0. DOCID:19558 SCORE: 0.00450743434550995
DOCNO: 1294331
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: isolation & purification
QUALIFIER: isolation & purification
QUALIFIER: chemistry
AUTHOR: M Arisawa M
AUTHOR: H Bai H
AUTHOR: S Shimizu S
AUTHOR: S Koshimura S
AUTHOR: M Tanaka M
AUTHOR: T Sasaki T
AUTHOR: N Morita N
AFFILIATION: Department of Medicinal Resources, Faculty of Pharmaceutical Sciences, Toyama Medical & Pharmaceutical University, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Chemical & pharmaceutical bulletin.
COUNTRY: JAPAN
TITLE: Isolation and identification of a cytotoxic principle from Chrysosplenium grayanum Maxim. (Saxifragaceae) and its antitumor activities.
PUBDATE: 19921201
A cytotoxic principle was newly isolated from Chrysosplenium grayanum Maxim. (Saxifragaceae) and identified as beta-peltoboykinolic acid (1) on the basis of spectral data. Cytotoxicity of compound 1 was tested against various human cancer cell lines in vitro, and antitumor effect of this compound was demonstrated on Meth.A mouse fibrosarcoma. The experiment of combined treatment with compound 1, mitomycin C, and OK-432 resulted in enhancing the antitumor effect against B16-BL6 mouse melanoma in C57BL/6 mice.


1. DOCID:19772 SCORE: 0.00446462368966077
DOCNO: 8451642
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: therapy
QUALIFIER: immunology
QUALIFIER: secondary
AUTHOR: H Takahashi H
AUTHOR: T Nakada T
AUTHOR: I Puisieux I
AFFILIATION: Molecular Hepatology Laboratory, Massachusetts General Hospital Cancer Center, Charlestown 02129.
PUBTYPE: Journal Article
JOURNALTITLE: Science.
COUNTRY: UNITED STATES
TITLE: Inhibition of human colon cancer growth by antibody-directed human LAK cells in SCID mice.
PUBDATE: 19930301
Advanced human colon cancer does not respond to lymphokine-activated killer (LAK) cells. In order to direct cytotoxic cells to the tumor, human LAK cells linked with antibodies to a tumor cell surface antigen were tested with established hepatic metastases in severe combined immunodeficient (SCID) mice. These cells had increased uptake into the tumor and suppression of tumor growth as compared with LAK cells alone, thereby improving the survival of tumor-bearing mice. Thus, tumor growth can be inhibited by targeted LAK cells, and SCID mice can be used to test the antitumor properties of human effector cells.


2. DOCID:18620 SCORE: 0.00419847975956488
DOCNO: 8383884
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Magnetic Resonance Imaging
DESCRIPTOR: Patient Care Planning
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: J Mäurer J
AUTHOR: M Busch M
AUTHOR: D Matthaei D
AUTHOR: A Helwig A
AUTHOR: E Dühmke E
AFFILIATION: Klinik und Poliklinik für Strahlentherapie, Georg-August-Universität Göttingen.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al].
COUNTRY: GERMANY
TITLE: [Diabetes insipidus and breast carcinoma--the importance of NMR tomography (MRT) in therapy planning]
PUBDATE: 19930201
In patients with advanced breast cancer the incidence of diabetes insipidus is between 0.1% and 0.9%. Satisfactory symptomatic relief can be obtained with Desmopressin-acetate. In the presence of this symptom complex magnetic resonance imaging (MRI) can aid in the detection of metastases to the posterior pituitary. By the use of magnetic resonance imaging, the incidence for and implementation of local radiotherapy can be firmly grounded.


3. DOCID:18311 SCORE: 0.00417758488573851
DOCNO: 7694353
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Pregnancy Complications
QUALIFIER: adverse effects
AUTHOR: A J Sasco AJ
AFFILIATION: Unité d'épidémiologie analytique, Centre international de recherche sur le cancer, Lyon.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: La Revue du praticien.
COUNTRY: FRANCE
TITLE: [Consequences of tobacco use on mothers and children]
PUBDATE: 19930501
The effects of smoking on female reproductive life are clear, with a longer time-lapse necessary for conception, alterations in hormonal and placental functions and an increased risk of extra-uterine pregnancy, prematurity and low birth-weight. The effects of passive smoking among children, irrespective of source, are linked to an increased risk of sudden infants death syndrome, as well as a higher frequency of otitis and respiratory ailments. Some authors have also found an increased risk of cancer in children and a negative impact on physical and psychological development.


4. DOCID:19791 SCORE: 0.00396924930037868
DOCNO: 1509119
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug effects
QUALIFIER: urine
QUALIFIER: chemically induced
QUALIFIER: pharmacokinetics
QUALIFIER: urine
AUTHOR: C I Chappel CI
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Regulatory toxicology and pharmacology : RTP.
COUNTRY: UNITED STATES
TITLE: A review and biological risk assessment of sodium saccharin.
PUBDATE: 19920601
Dietary sodium saccharin is associated with bladder tumors when fed at high levels to the male rat. Under these conditions urinary pH, sodium concentration, and volume are elevated and proliferative changes are present in the urothelium. Extensive epidemiological studies have shown that saccharin does not increase the risk of bladder cancer in humans and laboratory investigations have shown that sodium saccharin is not mutagenic and does not bind to DNA. Recent research indicates that the urothelium in male rats is damaged under conditions of high urinary pH and sodium levels by a mechanism that involves alpha 2u-globulin and possibly silicate crystalluria. These studies and their implications for human health risk are reviewed.


5. DOCID:19612 SCORE: 0.0039235325668981
DOCNO: 1855689
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
AUTHOR: G J Poston GJ
AUTHOR: J Gillespie J
AUTHOR: P J Guillou PJ
AFFILIATION: Academic Surgical Unit, St Mary's Hospital Medical School, London.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gut.
COUNTRY: ENGLAND
TITLE: Biology of pancreatic cancer.
PUBDATE: 19910701
Pancreatic cancer is the fifth leading cause of death from malignant disease in Western society. Apart from the fortunate few patients who present with a resectable small pancreatic adenocarcinoma, conventional treatment offers no hope of cure and has little palliative value. Over the past two decades major steps have been made in our understanding of the biology of pancreatic growth and neoplasia. This review sets out to explore these advances, firstly in the regulation of normal pancreatic growth, and secondly the mechanism which may be involved in malignant change of the exocrine pancreas. From an understanding of this new biology, new treatment strategies may be possible for patients with pancreatic cancer.


6. DOCID:19218 SCORE: 0.00380647067920124
DOCNO: 1530335
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Infusion Pumps, Implantable
QUALIFIER: drug therapy
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
AUTHOR: O Kobayashi O
AUTHOR: C Kuwae C
AUTHOR: A Kohyama A
AUTHOR: Y Yorinaga Y
AUTHOR: H Sudo H
AUTHOR: H Kitada H
AUTHOR: H Otsuka H
AUTHOR: T Minami T
AFFILIATION: Dept. of Gynecology, Tokyo Metropolitan Fuchu Hospital.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [A case of stage IVb ovarian carcinoma successfully treated with intra-arterial infusion chemotherapy using implantable reservoir system]
PUBDATE: 19920801
A patient with liver metastasis from ovarian cancer was treated by intra-arterial infusion chemotherapy (well differentiated adenocarcinoma--CDDP 50 mg/body, ADR 30 mg/body, CPA 500 mg/body (iv)). After the chemotherapy, the metastatic tumor appeared remarkably smaller and could be resected successfully at the second reduction surgery. This patient is active 30 months after the first appearance and enjoying a favorable quality of life.


7. DOCID:18746 SCORE: 0.00371380018397479
DOCNO: 2029198
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: T Nakajima T
AFFILIATION: Division of Gastrointestinal Surgery, Cancer Institute Hospital, Tokyo, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Issues of adjuvant chemotherapy in gastric cancer: its clinical significance]
PUBDATE: 19910501
Though many previous reports suggest the clinical significance of adjuvant chemotherapy in gastric cancer, they are not always confirmed by the statistics. Treatment failures could be attributed to the minor benefit of chemotherapy for advanced cases, too much tumor burdens after surgery relative to the antitumor effect of chemotherapy, and statistically inadequate operation of clinical study. Improvement would be expected in the near future by carrying out a well designed control study with incorporation of new drugs such as CDDP or etoposide, or powerful regimen with MTX and 5 FU, or 5 FU and Leucovorin.


8. DOCID:19670 SCORE: 0.0036860295243616
DOCNO: 1463349
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: Y Inaba Y
AUTHOR: M Chiba M
AUTHOR: S Watabe S
AUTHOR: K Kudo K
AUTHOR: K Hayashi K
AUTHOR: S Otsuka S
AFFILIATION: Division of General Surgery, Yamagata Prefectural Kahoku Hospital, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [A case of gastric carcinoma with peritonitis carcinomatosa responding remarkably to etoposide, adriamycin and cisplatin (EAP) therapy]
PUBDATE: 19921201
The patient was a 62-year-old male who had Borrmann 4 type gastric cancer. He presented massive ascites due to peritonitis carcinomatosa and the cytology of ascites was class V. He was treated with 3 courses of EAP (etoposide, adriamycin, cisplatin) therapy. Computed tomography showed ascites nearly disappeared. Remarkable improvement was observed by barium meal study and endoscopic examination, and partial remission (PR) was achieved. As for toxicity bone marrow suppression, alopecia and elevation of BUN were observed.


9. DOCID:19094 SCORE: 0.00347886261555596
DOCNO: 8313057
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Home Care Services
DESCRIPTOR: Motivation
QUALIFIER: nursing
AUTHOR: I Christopoulou I
PUBTYPE: Journal Article
JOURNALTITLE: European journal of cancer care.
COUNTRY: ENGLAND
TITLE: Factors affecting the decision of cancer patients to be cared for at home or in hospital.
PUBDATE: 19931201
Community health care and, more specifically, home health care are major developments over recent years. In many European countries there has been serious debate on the necessity of home care, the importance of this type of health care for the patient and family, and those factors influencing patient choice with regard to health care at home or in hospital. This question of choice between home and hospital care forms the basis of this piece of research, the aim of which is to examine the biosocial factors that influence the decision of cancer patients in Greece to choose health care at home or in hospital.


10. DOCID:18740 SCORE: 0.00340999143282915
DOCNO: 1872625
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: K Fujita K
AUTHOR: A Munakata A
AFFILIATION: Dept. of Urology, National Medical Center.
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Experience of oral hormone-chemotherapy in prostatic cancer]
PUBDATE: 19910801
Two oral anticancer agents, cyclophosphamide and UFT (mixture of futraful and uracil), were combined with hormone therapy for 42 patients with prostatic cancer. Although UFT could be taken for long periods, cyclophosphamide arose many problems such as the bone marrow suppression and gastrointestinal disturbances. The median length of the days they could take cyclophosphamide was sixty days. The survival rate of patients who were newly diagnosed and treated with this regimen was better than patients received hormone therapy only, and it suggests the possibility of the combined chemotherapy to inhibit the progression frequently observed after conventional hormone therapy.


11. DOCID:18772 SCORE: 0.00317939240776984
DOCNO: 8316347
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: C D'Arrigo C
AFFILIATION: Laboratorio di Ricerca, IDI Farmaceutici, Pomezia Roma.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Minerva medica.
COUNTRY: ITALY
TITLE: [New perspectives for antineoplastic chemotherapy with plant extracts that are pharmacologically unknown in oncology]
PUBDATE: 19930501
Experimental oncological research leads to the discovery of new weapons against cancer. The author has isolated two new antitumour substances from plants which have never been used for pharmacological purposes. The paper outlines the working hypothesis with which this result was achieved; it also discusses their presumed mechanism of action and their capacity to select tumour cells. Lastly, the author reports the results obtained in six experimental animal tumour models. Both substances showed a level of efficacy in both ascitic and solid tumours which far exceeds that of those agents currently known and used in human antitumour chemotherapy.


12. DOCID:18668 SCORE: 0.00314325150415615
DOCNO: 2261397
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
AUTHOR: R J Harte RJ
AUTHOR: R J Atkinson RJ
AFFILIATION: Northern Ireland Radiotherapy Centre, Belvoir Park Hospital.
PUBTYPE: Journal Article
JOURNALTITLE: Clinical oncology (Royal College of Radiologists (Great Britain))
COUNTRY: ENGLAND
TITLE: Cervical cancer in young women in Northern Ireland: 1970-1985.
PUBDATE: 19900301
From 1970 to 1985, 109 patients under 35 years of age developed invasive cervical cancer in Northern Ireland (NI). Information on incidence, staging, histology, primary treatment and survival was collected retrospectively and results compared with a community-based sample of all age groups from the West Midlands of England. Incidence increased in NI over the study period. Young patients presented with early stage disease, typical histology and had a stage for stage outcome similar to the all age groups. NI results do not demonstrate more aggressive disease in the under 35s.


13. DOCID:17906 SCORE: 0.00309878870532068
DOCNO: 2183979
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: A M Cohen AM
AUTHOR: B D Minsky BD
AFFILIATION: Colorectal Service, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Diseases of the colon and rectum.
COUNTRY: UNITED STATES
TITLE: Aggressive surgical management of locally advanced primary and recurrent rectal cancer. Current status and future directions.
PUBDATE: 19900501
Patients with locally advanced primary and recurrent rectal cancer without gross evidence of extrapelvic cancer represent a complex challenge to the surgeon. In selected patients, radical incontinuity resection or resection combined with radical radiation therapy offers a high likelihood of local tumor control and, to a lesser degree, the possibility of cure. This article defines current approaches to the aggressive management of such patients and investigative strategies for the future.


14. DOCID:19939 SCORE: 0.00308475643549066
DOCNO: 8293693
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Chromosome Aberrations
DESCRIPTOR: Sister Chromatid Exchange
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: C F Xu CF
AFFILIATION: Nanjing Medical College.
PUBTYPE: Journal Article
JOURNALTITLE: Zhonghua fu chan ke za zhi.
COUNTRY: CHINA
TITLE: [The frequencies of sister chromatid exchanges and chromosomal aberrations in the peripheral lymphocytes in patients with cervical carcinoma]
PUBDATE: 19930801
The study of the SCE frequencies and chromosome aberrations in 20 patients with cervical carcinoma and 20 cases of healthy women was carried out. The result showed that the SCE frequencies were as high as 9.28 +/- 0.34/cell in the patients with cervical cancer. They were significantly higher than those of the normal control group (P < 0.001). The chromosomal numerical changes and structural aberrations of the patients were much more than those of the normal women (P < 0.01). The important structural aberrations included ring chromosome, chromosomal restituation and breakage. Genetic instability and DNA repair level significantly suppressed in cancer patients were detected.