0. DOCID:27881 SCORE: 0.00476182038976815
DOCNO: 11764714
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Quality of Health Care
QUALIFIER: psychology
QUALIFIER: psychology
AUTHOR: B Zebrack B
AFFILIATION: Division of Cancer Prevention and Control Research, University of California-Los Angeles, Johsson Comprehensive Cancer Center, Los Angeles, CA, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Seminars in oncology nursing.
COUNTRY: United States
TITLE: An advocate's perspective on cancer survivorship.
PUBDATE: 20011101
OBJECTIVE: To illustrate the scope of advocacy in cancer survivorship and to emphasize the critical role that health care providers play to help improve the quality of life of cancer survivors. DATA SOURCES: Published articles, government reports, and books. CONCLUSIONS: The delivery of quality cancer care requires not only an understanding of cancer survivorship issues but also a strategy for advocacy efforts for cancer survivors and their families. IMPLICATIONS FOR NURSING PRACTICE: Advocacy efforts involve individual interventions and family-focused support, public and professional education, and programs and policies that enhance cancer care and quality of life.

1. DOCID:27961 SCORE: 0.00476181356570076
DOCNO: 11276397
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Aging
QUALIFIER: genetics
QUALIFIER: pathology
QUALIFIER: genetics
QUALIFIER: pathology
AUTHOR: A Aviv A
AUTHOR: C B Harley CB
AFFILIATION: Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA. avivab@umdnj.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current hypertension reports.
COUNTRY: United States
TITLE: How long should telomeres be?
PUBDATE: 20010401
What began as a study of the "end-replication problem" took on a new dimension as it became clear that telomeres are a "molecular clock" of replication in human somatic cells. Here we review the biology of telomeres in vitro and in vivo, in mice and humans. We suggest that, in humans, telomeres are involved in the biology of aging and pathobiology of disorders of aging, including cancer and cardiovascular disease. We also propose that the underlying dynamics of telomere biology is in line with broad principles of evolutionary theories.

2. DOCID:27964 SCORE: 0.00476181349875162
DOCNO: 11902516
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mass Screening
QUALIFIER: diagnosis
AUTHOR: S D Fosså SD
AUTHOR: L M Eri LM
AUTHOR: E Skovlund E
AUTHOR: K Tveter K
AUTHOR: L Vatten L
AFFILIATION: Norwegian Radium Hospital, Oslo. s.d.fossa@klinmed.uio.no
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The lancet oncology.
COUNTRY: England
TITLE: No randomised trial of prostate-cancer screening in Norway.
PUBDATE: 20011201
The Norwegian Urological Cancer Group (NUCG) decided against participating in the European Randomised Study on Screening for Prostate Cancer, to which they had planned to contribute data from a population of 75 000 men aged between 50 and 65. The plan was abandonned for three main reasons: Norwegian doubts about the statistical power of the trial, the possible ethical implications of screening a large number of men with no symptoms, and the belief that the trial would not produce clinically important results. In this review, the NUCG's reasons for not participating in the trial are discussed in full.

3. DOCID:19558 SCORE: 0.00450743434550995
DOCNO: 1294331
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: isolation & purification
QUALIFIER: isolation & purification
QUALIFIER: chemistry
AUTHOR: M Arisawa M
AUTHOR: H Bai H
AUTHOR: S Shimizu S
AUTHOR: S Koshimura S
AUTHOR: M Tanaka M
AUTHOR: T Sasaki T
AUTHOR: N Morita N
AFFILIATION: Department of Medicinal Resources, Faculty of Pharmaceutical Sciences, Toyama Medical & Pharmaceutical University, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Chemical & pharmaceutical bulletin.
COUNTRY: JAPAN
TITLE: Isolation and identification of a cytotoxic principle from Chrysosplenium grayanum Maxim. (Saxifragaceae) and its antitumor activities.
PUBDATE: 19921201
A cytotoxic principle was newly isolated from Chrysosplenium grayanum Maxim. (Saxifragaceae) and identified as beta-peltoboykinolic acid (1) on the basis of spectral data. Cytotoxicity of compound 1 was tested against various human cancer cell lines in vitro, and antitumor effect of this compound was demonstrated on Meth.A mouse fibrosarcoma. The experiment of combined treatment with compound 1, mitomycin C, and OK-432 resulted in enhancing the antitumor effect against B16-BL6 mouse melanoma in C57BL/6 mice.

4. DOCID:19772 SCORE: 0.00446462368966077
DOCNO: 8451642
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: therapy
QUALIFIER: immunology
QUALIFIER: secondary
AUTHOR: H Takahashi H
AUTHOR: T Nakada T
AUTHOR: I Puisieux I
AFFILIATION: Molecular Hepatology Laboratory, Massachusetts General Hospital Cancer Center, Charlestown 02129.
PUBTYPE: Journal Article
JOURNALTITLE: Science.
COUNTRY: UNITED STATES
TITLE: Inhibition of human colon cancer growth by antibody-directed human LAK cells in SCID mice.
PUBDATE: 19930301
Advanced human colon cancer does not respond to lymphokine-activated killer (LAK) cells. In order to direct cytotoxic cells to the tumor, human LAK cells linked with antibodies to a tumor cell surface antigen were tested with established hepatic metastases in severe combined immunodeficient (SCID) mice. These cells had increased uptake into the tumor and suppression of tumor growth as compared with LAK cells alone, thereby improving the survival of tumor-bearing mice. Thus, tumor growth can be inhibited by targeted LAK cells, and SCID mice can be used to test the antitumor properties of human effector cells.

5. DOCID:18620 SCORE: 0.00419847975956488
DOCNO: 8383884
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Magnetic Resonance Imaging
DESCRIPTOR: Patient Care Planning
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: J Mäurer J
AUTHOR: M Busch M
AUTHOR: D Matthaei D
AUTHOR: A Helwig A
AUTHOR: E Dühmke E
AFFILIATION: Klinik und Poliklinik für Strahlentherapie, Georg-August-Universität Göttingen.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al].
COUNTRY: GERMANY
TITLE: [Diabetes insipidus and breast carcinoma--the importance of NMR tomography (MRT) in therapy planning]
PUBDATE: 19930201
In patients with advanced breast cancer the incidence of diabetes insipidus is between 0.1% and 0.9%. Satisfactory symptomatic relief can be obtained with Desmopressin-acetate. In the presence of this symptom complex magnetic resonance imaging (MRI) can aid in the detection of metastases to the posterior pituitary. By the use of magnetic resonance imaging, the incidence for and implementation of local radiotherapy can be firmly grounded.

6. DOCID:18311 SCORE: 0.00417758488573851
DOCNO: 7694353
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Pregnancy Complications
QUALIFIER: adverse effects
AUTHOR: A J Sasco AJ
AFFILIATION: Unité d'épidémiologie analytique, Centre international de recherche sur le cancer, Lyon.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: La Revue du praticien.
COUNTRY: FRANCE
TITLE: [Consequences of tobacco use on mothers and children]
PUBDATE: 19930501
The effects of smoking on female reproductive life are clear, with a longer time-lapse necessary for conception, alterations in hormonal and placental functions and an increased risk of extra-uterine pregnancy, prematurity and low birth-weight. The effects of passive smoking among children, irrespective of source, are linked to an increased risk of sudden infants death syndrome, as well as a higher frequency of otitis and respiratory ailments. Some authors have also found an increased risk of cancer in children and a negative impact on physical and psychological development.

7. DOCID:23626 SCORE: 0.00406429773928851
DOCNO: 8867539
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: etiology
AUTHOR: J A Aviña-Zubieta JA
AUTHOR: H L Enkerlin HL
AUTHOR: G Galindo-Rodriguez G
AFFILIATION: Rheumatic Disease Unit, Hospital de Especialidades Centro Medico La Raza, Mexico City, Mexico.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in rheumatology.
COUNTRY: UNITED STATES
TITLE: Rheumatic manifestations of malignancy.
PUBDATE: 19960101
Rheumatic manifestations of malignancy include a wide spectrum of osteoarticular, muscular, glandular, endocrinologic, and systemic features, posing a therapeutic challenge. The clinician should be aware that Sjögren's syndrome, polymyositisdermatomyositis, rheumatoid and rheumatoid-like arthritis, polymyalgia rheumatica and temporal arteritis, and diverse osteomuscular conditions may be the immunopathogenic features of a neoplasm, the direct consequence of osteomuscular tumors, the effect of tumor-associated hormones, or the consequence of cancer therapy. The principal articles that have appeared in the past year on these associations are discussed. We also review the association of x-ray irradiation and cancer in patients with ankylosing spondylitis.

8. DOCID:27801 SCORE: 0.00402444752966631
DOCNO: 10958786
AUTHOR: M J Galko MJ
AUTHOR: M Tessier-Lavigne M
AFFILIATION: Department of Anatomy, Howard Hughes Medical Institute, University of California, San Francisco, CA 94143, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Science.
COUNTRY: UNITED STATES
TITLE: Function of an axonal chemoattractant modulated by metalloprotease activity.
PUBDATE: 20000801
The axonal chemoattractant netrin-1 guides spinal commissural axons by activating its receptor DCC (Deleted in Colorectal Cancer). We have found that chemical inhibitors of metalloproteases potentiate netrin-mediated axon outgrowth in vitro. We have also found that DCC is a substrate for metalloprotease-dependent ectodomain shedding, and that the inhibitors block proteolytic processing of DCC and cause an increase in DCC protein levels on axons within spinal cord explants. Thus, potentiation of netrin activity by inhibitors may result from stabilization of DCC on the axons, and proteolytic activity may regulate axon migration by controlling the number of functional extracellular axon guidance receptors.

9. DOCID:19791 SCORE: 0.00396924930037868
DOCNO: 1509119
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug effects
QUALIFIER: urine
QUALIFIER: chemically induced
QUALIFIER: pharmacokinetics
QUALIFIER: urine
AUTHOR: C I Chappel CI
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Regulatory toxicology and pharmacology : RTP.
COUNTRY: UNITED STATES
TITLE: A review and biological risk assessment of sodium saccharin.
PUBDATE: 19920601
Dietary sodium saccharin is associated with bladder tumors when fed at high levels to the male rat. Under these conditions urinary pH, sodium concentration, and volume are elevated and proliferative changes are present in the urothelium. Extensive epidemiological studies have shown that saccharin does not increase the risk of bladder cancer in humans and laboratory investigations have shown that sodium saccharin is not mutagenic and does not bind to DNA. Recent research indicates that the urothelium in male rats is damaged under conditions of high urinary pH and sodium levels by a mechanism that involves alpha 2u-globulin and possibly silicate crystalluria. These studies and their implications for human health risk are reviewed.

10. DOCID:19612 SCORE: 0.0039235325668981
DOCNO: 1855689
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
AUTHOR: G J Poston GJ
AUTHOR: J Gillespie J
AUTHOR: P J Guillou PJ
AFFILIATION: Academic Surgical Unit, St Mary's Hospital Medical School, London.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gut.
COUNTRY: ENGLAND
TITLE: Biology of pancreatic cancer.
PUBDATE: 19910701
Pancreatic cancer is the fifth leading cause of death from malignant disease in Western society. Apart from the fortunate few patients who present with a resectable small pancreatic adenocarcinoma, conventional treatment offers no hope of cure and has little palliative value. Over the past two decades major steps have been made in our understanding of the biology of pancreatic growth and neoplasia. This review sets out to explore these advances, firstly in the regulation of normal pancreatic growth, and secondly the mechanism which may be involved in malignant change of the exocrine pancreas. From an understanding of this new biology, new treatment strategies may be possible for patients with pancreatic cancer.

11. DOCID:19218 SCORE: 0.00380647067920124
DOCNO: 1530335
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Infusion Pumps, Implantable
QUALIFIER: drug therapy
QUALIFIER: administration & dosage
QUALIFIER: drug therapy
AUTHOR: O Kobayashi O
AUTHOR: C Kuwae C
AUTHOR: A Kohyama A
AUTHOR: Y Yorinaga Y
AUTHOR: H Sudo H
AUTHOR: H Kitada H
AUTHOR: H Otsuka H
AUTHOR: T Minami T
AFFILIATION: Dept. of Gynecology, Tokyo Metropolitan Fuchu Hospital.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [A case of stage IVb ovarian carcinoma successfully treated with intra-arterial infusion chemotherapy using implantable reservoir system]
PUBDATE: 19920801
A patient with liver metastasis from ovarian cancer was treated by intra-arterial infusion chemotherapy (well differentiated adenocarcinoma--CDDP 50 mg/body, ADR 30 mg/body, CPA 500 mg/body (iv)). After the chemotherapy, the metastatic tumor appeared remarkably smaller and could be resected successfully at the second reduction surgery. This patient is active 30 months after the first appearance and enjoying a favorable quality of life.

12. DOCID:18746 SCORE: 0.00371380018397479
DOCNO: 2029198
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
AUTHOR: T Nakajima T
AFFILIATION: Division of Gastrointestinal Surgery, Cancer Institute Hospital, Tokyo, Japan.
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [Issues of adjuvant chemotherapy in gastric cancer: its clinical significance]
PUBDATE: 19910501
Though many previous reports suggest the clinical significance of adjuvant chemotherapy in gastric cancer, they are not always confirmed by the statistics. Treatment failures could be attributed to the minor benefit of chemotherapy for advanced cases, too much tumor burdens after surgery relative to the antitumor effect of chemotherapy, and statistically inadequate operation of clinical study. Improvement would be expected in the near future by carrying out a well designed control study with incorporation of new drugs such as CDDP or etoposide, or powerful regimen with MTX and 5 FU, or 5 FU and Leucovorin.

13. DOCID:19670 SCORE: 0.0036860295243616
DOCNO: 1463349
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: Y Inaba Y
AUTHOR: M Chiba M
AUTHOR: S Watabe S
AUTHOR: K Kudo K
AUTHOR: K Hayashi K
AUTHOR: S Otsuka S
AFFILIATION: Division of General Surgery, Yamagata Prefectural Kahoku Hospital, Japan.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan to kagaku ryoho. Cancer & chemotherapy.
COUNTRY: JAPAN
TITLE: [A case of gastric carcinoma with peritonitis carcinomatosa responding remarkably to etoposide, adriamycin and cisplatin (EAP) therapy]
PUBDATE: 19921201
The patient was a 62-year-old male who had Borrmann 4 type gastric cancer. He presented massive ascites due to peritonitis carcinomatosa and the cytology of ascites was class V. He was treated with 3 courses of EAP (etoposide, adriamycin, cisplatin) therapy. Computed tomography showed ascites nearly disappeared. Remarkable improvement was observed by barium meal study and endoscopic examination, and partial remission (PR) was achieved. As for toxicity bone marrow suppression, alopecia and elevation of BUN were observed.

14. DOCID:21832 SCORE: 0.00357468192676693
DOCNO: 8160662
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Epidemiologic Methods
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: S W Samuels SW
AFFILIATION: Workplace Health Fund (IUD/AFL-CIO), Washington, DC.
PUBTYPE: Journal Article
JOURNALTITLE: American journal of industrial medicine.
COUNTRY: UNITED STATES
TITLE: An open systems approach to risk assessment.
PUBDATE: 19940301
The development of risk assessment in occupational and environmental cancer control is outlined, with emphasis on the differing assumptions of Doll and Selikoff. These differences are explained by philosophic perspectives from which closed and open system approaches to assessment were respectively chosen. Open system, with negative entropy and progressive organization, are characteristic of living systems and, heuristically, should be characteristic of risk assessment models. The abuse of either approach occurs when the "habit of truth" is overcome by consciously contrived confusion, a betrayal of society by les clercs.