pancreas, breast, malignant lymphoma etc.

7. DOCID:19710 SCORE: 0.00254376201228927
DOCNO: 1671606
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Taxoids
QUALIFIER: pharmacology
AUTHOR: I Ringel I
AUTHOR: S B Horwitz SB
AFFILIATION: Department of Pharmacology, Hadassah Medical School, Hebrew University, Jerusalem, Israel.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Studies with RP 56976 (taxotere): a semisynthetic analogue of taxol.
PUBDATE: 19910201
RP 56976 (taxotere), a new semisynthetic analogue of taxol, is a potentially important chemotherapeutic agent for the treatment of cancer. We report here that this drug is a potent inhibitor of cell replication and, like taxol, promotes the in vitro assembly of stable microtubules in the absence of guanosine triphosphate and induces microtubule-bundle formation in cells. Compared with taxol, RP 56976 is slightly more active as a promoter of tubulin polymerization. As an inhibitor of cell replication, RP 56976 is 2.5-fold more potent than taxol in J774.2 and P388 cells and at least 5-fold more potent in taxol-resistant cells.

8. DOCID:18188 SCORE: 0.00230391115441147
DOCNO: 10119215
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Decision Making, Organizational
DESCRIPTOR: Licensure
QUALIFIER: economics
QUALIFIER: organization & administration
QUALIFIER: drug therapy
AUTHOR: M E Ross ME
AUTHOR: R L Nydick RL
PUBTYPE: Journal Article
JOURNALTITLE: Journal of health care marketing.
COUNTRY: UNITED STATES
TITLE: Selection of licensing candidates in the pharmaceutical industry: an application of the analytic hierarchy process.
PUBDATE: 19920601
The ethical (prescription) pharmaceutical industry depends on a stream of innovative, patent-protected products to maintain growth and profitability. With Sterling Drug's entry into a new therapeutic area (oncology, the study and treatment of cancer), licensing and research collaborations have become an important part of the process of developing a pipeline of potential new drugs. The application of the analytic hierarchy process has led to improved articulation of the relevant criteria and better definition of organizational procedures, thereby benefiting Sterling's decision-making process.

9. DOCID:16529 SCORE: 0.00229222613752429
DOCNO: 2132556
AUTHOR: J H Malfetano JH
AFFILIATION: Department of Obstetrics and Gynecology, Albany Medical College, New York 12208.
PUBTYPE: Journal Article
JOURNALTITLE: Gynecologic oncology.
COUNTRY: UNITED STATES
TITLE: Tamoxifen-associated endometrial carcinoma in postmenopausal breast cancer patients.
PUBDATE: 19901001
Tamoxifen citrate, a nonsteroidal antiestrogen with agonistic properties, is prescribed as an adjuvant to surgery in the treatment of breast cancer. Recent reports have suggested that tamoxifen has an estrogenic property and may be implicated in the development of endometrial carcinomas. Seven new cases are reported to the existing literature in which endometrial carcinomas developed in postmenopausal women on tamoxifen therapy for breast carcinomas.

10. DOCID:18983 SCORE: 0.00227516898218872
DOCNO: 2237831
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Forssman Antigen
QUALIFIER: pharmacology
QUALIFIER: prevention & control
AUTHOR: A Casacó A
AUTHOR: D Carvajal D
AUTHOR: M Friman M
AUTHOR: M Noa M
AFFILIATION: Department of Pharmacology, National Center for Scientific Research, Havana, Cuba.
PUBTYPE: Journal Article
JOURNALTITLE: Thrombosis research.
COUNTRY: UNITED STATES
TITLE: Interference of levamisole with Forssman shock.
PUBDATE: 19900801
The anti-helminthic drug levamisole has been used as an adjunct in the treatment of some immunologic defects including cancer. Recently, it has been shown that this drug inhibits thromboxane synthetase as well. Since Forssman shock in guinea pig is used as a model for pulmonary thromboembolism involving thromboxane A2, we studied the interference of levamisole with bronchoconstriction, thrombocytopenia, endothelial cells and pulmonary damage induced by Forssman antiserum. Levamisole inhibited dose-dependently the pathological changes produced by Forssman antiserum raising the possibility that levamisole may be effective for the treatment of pulmonary thromboembolism in man.

11. DOCID:19003 SCORE: 0.00227516881590446
DOCNO: 1891857
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hyperthermia, Induced
DESCRIPTOR: Microwaves
QUALIFIER: therapeutic use
QUALIFIER: therapy
AUTHOR: V A Chernyĭ VA
AUTHOR: K A Galakhin KA
AUTHOR: E A Kolesnik EA
AUTHOR: O I Morgunova OI
PUBTYPE: Journal Article
JOURNALTITLE: Vrachebnoe delo.
COUNTRY: USSR
TITLE: [Endolymphatic polychemotherapy with local UHF hyperthermia in the surgical treatment of rectal neoplasms]
PUBDATE: 19910601
To reduce the risk of intraoperative metastases and increasing ablastic principles in radical surgical treatment of patients with cancer of the rectum the authors developed a scheme of preoperative treatment including endolymphatic polychemotherapy and UHF-hyperthermia. 5-fluorouracil and platidiam were used in the treatment of 30 patients with different histological types of adenocarcinomas of the rectum (grade III-IV). After treatment the viable epithelial component in the tumour was 26.5% as compared with 44.8% in the control. The effect of treatment was favourable both objectively and subjectively. The treatment was well tolerated.

12. DOCID:17960 SCORE: 0.00221184127089297
DOCNO: 2349847
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: methods
QUALIFIER: therapy
AUTHOR: M Bengtsson M
AUTHOR: J B Löfström JB
AFFILIATION: Department of Anaesthesiology, Linköping University, University Hospital, Sweden.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Acta chirurgica Scandinavica.
COUNTRY: SWEDEN
TITLE: Nerve block in pancreatic pain.
PUBDATE: 19900401
Pain from pancreatic cancer is, in most cases, both severe and debilitating. Large doses of morphine are sometimes not tolerated or accepted by the patient, and are often ineffective. It has been claimed that "coeliac plexus block is the simplest, most effective and least hazardous" means of palliation (49, 59); we think that this is true, and that coeliac plexus block should be considered more often than it is today, and at an earlier stage. Only in rare cases should pain from pancreatitis be treated with a nerve block.

13. DOCID:19971 SCORE: 0.00220862280386339
DOCNO: 1912064
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: mortality
AUTHOR: I H Burnley IH
AFFILIATION: School of Geography, University of New South Wales.
PUBTYPE: Journal Article
JOURNALTITLE: Australian journal of public health.
COUNTRY: AUSTRALIA
TITLE: Stomach cancer mortality in New South Wales and Sydney, 1980 to 1985.
PUBDATE: 19910601
Unit list mortality data for the period 1980-1985 are used to examine differential mortality from stomach cancer in New South Wales, with reference to age, marital status, occupational status and birthplace, and geographical variations in mortality in metropolitan Sydney. Ecological correlation and analysis of characteristics of persons dying in areas of high mortality in Sydney are undertaken to determine where populations at risk reside and whether different populations at risk inhabit particular areas, resulting in significantly higher mortality. This was found to be the case in certain areas and it appears that the immigrant population contributed considerably to mortality variation. The implications for health service provision and preventive measures are discussed.

14. DOCID:19521 SCORE: 0.00218009191214415
DOCNO: 2269687
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
AUTHOR: G Benhamou G
AUTHOR: J P Marmuse JP
AUTHOR: H Johanet H
AUTHOR: J Y Le Goff JY
AUTHOR: F Hecht F
AFFILIATION: Service de Chirurgie Digestive, Hôpital Bichat, Paris.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal de chirurgie.
COUNTRY: FRANCE
TITLE: [Therapeutic diagram in advanced cancers of the esophagus]
PUBDATE: 19901101
Only palliative treatment may be contemplated when advanced oesophageal cancers present with dysphagia. Operability depends on respiratory, hepatic and nutritional status. Resectability may be assessed on the information provided by bronchoscopy, thoracic CT scan and surgical exploration. Advanced resectable oesophageal cancers require oesophagectomy without thoracotomy and radiotherapy. We performed 93 oesophagectomies in 106 advanced oesophageal cancers with a mortality rate of less than 2%. Non resectable advanced oesophageal cancers require bypass procedures. We performed 13 in the 106 cases. Inoperable advanced oesophageal cancers require radiotherapy in the absence of a fistula, laser therapy or an endoprosthesis for dysphagia.