0. DOCID:10566 SCORE: 0.00537244467955721
DOCNO: 6312623
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: adverse effects
QUALIFIER: pharmacology
AUTHOR: J L Trudel JL
AUTHOR: M K Senterman MK
AUTHOR: R A Brown RA
PUBTYPE: Journal Article
JOURNALTITLE: Surgery.
COUNTRY: UNITED STATES
TITLE: The fat/fiber antagonism in experimental colon carcinogenesis.
PUBDATE: 19831001
Current epidemiologic and experimental data emphasize the importance of nutrition in colon carcinogenesis. The interactions between dietary fat and dietary fiber were studied in the dimethylhydrazine model for colon cancer. A strict pair-feeding system was developed, and rats were fed one of five semisynthetic diets containing various amounts and types of fat and fiber. The incidence and number of tumors per animal were increased in all fat-fed groups. Adding fiber to the diets provided either partial (polyunsaturated fat) or complete (saturated fat) protection against the deleterious effect of fat. The antagonism between fat and fiber and the clinical relevance of these data are discussed.

1. DOCID:11552 SCORE: 0.00524582242426296
DOCNO: 6645064
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: H Konno H
AUTHOR: K Okuyama K
AUTHOR: K Isono K
AUTHOR: S Onoda S
AUTHOR: H Hirasawa H
AUTHOR: H Satoh H
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Thoracic esophageal cancer in a young adult]
PUBDATE: 19831001
A 34-year-old Japanese male was admitted to the Second Department of Surgery, Chiba University Hospital complaining of swallowing difficulties of three months duration. Radiological examination with barium swallowing revealed thoracic esophageal cancer, classified as EiEa, was 6cm long and of the serrated type. Preoperative combined therapy included Fast Neutron, Pepleomycin, Bestatin and hyperthermia. The operative procedure was total thoracic esophagectomy and ante-thoracic esophago-gastrostomy using the right thoracotomy approach plus laparotomy. Postoperative combined therapy included Linac irradiation and Cisplatin. His postoperative course was uneventful and he was discharged without complications. The tumor was of ill-defined ulcerative type macroscopically; the pathological diagnosis was moderately differentiated squamous cell carcinoma.

2. DOCID:11395 SCORE: 0.00450680410195997
DOCNO: 6884824
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: therapeutic use
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: D Nori D
AUTHOR: J M Cain JM
AUTHOR: B S Hilaris BS
AUTHOR: W B Jones WB
AUTHOR: J L Lewis JL
PUBTYPE: Journal Article
JOURNALTITLE: Gynecologic oncology.
COUNTRY: UNITED STATES
TITLE: Metronidazole as a radiosensitizer and high-dose radiation in advanced vulvovaginal malignancies, a pilot study.
PUBDATE: 19830801
Advanced vulvovaginal cancers have a survival of less than 25% in 5 years when treated with radiotherapy alone. The radiosensitizer metronidazole was used with unconventional radiation fractions in 10 patients. Local control was achieved in 9 out of 10 patients treated. Five of 10 patients have remained free of disease 9-30 months postdiagnosis. Two patients died with metastatic disease, but with local control. In only 1 patient did this approach fail to control local disease. The outcome of these 10 patients represents a significant improvement over conventional radiation. A randomized prospective study has been started on the basis of this pilot study.

3. DOCID:11193 SCORE: 0.00450486553275067
DOCNO: 2995755
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: methods
QUALIFIER: therapy
QUALIFIER: methods
AUTHOR: S L Dar'ialova SL
AUTHOR: P G Bitiutskiĭ PG
AUTHOR: V A Sukirko VA
AUTHOR: A L Klochikhin AL
AUTHOR: G A Frank GA
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Meditsinskaia radiologiia.
COUNTRY: USSR
TITLE: [Preoperative irradiation of laryngeal cancer patients under different oxygen regimens]
PUBDATE: 19850901
Radiation therapy under the conditions of hyperbaric oxygenation (HBO) using the method of mean fractionation (3.3 Gy 3 times a week up to the summary dose of 33 Gy) was employed to overcome tumor hypoxia and to raise selectively radiosensitivity of laryngeal cancer. A randomized study of 120 patients has shown that the use of radiation therapy under HBO conditions makes it possible to reduce the frequency of radiation reactions, to increase tumor resorption and the degree of radiation damage, to reduce the frequency of postoperative purulent complications, and to prevent the occurrence of early and late recurrences and metastases.

4. DOCID:10805 SCORE: 0.00421163139045689
DOCNO: 6525600
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
AUTHOR: G Ehninger G
AUTHOR: K H Weible KH
AUTHOR: E G Heidemann EG
AUTHOR: H D Waller HD
PUBTYPE: Journal Article
JOURNALTITLE: Cancer treatment reports.
COUNTRY: UNITED STATES
TITLE: Mitoxantrone and cyclophosphamide in patients with advanced breast cancer.
PUBDATE: 19841001
Twenty-eight patients with advanced breast cancer who had no prior chemotherapy received 14 mg/m2 of mitoxantrone iv on Day 1 and 600 mg/m2 of cyclophosphamide on Day 2, repeated every 4 weeks. Three patients (10%) achieved complete response and ten (36%) achieved partial response. The dose-limiting toxicity was leukopenia, and no septicemia occurred. Slightly greater than 50% of the patients had a wbc count nadir less than 2000/mm3. Based on the remarkably good tolerability, ie, mild nausea, rarely severe alopecia, and observed remission rate, this combination represents a positive addition to chemotherapy for advanced breast cancer.

5. DOCID:11088 SCORE: 0.00418477912476748
DOCNO: 6737706
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: prevention & control
AUTHOR: T Hirayama T
PUBTYPE: Journal Article
JOURNALTITLE: Japanese journal of clinical oncology.
COUNTRY: JAPAN
TITLE: Epidemiology of stomach cancer in Japan. With special reference to the strategy for the primary prevention.
PUBDATE: 19840601
Characteristics of both descriptive and analytic epidemiology of stomach cancer were summarised. Dietary changes, especially reduced intake of salted food mainly due to the wider use of electric refrigerator, were considered as the major reasons of recent decline in mortality. Other features of descriptive epidemiology such as socio-economic variation, lower risk in Okinawa residents and Japanese migrants to the U.S.A. were also described. In analytic epidemiology, daily cigarette smoking was found as a risk-enhancing factor in addition to frequent intake of salted food. Daily intake of green-yellow vegetables, soybean paste soup and milk were considered as risk reducing factors. Possibilities of primary prevention of stomach cancer was discussed based on these findings.

6. DOCID:9978 SCORE: 0.00372586763374533
DOCNO: 3004858
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: S Q Huang SQ
PUBTYPE: Journal Article
JOURNALTITLE: Zhonghua zhong liu za zhi [Chinese journal of oncology].
COUNTRY: CHINA
TITLE: [Fibrobronchoscopy in lung cancer--an analysis of 560 cases]
PUBDATE: 19850901
560 cases of lung cancer were detected from 1100 cases examined by fibrobronchoscopy. 91.2% of these cases were diagnosed by histology or/and cytology. 71.9% were squamous cell carcinoma. The fibrobronchoscopy gave a positive detection rate of 89.8%, and in 51.1% of cases, it was able to see the tumor or the tumor with necrosis. The positive rate of the cellular brushings was 48%, and that of biopsy, 73.7%. The fibrobronchoscopy is most efficient in localizing the occult lung cancer (positive cytology but negative chest films). The false negative causes of the biopsy or cellular brushings are discussed.

7. DOCID:10118 SCORE: 0.00363639200706548
DOCNO: 6213357
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: K M Lay KM
AUTHOR: K Sein K
AUTHOR: A Myint A
AUTHOR: S K Ko SK
AUTHOR: J J Pindborg JJ
PUBTYPE: Journal Article
JOURNALTITLE: Community dentistry and oral epidemiology.
COUNTRY: DENMARK
TITLE: Epidemiologic study of 600 villagers of oral precancerous lesions in Bilugyun: preliminary report.
PUBDATE: 19820601
A house-to-house survey of 11 villages selected by random sampling was carried out in Bilugyun. Chaung-zone township. Mon State of South Eastern Burma to study the prevalence of oral precancerous lesions and smoking and chewing. A total of 6000 villagers who were above 15 years at the time of this study were examined. The prevalence of preleukoplakia was 0.3%, leukoplakia 1.7%, lichen planus 0.4%, leukokeratosis nicotina palati 2.3, erythroplakia 0.1%, submucous fibrosis 0.1%, and cancer 0.03%. A correlation was done between habits and lesions.

8. DOCID:10513 SCORE: 0.00347688246960315
DOCNO: 7173718
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: enzymology
QUALIFIER: enzymology
QUALIFIER: enzymology
QUALIFIER: metabolism
AUTHOR: B Higley B
AUTHOR: J Oakes J
AUTHOR: J De Mello J
AUTHOR: G R Giles GR
PUBTYPE: Journal Article
JOURNALTITLE: Gut.
COUNTRY: ENGLAND
TITLE: Pyrimidine nucleoside phosphorylase activity in tumour and matched normal gastrointestinal mucosa.
PUBDATE: 19821201
5-Fluorouracil (5-FU) requires activation to the metabolites FdUMP and FUTP for its cytotoxic effect. This activation involves the intracellular enzymes uridine and thymidine phosphorylase. We have assayed the levels of these enzymes in colorectal and gastric cancers and have shown that, in the majority of cases, the enzyme levels were higher than in the adjacent normal mucosa. It is suggested that, while the ratio tumour/normal mucosa enzyme activity may give some indication of the relative toxicity of 5-FU in these tissues, the absolute activities of the phosphorylases in tumour tissue could give a better indication of tumour responsiveness.

9. DOCID:11049 SCORE: 0.00346403273020997
DOCNO: 6753807
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Surgical Flaps
QUALIFIER: surgery
AUTHOR: P G Smith PG
AUTHOR: H R Muntz HR
AUTHOR: S E Thawley SE
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Archives of otolaryngology (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Local myocutaneous advancement flaps. Alternatives to cross-lip and distant flaps in the reconstruction of ablative lip defects.
PUBDATE: 19821101
Cross-lip and distal flaps are still advocated in current literature for the reconstruction of large, traumatic, or surgically created lip defects. Myocutaneous advancement flaps, however, have yielded a functionally and cosmetically superior result. Moreover, they represent single-stage repairs that are technically easy to create. The most common complication noted with the use of a Karapandzic labioplasty has been a relative microstomia. An easily introduced, tripartite maxillary denture has been designed for thus affected edentulous patients. The use of these flaps in the management of advanced lip cancers dictates careful perioperative planning, principles of which are described.

10. DOCID:10110 SCORE: 0.00344535871001401
DOCNO: 6863443
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analogs & derivatives
QUALIFIER: analogs & derivatives
AUTHOR: D H Russell DH
AUTHOR: J D Ellingson JD
AUTHOR: T P Davis TP
PUBTYPE: Journal Article
JOURNALTITLE: Journal of chromatography.
COUNTRY: NETHERLANDS
TITLE: Analysis of polyamines and acetyl derivatives by a single automated amino acid analyzer technique.
PUBDATE: 19830401
In a single, rapid and precise analysis, monoacetylputrescine, N8-acetylspermidine, N1-acetylspermidine, putrescine, spermidine, and spermine can be separated using a five-buffer system on an automatic amino acid analyzer. This method allows, for the first time, the separation of all the known acetyl derivatives of putrescine and spermidine as well as the parent compounds in urine and tissues with a single automated procedure. The method has been applied to the analysis of biological samples from normal volunteers, cancer patients and a rat liver supernatant. Mass spectral confirmation was obtained for each compound.

11. DOCID:10601 SCORE: 0.00337859389091482
DOCNO: 4027925
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Clinical Trials
DESCRIPTOR: Patient Care Team
QUALIFIER: therapy
AUTHOR: J M Boyett JM
AUTHOR: T J Vietti TJ
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Statistics of conducting clinical trials for children with brain tumors.
PUBDATE: 19851001
Even though intracranial tumors are the second most common neoplasm in childhood, controlled trials for children with brain tumors are unusually difficult to conduct. The major hindrance to these studies appears to be a lack of numbers in each of the histologic subtypes and a lack of an effective collaborative effort among neurosurgeons, neurologists, radiotherapists, and pediatric oncologists, all of whom have some degree of responsibility for the primary care of these children. Improved communication between the Children's Cancer Study Group and the Pediatric Oncology Group, as well as the disciplines mentioned above, could result in significant advances in the understanding and treatment of children with brain tumors.

12. DOCID:11993 SCORE: 0.00332146488979387
DOCNO: 7070988
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: T Le Chevalier T
AUTHOR: J Rouësse J
AUTHOR: G Lemoine G
AUTHOR: P Baldeyrou P
AUTHOR: M H Pejovic MH
AUTHOR: R Arriagada R
PUBTYPE: Journal Article
JOURNALTITLE: La Nouvelle presse médicale.
COUNTRY: FRANCE
TITLE: [Surgical treatment of pulmonary metastases in adult patients (author's transl)]
PUBDATE: 19820301
During the period 1968-79, a total of 90 thoracotomies for lung metastases was performed in 76 adult patients (42 men and 34 women, aged from 16 to 72 years) treated at the Gustave Roussy Institute, Paris. Forty-three had carcinoma, 29 had sarcoma and 4 had melanoma. Thoracotomy was performed once in 64 patients, twice in 10 patients and 3 times in 2 patients. Complete resection could be performed in 88%. The operative mortality rate was 1.1%. Four benign lesions were encountered. The survival rate was 56% at 2 years and 43% at 3 years. Several prognostic factors were identified. The indications for pulmonary metastasectomy within the overall strategy of metastatic cancer treatment are discussed.

13. DOCID:10253 SCORE: 0.00324301122955644
DOCNO: 7101283
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: Y Tanno Y
AUTHOR: K Nishioka K
AUTHOR: T Takishima T
PUBTYPE: Journal Article
JOURNALTITLE: The Tohoku journal of experimental medicine.
COUNTRY: JAPAN
TITLE: Carcinoembryonic antigen in sputum.
PUBDATE: 19820501
Carcinoembryonic antigen (CEA) levels in sputum from patients with lung cancers (15), other malignancies (7) and non-malignant pulmonary diseases (30) were measured by enzyme immunoassay. The mean value +/- S.E. (ng/ml) of CEA levels in sputum was 3,682 +/- 1,648, 630 +/- 473 and 444 +/- 102, respectively. There was a significant difference in CEA levels between lung cancers and benign pulmonary diseases (p less than 0.01), while no correlation between the serum levels and sputum levels was found. These observations led us to conclude that assay of CEA in sputum appears to be a useful simple test for the diagnosis of bronchopulmonary neoplasms.

14. DOCID:9464 SCORE: 0.00310861189128209
DOCNO: 6621282
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radionuclide imaging
QUALIFIER: radionuclide imaging
AUTHOR: S A Bykov SA
AUTHOR: L A Iakovleva LA
PUBTYPE: Journal Article
JOURNALTITLE: Meditsinskaia radiologiia.
COUNTRY: USSR
TITLE: [Lymphatic duct scintigraphy of cancer patients]
PUBDATE: 19830901
A total of 138 patients with various tumor sites were examined using lymphoductoscintigraphy with 113mIn. A distinct image of the thoracic lymphatic duct was obtained in 72 cases; 3 variants of normal lymphoscintigrams were singled out. In 66 out of 138 patients no distinct image of the thoracic lymphatic duct was obtained; the retardation of the radiopharmaceutical at the level of the chief lymphatic collector, its winding shift, reflux to the intercostal lymphatic vessels, sometimes to the liver, spleen and kidneys were observed. The importance of lymphoductoscintigraphy in esophageal and gastric cancer is emphasized.