0. DOCID:3992 SCORE: 0.00664564386053655
DOCNO: 1248000
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: genetics
AUTHOR: M Swift M
AUTHOR: L Sholman L
AUTHOR: M Perry M
AUTHOR: C Chase C
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Malignant neoplasms in the families of patients with ataxia-telangiectasia.
PUBDATE: 19760101
Ataxia-telangiectasia (A-T) is an autosomal recessive syndrome associated with a greatly increased incidence of malignant neoplasms in homozygous affected individuals. Heterozygotes for the gene for A-T are thought to comprise about 1% of the general population and, therefore, it is important to know whether this gene also predisposes the heterozygous carrier to cancers. Heterozygous carriers of this gene are common among the close relatives of patients with A-T, although individual carriers cannot be identified by any clinical criterion or laboratory test. For this reason, we compared the incidence of death from malignant neoplasms in 2 families of patients with A-T to that expected in a random sample of the general population. There were 59 deaths from malignant neoplasms in relatives dying before age 75, compared to 42.6 expected (p less than 0.02). For A-T heterozygotes younger than age 45, the risk of dying from a malignant neoplasm was estimated to be greater than 5 times the risk for the general population. A-T heterozygotes may comprise more than 5% of all persons dying from a cancer before age 45. The incidence of ovarian, gastric, and biliary system carcinomas and of leukemia and lymphoma was increased in these A-T families. Other neoplasms that may be associated with this gene in heterozygotes include pancreatic, basal cell, colonic, breast, and cervical carcinomas.


1. DOCID:7398 SCORE: 0.00553532761319761
DOCNO: 6116444
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: trends
AUTHOR: J D Schwarzmeier JD
PUBTYPE: Journal Article
JOURNALTITLE: Aktuelle Gerontologie.
COUNTRY: GERMANY, WEST
TITLE: [New aspects in oncological research (author's transl)]
PUBDATE: 19810301
Following the presentation of some theories of cancer etiology the significance of the cell membrane in neoplastic transformation is stressed. Alterations of the cell surface are blamed responsible for the abnormal proliferative behaviour and metastasis of cancer cells. In addition, the disturbance of membrane-bound receptor structures might result in defects of "endocrine" control mechanisms leading to the typical uncontrolled growth of tumor cells. In this context, the membrane-bound adenylate-cyclase system deserves special interest, since hormone impulses stimulate this enzyme via specific receptors to produce cyclic AMP. This nucleotide transmits hormonal signals within the cell. Our own studies on lymphoma and leukemic cells are mentioned because they demonstrate alterations of the cAMP producing system in malignant cells. Finally, the phenomenon of cell fusion is discussed. Recently great attention has been paid to this technique, since hybridization experiments enable us to get new insight into the process of neoplastic transformation.


2. DOCID:7397 SCORE: 0.00528508175806049
DOCNO: 7290965
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radionuclide imaging
QUALIFIER: radionuclide imaging
QUALIFIER: diagnostic use
AUTHOR: P Gabelle P
AUTHOR: M Comet M
AUTHOR: J P Bodin JP
AUTHOR: A Dupré A
AUTHOR: E Carpentier E
AUTHOR: M Bolla M
AUTHOR: P Swiercz P
PUBTYPE: Journal Article
JOURNALTITLE: La Nouvelle presse médicale.
COUNTRY: FRANCE
TITLE: [Mammary lymphatic scintiscans by intratumoral injection in the assessment of breast cancer. 105 examination in 100 patients (author's transl)]
PUBDATE: 19811001
One hundred and five scintiscans of the mammary lymphatic system were performed in 100 patients with breast cancer by intratumoral injection of 99 m Tc-labelled colloidal rhenium. The progression of the radioactive colloidal agent was followed on a series of films taken 1, 2 and 4 hours after the injection, and the images obtained were compared with post-operative findings of lymph node involvement. Patients with more than 3 carcinomatous lymph nodes had less than 2 foci of activity, while those with less than 3 carcinomatous lymph nodes had more than 2 foci of activity, owing to more rapid progression of the compound. The difference was highly significant (p less than 0,001).


3. DOCID:3995 SCORE: 0.00470908741075036
DOCNO: 838858
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: metabolism
AUTHOR: M D Benson MD
AUTHOR: M A Scheinberg MA
AUTHOR: T Shirahama T
AUTHOR: E S Cathcart ES
AUTHOR: M Skinner M
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of clinical investigation.
COUNTRY: UNITED STATES
TITLE: Kinetics of serum amyloid protein A in casein-induced murine amyloidosis.
PUBDATE: 19770301
Serum amyloid protein A (SAA), the precursor of secondary amyloid protein, is elevated in chronic diseases which are associated with an increased incidence of amyloid. However, SAA is also elevated in acute bacterial and viral infections and somes forms of cancer. The murine model of casein-induced amyloidosis was studied to determine the relationship between SAA production and amyloid deposition. SAA levels measured by radioimmunoassay were found to be as high as 200 times the normal level in CBA/J mice receiving daily parenteral casein. After a single injection of casein the SAA level was elevated by 3h and peaked by 12-18 h. Similar levels were found in casein-treated A/J mice, a strain less susceptible to the induction of amyloid. Parenterally administered bovine serum albumin, which has low potential for amyloid induction, gave SAA levels in CBA/J and A/J mice comparable to casein treatment. These data show that, while SAA levels are elevated during chronic antigenic stimulation, there are other factors involved in amyloid formation. These factors may include alterations in the degradation of SAA by the reticuloendothelial system caused by substances such as casein. Nude (athymic) mice were shown to attain high levels of SAA after receiving casein parenterally. Therefore, thymus-derived lymphocytes are not necessary for the synthesis of SAA.


4. DOCID:3978 SCORE: 0.00422061185206635
DOCNO: 1260761
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunity, Cellular
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: E T Bloom ET
AUTHOR: R C Seeger RC
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Disease and non-disease-related cell-mediated cytotoxicity in humans.
PUBDATE: 19760401
The human bladder cancer/T24 system was used to investigate disease and non-disease-related cell-mediated cytotoxicity (CMC). CMC was determined in a modification of the microcytotoxicity assay of Takasugi and Klein. Analysis of data of groups of patients confirmed previous findings that effector cells (EC) from bladder cancer patients were more cytotoxic against T24 than were EC from normal individuals or from patients with other genitourinary cancers. Differences between patients with bladder cancer and other patients were not observed for other target cells. During the course of these experiments, non-disease-associated CMC by EC from individual normal donors and patients was observed. This phenomenon was investigated to determine its reproducibility and its relationship to different methods of preparing EC. Reproducibility of non-disease-related CMC was ascertained using EC prepared from heparinized blood by centrifugation over Ficoll-Hypaque (FH). A total of 126 experiments were performed in which 18 normal donors were tested 2 to 7 times each against 4 target cell lines. Of the resulting 46 combinations or groups of repeated assays, only 7 showed significant variability. Each normal donor had consistent CMC with differences from others being reproducible. CMC was therefore not due to crowding or physical effects. CMC mediated by EC prepared in this manner was then compared to that mediated by EC prepared by other methods in simultaneous tests.


5. DOCID:3919 SCORE: 0.0041984507102481
DOCNO: 1251298
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
AUTHOR: W B Gill WB
AUTHOR: M Bibbo M
AUTHOR: S Thomsen S
AUTHOR: C T Lu CT
PUBTYPE: Journal Article
JOURNALTITLE: The Surgical clinics of North America.
COUNTRY: UNITED STATES
TITLE: Evaluation of renal masses including retrograde renal brushing.
PUBDATE: 19760201
1.The evaluation of renal masses has become an increasingly important topic because of the increasing incidence of kidney cancer, the improved cure rate of renal carcinoma with the proper preoperative diagnosis, and the proliferation in renal mass diagnostic methodology. 2. A variety of benign entities can produce an abnormal renal mass with attendant difficulties in being distinguished from malignant neoplasms. Among these benign lesions are: simple renal cysts, polycystic kidneys, congenital variations in renal size and shape, segmental renal hypertrophy, renal infarcts, intrarenal hematomas, renal hamartomas, renal leiomyomas, renal adenomas, renal angiomas, renal fibrolipomatosis, hydronephrosis of a duplicated collecting system, renal abscesses, and xanthogranulomatous pyelonephritis. 3. Nephrotomography, nephrosonography (ultrasound), adrenalin renal arteriography, selective magnification renal arteriography, renal venography and cavography, lymphangiography, renal scintillation scanning, abnormal levels of enzymes in blood and urine, immunologic studies (circulating antibodies and tumor-associated antigens), percutaneous needle aspirations, and retrograde renal brushing have all increased the diagnostic accuracy of determining the etiology of renal masses. None of these diagnostic procedures is infallible. A judicious combination of procedures gives the most reliable diagnostic results. 4. A search continues for (a) chemical agent(s) or a chemical profile in the blood or urine which is (are) specific for renal carcinoma, but as yet this is an investigational area and not a practical clinical reality.


6. DOCID:6701 SCORE: 0.00402474202534809
DOCNO: 6116001
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: complications
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: B S Tepperman BS
AUTHOR: P J Fitzpatrick PJ
PUBTYPE: Journal Article
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: Second respiratory and upper digestive tract cancers after oral cancer.
PUBDATE: 19810901
Between 1958 and 1975, 377 patients with squamous cell carcinoma of the floor of the mouth were treated. 123 new cancers (not recurrences) developed in 101 (27%) of these patients after treatment. 82 (67%) were squamous cell carcinomas of the respiratory and upper digestive tracts, one-third of these being in the mouth. These tumors developed at a constant rate of 3.6% per year and led to excess mortality of 5.2% per year. Men with oral cancer have a relative risk of 13.4 for new tumours in the upper respiratory and upper digestive tracts compared with the general population; in females the relative risk for all sites is 82.6. All patients with mouth cancer should thus be examined regularly because of this high risk of new cancers.


7. DOCID:3686 SCORE: 0.00395483782785522
DOCNO: 175527
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Receptors, Cell Surface
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: K B Horwitz KB
AUTHOR: M E Costlow ME
AUTHOR: W L McGuire WL
PUBTYPE: Journal Article
JOURNALTITLE: Steroids.
COUNTRY: UNITED STATES
TITLE: MCF-7; a human breast cancer cell line with estrogen, androgen, progesterone, and glucocorticoid receptors.
PUBDATE: 19751201
We have identified receptors for glucocorticoids, progestins, and androgens in a human breast tumor cell line (MCF-7) known to have estrogen receptor. Sucrose density gradients show that MCF-7 cytosol contains approximately 100 fm/mg protein estradiol (E2-3H) receptor, more than 300 fm/mg protein progesterone receptor (measured with R5020-3H), about 40 fm/mg protein 5alpha-dihydrotestosterone (5alpha-DHT-3H) receptor, and 800 fm/mg glucocorticoid receptor (measured with dexamethasone-3H). Dissociation constants obtained by Scatchard analyses were approximately 0.6 x 10(-10)M (E2), 1 x 10(-9)M (R5020), 2.8 x 10(-10)M (5alpha-DHT) and 8 x 10(-9)M (dexamethasone). No cross competition was found for estrogen receptor, but progestins competed for androgen and glucocorticoid binding. The androgen, but not the glucocorticoid, partially competed for R5020 binding to progesterone receptor. This first demonstration of 4 classes of steroid receptors in human breast cancer means that MCF-7 may be an excellent in vitro model for studying the mechanism of tumor response to endocrine therapy as well as the complex relationships between binding and biological actions of these hormones.


8. DOCID:7980 SCORE: 0.00376732667979342
DOCNO: 637580
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: adverse effects
QUALIFIER: surgery
QUALIFIER: etiology
AUTHOR: T J Eberlein TJ
AUTHOR: F V Lorenzo FV
AUTHOR: M W Webster MW
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Annals of surgery.
COUNTRY: UNITED STATES
TITLE: Gastric carcinoma following operation for peptic ulcer disease.
PUBDATE: 19780301
Gastric carcinoma following operation for benign peptic ulcer disease has been considered rare but nine patients have been seen during the past five years. All were male patients, the average time interval from prior ulcer operation to development of cancer was 17 years, but was a short as ten years. The symptoms of cancer are vague and the diagnosis is often delayed. Fiberoptic endoscopy with biopsy of suspicious areas is the most accurate diagnostic approach. Resection of the tumor is indicated if feasible. The poor prognosis of this malignancy is documented. The evidence is reviewed that the creation of achlorhydria with bile reflux increases the risk of development of gastric carcinoma. All patients who undergo peptic ulcer operation require careful long-term follow-up. Vague gastrointestinal symptoms occurring ten years or more after peptic ulcer operation require full evaluation to exclude the presence of gastric cancer.


9. DOCID:1892 SCORE: 0.00375428856794415
DOCNO: 764957
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: enzymology
QUALIFIER: enzymology
AUTHOR: M K Schwartz MK
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Enzymes in colon cancer. General information.
PUBDATE: 19751201
Serum enzymes have not proved useful in evaluation of patients with early colon cancer, but certain enzymes such as transpeptidase, phosphohexone isosomerase, or 5'-nucleotidase have been of assistance in following the course of the disease, particularly in patients with metastatic spread to the liver. Attempts have been made to improve the utility of enzyme analysis in colon cancer by examination of enzyme patterns in colon biopsy specimens, feces, and colon washings. These studies, which will be summarized, are of importance in the possible development of diagnostic tools and as probes in the understanding of the etiology of colon cancer. The technical problems in carrying out these assays in humans, as well as the significance of the activity of aryl sulfatase, beta-glucuronidase, beta-glucosidase, lactic dehydrogenase, glucose-6-p-osphate dehydrogenase, and other enzymes will be considered.


10. DOCID:7841 SCORE: 0.00373022364982203
DOCNO: 7222003
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Dietary Proteins
DESCRIPTOR: Food
DESCRIPTOR: Public Health
AUTHOR: R J Hermus RJ
AUTHOR: R Kroes R
PUBTYPE: Journal Article
JOURNALTITLE: Tijdschrift voor diergeneeskunde.
COUNTRY: NETHERLANDS
TITLE: [Foods of animal origin and public health (author's transl)]
PUBDATE: 19810301
Modern society adopts a highly ambiguous attitude towards foods of animal origin in human nutrition. Animal protein is of great biological value. However, the wealthy part of the world already consumes more than sufficient protein, which renders this value superfluous. On the other hand, a rich diet including a large share of animal products is suspect from the point of view of cardiovascular disease, cancer, osteoporosis and nephrolithiasis. The role of fat, protein, cholesterol, salt, calcium and a number of minor components is discussed. It is concluded that as far as fats are concerned, reduction is indicated. There is a large individual variability in response to salt and cholesterol as well as interactions with other components of the diet. A role of animal protein in affecting calcium metabolism is plausible, though not definitely established. Public health hazards due to contaminants are probably small compared with those caused by the major components.


11. DOCID:3812 SCORE: 0.00356838200910841
DOCNO: 1138537
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
AUTHOR: J I Hamburger JI
PUBTYPE: Journal Article
JOURNALTITLE: The American journal of medicine.
COUNTRY: UNITED STATES
TITLE: Solitary autonomously functioning thyroid lesions. Diagnosis, clinical features and pathogenetic considerations.
PUBDATE: 19750601
One hundred sixty-four patients with autonomously functioning thyroid lesions (AFTL), 140 with nontoxic and 24 with toxic lesions, were studied over 12 years. To avoid pitfalls in diagnosis of nontoxic AFTL, a suppression procedure should precede the repeat scan after the administration of thyroid stimulating hormone. Women outnumbered men by 13 to 1 for nontoxic AFTL and 3.8 to 1 for toxic AFTL. Larger and toxic lesions were found in older patients, suggesting their derivation from smaller nontoxic lesions. Serum triiodothyronine (T3) and thyroxine concentrations exhibited parallel deviations from average normal levels for most of 29 patients with hot AFTL. T3 toxicosis was not seen. Ultrasound was more sensitive than scanning in detecting cystic degeneration. Observation was advised for patients with nontoxic AFTL unless toxicity appeared imminent. Of 51 such patients, followed from 1 to 12 years, none became hyperthyroid, but 10 AFTL increased from slightly to fourfold in size or showed evidence of degeneration. Of 24 patients with toxic AFTL, 20 were treated with radioiodine and the remaining 4 surgically; surgery is the preferred treatment for patients under 40 years of age. Three of 29 patients who were treated surgically had thyroid cancer. Since AFTL have histologic and pathophysiologic features characteristic of benign endocrine neoplasms, the association with cancer may be more than coincidental.


12. DOCID:3835 SCORE: 0.00341045370056595
DOCNO: 915570
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Copper
DESCRIPTOR: Metallurgy
DESCRIPTOR: Mining
DESCRIPTOR: Mortality
AUTHOR: A C Rencher AC
AUTHOR: M W Carter MW
AUTHOR: D W McKee DW
PUBTYPE: Journal Article
JOURNALTITLE: Journal of occupational medicine. : official publication of the Industrial Medical Association.
COUNTRY: UNITED STATES
TITLE: A retrospective epidemiological study of mortality at a large western copper smelter.
PUBDATE: 19771101
In comparing the smelter with the mine, concentrator, and State of Utah, it was found that they were very similar in the percentage of deaths due to all causes except lung cancer; 7.0% of all deaths at the smelter were due to lung cancer compared to 2.2% for the mine, 2.2% for the concentrator, and 2.7% for the state. The excess at the smelter was statistically significant. Approximate age-adjusted death rates were obtained for various causes of death. The rates for the smelter are higher than for the mine and the state for lung cancer and for all causes combined. The average age at death for smelter workers is nearly the same as for mine employees, even for those who died of lung cancer. Smoking data was examined and there was no indication of a smoking synergism. Cumulative exposure indices for SO2, H2SO4 mist, As, Pb, and Cu were computed for each deceased smelter worker based n the length of time he worked in each of 12 major areas. Those who died of lung cancer had the highest average exposure index for all five constituents. Stack emission data showed much higher levels of As and SO2 prior to 1959.


13. DOCID:3672 SCORE: 0.00321927126636927
DOCNO: 197261
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: veterinary
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: analysis
AUTHOR: H L Niman HL
AUTHOR: M B Gardner MB
AUTHOR: J R Stephenson JR
AUTHOR: P Roy-Burman P
PUBTYPE: Journal Article
JOURNALTITLE: Journal of virology.
COUNTRY: UNITED STATES
TITLE: Endogenous RD-114 virus genome expression in malignant tissues of domestic cats.
PUBDATE: 19770901
Endogenous xenotropic cat type C virus (RD-114)- and infectious feline leukemia virus (FeLV)-specific gene expressions were measured in spontaneous sarcomas carcinomas, and nonmalignant cat tissues by molecular hybridization for virus-specific RNA and competition radio-immunoassays for the major internal protein (p30) of these two viruses. The results indicate that RD-114 gene expression in sarcomas and carcinomas at both RNA and p30 levels is significantly higher than histologically normal tissues from cats free of cancer. In contrast, the levels of FeLV viral RNA and p30 are fount to be low or undetectable in the majority of these tumored and normal tissues examined. Whereas variability in the amounts of RD-114 OR FeLV RNA and p30 expressed is found in tissues from different cats, their expression is fairly uniform in multiple malignant tissues of the same cat. The finding of widespread occurrence of elevated RD-114 gene expression in sarcomas and carcinomas is consistent with our similar observation with natural lymphomas of domestic cats and suggests that expression of certain functions of this endogenous virus may be etiologically involved in the development of many different spontaneous neoplasms of cats.


14. DOCID:6498 SCORE: 0.00319658279672577
DOCNO: 7403821
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Alcohol Drinking
DESCRIPTOR: Diet
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: complications
AUTHOR: F Infante F
AUTHOR: M Voirol M
AUTHOR: O Brahime-Reteno O
AUTHOR: L Raymond L
AUTHOR: V Hollenweger V
AUTHOR: E Loizeau E
PUBTYPE: Journal Article
JOURNALTITLE: Schweizerische medizinische Wochenschrift.
COUNTRY: SWITZERLAND
TITLE: [Alcohol, tobacco and food consumption in liver cancer and cirrhosis. Preliminary results]
PUBDATE: 19800501
In German the consumption of food among cirrhotic patients, whether male or female and among male patients with primary liver cancer (PLC), is virtually the same as in normals. Alcohol consumption is very high in all three groups. The heaviest drinkers are the cirrhotic males, but the highest patient/control ratio is found among cirrhotic females (X 5.4). Total alcohol ingestion during life appears to be higher in patients with PLC plus cirrhosis than in those with PLC without cirrhosis. Tobacco consumption by male cirrhotic and PLC patients is the same as in controls. Conversely, cirrhotic females smoke seven times as much as their standardized controls.