0. DOCID:26616 SCORE: 0.00384287024713037
DOCNO: 9858290
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnostic use
QUALIFIER: radionuclide imaging
QUALIFIER: diagnostic use
QUALIFIER: diagnostic use
QUALIFIER: methods
QUALIFIER: methods
AUTHOR: R Burt R
AFFILIATION: Department of Radiology, VAMC and Indiana University, Indianapolis 46202, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Clinical nuclear medicine.
COUNTRY: UNITED STATES
TITLE: Dual isotope F-18 FDG and Tc-99m RBC imaging for lung cancer.
PUBDATE: 19981201
PURPOSE: To produce fluorodeoxyglucose (FDG) images with markers for normal organs and large blood vessels in patients with suspected lung cancer. METHODS: Dual isotope SPECT images were made using F-18 FDG- and Tc-99m-labeled autologous red cells. RESULTS: FDG-positive lesions are localized in relation to major structures when they are viewed in a fused rotating three-dimensional display or in cross sections. CONCLUSIONS: Tc-99m red cell and FDG fusion imaging provides relative location information for lung tumors.

1. DOCID:25770 SCORE: 0.00376960591400527
DOCNO: 9922817
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Extracorporeal Membrane Oxygenation
DESCRIPTOR: Pneumonectomy
DESCRIPTOR: Postoperative Complications
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: therapy
AUTHOR: H Verhelst H
AUTHOR: J Vranken J
AUTHOR: F Muysoms F
AUTHOR: L Rondelez L
AUTHOR: H Schroë H
AUTHOR: R De Jongh R
AFFILIATION: Department of Thoracovascular Surgery, Ziekenhuis Oost-Limburg, Genk, Belgium.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Acta chirurgica Belgica.
COUNTRY: BELGIUM
TITLE: The use of extracorporeal membrane oxygenation in postpneumonectomy pulmonary oedema.
PUBDATE: 19981201
A 59-year-old male developed a severe adult respiratory distress syndrome following a right pneumonectomy for pulmonary cancer. Extracorporeal membrane oxygenation for 11 days was life-saving. The operation was considered curative, but the patient died nine months later with multiple metastases. The pathogenesis and treatment for postpneumonectomy pulmonary oedema and an explanation for rapid dissemination of the cancer are stated.

2. DOCID:26246 SCORE: 0.00365047209715153
DOCNO: 10575902
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Isoflavones
QUALIFIER: prevention & control
QUALIFIER: administration & dosage
QUALIFIER: prevention & control
AUTHOR: L M Chiechi LM
AUTHOR: A Lobascio A
AUTHOR: A Grillo A
AUTHOR: T Valerio T
AFFILIATION: Clinica Ostetrica e Ginecologica III, Università degli Studi, Bari. m.chiechi@pangeanet.it
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Minerva ginecologica.
COUNTRY: ITALY
TITLE: [Phytoestrogen-containing food and prevention of postmenopausal osteoporosis and cardiovascular diseases]
PUBDATE: 19990901
Food phytestrogens and prevention of postmenopausal osteoporotic and cardiovascular disease. Phytestrogens are diphenolic compounds, widely found in plants and foods, with structural and biological estrogen-like similarities. Their anti-estrogenic effects are well known and studied due to the possibility to prevent some tumors such as breast and prostate cancer. In menopause they have an estrogenic-like action on lipidic and bone metabolism. Phytestrogens rich foods can positively affect the postmenopausal osteoporotic and cardiovascular pathology.

3. DOCID:25968 SCORE: 0.00303124272249125
DOCNO: 10966154
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: analogs & derivatives
QUALIFIER: pharmacology
AUTHOR: S Suzen S
AUTHOR: E Buyukbingol E
AFFILIATION: Department of Pharmaceutical Chemistry, Faculty of Pharmacy (ECZACILIK), Ankara University, Turkey. sibel@pharmacy.ankara.edu.tr
PUBTYPE: Journal Article
JOURNALTITLE: Farmaco (Società chimica italiana : 1989)
COUNTRY: ITALY
TITLE: Anti-cancer activity studies of indolalthiohydantoin (PIT) on certain cancer cell lines.
PUBDATE: 20000401
5-(2-Phenyl-3'-indolal)-2-thiohydantoin (PIT) has been evaluated as an anti-cancer compound on several cancer lines organised in to subpanels representing leukemia, melanoma, and cancer of lung, colon, kidney, ovary, breast, prostate and central nervous system by the National Cancer Institute (NCI) anti-cancer drug screen programme. The compound showed inhibitory activity on several cancer cell lines. No information is available on anti-cancer potency of this compound with normal cell lines.

4. DOCID:27933 SCORE: 0.00294121590334278
DOCNO: 10652481
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gene Therapy
QUALIFIER: genetics
QUALIFIER: therapy
AUTHOR: G A Chung-Faye GA
AUTHOR: D J Kerr DJ
AUTHOR: L S Young LS
AUTHOR: P F Searle PF
AFFILIATION: CRC Institute of Cancer Studies, University of Birmingham, Birmingham, UK B15 2TA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Molecular medicine today.
COUNTRY: ENGLAND
TITLE: Gene therapy strategies for colon cancer.
PUBDATE: 20000201
Colorectal cancer is the second most common cause of cancer mortality in Western countries. Gene therapy represents a novel approach to the treatment of colorectal cancer, and this review addresses the current strategies and ongoing clinical trials, including gene correction, immunomodulatory approaches and virus-directed enzyme-prodrug systems. Although the pre-clinical results for these strategies have been encouraging, clinical trials have not yet reflected these data. However, gene therapy for colorectal cancer is still in the early stages of development, and its potential, particularly in combination with conventional cancer therapies, warrants further investigation.

5. DOCID:25977 SCORE: 0.00283775041997066
DOCNO: 10740253
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: physiopathology
AUTHOR: L J McCawley LJ
AUTHOR: L M Matrisian LM
AFFILIATION: Department of Cell Biology, Vanderbilt University Medical Center, 1161 21st Avenue South, Nashville, TN 37232, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Molecular medicine today.
COUNTRY: ENGLAND
TITLE: Matrix metalloproteinases: multifunctional contributors to tumor progression.
PUBDATE: 20000401
Matrix metalloproteinases (MMPs) are a family of extracellular matrix degrading proteinases. Owing to their matrix-degrading abilities and high expression in advanced tumors, MMPs were originally implicated in invasion and metastasis during cancer progression. However, recent work extends a role for MMPs during multiple stages of tumor progression to include other functions such as growth, angiogenesis and migration. Based on studies in animal models implicating MMP activity in cancer, synthetic MMP inhibitors are currently being tested in a clinical setting.

6. DOCID:26012 SCORE: 0.0028011759647914
DOCNO: 10565385
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: microbiology
QUALIFIER: microbiology
QUALIFIER: prevention & control
QUALIFIER: metabolism
QUALIFIER: therapeutic use
AUTHOR: J H Cummings JH
AFFILIATION: Dunn Clinical Nutrition Centre, Cambridge, UK. john.cummings@mrc-dunn.cam.ac.uk
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in clinical nutrition and metabolic care.
COUNTRY: ENGLAND
TITLE: Dietary carbohydrates and the colonic microflora.
PUBDATE: 19980901
The world of the colonic microflora has lain dormant in recent years, but is coming alive now with the advent of new chemical and molecular technologies for identifying bacteria, and the emergence of the concepts of biofilms, pro- and prebiotics. That bacteria play an essential role in barrier resistance to infection, ulcerative colitis and colorectal cancer is slowly becoming clear. New potential therapeutic avenues using bacteria should soon start to open up. Scientifically we lack an understanding of the mechanisms at work.

7. DOCID:26002 SCORE: 0.00280117593045439
DOCNO: 9567059
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cheek
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: A Kübler A
AUTHOR: C Ziegler C
AUTHOR: T Barth T
AUTHOR: J Zöller J
AFFILIATION: Klinik und Poliklinik für Mund-,Kiefer- und Gesichtschirurgie, Universität Heidelberg.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Mund-, Kiefer- und Gesichtschirurgie : MKG.
COUNTRY: GERMANY
TITLE: [Squamous epithelial carcinoma in a 27-year-old patient with cellular immune defect]
PUBDATE: 19980301
Squamous cell cancer of the oral cavity mainly occurs in older patients or in patients with alcohol or nicotine abuse. Younger patients are seldom involved. The case of a 27-year-old woman with a squamous cell cancer of the right cheek will be presented. Without any risk factors, an immune defect resulting in chronic Candida infection of the oral cavity seems to be responsible for the carcinogenesis.

8. DOCID:27890 SCORE: 0.00275176854652876
DOCNO: 11561985
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: R Dreicer R
AFFILIATION: Department of Hematology, The Urologic Institute, Cleveland Clinic Foundation, OH 44195, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in urologic oncology.
COUNTRY: United States
TITLE: Neoadjuvant chemotherapy in the management of muscle-invasive bladder cancer.
PUBDATE: 20010801
Muscle-invasive bladder cancer is typically an aggressive solid tumor with the propensity for early systemic dissemination. Although radical cystectomy remains the gold standard intervention, the high rate of systemic failure has prompted investigators to evaluate various strategies to attempt to improve survival, including the early administration of systemic chemotherapy. These efforts have provided mixed results with two recently completed trials providing conflicting results. Other strategies include attempts to both preserve the bladder using combinations of limited surgical resection, systemic chemotherapy, and radiotherapy. This review focuses on the potential of neoadjuvantly administered therapies to impact the management of muscle-invasive bladder cancer.

9. DOCID:27556 SCORE: 0.00272614184374704
DOCNO: 11831974
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: X Chen X
AUTHOR: Z Wu Z
AUTHOR: F Qiu F
AFFILIATION: Hepatic Surgery Center, Tongji Hospital Tongji Medical University, 430030 Wuhan, China.
PUBTYPE: Journal Article
JOURNALTITLE: Zhonghua wai ke za zhi [Chinese journal of surgery].
COUNTRY: China
TITLE: Hepatectomy for huge primary liver cancer: report of 171 patients.
PUBDATE: 20000101
OBJECTIVE: To discuss the safety and feasibility of hepatectomy for huge primary liver cancer (PLC). METHODS: The effect of resection of huge PLC was examined retrospectively. Some problems about resection of huge PLC were discussed. RESULTS: In 171 patients with huge PLC undergoing hepatectomy, 2 (1.2%) died in one month after operation. The 1-, 2-, 3-, 5- and 10-year survival rates of the patients were 66.1%, 42.1%, 32.7%, 12.2% and 2.3%, respectively. The effect of prolonging survival time was significant. CONCLUSION: Hepatectomy for huge PLC is safe, feasible, and effective.

10. DOCID:25044 SCORE: 0.0026817090591765
DOCNO: 10574787
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: pharmacology
QUALIFIER: antagonists & inhibitors
QUALIFIER: genetics
AUTHOR: C Autexier C
AFFILIATION: Bloomfield Center for Research in Aging, Lady Davis Institute for Medical Research, Jewish General Hospital, Montréal, Canada. mcfj@musica.mcgill.ca
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Chemistry & biology.
COUNTRY: ENGLAND
TITLE: Telomerase as a possible target for anticancer therapy.
PUBDATE: 19991101
Telomeres, the termini of chromosomes, provide essential stability to linear eukaryotic chromosomes. The enzyme telomerase is one mechanism that maintains telomeres, and is activated in 85% of human cancer cells. New studies on peptide nucleic acids (PNAs) that inhibit telomerase have demonstrated that unexpected regions of the enzyme can serve as targets for inhibitors. The novel delivery method used expands the utility of PNAs.

11. DOCID:26408 SCORE: 0.00264439472880188
DOCNO: 10452939
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Evidence-Based Medicine
DESCRIPTOR: Mass Screening
QUALIFIER: prevention & control
AUTHOR: G M Strauss GM
AFFILIATION: Department of Adult Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Surgical oncology clinics of North America.
COUNTRY: UNITED STATES
TITLE: Screening for lung cancer: An evidence-based synthesis.
PUBDATE: 19991001
At present, screening for lung cancer is not recommended; however, consideration of the evidence on the basis of conventional screening criteria, including burden of disease, detectable preclinical phase, accuracy, and acceptability, suggests that screening is likely to be highly beneficial. The most important question relates to effectiveness and cost-effectiveness, which in turn is paradigm dependent. An evidence-based synthesis supports the conclusion that chest radiographs deserve to become the community standard for those at high risk for lung cancer.

12. DOCID:27758 SCORE: 0.00261589196503123
DOCNO: 10797827
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: prevention & control
QUALIFIER: complications
QUALIFIER: drug therapy
AUTHOR: B Paule B
AUTHOR: D Clerc D
AUTHOR: N Brion N
AFFILIATION: Service de Rhumatologie, Hôpital de Bicêtre, Le Kremlin Bicêtre.
PUBTYPE: Journal Article
JOURNALTITLE: Presse médicale (Paris, France : 1983)
COUNTRY: FRANCE
TITLE: [Biosphonates in oncology]
PUBDATE: 20000401
MECHANISM OF ACTION: Tumor-induced osteolysis or lytic bone disease is mediated by osteoclast activation. Bisphosphonates inhibit bone resorption by reducing osteoclastic activity. INDICATIONS: Bisphosphonates were shown to be effective in treating cancer-related hypercalcemia. Recent large randomized clinical trials have shown the efficacy of bisphosphonates in reducing bone pain, pathological fractures and spinal cord compression for patients with multiple myeloma and breast cancer metastatic to bone. The potential survival benefit from pamidronate in patients with advanced myeloma warrants further study. FUTURE: Future clinical trials will use more potent bisphosphonates (zoledronate, ibandronate) with the ultimate goal of trying to prevent bone metastases.

13. DOCID:27720 SCORE: 0.00261589134122418
DOCNO: 11499001
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pharmacology
QUALIFIER: cytology
QUALIFIER: pathology
QUALIFIER: drug effects
AUTHOR: Y Zhang Y
AUTHOR: X M Yang XM
AUTHOR: G Wang G
AUTHOR: F C He FC
AFFILIATION: Institute of Radiation Medicine, Beijing 100850.
PUBTYPE: Journal Article
JOURNALTITLE: Sheng li xue bao [Acta physiologica Sinica].
COUNTRY: China
TITLE: [Biological activity of recombinant human hepatopoietin]
PUBDATE: 19990601
We examined the effects of rhHPO on the cell growth and DNA synthesis of both rat primarily cultured hepatocytes and hepatic carcinoma cell line in vitro by MTS and 3H-TdR in corporation methods. It was indicated that rhHPO is an important stimulating factor of regeneration, which may be developed as a potential drug for the treatment of severe hepatic diseases. We also found an inhibitory effect of rhHPO on the DNA synthesis of lung cancer cell lines GLC-82 in vitro, which might provide a valuable indicator for the study of its specificity and mechanisms.

14. DOCID:27249 SCORE: 0.00257265266880597
DOCNO: 11357144
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Genome
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: J H Hoeijmakers JH
AFFILIATION: MGC Department of Cell Biology and Genetics, Centre for Biomedical Genetics, Erasmus University, PO Box 1738, 3000DR Rotterdam, The Netherlands. Hoeijmakers@gen.fgg.eur.nl
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nature.
COUNTRY: England
TITLE: Genome maintenance mechanisms for preventing cancer.
PUBDATE: 20010501
The early notion that cancer is caused by mutations in genes critical for the control of cell growth implied that genome stability is important for preventing oncogenesis. During the past decade, knowledge about the mechanisms by which genes erode and the molecular machinery designed to counteract this time-dependent genetic degeneration has increased markedly. At the same time, it has become apparent that inherited or acquired deficiencies in genome maintenance systems contribute significantly to the onset of cancer. This review summarizes the main DNA caretaking systems and their impact on genome stability and carcinogenesis.