0. DOCID:15861 SCORE: 0.00697346652404484
DOCNO: 2481893
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Palliative Care
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: L Gran L
AUTHOR: C F Borchgrevink CF
PUBTYPE: Journal Article
JOURNALTITLE: Tidsskrift for den Norske laegeforening.
COUNTRY: NORWAY
TITLE: [Pain treatment of patients with cancer]
PUBDATE: 19891101
In Vestfold, with a population of 192,200, all patients who died from cancer in 1987 were followed retrospectively through their last six months. 61% (n = 342) had cancer-related pain and received analgesic treatment. In 9% pain remained a problem. In the same group, 74% suffered from other symptoms, such as nausea, dyspnoea, anxiety and depression. These symptoms were reduced efficiently in only 58%. Nausea was the main problem. We found a significant connection between nausea, chemotherapy and opiate treatment. Anxiety and depression were recognised in about 20% of the patients, and were seldom adequately relieved. In order to provide optimal quality of life, more attention should be drawn not only to pain but also to the other symptoms.


1. DOCID:3992 SCORE: 0.00664564386053655
DOCNO: 1248000
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: genetics
AUTHOR: M Swift M
AUTHOR: L Sholman L
AUTHOR: M Perry M
AUTHOR: C Chase C
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Malignant neoplasms in the families of patients with ataxia-telangiectasia.
PUBDATE: 19760101
Ataxia-telangiectasia (A-T) is an autosomal recessive syndrome associated with a greatly increased incidence of malignant neoplasms in homozygous affected individuals. Heterozygotes for the gene for A-T are thought to comprise about 1% of the general population and, therefore, it is important to know whether this gene also predisposes the heterozygous carrier to cancers. Heterozygous carriers of this gene are common among the close relatives of patients with A-T, although individual carriers cannot be identified by any clinical criterion or laboratory test. For this reason, we compared the incidence of death from malignant neoplasms in 2 families of patients with A-T to that expected in a random sample of the general population. There were 59 deaths from malignant neoplasms in relatives dying before age 75, compared to 42.6 expected (p less than 0.02). For A-T heterozygotes younger than age 45, the risk of dying from a malignant neoplasm was estimated to be greater than 5 times the risk for the general population. A-T heterozygotes may comprise more than 5% of all persons dying from a cancer before age 45. The incidence of ovarian, gastric, and biliary system carcinomas and of leukemia and lymphoma was increased in these A-T families. Other neoplasms that may be associated with this gene in heterozygotes include pancreatic, basal cell, colonic, breast, and cervical carcinomas.


2. DOCID:7398 SCORE: 0.00553532761319761
DOCNO: 6116444
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: trends
AUTHOR: J D Schwarzmeier JD
PUBTYPE: Journal Article
JOURNALTITLE: Aktuelle Gerontologie.
COUNTRY: GERMANY, WEST
TITLE: [New aspects in oncological research (author's transl)]
PUBDATE: 19810301
Following the presentation of some theories of cancer etiology the significance of the cell membrane in neoplastic transformation is stressed. Alterations of the cell surface are blamed responsible for the abnormal proliferative behaviour and metastasis of cancer cells. In addition, the disturbance of membrane-bound receptor structures might result in defects of "endocrine" control mechanisms leading to the typical uncontrolled growth of tumor cells. In this context, the membrane-bound adenylate-cyclase system deserves special interest, since hormone impulses stimulate this enzyme via specific receptors to produce cyclic AMP. This nucleotide transmits hormonal signals within the cell. Our own studies on lymphoma and leukemic cells are mentioned because they demonstrate alterations of the cAMP producing system in malignant cells. Finally, the phenomenon of cell fusion is discussed. Recently great attention has been paid to this technique, since hybridization experiments enable us to get new insight into the process of neoplastic transformation.


3. DOCID:10566 SCORE: 0.00537244467955721
DOCNO: 6312623
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: adverse effects
QUALIFIER: pharmacology
AUTHOR: J L Trudel JL
AUTHOR: M K Senterman MK
AUTHOR: R A Brown RA
PUBTYPE: Journal Article
JOURNALTITLE: Surgery.
COUNTRY: UNITED STATES
TITLE: The fat/fiber antagonism in experimental colon carcinogenesis.
PUBDATE: 19831001
Current epidemiologic and experimental data emphasize the importance of nutrition in colon carcinogenesis. The interactions between dietary fat and dietary fiber were studied in the dimethylhydrazine model for colon cancer. A strict pair-feeding system was developed, and rats were fed one of five semisynthetic diets containing various amounts and types of fat and fiber. The incidence and number of tumors per animal were increased in all fat-fed groups. Adding fiber to the diets provided either partial (polyunsaturated fat) or complete (saturated fat) protection against the deleterious effect of fat. The antagonism between fat and fiber and the clinical relevance of these data are discussed.


4. DOCID:15611 SCORE: 0.00528771683351383
DOCNO: 3167795
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: prevention & control
QUALIFIER: prevention & control
AUTHOR: A W Kopf AW
AFFILIATION: Department of Dermatology, New York University School of Medicine, NY.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Prevention and early detection of skin cancer/melanoma.
PUBDATE: 19881001
In the USA malignant neoplasms of the skin are the most common cancers of man. Annually, over 500,000 new cutaneous cancers are diagnosed. Of particular concern is the inexorable increase in the incidence and mortality rate of malignant melanoma (in 1978: 25,000 new cases; 5800 deaths). There are substantial data that (1) implicate sunlight as the probable cause of many cancers of the skin, and that, (2) indicate early diagnosis and prompt treatment results in cure in most instances. The time has come to create, implement, and evaluate a National Program on Education of the Medical Profession and the Public on Cancers of the Skin with emphasis on cutaneous malignant melanoma.


5. DOCID:7397 SCORE: 0.00528508175806049
DOCNO: 7290965
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radionuclide imaging
QUALIFIER: radionuclide imaging
QUALIFIER: diagnostic use
AUTHOR: P Gabelle P
AUTHOR: M Comet M
AUTHOR: J P Bodin JP
AUTHOR: A Dupré A
AUTHOR: E Carpentier E
AUTHOR: M Bolla M
AUTHOR: P Swiercz P
PUBTYPE: Journal Article
JOURNALTITLE: La Nouvelle presse médicale.
COUNTRY: FRANCE
TITLE: [Mammary lymphatic scintiscans by intratumoral injection in the assessment of breast cancer. 105 examination in 100 patients (author's transl)]
PUBDATE: 19811001
One hundred and five scintiscans of the mammary lymphatic system were performed in 100 patients with breast cancer by intratumoral injection of 99 m Tc-labelled colloidal rhenium. The progression of the radioactive colloidal agent was followed on a series of films taken 1, 2 and 4 hours after the injection, and the images obtained were compared with post-operative findings of lymph node involvement. Patients with more than 3 carcinomatous lymph nodes had less than 2 foci of activity, while those with less than 3 carcinomatous lymph nodes had more than 2 foci of activity, owing to more rapid progression of the compound. The difference was highly significant (p less than 0,001).


6. DOCID:11552 SCORE: 0.00524582242426296
DOCNO: 6645064
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: H Konno H
AUTHOR: K Okuyama K
AUTHOR: K Isono K
AUTHOR: S Onoda S
AUTHOR: H Hirasawa H
AUTHOR: H Satoh H
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Thoracic esophageal cancer in a young adult]
PUBDATE: 19831001
A 34-year-old Japanese male was admitted to the Second Department of Surgery, Chiba University Hospital complaining of swallowing difficulties of three months duration. Radiological examination with barium swallowing revealed thoracic esophageal cancer, classified as EiEa, was 6cm long and of the serrated type. Preoperative combined therapy included Fast Neutron, Pepleomycin, Bestatin and hyperthermia. The operative procedure was total thoracic esophagectomy and ante-thoracic esophago-gastrostomy using the right thoracotomy approach plus laparotomy. Postoperative combined therapy included Linac irradiation and Cisplatin. His postoperative course was uneventful and he was discharged without complications. The tumor was of ill-defined ulcerative type macroscopically; the pathological diagnosis was moderately differentiated squamous cell carcinoma.


7. DOCID:14451 SCORE: 0.00518945829471893
DOCNO: 3436510
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Vaginal Smears
QUALIFIER: secondary
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: secondary
AUTHOR: V Jaluvka V
AUTHOR: W Engelhardt W
AFFILIATION: Frauenklinik und Poliklinik, Freien Universität im Klinikum Steglitz.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Geburtshilfe und Frauenheilkunde.
COUNTRY: GERMANY, WEST
TITLE: [Cervix cytology and primary malignancies of the gastrointestinal tract]
PUBDATE: 19871201
During the cancer check-up of a 46-year-old woman a PAP V was diagnosed in the cervical scrapings. The atypical cells of the abrasion specimens from the corpus uteri arouse strong suspicion of malignancy. Connected with the clinical data, this finding primarily indicated a metastatic involvement of the inner genitals. This suspicion was confirmed by exploratory surgery laparotomy. A large tumor was found intraoperatively which was occupying the entire stomach. Concurrently, a diffuse peritoneal carcinomatosis was found with involvement of the left adnexae in the sense of a Krukenberg's tumor.


8. DOCID:3995 SCORE: 0.00470908741075036
DOCNO: 838858
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: metabolism
AUTHOR: M D Benson MD
AUTHOR: M A Scheinberg MA
AUTHOR: T Shirahama T
AUTHOR: E S Cathcart ES
AUTHOR: M Skinner M
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of clinical investigation.
COUNTRY: UNITED STATES
TITLE: Kinetics of serum amyloid protein A in casein-induced murine amyloidosis.
PUBDATE: 19770301
Serum amyloid protein A (SAA), the precursor of secondary amyloid protein, is elevated in chronic diseases which are associated with an increased incidence of amyloid. However, SAA is also elevated in acute bacterial and viral infections and somes forms of cancer. The murine model of casein-induced amyloidosis was studied to determine the relationship between SAA production and amyloid deposition. SAA levels measured by radioimmunoassay were found to be as high as 200 times the normal level in CBA/J mice receiving daily parenteral casein. After a single injection of casein the SAA level was elevated by 3h and peaked by 12-18 h. Similar levels were found in casein-treated A/J mice, a strain less susceptible to the induction of amyloid. Parenterally administered bovine serum albumin, which has low potential for amyloid induction, gave SAA levels in CBA/J and A/J mice comparable to casein treatment. These data show that, while SAA levels are elevated during chronic antigenic stimulation, there are other factors involved in amyloid formation. These factors may include alterations in the degradation of SAA by the reticuloendothelial system caused by substances such as casein. Nude (athymic) mice were shown to attain high levels of SAA after receiving casein parenterally. Therefore, thymus-derived lymphocytes are not necessary for the synthesis of SAA.


9. DOCID:15359 SCORE: 0.00470382335156632
DOCNO: 2820741
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: D A Morgan DA
AUTHOR: D Gilson D
AUTHOR: J Fletcher J
AFFILIATION: Hogarth Centre of Radiotherapy and Oncology, General Hospital, Nottingham, England.
PUBTYPE: Journal Article
JOURNALTITLE: European journal of cancer & clinical oncology.
COUNTRY: ENGLAND
TITLE: Vincristine and etoposide: an effective chemotherapy regimen with reduced toxicity in extensive small-cell lung cancer.
PUBDATE: 19870601
Chemotherapy prolongs survival of patients with small-cell lung cancer, but very few are cured, and the treatment is unpleasant. Thirty patients, 28 with advanced disease, were treated with etoposide 250 mg/m2 orally, daily for 5 days, plus vincristine 2 mg intravenously on the first day, the cycle being repeated 3-weekly, to a maximum of 6. There was a response rate of 70%, a median survival of 249 days, and an 11% 2-year survival. Symptomatic side-effects were less pronounced than with most other regimens of comparable efficacy.


10. DOCID:14776 SCORE: 0.00469442942094938
DOCNO: 3172524
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: therapy
QUALIFIER: therapeutic use
AUTHOR: R Nakamura R
AUTHOR: M Watanabe M
AUTHOR: Y Sugimura Y
AUTHOR: M Kondoh M
AUTHOR: K Saitoh K
AUTHOR: S Sasou S
AFFILIATION: Dept. of Surgery I, Iwate Medical Univ., School of Med.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Early esophageal cancer discovered 6 months after endoscopic injection sclerotherapy of esophageal varices]
PUBDATE: 19880801
Early esophageal cancer was discovered in a 55-year-old male with liver cirrhosis six months after the start of treatment for esophageal varices by a series of endoscopic sclerotherapeutic injections using 5% ethanolamine oleate. A histological examination of the entire length of the resected esophageal wall revealed a carcinomatous lesion oralwards and far removed from the lesion where subsequent changes due to sclerotherapy were prominent. Further, the causal relationship between sclerotherapy and carcinoma is discussed.


11. DOCID:11395 SCORE: 0.00450680410195997
DOCNO: 6884824
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: therapeutic use
QUALIFIER: radiotherapy
QUALIFIER: radiotherapy
AUTHOR: D Nori D
AUTHOR: J M Cain JM
AUTHOR: B S Hilaris BS
AUTHOR: W B Jones WB
AUTHOR: J L Lewis JL
PUBTYPE: Journal Article
JOURNALTITLE: Gynecologic oncology.
COUNTRY: UNITED STATES
TITLE: Metronidazole as a radiosensitizer and high-dose radiation in advanced vulvovaginal malignancies, a pilot study.
PUBDATE: 19830801
Advanced vulvovaginal cancers have a survival of less than 25% in 5 years when treated with radiotherapy alone. The radiosensitizer metronidazole was used with unconventional radiation fractions in 10 patients. Local control was achieved in 9 out of 10 patients treated. Five of 10 patients have remained free of disease 9-30 months postdiagnosis. Two patients died with metastatic disease, but with local control. In only 1 patient did this approach fail to control local disease. The outcome of these 10 patients represents a significant improvement over conventional radiation. A randomized prospective study has been started on the basis of this pilot study.


12. DOCID:11193 SCORE: 0.00450486553275067
DOCNO: 2995755
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: therapy
QUALIFIER: methods
QUALIFIER: therapy
QUALIFIER: methods
AUTHOR: S L Dar'ialova SL
AUTHOR: P G Bitiutskiĭ PG
AUTHOR: V A Sukirko VA
AUTHOR: A L Klochikhin AL
AUTHOR: G A Frank GA
PUBTYPE: Clinical Trial
PUBTYPE: Journal Article
PUBTYPE: Randomized Controlled Trial
JOURNALTITLE: Meditsinskaia radiologiia.
COUNTRY: USSR
TITLE: [Preoperative irradiation of laryngeal cancer patients under different oxygen regimens]
PUBDATE: 19850901
Radiation therapy under the conditions of hyperbaric oxygenation (HBO) using the method of mean fractionation (3.3 Gy 3 times a week up to the summary dose of 33 Gy) was employed to overcome tumor hypoxia and to raise selectively radiosensitivity of laryngeal cancer. A randomized study of 120 patients has shown that the use of radiation therapy under HBO conditions makes it possible to reduce the frequency of radiation reactions, to increase tumor resorption and the degree of radiation damage, to reduce the frequency of postoperative purulent complications, and to prevent the occurrence of early and late recurrences and metastases.


13. DOCID:12816 SCORE: 0.00427236357136497
DOCNO: 3627614
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Pelvic Exenteration
QUALIFIER: transplantation
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: J E Delmore JE
AUTHOR: D A Turner DA
AUTHOR: D M Gershenson DM
AUTHOR: D V Horbelt DV
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Perineal hernia repair using human dura.
PUBDATE: 19870901
A patient developed a large perineal hernia and prolapse of a myocutaneous neovagina 13 months after total pelvic exenteration for recurrent squamous cell cancer of the cervix and gracilis myocutaneous vaginal reconstruction. The neovagina was removed and the pelvic floor defect was repaired with preserved human dura. Twelve months postoperatively, the patient remained asymptomatic. Current and potential uses for human dura allografts are discussed.


14. DOCID:3978 SCORE: 0.00422061185206635
DOCNO: 1260761
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Immunity, Cellular
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: E T Bloom ET
AUTHOR: R C Seeger RC
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Disease and non-disease-related cell-mediated cytotoxicity in humans.
PUBDATE: 19760401
The human bladder cancer/T24 system was used to investigate disease and non-disease-related cell-mediated cytotoxicity (CMC). CMC was determined in a modification of the microcytotoxicity assay of Takasugi and Klein. Analysis of data of groups of patients confirmed previous findings that effector cells (EC) from bladder cancer patients were more cytotoxic against T24 than were EC from normal individuals or from patients with other genitourinary cancers. Differences between patients with bladder cancer and other patients were not observed for other target cells. During the course of these experiments, non-disease-associated CMC by EC from individual normal donors and patients was observed. This phenomenon was investigated to determine its reproducibility and its relationship to different methods of preparing EC. Reproducibility of non-disease-related CMC was ascertained using EC prepared from heparinized blood by centrifugation over Ficoll-Hypaque (FH). A total of 126 experiments were performed in which 18 normal donors were tested 2 to 7 times each against 4 target cell lines. Of the resulting 46 combinations or groups of repeated assays, only 7 showed significant variability. Each normal donor had consistent CMC with differences from others being reproducible. CMC was therefore not due to crowding or physical effects. CMC mediated by EC prepared in this manner was then compared to that mediated by EC prepared by other methods in simultaneous tests.