0. DOCID:7398 SCORE: 0.00553532761319761
DOCNO: 6116444
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: trends
AUTHOR: J D Schwarzmeier JD
PUBTYPE: Journal Article
JOURNALTITLE: Aktuelle Gerontologie.
COUNTRY: GERMANY, WEST
TITLE: [New aspects in oncological research (author's transl)]
PUBDATE: 19810301
Following the presentation of some theories of cancer etiology the significance of the cell membrane in neoplastic transformation is stressed. Alterations of the cell surface are blamed responsible for the abnormal proliferative behaviour and metastasis of cancer cells. In addition, the disturbance of membrane-bound receptor structures might result in defects of "endocrine" control mechanisms leading to the typical uncontrolled growth of tumor cells. In this context, the membrane-bound adenylate-cyclase system deserves special interest, since hormone impulses stimulate this enzyme via specific receptors to produce cyclic AMP. This nucleotide transmits hormonal signals within the cell. Our own studies on lymphoma and leukemic cells are mentioned because they demonstrate alterations of the cAMP producing system in malignant cells. Finally, the phenomenon of cell fusion is discussed. Recently great attention has been paid to this technique, since hybridization experiments enable us to get new insight into the process of neoplastic transformation.


1. DOCID:7397 SCORE: 0.00528508175806049
DOCNO: 7290965
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radionuclide imaging
QUALIFIER: radionuclide imaging
QUALIFIER: diagnostic use
AUTHOR: P Gabelle P
AUTHOR: M Comet M
AUTHOR: J P Bodin JP
AUTHOR: A Dupré A
AUTHOR: E Carpentier E
AUTHOR: M Bolla M
AUTHOR: P Swiercz P
PUBTYPE: Journal Article
JOURNALTITLE: La Nouvelle presse médicale.
COUNTRY: FRANCE
TITLE: [Mammary lymphatic scintiscans by intratumoral injection in the assessment of breast cancer. 105 examination in 100 patients (author's transl)]
PUBDATE: 19811001
One hundred and five scintiscans of the mammary lymphatic system were performed in 100 patients with breast cancer by intratumoral injection of 99 m Tc-labelled colloidal rhenium. The progression of the radioactive colloidal agent was followed on a series of films taken 1, 2 and 4 hours after the injection, and the images obtained were compared with post-operative findings of lymph node involvement. Patients with more than 3 carcinomatous lymph nodes had less than 2 foci of activity, while those with less than 3 carcinomatous lymph nodes had more than 2 foci of activity, owing to more rapid progression of the compound. The difference was highly significant (p less than 0,001).


2. DOCID:6701 SCORE: 0.00402474202534809
DOCNO: 6116001
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: complications
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: B S Tepperman BS
AUTHOR: P J Fitzpatrick PJ
PUBTYPE: Journal Article
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: Second respiratory and upper digestive tract cancers after oral cancer.
PUBDATE: 19810901
Between 1958 and 1975, 377 patients with squamous cell carcinoma of the floor of the mouth were treated. 123 new cancers (not recurrences) developed in 101 (27%) of these patients after treatment. 82 (67%) were squamous cell carcinomas of the respiratory and upper digestive tracts, one-third of these being in the mouth. These tumors developed at a constant rate of 3.6% per year and led to excess mortality of 5.2% per year. Men with oral cancer have a relative risk of 13.4 for new tumours in the upper respiratory and upper digestive tracts compared with the general population; in females the relative risk for all sites is 82.6. All patients with mouth cancer should thus be examined regularly because of this high risk of new cancers.


3. DOCID:7980 SCORE: 0.00376732667979342
DOCNO: 637580
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: adverse effects
QUALIFIER: surgery
QUALIFIER: etiology
AUTHOR: T J Eberlein TJ
AUTHOR: F V Lorenzo FV
AUTHOR: M W Webster MW
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Annals of surgery.
COUNTRY: UNITED STATES
TITLE: Gastric carcinoma following operation for peptic ulcer disease.
PUBDATE: 19780301
Gastric carcinoma following operation for benign peptic ulcer disease has been considered rare but nine patients have been seen during the past five years. All were male patients, the average time interval from prior ulcer operation to development of cancer was 17 years, but was a short as ten years. The symptoms of cancer are vague and the diagnosis is often delayed. Fiberoptic endoscopy with biopsy of suspicious areas is the most accurate diagnostic approach. Resection of the tumor is indicated if feasible. The poor prognosis of this malignancy is documented. The evidence is reviewed that the creation of achlorhydria with bile reflux increases the risk of development of gastric carcinoma. All patients who undergo peptic ulcer operation require careful long-term follow-up. Vague gastrointestinal symptoms occurring ten years or more after peptic ulcer operation require full evaluation to exclude the presence of gastric cancer.


4. DOCID:7841 SCORE: 0.00373022364982203
DOCNO: 7222003
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Dietary Proteins
DESCRIPTOR: Food
DESCRIPTOR: Public Health
AUTHOR: R J Hermus RJ
AUTHOR: R Kroes R
PUBTYPE: Journal Article
JOURNALTITLE: Tijdschrift voor diergeneeskunde.
COUNTRY: NETHERLANDS
TITLE: [Foods of animal origin and public health (author's transl)]
PUBDATE: 19810301
Modern society adopts a highly ambiguous attitude towards foods of animal origin in human nutrition. Animal protein is of great biological value. However, the wealthy part of the world already consumes more than sufficient protein, which renders this value superfluous. On the other hand, a rich diet including a large share of animal products is suspect from the point of view of cardiovascular disease, cancer, osteoporosis and nephrolithiasis. The role of fat, protein, cholesterol, salt, calcium and a number of minor components is discussed. It is concluded that as far as fats are concerned, reduction is indicated. There is a large individual variability in response to salt and cholesterol as well as interactions with other components of the diet. A role of animal protein in affecting calcium metabolism is plausible, though not definitely established. Public health hazards due to contaminants are probably small compared with those caused by the major components.


5. DOCID:6498 SCORE: 0.00319658279672577
DOCNO: 7403821
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Alcohol Drinking
DESCRIPTOR: Diet
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: complications
AUTHOR: F Infante F
AUTHOR: M Voirol M
AUTHOR: O Brahime-Reteno O
AUTHOR: L Raymond L
AUTHOR: V Hollenweger V
AUTHOR: E Loizeau E
PUBTYPE: Journal Article
JOURNALTITLE: Schweizerische medizinische Wochenschrift.
COUNTRY: SWITZERLAND
TITLE: [Alcohol, tobacco and food consumption in liver cancer and cirrhosis. Preliminary results]
PUBDATE: 19800501
In German the consumption of food among cirrhotic patients, whether male or female and among male patients with primary liver cancer (PLC), is virtually the same as in normals. Alcohol consumption is very high in all three groups. The heaviest drinkers are the cirrhotic males, but the highest patient/control ratio is found among cirrhotic females (X 5.4). Total alcohol ingestion during life appears to be higher in patients with PLC plus cirrhosis than in those with PLC without cirrhosis. Tobacco consumption by male cirrhotic and PLC patients is the same as in controls. Conversely, cirrhotic females smoke seven times as much as their standardized controls.


6. DOCID:6643 SCORE: 0.00307472155713378
DOCNO: 501779
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Lymphatic Metastasis
QUALIFIER: secondary
QUALIFIER: secondary
AUTHOR: R Dickson R
AUTHOR: D R Vargas DR
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of otolaryngology.
COUNTRY: CANADA
TITLE: Occult primary of the head and neck.
PUBDATE: 19791001
This paper reviews clinical presentation, diagnosis, and treatment of 199 cases of metastatic carcinoma of the neck with an occult primary, seen at the Cancer Control Agency of British Columbia from 1950-1975. In 35 patients a primary tumor was ultimately found, with the commonest location the nasopharynx. In a further 46 patients a primary was suspected on a clinical basis only. The other 118 cases remained occult. Therapeutic results of the whole series and individual groups are analyzed. Best survival was found in those in whom a primary source was ultimately demonstrated. Single, small, mobile cervical nodes had the best prognosis. Supraclavicular nodes indicated a poor prognosis and an even greater need to search for an infraclavicular primary. A comparative review of the literature is included.


7. DOCID:6127 SCORE: 0.00302095025766758
DOCNO: 7317752
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Palpation
DESCRIPTOR: Ultrasonography
QUALIFIER: diagnosis
AUTHOR: P J Brooman PJ
AUTHOR: W B Peeling WB
AUTHOR: G J Griffiths GJ
AUTHOR: E Roberts E
AUTHOR: K Evans K
PUBTYPE: Journal Article
JOURNALTITLE: British journal of urology.
COUNTRY: ENGLAND
TITLE: A comparison between digital examination and per-rectal ultrasound in the evaluation of the prostate.
PUBDATE: 19811201
Three hundred and fifty-two patients have been examined by per-rectal ultrasound and histological confirmation of the diagnosis was obtained in 242 cases. Per-rectal ultrasound compared favourably with digital palpation both as a method of diagnosing prostatic cancer and also as a method of staging a primary tumour. Confirmation of the accuracy of this technique as a method of staging was gained by a study involving the use of cadaver material. Repeat examinations on patients with prostatic carcinoma have shown that per-rectal ultrasound is an ideal method for monitoring response of the primary tumor to treatment.


8. DOCID:6271 SCORE: 0.0027673815681606
DOCNO: 6793738
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
AUTHOR: W M Murphy WM
AUTHOR: M S Soloway MS
AUTHOR: P J Finebaum PJ
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: Pathological changes associated with topical chemotherapy for superficial bladder cancer.
PUBDATE: 19811001
With use of previous observations in experimental animals as a basis for comparison the cytologic and histologic changes in human patients who underwent topical chemotherapy for superficial bladder cancer were documented. Despite the potential for inhibition of deoxyribonucleic acid replication these drugs apparently act in vivo as toxic substances, causing increased exfoliation with denudation of papillary and/or flat urothelium. Multinucleation was common but confined to superficial cells. Atypical cells, such as those observed after systemic chemotherapy with cyclophosphamide, rarely were present and could be distinguished readily from neoplastic elements. Although topical chemotherapy may suppress tumor growth and progression it apparently does not eradicate the neoplastic process.


9. DOCID:7096 SCORE: 0.00265541673632871
DOCNO: 7436853
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: C T Chung CT
AUTHOR: D D Rabuzzi DD
AUTHOR: R H Sagerman RH
AUTHOR: G A King GA
AUTHOR: R R Gacek RR
PUBTYPE: Journal Article
JOURNALTITLE: Archives of otolaryngology (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Radiotherapy for carcinoma of the nasal cavity.
PUBDATE: 19801201
Twenty-five patients with primary epithelial carcinoma of the nasal cavity without nodal or distant metastases were treated by irradiation between 1967 and 1978. Small field, beam-directed techniques delivered 6,000 to 7,000 rads with conventional fractionation. Control of the primary tumor was achieved in 21 (84%) patients after irradiation. All five treatment failures (one infield only, three infield recurrence with lymph node metastases, and one regional cervical node metastasis) were evident within six months; all five patients died of cancer. The adjusted actuarial survival rate at three years was 76%. Failure in the untreated neck was only 5% when the primary carcinoma was controlled and 16% overall. The literature has been reviewed with attention to tumor control rates and survival.


10. DOCID:7456 SCORE: 0.00263959043293137
DOCNO: 7425243
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: J Y Suen JY
AUTHOR: R K Newman RK
AUTHOR: K Hannahs K
AUTHOR: J Fisher J
PUBTYPE: Journal Article
JOURNALTITLE: American journal of surgery.
COUNTRY: UNITED STATES
TITLE: Evaluation of the effectiveness of postoperative radiation therapy for the control of local disease.
PUBDATE: 19801001
Although we agree that postoperative irradiation does improve the local and regional control, our findings indicate that the rate of control, especially local control, is somewhat less than 90 percent. Our data reveal a recurrence rate of 32.7 percent in advanced, stage III and IV, squamous cell carcinomas in the head and neck treated by surgery and postoperative irradiation; this rate may be even greater with longer follow-up. We recommend that surgeons avoid "close" surgical margins (less than 5 mm) when resecting primary cancers and not rely too heavily on radiation therapy to control residual subclinical disease. It appears that continued study is needed to establish the true efficacy of irradiation in the control of subclinical disease, and that local recurrence must be differentiated from regional recurrence when reporting these results.


11. DOCID:7654 SCORE: 0.00258967446478406
DOCNO: 7235946
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: R C Hickey RC
AUTHOR: N A Samaan NA
AUTHOR: G L Jackson GL
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Archives of surgery (Chicago, Ill. : 1960)
COUNTRY: UNITED STATES
TITLE: Hypercalcemia in patients with breast cancer. Osseous metastases, hyperplastic parathyroid tissue, or pseudohyperparathyroidism?
PUBDATE: 19810501
Breast cancer is the malignant neoplasm most commonly associated with hypercalcemia. At the University of Texas M. D. Anderson Hospital, Houston, during the fiscal year 1977 to 1978, of 16,887 patients having calcium determinations, 7.8% had hypercalcemia. From 1969 to 1979, 13 patients had proved and three had presumed primary hyperparathyroidism associated with breast cancer. Two other patients had pseudohyperparathyroidism. Selective neck vein catheterization was used in 17 of the 18 patients and helped localize and confirm the diagnosis of primary hyperparathyroidism. Chloride-phosphate ratios were elevated in 13 of the 14 patients with proved or presumed primary hyperparathyroidism. This condition may mimic osseous metastases by producing brown tumors or compression fractures. In patients with breast cancer and hypercalcemia, particularly without osseous metastases, a careful diagnostic evaluation is warranted to rule out primary hyperparathyroidism.


12. DOCID:6866 SCORE: 0.00246511455242608
DOCNO: 7304822
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: anatomy & histology
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: A Shafik A
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: American journal of surgery.
COUNTRY: UNITED STATES
TITLE: A new concept of the anatomy of the anal sphincter mechanism and the physiology of defecation. XII. Anorectal mobilization: a new surgical access to rectal lesions. Preliminary report.
PUBDATE: 19811101
A new technique for the removal of inaccessible benign intrarectal lesions and malignant lower third rectal tumors with sphincter preservation is presented. The procedure was performed in eight patients, four with huge bilharzial papillomas and four with malignant lower third rectal tumors. The essential feature of the operation is preservation of the levator tunnel, which is responsible for maintaining normal, voluntary continence and defecation. The results were satisfactory. The technique provides easy access to the interior of the rectum, and it extends the indications for sphincter-saving operations to include malignant lower third rectal tumors. It is hoped that this procedure will eliminate the use of abdominoperineal excision in the treatment of rectal cancer.


13. DOCID:6536 SCORE: 0.00245993231153723
DOCNO: 7425530
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
AUTHOR: E P Tock EP
AUTHOR: K Shanmugaratnam K
PUBTYPE: Journal Article
JOURNALTITLE: Annals of the Academy of Medicine, Singapore.
COUNTRY: SINGAPORE
TITLE: Epidemiology or primary liver cancer in Singapore.
PUBDATE: 19800401
Primary Liver Cancer occurs with high frequency in most parts of the East and South East Asia. The age standarised rates for most Western countries are below 2 per 100,000 per year for males and below 1 for females. In Singapore, the rate is 29.1 for males and 7.7 for females. There is a male preponderance in Singapore by a ratio of male to female of 3.8 in age standardised incidence rates. The peak incidence is the 6th decade (30.1% of cases) and in the 7th decade (31.7% of cases). The Chinese have the highest incidence amongst the different ethnic races. Epidemiological studies done on migrant population strongly suggest that environmental factors are more important than genetic factors in the aetiology of liver cancer.


14. DOCID:5891 SCORE: 0.00231049978822751
DOCNO: 92346
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Blood Transfusion
DESCRIPTOR: Graft Survival
DESCRIPTOR: Kidney Transplantation
AUTHOR: G Proud G
AUTHOR: B K Shenton BK
AUTHOR: B M Smith BM
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of surgery.
COUNTRY: ENGLAND
TITLE: Blood transfusion and renal transplantation.
PUBDATE: 19791001
Blood transfusions given to potential renal transplant recipients are beneficial to subsequent graft survival. This study has shown an association graft survival. This study has shown an association between the inhibitory activity of patients' plasma on their own non-specific lymphocyte responses to antigen and the administration of blood transfusions. Most of the inhibitory activity was related to alpha-2 macroglobulin. Alpha-2 macroglobulin was able to prolong the survival of rat cardiac allografts. Immunoregulatory activity related to the alpha globulins of plasma has been described in a wide variety of conditions (i.e. cancer, pregnancy, diabetes) and this study has shown similar activity following blood transfusions.