0. DOCID:27881 SCORE: 0.00476182038976815
DOCNO: 11764714
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Quality of Health Care
QUALIFIER: psychology
QUALIFIER: psychology
AUTHOR: B Zebrack B
AFFILIATION: Division of Cancer Prevention and Control Research, University of California-Los Angeles, Johsson Comprehensive Cancer Center, Los Angeles, CA, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Seminars in oncology nursing.
COUNTRY: United States
TITLE: An advocate's perspective on cancer survivorship.
PUBDATE: 20011101
OBJECTIVE: To illustrate the scope of advocacy in cancer survivorship and to emphasize the critical role that health care providers play to help improve the quality of life of cancer survivors. DATA SOURCES: Published articles, government reports, and books. CONCLUSIONS: The delivery of quality cancer care requires not only an understanding of cancer survivorship issues but also a strategy for advocacy efforts for cancer survivors and their families. IMPLICATIONS FOR NURSING PRACTICE: Advocacy efforts involve individual interventions and family-focused support, public and professional education, and programs and policies that enhance cancer care and quality of life.

1. DOCID:27961 SCORE: 0.00476181356570076
DOCNO: 11276397
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Aging
QUALIFIER: genetics
QUALIFIER: pathology
QUALIFIER: genetics
QUALIFIER: pathology
AUTHOR: A Aviv A
AUTHOR: C B Harley CB
AFFILIATION: Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA. avivab@umdnj.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current hypertension reports.
COUNTRY: United States
TITLE: How long should telomeres be?
PUBDATE: 20010401
What began as a study of the "end-replication problem" took on a new dimension as it became clear that telomeres are a "molecular clock" of replication in human somatic cells. Here we review the biology of telomeres in vitro and in vivo, in mice and humans. We suggest that, in humans, telomeres are involved in the biology of aging and pathobiology of disorders of aging, including cancer and cardiovascular disease. We also propose that the underlying dynamics of telomere biology is in line with broad principles of evolutionary theories.

2. DOCID:27964 SCORE: 0.00476181349875162
DOCNO: 11902516
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mass Screening
QUALIFIER: diagnosis
AUTHOR: S D Fosså SD
AUTHOR: L M Eri LM
AUTHOR: E Skovlund E
AUTHOR: K Tveter K
AUTHOR: L Vatten L
AFFILIATION: Norwegian Radium Hospital, Oslo. s.d.fossa@klinmed.uio.no
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The lancet oncology.
COUNTRY: England
TITLE: No randomised trial of prostate-cancer screening in Norway.
PUBDATE: 20011201
The Norwegian Urological Cancer Group (NUCG) decided against participating in the European Randomised Study on Screening for Prostate Cancer, to which they had planned to contribute data from a population of 75 000 men aged between 50 and 65. The plan was abandonned for three main reasons: Norwegian doubts about the statistical power of the trial, the possible ethical implications of screening a large number of men with no symptoms, and the belief that the trial would not produce clinically important results. In this review, the NUCG's reasons for not participating in the trial are discussed in full.

3. DOCID:27801 SCORE: 0.00402444752966631
DOCNO: 10958786
AUTHOR: M J Galko MJ
AUTHOR: M Tessier-Lavigne M
AFFILIATION: Department of Anatomy, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Science.
COUNTRY: UNITED STATES
TITLE: Function of an axonal chemoattractant modulated by metalloprotease activity.
PUBDATE: 20000801
The axonal chemoattractant netrin-1 guides spinal commissural axons by activating its receptor DCC (Deleted in Colorectal Cancer). We have found that chemical inhibitors of metalloproteases potentiate netrin-mediated axon outgrowth in vitro. We have also found that DCC is a substrate for metalloprotease-dependent ectodomain shedding, and that the inhibitors block proteolytic processing of DCC and cause an increase in DCC protein levels on axons within spinal cord explants. Thus, potentiation of netrin activity by inhibitors may result from stabilization of DCC on the axons, and proteolytic activity may regulate axon migration by controlling the number of functional extracellular axon guidance receptors.

4. DOCID:27901 SCORE: 0.00348248305854043
DOCNO: 11254867
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: prevention & control
AUTHOR: C Isaacs C
AUTHOR: V Stearns V
AUTHOR: D F Hayes DF
AFFILIATION: Breast Cancer Program, Lombardi Cancer Center, Georgetown University, Washington, DC, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Seminars in oncology.
COUNTRY: United States
TITLE: New prognostic factors for breast cancer recurrence.
PUBDATE: 20010201
Decisions regarding the use of adjuvant therapy for breast cancer are strongly influenced by the risk of disease recurrence and death. These risks are now determined by examining the currently recognized breast cancer prognostic factors including clinical stage, axillary nodal status, tumor size and grade, hormone receptor status, and presence of lymphovascular involvement. Newer factors are being evaluated in an attempt to more precisely define disease-related prognosis. This article provides an overview of issues that need to be considered when analyzing studies of prognostic factors, as well as a review of the currently recognized and the newer candidate prognostic factors.

5. DOCID:27465 SCORE: 0.00337038117127654
DOCNO: 10872425
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: S E Kern SE
AFFILIATION: Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. sk@jhmi.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The Medical clinics of North America.
COUNTRY: UNITED STATES
TITLE: Molecular genetic alterations in ductal pancreatic adenocarcinomas.
PUBDATE: 20000501
Pancreatic ductal adenocarcinomas are known to harbor a distinct variety of genetic alterations in oncogenes, tumor-suppressor genes, and occasionally genes that carry out DNA mismatch repair. Although this malignancy occurs at an elevated frequency in patients with familial recurrent acute pancreatitis, the genetic alterations of these particular tumors have not been reported. The changes are likely to be similar to those of sporadic pancreatic cancer; if so, this would provide useful clues for studying the progression of early and advanced neoplasia in such pancreatitis patients to aid their clinical monitoring and provision of therapeutic recommendations.

6. DOCID:27915 SCORE: 0.0031879843268931
DOCNO: 10969992
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemical synthesis
QUALIFIER: pharmacology
QUALIFIER: chemical synthesis
QUALIFIER: pharmacology
QUALIFIER: chemical synthesis
QUALIFIER: pharmacology
AUTHOR: A Scozzafava A
AUTHOR: A Mastrolorenzo A
AUTHOR: C T Supuran CT
AFFILIATION: Università degli Studi, Laboratorio di Chimica Inorganica e Bioinorganica, Florence, Italy.
PUBTYPE: Journal Article
JOURNALTITLE: Bioorganic & medicinal chemistry letters.
COUNTRY: ENGLAND
TITLE: Arylsulfonyl-N,N-diethyl-dithiocarbamates: a novel class of antitumor agents.
PUBDATE: 20000801
A series of alkyl/arylsulfonyl-N,N-diethyl-dithiocarbamates has been prepared by reaction of sodium N,N-diethyldithiocarbamate with alkyl/arylsulfonyl halides. The reactivity of these new derivatives against cysteine and glutathione has been investigated in order to identify derivatives that might label a critical cysteine residue of tubulin (Cys 239 of human beta2 tubulin chain). Some of the most reactive compounds showed moderate to powerful tumor growth inhibitory properties against several leukemia, non-small cell lung, ovarian, melanoma, colon, CNS, renal, prostate and breast cancer cell lines in vitro.

7. DOCID:27046 SCORE: 0.00318476741120923
DOCNO: 11139682
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: chemically induced
QUALIFIER: etiology
QUALIFIER: chemically induced
QUALIFIER: adverse effects
AUTHOR: X Dray X
AUTHOR: M H Tainturier MH
AUTHOR: P De La Lande P
AUTHOR: O Marty O
AUTHOR: L Mallet L
AFFILIATION: Service de Gastroentérologie, Proctologie et Médecine Interne, Fondation Hôpital Saint-Joseph, Paris.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gastroentérologie clinique et biologique.
COUNTRY: FRANCE
TITLE: [Cirrhosis with non alcoholic steatohepatitis: role of tamoxifen]
PUBDATE: 20001101
We report a case of non-alcoholic steatohepatitis with cirrhosis in a woman receiving tamoxifen as adjuvant treatment for breast cancer. Despite the presence of other risk factors for non-alcoholic steatohepatitis (such as diabetes, obesity and hyperlipidemia), the patient developed non-alcoholic steatohepatitis and cirrhosis only after tamoxifen was started. We suggest that patients receiving tamoxifen, especially patients with predisposing metabolic disorders, should be evaluated for non-alcoholic steatohepatitis, because progression to cirrhosis may occur.

8. DOCID:27618 SCORE: 0.00297278419013629
DOCNO: 9682325
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Models, Statistical
DESCRIPTOR: Risk
DESCRIPTOR: Risk Factors
AUTHOR: P Roy P
AUTHOR: J Esteve J
AFFILIATION: International Agency for Research on Cancer, Lyon, France.
PUBTYPE: Journal Article
JOURNALTITLE: Statistics in medicine.
COUNTRY: ENGLAND
TITLE: Using relative risk models for estimating synergy between two risk factors.
PUBDATE: 19980601
The synergy between two risk factors measures the extent to which each of them is more harmful in combination with the other than when acting alone. Relative risk models which describe interaction between risk factors with a few parameters are well adapted to the quantification of synergy. A simple measure of synergy and a method for its estimation with the help of relative risk models are proposed. This concept of synergy provides a simple interpretation of the non-linear parameter of several classical relative risk models. The discussion is illustrated with examples taken from cancer epidemiology of the upper aerodigestive tract.

9. DOCID:25750 SCORE: 0.00281111419936113
DOCNO: 10830988
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: A Ozet A
AUTHOR: A A Yavuz AA
AUTHOR: S Kömürcü S
AUTHOR: B Oztürk B
AUTHOR: M Safali M
AUTHOR: F Arpaci F
AUTHOR: Z Caliskaner Z
AFFILIATION: Gülhane Military Academy, Department of Medical Oncology and BMT Center, Ankara, Turkey. aozet@gata.edu.tr
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Japanese journal of clinical oncology.
COUNTRY: JAPAN
TITLE: Bilateral male breast cancer and prostate cancer: a case report.
PUBDATE: 20000401
Male breast cancer, consisting only 1% of all breast cancers, is occasionally associated with other primary malignancies, especially in patients with familial breast cancer history. Sporadic male breast cancers with another primary tumor are extremely rare. We report a 67-year-old male with asynchronous bilateral breast cancer and prostate cancer without familial breast cancer history.

10. DOCID:25618 SCORE: 0.00276840227808204
DOCNO: 10578691
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Apoptosis
AUTHOR: L F Bovin LF
AUTHOR: K Bendtzen K
AFFILIATION: Rigshospitalet, Finsencentret, institut for inflammationsforskning.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Ugeskrift for laeger.
COUNTRY: DENMARK
TITLE: [Apoptosis--programmed cell death]
PUBDATE: 19991001
The health of multicellular organisms depends not only on the body's ability to produce new cells but also on controlled cell death. Apoptosis, or programmed cell death, is the opposite of mitosis. It is an active process for destruction of unwanted and superfluous cells. Changes in cell survival contribute to the pathogenesis of such varied disorders as cancer, many viral infections, neuropathies and immunopathies. The growing understanding of apoptosis forms the basis for development of new therapeutic strategies controlling cell death. This article describes mechanisms involved in the programmed cellular suicide.

11. DOCID:25634 SCORE: 0.00276840214680906
DOCNO: 11018340
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: physiopathology
AUTHOR: R J Dunlop RJ
AUTHOR: C W Campbell CW
AFFILIATION: St. Christopher's Hospice, Esher, Surrey, United Kingdom.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Journal of pain and symptom management.
COUNTRY: UNITED STATES
TITLE: Cytokines and advanced cancer.
PUBDATE: 20000901
Cytokines have a major role in promoting the growth and spread of cancers. Elevated levels of several cytokines have been described in cancer patients. Evidence from animal and human studies suggests that cytokines may contribute to a wide range of symptoms in advanced cancer, including: asthenia, pain, drowsiness, cognitive failure, agitated delirium, autonomic dysfunction, anorexia, cachexia, fever and metabolic abnormalities. Considerable effort is being directed at finding anticytokine treatments, raising the possibility of new options for symptoms that are currently difficult to control.

12. DOCID:27687 SCORE: 0.00268711319033109
DOCNO: 10975548
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: R Willemze R
AFFILIATION: Department of Dermatology, Leiden University Medical Center, The Netherlands. willemze.dermatology@lumc.nl
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in oncology.
COUNTRY: UNITED STATES
TITLE: Primary cutaneous lymphomas.
PUBDATE: 20000901
Primary cutaneous lymphomas have a distinct clinical behavior and prognosis, and therefore require a different therapeutic approach, as compared with their primary nodal equivalents. The European Organization for Research and Treatment of Cancer (EORTC) classification for primary cutaneous lymphomas recognizes a limited number of cutaneous T-cell lymphomas and cutaneous B-cell lymphomas and is at present the best guide to optimal management and treatment of these conditions. Herein, the relationship between the EORTC classification and the recently published World Health Organization classification is discussed, and recent developments regarding the main types of cutaneous T-cell lymphomas and cutaneous B-cell lymphomas recognized in the EORTC classification are presented.

13. DOCID:27775 SCORE: 0.00251148089324961
DOCNO: 11518882
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Vulvar Neoplasms
AUTHOR: G B Ghurani GB
AUTHOR: M A Penalver MA
AFFILIATION: Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Miami School of Medicine, Miami, FL 33136, USA.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: American journal of obstetrics and gynecology.
COUNTRY: United States
TITLE: An update on vulvar cancer.
PUBDATE: 20010801
Vulvar cancer is a rare gynecologic malignancy whose primary treatment is surgical. It is not uncommon for patients to delay seeking medical attention or for physicians to delay diagnosing the condition. The most prevalent vulvar cancer is squamous cell carcinoma, with vulvar melanoma being the second most common. The basic understanding of the anatomy and the mechanisms of lymphatic spread have made modifications in surgical technique possible, allowing less radical excisions with significantly less morbidity. New approaches using lymphatic mapping with sentinel node dissection appear promising for the future treatment of early vulvar cancers.

14. DOCID:27171 SCORE: 0.00250919559251618
DOCNO: 10724455
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: DNA Replication
DESCRIPTOR: Recombination, Genetic
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: A R Venkitaraman AR
AFFILIATION: CRC Department of Oncology, University of Cambridge, UK.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Philosophical transactions of the Royal Society of London. Series B, Biological sciences.
COUNTRY: ENGLAND
TITLE: The breast cancer susceptibility gene, BRCA2: at the crossroads between DNA replication and recombination?
PUBDATE: 20000201
The identification and cloning of the familial breast cancer susceptibility gene, BRCA2, has excited much interest in its biological functions. Here, evidence is reviewed that the protein encoded by BRCA2 has an essential role in DNA repair through its association with mRad51, a mammalian homologue of bacterial and yeast proteins involved in homologous recombination. A model is proposed that the critical requirement for BRCA2 in cell division and the maintenance of chromosome stability stems from its participation in recombinational processes essential for DNA replication.