0. DOCID:7376 SCORE: 0.00420524434954915
DOCNO: 222140
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Menopause
QUALIFIER: therapeutic use
AUTHOR: L Rosenberg L
AUTHOR: S Shapiro S
AUTHOR: D W Kaufman DW
AUTHOR: D Slone D
AUTHOR: O S Miettinen OS
AUTHOR: P D Stolley PD
PUBTYPE: Journal Article
JOURNALTITLE: American journal of epidemiology.
COUNTRY: UNITED STATES
TITLE: Patterns and determinants of conjugated estrogen use.
PUBDATE: 19790601
In view of the carcinogenic potential and widespread use of conjugated estrogens (CEs), this study evaluated patterns and determinants of oral ambulatory CE use. Among 1273 women 30 to 69 years of age interviewed in Greater-Boston hospitals, there were 161 (13%) ever-users of CEs; 88 (7%) had used the drug within the preceding year. The median duration of use was three years. Prominent determinants of use were age, menopause and history of menopausal symptoms. Physician prescription survey data from an independent source suggest that CE use has been common throughout the United States, and may have declined after the reports linking CEs to endometrial cancer were published in 1975. If CE use indeed increases the risk of endometrial cancer some fivefold, an important public health problem exists.


1. DOCID:7333 SCORE: 0.00329776280469434
DOCNO: 719614
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: blood
AUTHOR: B Chernow B
AUTHOR: S F Wallner SF
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Variables predictive of bone marrow metastasis.
PUBDATE: 19781101
Metastasis to bone marrow, though frequently occult, is an important clinical finding. Variables which correlate with carcinoma metastatic to bone marrow were studied retrospectively in 103 patients with malignancy whose bone marrow biopsies demonstrated metastatic disease. Sixty-six patients with metastatic cancer whose bone marrow biopsies were negative, served as controls. Since no single finding was diagnostic of marrow cancer, multiple variables were analyzed by stepwise discriminate analysis program. The four parameters which strongly correlated with marrow involvement were the leukoerythroblastic blood pattern, a serum lactic dehydrogenase over 500 IU/liter, a platelet count under 100,000/microliter and bone pain. Four parameters correlated less well and included a positive bone scan, hematocrit under 30%, uric acid over 10 mg/dl and blood urea nitrogen over 25 mg/dl. These data should help the clinician select those cancer patients with a high probability of marrow involvement.


2. DOCID:7937 SCORE: 0.0031874836880087
DOCNO: 7292383
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: immunology
AUTHOR: J Lowe J
AUTHOR: A Segal-Eiras A
AUTHOR: P B Iles PB
AUTHOR: R W Baldwin RW
PUBTYPE: Journal Article
JOURNALTITLE: Thorax.
COUNTRY: ENGLAND
TITLE: Circulating immune complexes in patients with lung cancer.
PUBDATE: 19810101
Sera from 41 patients with lung cancer and 41 age and sex-matched hospital inpatients with non-malignant disease were tested for the presence of immune complexes using the 125Iodine Clq binding test. All patients were untreated or had recurrences after surgery. An increased Clq binding activity was found in 34% of patients with lung cancer and 24% of patients with non-malignant disease. There was no significant association between increased serum Clq binding activity and histological tumour type or survival but there was an association with the extent of malignant disease. No patient with limited (state 1) disease had raised Clq binding activity but in 42% of patients with extensive disease it was increased. Increased Clq binding activity did not correlate with either an increased total white cell count of ESR. Measurement of Clq binding activity may be of value in serial monitoring of disease progress and response to treatment.


3. DOCID:7846 SCORE: 0.0030871217089818
DOCNO: 6155005
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: complications
QUALIFIER: therapy
AUTHOR: E Sieberth E
PUBTYPE: Journal Article
JOURNALTITLE: Wiener medizinische Wochenschrift (1946)
COUNTRY: AUSTRIA
TITLE: [On the problems of geriatric carcinomas (author's transl)]
PUBDATE: 19800201
Generally the cancer of the rectum is one besides several other diseases of the patient; clinically it recedes often far into the background of the actual happening. With increasing age the real geriatric diseases come to the foreground of the clinical findings dominated by the arteriosclerosis in all its variations. Therefore the treatment has to take into account the true secondary diseases besides the cancer. Judging the progress of the illness and the therapeutic effect these facts must be considered. Due to the intanglement of geriatric and oncological symptoms it is impossible to separate geriatrics from oncology. Concerning these connections it seems to be justified to characterize the rectum cancer--and also some other cancers--as a particularly geriatric one. The practical consequence of this hypothesis is a change of therapeutic planning, coordinating oncological and geriatric points of view according to the respective requirements. At this psychological and social-medical problems have to be taken into consideration.


4. DOCID:7974 SCORE: 0.00283459981283224
DOCNO: 89882
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Precancerous Conditions
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: complications
QUALIFIER: cytology
AUTHOR: M E Beyer-Boon ME
AUTHOR: L H Cuypers LH
AUTHOR: H J de Voogt HJ
AUTHOR: J A Brussee JA
PUBTYPE: Journal Article
JOURNALTITLE: British journal of urology.
COUNTRY: ENGLAND
TITLE: Cytological changes due to urinary calculi: a consideration of the relationship between calculi and the development of urothelial carcinoma.
PUBDATE: 19780401
Urinary calculi can induce urothelial cellular abnormalities comparable with those of malignancy; this was found in 11 out of 62 lithiasis cases. Severe cellular changes, comparable with those of carcinoma in situ, may be seen in the epithelium adjacent to a calculus. Squamous metaplasia was frequently observed in cases with staghorn stones in the renal pelvis. The abrasive effect of the calculus may result in many multinucleated cells in the sediment. When the calculi are removed the cytological atypia and the observed multinucleation disappeared, and none of these 62 patients developed urothelial carcinoma. A possible relationship was found between a long-term clinical history of lithiasis and the development of cancer of the upper urinary tract in a study of 92 cases of carcinoma of the ureter and renal pelvis.


5. DOCID:6658 SCORE: 0.00280101830123299
DOCNO: 415810
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: blood
AUTHOR: D P Rose DP
AUTHOR: T E Davis TE
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Plasma thyroid-stimulating hormone and thyroxine concentrations in breast cancer.
PUBDATE: 19780201
Plasma TSH and thyroxine levels were measured in 74 early breast cancer patients and 53 with advanced disease, 77 patients with cancer arising in other organs and 67 healthy women of similar age. The mean plasma TSH levels were higher in the breast cancer cases than the other two groups; the difference was statistically significant only in those with advanced disease. Twelve percent of the early breast cancer and 15% of the advanced breast cancer patients had elevated plasma TSH concentrations, compared with only 1% of the other cancer patients and 3% of the controls. Four breast cancer patients with plasma TSH levels above 85 microIU/ml had subnormal plasma thyroxine levels. Five of 29 (17%) early breast cancer patients had excessive plasma TSH responses to TRH.


6. DOCID:6553 SCORE: 0.00278902376468082
DOCNO: 109527
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Antigen-Antibody Reactions
AUTHOR: T Nishimaki T
AUTHOR: K Kano K
AUTHOR: F Milgrom F
PUBTYPE: Journal Article
JOURNALTITLE: Journal of immunology (Baltimore, Md. : 1950)
COUNTRY: UNITED STATES
TITLE: Hanganutziu-Deicher antigen and antibody in pathologic sera and tissues.
PUBDATE: 19790601
Heterophile, Hanganutziu-Deicher (H-D) antigen was studied in pathologic sera by means of inhibition of agglutination of bovine erythrocytes by H-D antibodies. H-D antigen was demonstrated in 38% of random cancer sera, 25% of lymphoma or leukemia sera, 25% of leprosy sera, 8% of infectious mononucleosis sera, 6% of rheumatoid arthritis sera, and 27% of synovial fluids of rheumatoid arthritis patients. None of 134 normal human sera gave positive results. Some of the inhibition-positive cancer sera formed precipitation lines with H-D antibody-containing sera. Over 50% of various extracts of cancer tissues as well as spleens of lymphoma or leukemia patients were shown to contain H-D antigen by means of the inhibition test.


7. DOCID:7751 SCORE: 0.00278830874576289
DOCNO: 7257136
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mammary Glands, Animal
QUALIFIER: etiology
QUALIFIER: veterinary
AUTHOR: H M Hayes HM
AUTHOR: K L Milne KL
AUTHOR: C P Mandell CP
PUBTYPE: Journal Article
JOURNALTITLE: The Veterinary record.
COUNTRY: ENGLAND
TITLE: Epidemiological features of feline mammary carcinoma.
PUBDATE: 19810501
An epidemiological survey involving 132 cats with mammary neoplasia, seen at 15 North American veterinary medical teaching hospitals, was conducted. The ratio of malignant to benign tumours was 9:1. There were 113 cases of carcinomas of all types (including two males), with adenocarcinoma being the predominant cell-type. Relative risk analysis indicated that the Siamese breed had twice the risk (P less than 0.01) of developing mammary carcinoma compared to all breeds combined. The age at diagnosis in Siamese females tended to be younger than in other breeds. Comparison of clinical and pathological features of breast cancer suggests that the cat is an appropriate surrogate for the experimental study of human breast cancer. The apparent lack of oestrogen dependency in feline breast cancer also suggests that the cat may be especially suited for evaluating therapeutic regimens for breast cancers that do not respond to hormonal manipulation.


8. DOCID:7792 SCORE: 0.00259201809713744
DOCNO: 6271389
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: analysis
QUALIFIER: metabolism
AUTHOR: T Horai T
AUTHOR: N Nakamura N
AUTHOR: R Tateishi R
AUTHOR: S Hattori S
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Glycosaminoglycans in human lung cancer.
PUBDATE: 19811101
The quantitative changes of glycosaminoglycans in tumor tissue of human lung cancers (2 squamous cell carcinomas, 4 adenocarcinomas and 5 small cell carcinomas) were studied. The total amount of glycosaminoglycans in human lung cancer tissues increased 1.4 to 4 times in comparison with that in normal lung tissues. The increase in tissue content of glycosaminoglycans was accompanied by an increase in the chondroitin sulfate level in every histologic type of lung cancer, as well as by a marked increase in hyaluronic acid level in squamous cell carcinomas, and a moderate increase in its level in small cell carcinomas. The concentrations of dermatan sulfate and heparan sulfate in lung cancer tissues did not show any significant changes compared with those in normal lung tissues. The increase in total amount and changes in the composition of glycosaminoglycans in human lung cancer tissue were closely related to the histologic type of the tumor.


9. DOCID:7875 SCORE: 0.00256753817465014
DOCNO: 6460552
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: A C Chovil AC
AUTHOR: W J McCracken WJ
AUTHOR: E C Dowd EC
AUTHOR: C Stewart C
AUTHOR: D F Burton DF
AUTHOR: D W Dyer DW
PUBTYPE: Journal Article
JOURNALTITLE: Canadian Medical Association journal.
COUNTRY: CANADA
TITLE: Occupational cancer: experience in Ontario.
PUBDATE: 19811201
This paper reviews the experience of the Workmen's Compensation Board of Ontario in identifying cases of cancer that could be attributed to occupational hazards. Worker's claims for compensation are allowed if there is reasonable medical evidence that their cancer was caused by exposure to risk factors associated with their occupation. Details of the types of cancer associated with specific carcinogens or fields of employment are discussed. About 50% of the cases were related to exposure in particular industrial operations that functioned for relatively brief periods. The number of deaths from cancer identified as being caused by occupational factors is compared with the total for cancer from all causes in Ontario during the period 1971 through 1975. Although all workers eligible for compensation may not have been identified, the data suggest that less than 1% of cancer is presently caused by occupational factors.


10. DOCID:7206 SCORE: 0.0025327956221577
DOCNO: 7449590
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: J Traube J
AUTHOR: S Simpson S
AUTHOR: R H Riddell RH
AUTHOR: B Levin B
AUTHOR: J B Kirsner JB
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Digestive diseases and sciences.
COUNTRY: UNITED STATES
TITLE: Crohn's disease and adenocarcinoma of the bowel.
PUBDATE: 19801201
We present six cases of cancer associated with Crohn's disease and stress the importance of the earlier age of onset than spontaneously arising small-bowel carcinoma, the long period of latency from the time of diagnosis of Crohn's disease to that of carcinoma, and the generally poor prognosis. We emphasize, furthermore, the frequent association with fistulas and the predisposition of bypassed or excluded segments of bowel to undergo malignant transformation. The occurrence of carcinoma in an excluded rectal stump has not previously been reported and stresses the necessity of resecting, rather than excluding, segments of bowel involved with Crohn's disease. These tumors are often not readily apparent by radiographic or endoscopic examination and in fact, may be discovered only after microscopic examination of resected or biopsied tissue.


11. DOCID:7833 SCORE: 0.00253177809353868
DOCNO: 647622
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: administration & dosage
AUTHOR: Y Kinami Y
AUTHOR: I Miyazaki I
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: The superselective and the selective one shot methods for treating inoperable cancer of the liver.
PUBDATE: 19780501
Forty-five patients with inoperable cancer of the liver were treated by the one shot administration of 15-40 mg of Mitomycin C into the hepatic artery, either by the superselective or by the selective one shot method. Fourteen of the patients had primary cancers of the liver, and 31 had metastases to the liver from primary cancers of the stomach, or from the colorectal or other organs. Subjective symptoms improved in 73%, and objective signs improved in 60%. Nineteen patients who received this treatment more than twice showed a mean survival time of 10 months and a 50% survival time of 7.8 months. Therapeutic effects of the selective one shot method were recognized mostly in patients with tumors which were rich in vessels. However, a fairly good result was obtained using the superselective one shot method, even in patients with tumors having relatively few vessels.


12. DOCID:5542 SCORE: 0.00246531093052903
DOCNO: 7226119
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: R M Byers RM
AUTHOR: R Newman R
AUTHOR: N Russell N
AUTHOR: A Yue A
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Results of treatment for squamous carcinoma of the lower gum.
PUBDATE: 19810501
The records of 61 patients with a diagnosis of squamous carcinoma of the lower alveolar ridge were reviewed. The overall two-year survival was 67% with a local or regional failure of 5%. The majority of patients were treated with surgery initially with an excellent local control of 98%, if the patient who died in the postoperative period and the patient lost to follow-up are excluded. Radiation therapy should be used postoperatively for those patients whose cancer exhibits some of the adverse findings such as extensive nodal metastasis, perineural invasion, or inadequate margins of surgical resection.


13. DOCID:6802 SCORE: 0.00241053181227864
DOCNO: 7353772
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: H G Kochem HG
AUTHOR: C N Schremmer CN
AUTHOR: H Hirche H
PUBTYPE: Journal Article
JOURNALTITLE: Geburtshilfe und Frauenheilkunde.
COUNTRY: GERMANY, WEST
TITLE: [The significance of the nipple in carcinoma of the female breast (author's transl)]
PUBDATE: 19800101
In 1,000 specimens of mastectomy with microscopically proven carcinoma of the breast, cancer was found in the nipple in approximately every fifth case. Extension of the carcinoma into the nipple is more frequent in the higher age group of women. Extension into the nipple is more common with larger tumor size. The microscopic growth pattern of the carcinoma has an influence on the presence of tumor in the nipple whereas the microscopic grading for malignancy according to WHO has no clear cut correlation to tumor in the nipple. The frequency of extension of carcinoma of the breast in the nipple in our series and in most series in the literature is in our opinion a contra-indication to conservative types of operation.


14. DOCID:5933 SCORE: 0.0023844592517757
DOCNO: 7411713
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: urine
AUTHOR: M N El-Bolkainy MN
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: Cytology of bladder carcinoma.
PUBDATE: 19800701
Urine cytology is a valuable adjunct but not a substitute for other urologic diagnostic procedures. Cytology offers particular advantage in the detection of pre-clinical cancer and the primary diagnosis of high grade carcinomas. The procedure is of limited value in the diagnosis of benign papilloma and low grade tumors. However, in such cases diagnostic accuracy could be improved by examining bladder irrigation samples, multiple samples, and basing the diagnosis of the identification of papillary clusters rather than individual cellular changes. To ensure comparability of reports in the future there is a great need to standarize several variables, that is the histopathologic classification of tumors, cytologic diagnostic criteria and reporting, as well as the methods adopted to measure validity.