0. DOCID:3906 SCORE: 0.00506028302038381
DOCNO: 127512
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: K Orita K
AUTHOR: N Onishi N
AUTHOR: K Kunisada K
AUTHOR: E Konaga E
AUTHOR: Y Kokumai Y
PUBTYPE: Journal Article
JOURNALTITLE: Acta medica Okayama.
COUNTRY: JAPAN
TITLE: Allogeneic inhibitory activity of regional lymph node cells in the mouse isografted with methylcholanthrene-induced tumor.
PUBDATE: 19750601
In mouse bearing progressive cancer a decrease was present in the allogeneic inhibitory activity of T-lymphocytes, which constitutes the core of immunological surveillance system in mammalians. For tests, methylcholanthrene-induced tumor (MC-tumor) was isografted subcutaneously on the back between scapulae of C3H mice, and the lymphocytes were prepared from the regional axillary lymph nodes removed from these mice at 1, 2, 3, or 4 weeks after grafting. These lymph nodes cells were cultured together with 40-fold numbers of allogeneic JTC-11 cells derived from Ehrlich cancer cells in a culture medium containing 2.0% (v/v) PHA for 24 or 48 hours. The proliferation rate of JTC-11 cells (increased numbers) at weekly interval was considered the allogeneic inhibitory activity of lymph node cells. As a result it was demonstrated that in the early stage after tumor transplantation, i.e., in the first or second week, regional lymph node cells showed a strong allogeneic inhibitory activity, as in the case with lymph-node cells from normal mice, but at progressive stage of cancer, i.e., the third or fourth week when tumors were larger, such activity was completely lost. It seems that mice with progressive cancer showed a decrease of allogeneic inhibitory activity, i.e., a disruption of homeostasis was present.

1. DOCID:3678 SCORE: 0.0044467844454907
DOCNO: 132786
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
AUTHOR: K Höffken K
AUTHOR: S Seeber S
AUTHOR: W R Boecker WR
AUTHOR: C G Schmidt CG
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
JOURNALTITLE: Zeitschrift für Krebsforschung und klinische Onkologie. Cancer research and clinical oncology.
COUNTRY: GERMANY, WEST
TITLE: [Adriamycin, cyclophosphamide, and 5-fluorouracil in the treatment of metastasizing breast cancer (author's transl)]
PUBDATE: 19760601
In a prospective study eleven patients with metastasizing breast cancer were treated with 5-fluorouracil, adriamycin, and cyclophosphamide )FAC). Complete remission occurred in three patients, with two of them still in remission four and thirteen months later. Partial remission (50% decrease in tumour size for more than four weeks) was achieved in five cases, with three of them still in remission. Time for remission induction was one to three months. The mean duration of complete remissions is not yet reached after thirteen months- that of partial remissions was 6.5 months. Two patients showed stable disease for four and more than eleven months, respectively. Only in one case progressive disease was noticed. Mean survival time from the start of therapy was 7.5 months for all patients. For complete and partial responders mean survival is not yet reached after eighteen months. With one exception therapy was given on an outpatient basis. Experimental and clinical data on therapeutic synergism of adriamycin, cyclophosphamide, and 5-fluorouracil show no advantage of the three-drug combination over the combination of adriamycin and cylophosphamide alone.

2. DOCID:3783 SCORE: 0.00440072439384395
DOCNO: 1150006
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: administration & dosage
QUALIFIER: administration & dosage
QUALIFIER: administration & dosage
QUALIFIER: administration & dosage
QUALIFIER: pathology
AUTHOR: Y Kohli Y
AUTHOR: Y Hashimoto Y
AUTHOR: S Takeda S
AUTHOR: K Kawai K
PUBTYPE: Journal Article
JOURNALTITLE: Gann = Gan.
COUNTRY: JAPAN
TITLE: Cell kinetics of gastric carcinoma and other gastric lesions in rats by N-methyl-N'-nitro-N-nitrosoguanidine with or without Tween 60.
PUBDATE: 19750401
Male Wistar rats were divided into three groups for studying the chronic effect of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), in continuous dose of 50 mg/L in drinking water, or 50 mg/L MNNG and 0.4% Tween 60 in drinking water. From the 2nd to 50th week after the administration of MNNG, every 3 or 5 rats were sacrificed and autopsied after the intraperitoneal injection of 1 muCi 3-H-thymidine/g body weight at 2- or 3-week intervals. The resected stomachs were studied morphologically and autoradiographically. Six cases of experimental gastric cancer were produced that fulfilled Stewart's criteria. Autoradiographically, there was no significant different in the flash labeling index in the normal antral mucosa, in the non-pathologic antral mucosa, and in the cancerous lesion, but generation time and DNA synthesizing time of the cancerous lesion were 2 or 3 times longer than those of the glandular stomach of normal rats reported by Galjaard. They were also longer than those of the non-pathologic antral mucosa of rats treated with MNNG. These experiments results were discussed, comparing with cell kinetics of the gastrointestinal tracts in man.

3. DOCID:11473 SCORE: 0.00437277703399581
DOCNO: 6876406
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gastrectomy
QUALIFIER: etiology
QUALIFIER: etiology
AUTHOR: O Sasaki O
AUTHOR: T Sano T
AUTHOR: T Kamegawa T
AUTHOR: T Okamura T
AUTHOR: Y Kodama Y
AUTHOR: R Kumashiro R
AUTHOR: K Inokuchi K
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Clinical significance of colorectal cancers arising after partial or total gastrectomy]
PUBDATE: 19830501
Among colorectal cancer patients operated at the 2nd Department of Surgery, Kyushu University Hospital between 1974 to 1980. 6 developed this cancer after partial or total gastrectomy for gastric cancer or ulcer. The interval between the gastric operation and colorectal surgery ranged from 15 months to 17 years. The colorectal cancers arose in the transverse colon (1) the sigmoid colon (2), there were 3 rectal cancers. Therefore, not only the occurrence of recurrent or primary cancer in the remnant stomach, but also the occurrence of colorectal cancer should be monitored carefully after partial or total gastrectomy for gastric cancer or ulcer.

4. DOCID:7376 SCORE: 0.00420524434954915
DOCNO: 222140
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Menopause
QUALIFIER: therapeutic use
AUTHOR: L Rosenberg L
AUTHOR: S Shapiro S
AUTHOR: D W Kaufman DW
AUTHOR: D Slone D
AUTHOR: O S Miettinen OS
AUTHOR: P D Stolley PD
PUBTYPE: Journal Article
JOURNALTITLE: American journal of epidemiology.
COUNTRY: UNITED STATES
TITLE: Patterns and determinants of conjugated estrogen use.
PUBDATE: 19790601
In view of the carcinogenic potential and widespread use of conjugated estrogens (CEs), this study evaluated patterns and determinants of oral ambulatory CE use. Among 1273 women 30 to 69 years of age interviewed in Greater-Boston hospitals, there were 161 (13%) ever-users of CEs; 88 (7%) had used the drug within the preceding year. The median duration of use was three years. Prominent determinants of use were age, menopause and history of menopausal symptoms. Physician prescription survey data from an independent source suggest that CE use has been common throughout the United States, and may have declined after the reports linking CEs to endometrial cancer were published in 1975. If CE use indeed increases the risk of endometrial cancer some fivefold, an important public health problem exists.

5. DOCID:15129 SCORE: 0.00386901036529241
DOCNO: 3026668
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: A Ardizzoni A
AUTHOR: L Canobbio L
AUTHOR: P Pronzato P
AUTHOR: L Repetto L
AUTHOR: J Serrano J
AUTHOR: F Benvenuto F
AUTHOR: C Simonassi C
AUTHOR: F Baracco F
AUTHOR: B Faravelli B
AUTHOR: M Nosenzo M
PUBTYPE: Journal Article
JOURNALTITLE: Chemioterapia : international journal of the Mediterranean Society of Chemotherapy.
COUNTRY: ITALY
TITLE: Adriamycin, cyclophosphamide and etoposide (ACE) in the treatment of small cell lung cancer.
PUBDATE: 19861201
Thirty-five small cell lung cancer (SCLC) patients were treated with combination chemotherapy including adriamycin, cyclophosphamide, etoposide (ACE). Out of 32 evaluable patients there were 21.9% complete responses and 53.1% partial responses with an overall median survival of 37 weeks (50 weeks for patients with limited disease and 34 weeks for patients with extended disease). Toxicity was generally well tolerated. In conclusion the ACE regimen results in being active and safe in the treatment of SCLC.

6. DOCID:3326 SCORE: 0.00364996543892815
DOCNO: 193020
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasm Regression, Spontaneous
QUALIFIER: pathology
AUTHOR: H I Firminger HI
PUBTYPE: Journal Article
JOURNALTITLE: National Cancer Institute monograph.
COUNTRY: UNITED STATES
TITLE: A pathologist looks at spontaneous regression of cancer.
PUBDATE: 19761101
We are all subjected to varying amounts of mutating, potential cancer-inducing events, which are cumulative. In most instances, the accumulations are repaired or are lethal. If a viable clone survives, it must proliferate in order to become manifest and eventually to overpower the host's normal regulatory and defense mechanisms. The proliferation may be incited and sustained by cocarcinogens, hormone excess, chronic infections such as schistosomiasis, and in the case of lymphoid cells, by immune incompetence. On the other side are the protective reparing enzymes, which serve to cut out the damaged segments of DNA and repair them as fast as they can. The normal homeostatic mechanisms tend to keep cell proliferation and activity within the beneficial bounds of need. The controlling forces that cause cells to stop reproducing themselves and differentiate to perform a useful function also tend to slow or even stop the useless proliferation if all the cells can undergo maturation to a postmitotic state. There are also the protective mechanisms of immunity: Sensitized B lymphocytes tag the antigenic sites of tumor cells and activate the T-cell macrophages to destroy the tagged cells.

7. DOCID:15745 SCORE: 0.00360106010230919
DOCNO: 3712610
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: W S McDougal WS
AUTHOR: F K Kirchner FK
AUTHOR: R H Edwards RH
AUTHOR: L T Killion LT
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: Treatment of carcinoma of the penis: the case for primary lymphadenectomy.
PUBDATE: 19860701
There were 65 patients with squamous cell carcinoma of the penis followed for a minimum of 5 years. Patients with stage I disease uniformly survived with local treatment only. Of the patients with stages II and III carcinoma of the penis 88 and 66 per cent, respectively, were free of disease if lymphadenectomy was performed shortly following treatment of the primary lesion, compared to only 38 and 0 per cent, respectively, if the primary lesion was treated locally and no lymphadenectomy was performed. These data support the concept that lymphadenectomy should be an integral part of the primary treatment in patients with stages II and III penile cancer.

8. DOCID:10632 SCORE: 0.00357302421538423
DOCNO: 6632911
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Teaching
QUALIFIER: education
QUALIFIER: education
AUTHOR: W R Jewell WR
AUTHOR: M P Deslauriers MP
PUBTYPE: Journal Article
JOURNALTITLE: Journal of surgical oncology.
COUNTRY: UNITED STATES
TITLE: Teaching surgical oncology to medical students.
PUBDATE: 19831101
A recent review of the curriculum at University of Kansas Medical Center-Kansas City revealed several deficiencies in oncology teaching in the medical school curriculum. Analysis of the surgery core course final examination showed a weaker response by students to surgical oncology items than nononcologic questions. A multidisciplinary cancer course and tumor conference were then added to the surgery core curriculum. Analysis of student performance since this addition reveals that the multimodal course improved the successful response rate to surgical oncology questions on the final examination. This effect has been sustained through nine consecutive student group rotations. These results suggest that surgical oncology teaching can be effectively improved by a multidisciplinary effort.

9. DOCID:3635 SCORE: 0.00351764467272963
DOCNO: 1112843
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: S E Larsson SE
AUTHOR: R Lorentzon R
AUTHOR: L Boquist L
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of bone and joint surgery. American volume.
COUNTRY: UNITED STATES
TITLE: Giant-cell tumor of bone. A demographic, clinical, and histopathological study of all cases recorded in the Swedish Cancer Registry for the years 1958 through 1968.
PUBDATE: 19750301
All seventy-five cases recorded as giant-cell tumor of bone in the Swedish Cancer Registry for the years 1958 through 1968 were analyzed. At reexamination, fifty-three cases constituted genuine giant-cell tumor of bone and twenty cases were so-called "giant-cell variants". The genuine giant-cell tumors showed a significantly higher incidence in the urban than in the rural population. The recurrence rate was 42 per cent. Patients under the age of twenty-five rarely had recurrences. A high recurrence rate was found among patients with tumors located in the distal end of the femur and the proximal end of the tibia. Tumors penetrating through the bone cortex were more aggressive than those located entirely within bone, regardless of tumor size and presence or absence of spontaneous fracture. A malignant course was found in 11.3 per cent of cases, predominantly in patients with tumors in the femur. Histopathological grading was of no prognostic value. Primary en bloc resection with or without prosthetic replacement is recommended in patients over the age of twenty-five.

10. DOCID:2875 SCORE: 0.00346878218506793
DOCNO: 59126
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemically induced
QUALIFIER: drug therapy
QUALIFIER: adverse effects
AUTHOR: B Armstrong B
AUTHOR: D Skegg D
AUTHOR: G White G
AUTHOR: R Doll R
PUBTYPE: Journal Article
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: Rauwolfia derivatives and breast cancer in hypertensive women.
PUBDATE: 19760701
Three groups of women were selected from a sample of death certificates that had been coded by the Office of Population Censuses and Surveys for all conditions mentioned on them: (1) all women with reference to both breast cancer and hypertension; (2) all women with reference to hypertension and other cancers; (3) a group of women with reference to hypertension without cancer, selected to match the breast-cancer patients with respect to five features. When the women with breast cancer were compared with both the women with other cancers and the women without cancer, there was a positive association between breast cancer and the use of rauwolfia derivatives, although neither the differences in the frequency nor duration observed were statistically significant. The association appeared to be strongest for use near the time of diagnosis of the cancer. This agrees with nearly all other data and would be expected if rauwolfia derivatives promoted the development of breast cancer from previously initiated cells.

11. DOCID:3309 SCORE: 0.00345707693523976
DOCNO: 60119
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunologic Techniques
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: A Shaw A
AUTHOR: G Ettin G
AUTHOR: T A McPherson TA
PUBTYPE: Journal Article
JOURNALTITLE: British journal of cancer.
COUNTRY: ENGLAND
TITLE: Responses of cancer patients in the MEM test: not just a function of charge on basic proteins.
PUBDATE: 19760701
It has been reported that lymphocytes from cancer patients give positive responses to PPD, myelin basic protein, tumour basic protein, and certain histone fractions in the MEM test. The underlying mechanisms of the MEM test are poorly understood, but it is widely assumed that it detects immunological sensitization to specific antigenic determinants. The cross-reactivity experienced is interpreted as indicating shared antigenicity. Since all the stimulatory proteins are strongly basic we investigated an alternative explanation that responsiveness is a function of electrical charge by comparing the known stimulatory proteins in the MEM test with two others of similar basicity: lysozyme and cytochrome-C. We obtained highly significant stimulation with PPD, tryptophane peptide of myelin, and tumour basic protein using Mantoux + cancer patients, but found no response to other basic proteins. We failed to confirm the reported activity of histone F2a. Our results indicate that basicity alone is insufficient to elicit response, and strengthens the concept that the MEM test is measuring sensitization to the determinants shared by myelin and tumour basic protein.

12. DOCID:3831 SCORE: 0.00340744065789917
DOCNO: 45892
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Staining and Labeling
DESCRIPTOR: Tolonium Chloride
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: R Lepage R
AUTHOR: G de Lamirande G
AUTHOR: R Daoust R
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Biochemical estimation of the basic dye-binding capacity of RNA from rat hepatoma.
PUBDATE: 19750101
Areas of hyperplastic livers that acquire hyperbasophilic properties at advanced stages of carcinogenesis apparently represent the sites of neoplastic trasnformation, and hyperstaining of cytoplasmic RNA with basic dyes also characterizes the cancer cells. Estimations of the RNA content of cell fractions from normal rat liver and solid Novikoff hepatoma provided no evidence that the intense staining of cancer cells could be explained on the basis of an increase in cytoplasmic RNA content. The possibility that cytoplasmic fractions of Novikoff hepatoma show greater affinity for basic dyes than corresponding normal fractions has been examined by means of a test-tube toluidine blue-binding assay. The results revealed that the dye-binding capacity of total cytoplasmic fractions from tumors is 75% higher than normal after Carnoy fixation which retains mostly ribosomal RNA. Assays on fresh ribosomes indicated that tumor ribosomes bind 71% more toluidine blue per mg of RNA than the ribosomal preparation from normal liver. This study thus demonstrates a greater affinity of tumor RNA for basic dyes, and a comparison of biochemical and cytophotometric analyses suggests that an increase in basophilia by a factor OF ABOUT 2 WOULD BE DUE TO A qualitative alteration in robosomal RNA molecules and/or ribosome structure in cnacer cells.

13. DOCID:11630 SCORE: 0.00338001446374236
DOCNO: 6577224
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: toxicity
QUALIFIER: toxicity
AUTHOR: E L Wynder EL
AUTHOR: M Goodman M
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Epidemiology of breast cancer and hair dyes.
PUBDATE: 19830901
In a case-control study of 401 breast cancer cases and 625 age-matched controls, the possible etiologic role of hair dye usage was investigated. No association was found between hair dye use and breast cancer (odds ratio = 1.02; 95% confidence interval = 0.77-1.32) or any factors affecting dosage, frequency, duration, type, or color of hair dye. Important confounders of hair dye use included religion and smoking status. When stratified by 10-year age groups, there was no appreciable trend in risk status between case and referent populations. No dose-response relationship (frequency X duration X shade X type of dye used) was found, even after controlling for factors affecting hair dye use. A multiple logistic regression analysis supported the absence of this relationship.

14. DOCID:11828 SCORE: 0.00334695150669181
DOCNO: 6543318
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: urine
QUALIFIER: therapeutic use
QUALIFIER: urine
QUALIFIER: drug therapy
AUTHOR: E Crovato E
AUTHOR: R Salvini R
PUBTYPE: Journal Article
JOURNALTITLE: Bollettino della Società italiana di biologia sperimentale.
COUNTRY: ITALY
TITLE: [Antineoplastic therapy and urinary enzymes. Preliminary note on the determination of urinary N-acetyl-beta-D-glucosaminidase in patients treated with cisplatin]
PUBDATE: 19841201
We discussed the diagnostic value of urinary enzymes as non invasive test of renal integrity in medicine. Then we assayed the N-Acetyl-beta-D-glucosaminidase (NAG) excretion in urines of inpatients receiving cis-platinum, a useful anti-cancer but nephrotoxic agent fort the proximal tubule; we used the colorimetric instead of fluorimetric procedure, recently described in detail by Price who tested it on patients with a variety of renal diseases. The results demonstrated the sensibility and the specificity of colorimetric procedure, and therefore we concluded that the assay of urinary NAG activity may be used in the clinical chemistry and toxicology laboratory, because the test is simple to perform.