0. DOCID:15861 SCORE: 0.00697346652404484
DOCNO: 2481893
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Palliative Care
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: L Gran L
AUTHOR: C F Borchgrevink CF
PUBTYPE: Journal Article
JOURNALTITLE: Tidsskrift for den Norske laegeforening.
COUNTRY: NORWAY
TITLE: [Pain treatment of patients with cancer]
PUBDATE: 19891101
In Vestfold, with a population of 192,200, all patients who died from cancer in 1987 were followed retrospectively through their last six months. 61% (n = 342) had cancer-related pain and received analgesic treatment. In 9% pain remained a problem. In the same group, 74% suffered from other symptoms, such as nausea, dyspnoea, anxiety and depression. These symptoms were reduced efficiently in only 58%. Nausea was the main problem. We found a significant connection between nausea, chemotherapy and opiate treatment. Anxiety and depression were recognised in about 20% of the patients, and were seldom adequately relieved. In order to provide optimal quality of life, more attention should be drawn not only to pain but also to the other symptoms.


1. DOCID:3992 SCORE: 0.00664564386053655
DOCNO: 1248000
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: complications
QUALIFIER: genetics
AUTHOR: M Swift M
AUTHOR: L Sholman L
AUTHOR: M Perry M
AUTHOR: C Chase C
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Malignant neoplasms in the families of patients with ataxia-telangiectasia.
PUBDATE: 19760101
Ataxia-telangiectasia (A-T) is an autosomal recessive syndrome associated with a greatly increased incidence of malignant neoplasms in homozygous affected individuals. Heterozygotes for the gene for A-T are thought to comprise about 1% of the general population and, therefore, it is important to know whether this gene also predisposes the heterozygous carrier to cancers. Heterozygous carriers of this gene are common among the close relatives of patients with A-T, although individual carriers cannot be identified by any clinical criterion or laboratory test. For this reason, we compared the incidence of death from malignant neoplasms in 2 families of patients with A-T to that expected in a random sample of the general population. There were 59 deaths from malignant neoplasms in relatives dying before age 75, compared to 42.6 expected (p less than 0.02). For A-T heterozygotes younger than age 45, the risk of dying from a malignant neoplasm was estimated to be greater than 5 times the risk for the general population. A-T heterozygotes may comprise more than 5% of all persons dying from a cancer before age 45. The incidence of ovarian, gastric, and biliary system carcinomas and of leukemia and lymphoma was increased in these A-T families. Other neoplasms that may be associated with this gene in heterozygotes include pancreatic, basal cell, colonic, breast, and cervical carcinomas.


2. DOCID:7398 SCORE: 0.00553532761319761
DOCNO: 6116444
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: trends
AUTHOR: J D Schwarzmeier JD
PUBTYPE: Journal Article
JOURNALTITLE: Aktuelle Gerontologie.
COUNTRY: GERMANY, WEST
TITLE: [New aspects in oncological research (author's transl)]
PUBDATE: 19810301
Following the presentation of some theories of cancer etiology the significance of the cell membrane in neoplastic transformation is stressed. Alterations of the cell surface are blamed responsible for the abnormal proliferative behaviour and metastasis of cancer cells. In addition, the disturbance of membrane-bound receptor structures might result in defects of "endocrine" control mechanisms leading to the typical uncontrolled growth of tumor cells. In this context, the membrane-bound adenylate-cyclase system deserves special interest, since hormone impulses stimulate this enzyme via specific receptors to produce cyclic AMP. This nucleotide transmits hormonal signals within the cell. Our own studies on lymphoma and leukemic cells are mentioned because they demonstrate alterations of the cAMP producing system in malignant cells. Finally, the phenomenon of cell fusion is discussed. Recently great attention has been paid to this technique, since hybridization experiments enable us to get new insight into the process of neoplastic transformation.


3. DOCID:10566 SCORE: 0.00537244467955721
DOCNO: 6312623
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: adverse effects
QUALIFIER: pharmacology
AUTHOR: J L Trudel JL
AUTHOR: M K Senterman MK
AUTHOR: R A Brown RA
PUBTYPE: Journal Article
JOURNALTITLE: Surgery.
COUNTRY: UNITED STATES
TITLE: The fat/fiber antagonism in experimental colon carcinogenesis.
PUBDATE: 19831001
Current epidemiologic and experimental data emphasize the importance of nutrition in colon carcinogenesis. The interactions between dietary fat and dietary fiber were studied in the dimethylhydrazine model for colon cancer. A strict pair-feeding system was developed, and rats were fed one of five semisynthetic diets containing various amounts and types of fat and fiber. The incidence and number of tumors per animal were increased in all fat-fed groups. Adding fiber to the diets provided either partial (polyunsaturated fat) or complete (saturated fat) protection against the deleterious effect of fat. The antagonism between fat and fiber and the clinical relevance of these data are discussed.


4. DOCID:15611 SCORE: 0.00528771683351383
DOCNO: 3167795
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: prevention & control
QUALIFIER: prevention & control
AUTHOR: A W Kopf AW
AFFILIATION: Department of Dermatology, New York University School of Medicine, NY.
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Prevention and early detection of skin cancer/melanoma.
PUBDATE: 19881001
In the USA malignant neoplasms of the skin are the most common cancers of man. Annually, over 500,000 new cutaneous cancers are diagnosed. Of particular concern is the inexorable increase in the incidence and mortality rate of malignant melanoma (in 1978: 25,000 new cases; 5800 deaths). There are substantial data that (1) implicate sunlight as the probable cause of many cancers of the skin, and that, (2) indicate early diagnosis and prompt treatment results in cure in most instances. The time has come to create, implement, and evaluate a National Program on Education of the Medical Profession and the Public on Cancers of the Skin with emphasis on cutaneous malignant melanoma.


5. DOCID:7397 SCORE: 0.00528508175806049
DOCNO: 7290965
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radionuclide imaging
QUALIFIER: radionuclide imaging
QUALIFIER: diagnostic use
AUTHOR: P Gabelle P
AUTHOR: M Comet M
AUTHOR: J P Bodin JP
AUTHOR: A Dupré A
AUTHOR: E Carpentier E
AUTHOR: M Bolla M
AUTHOR: P Swiercz P
PUBTYPE: Journal Article
JOURNALTITLE: La Nouvelle presse médicale.
COUNTRY: FRANCE
TITLE: [Mammary lymphatic scintiscans by intratumoral injection in the assessment of breast cancer. 105 examination in 100 patients (author's transl)]
PUBDATE: 19811001
One hundred and five scintiscans of the mammary lymphatic system were performed in 100 patients with breast cancer by intratumoral injection of 99 m Tc-labelled colloidal rhenium. The progression of the radioactive colloidal agent was followed on a series of films taken 1, 2 and 4 hours after the injection, and the images obtained were compared with post-operative findings of lymph node involvement. Patients with more than 3 carcinomatous lymph nodes had less than 2 foci of activity, while those with less than 3 carcinomatous lymph nodes had more than 2 foci of activity, owing to more rapid progression of the compound. The difference was highly significant (p less than 0,001).


6. DOCID:11552 SCORE: 0.00524582242426296
DOCNO: 6645064
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
AUTHOR: H Konno H
AUTHOR: K Okuyama K
AUTHOR: K Isono K
AUTHOR: S Onoda S
AUTHOR: H Hirasawa H
AUTHOR: H Satoh H
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Thoracic esophageal cancer in a young adult]
PUBDATE: 19831001
A 34-year-old Japanese male was admitted to the Second Department of Surgery, Chiba University Hospital complaining of swallowing difficulties of three months duration. Radiological examination with barium swallowing revealed thoracic esophageal cancer, classified as EiEa, was 6cm long and of the serrated type. Preoperative combined therapy included Fast Neutron, Pepleomycin, Bestatin and hyperthermia. The operative procedure was total thoracic esophagectomy and ante-thoracic esophago-gastrostomy using the right thoracotomy approach plus laparotomy. Postoperative combined therapy included Linac irradiation and Cisplatin. His postoperative course was uneventful and he was discharged without complications. The tumor was of ill-defined ulcerative type macroscopically; the pathological diagnosis was moderately differentiated squamous cell carcinoma.


7. DOCID:14451 SCORE: 0.00518945829471893
DOCNO: 3436510
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Vaginal Smears
QUALIFIER: secondary
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: secondary
AUTHOR: V Jaluvka V
AUTHOR: W Engelhardt W
AFFILIATION: Frauenklinik und Poliklinik, Freien Universität im Klinikum Steglitz.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Geburtshilfe und Frauenheilkunde.
COUNTRY: GERMANY, WEST
TITLE: [Cervix cytology and primary malignancies of the gastrointestinal tract]
PUBDATE: 19871201
During the cancer check-up of a 46-year-old woman a PAP V was diagnosed in the cervical scrapings. The atypical cells of the abrasion specimens from the corpus uteri arouse strong suspicion of malignancy. Connected with the clinical data, this finding primarily indicated a metastatic involvement of the inner genitals. This suspicion was confirmed by exploratory surgery laparotomy. A large tumor was found intraoperatively which was occupying the entire stomach. Concurrently, a diffuse peritoneal carcinomatosis was found with involvement of the left adnexae in the sense of a Krukenberg's tumor.


8. DOCID:27881 SCORE: 0.00476182038976815
DOCNO: 11764714
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Quality of Health Care
QUALIFIER: psychology
QUALIFIER: psychology
AUTHOR: B Zebrack B
AFFILIATION: Division of Cancer Prevention and Control Research, University of California-Los Angeles, Johsson Comprehensive Cancer Center, Los Angeles, CA, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Seminars in oncology nursing.
COUNTRY: United States
TITLE: An advocate's perspective on cancer survivorship.
PUBDATE: 20011101
OBJECTIVE: To illustrate the scope of advocacy in cancer survivorship and to emphasize the critical role that health care providers play to help improve the quality of life of cancer survivors. DATA SOURCES: Published articles, government reports, and books. CONCLUSIONS: The delivery of quality cancer care requires not only an understanding of cancer survivorship issues but also a strategy for advocacy efforts for cancer survivors and their families. IMPLICATIONS FOR NURSING PRACTICE: Advocacy efforts involve individual interventions and family-focused support, public and professional education, and programs and policies that enhance cancer care and quality of life.


9. DOCID:27961 SCORE: 0.00476181356570076
DOCNO: 11276397
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Aging
QUALIFIER: genetics
QUALIFIER: pathology
QUALIFIER: genetics
QUALIFIER: pathology
AUTHOR: A Aviv A
AUTHOR: C B Harley CB
AFFILIATION: Hypertension Research Center, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA. avivab@umdnj.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current hypertension reports.
COUNTRY: United States
TITLE: How long should telomeres be?
PUBDATE: 20010401
What began as a study of the "end-replication problem" took on a new dimension as it became clear that telomeres are a "molecular clock" of replication in human somatic cells. Here we review the biology of telomeres in vitro and in vivo, in mice and humans. We suggest that, in humans, telomeres are involved in the biology of aging and pathobiology of disorders of aging, including cancer and cardiovascular disease. We also propose that the underlying dynamics of telomere biology is in line with broad principles of evolutionary theories.


10. DOCID:27964 SCORE: 0.00476181349875162
DOCNO: 11902516
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Mass Screening
QUALIFIER: diagnosis
AUTHOR: S D Fosså SD
AUTHOR: L M Eri LM
AUTHOR: E Skovlund E
AUTHOR: K Tveter K
AUTHOR: L Vatten L
AFFILIATION: Norwegian Radium Hospital, Oslo. s.d.fossa@klinmed.uio.no
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The lancet oncology.
COUNTRY: England
TITLE: No randomised trial of prostate-cancer screening in Norway.
PUBDATE: 20011201
The Norwegian Urological Cancer Group (NUCG) decided against participating in the European Randomised Study on Screening for Prostate Cancer, to which they had planned to contribute data from a population of 75 000 men aged between 50 and 65. The plan was abandonned for three main reasons: Norwegian doubts about the statistical power of the trial, the possible ethical implications of screening a large number of men with no symptoms, and the belief that the trial would not produce clinically important results. In this review, the NUCG's reasons for not participating in the trial are discussed in full.


11. DOCID:3995 SCORE: 0.00470908741075036
DOCNO: 838858
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: metabolism
AUTHOR: M D Benson MD
AUTHOR: M A Scheinberg MA
AUTHOR: T Shirahama T
AUTHOR: E S Cathcart ES
AUTHOR: M Skinner M
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of clinical investigation.
COUNTRY: UNITED STATES
TITLE: Kinetics of serum amyloid protein A in casein-induced murine amyloidosis.
PUBDATE: 19770301
Serum amyloid protein A (SAA), the precursor of secondary amyloid protein, is elevated in chronic diseases which are associated with an increased incidence of amyloid. However, SAA is also elevated in acute bacterial and viral infections and somes forms of cancer. The murine model of casein-induced amyloidosis was studied to determine the relationship between SAA production and amyloid deposition. SAA levels measured by radioimmunoassay were found to be as high as 200 times the normal level in CBA/J mice receiving daily parenteral casein. After a single injection of casein the SAA level was elevated by 3h and peaked by 12-18 h. Similar levels were found in casein-treated A/J mice, a strain less susceptible to the induction of amyloid. Parenterally administered bovine serum albumin, which has low potential for amyloid induction, gave SAA levels in CBA/J and A/J mice comparable to casein treatment. These data show that, while SAA levels are elevated during chronic antigenic stimulation, there are other factors involved in amyloid formation. These factors may include alterations in the degradation of SAA by the reticuloendothelial system caused by substances such as casein. Nude (athymic) mice were shown to attain high levels of SAA after receiving casein parenterally. Therefore, thymus-derived lymphocytes are not necessary for the synthesis of SAA.


12. DOCID:15359 SCORE: 0.00470382335156632
DOCNO: 2820741
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug therapy
AUTHOR: D A Morgan DA
AUTHOR: D Gilson D
AUTHOR: J Fletcher J
AFFILIATION: Hogarth Centre of Radiotherapy and Oncology, General Hospital, Nottingham, England.
PUBTYPE: Journal Article
JOURNALTITLE: European journal of cancer & clinical oncology.
COUNTRY: ENGLAND
TITLE: Vincristine and etoposide: an effective chemotherapy regimen with reduced toxicity in extensive small-cell lung cancer.
PUBDATE: 19870601
Chemotherapy prolongs survival of patients with small-cell lung cancer, but very few are cured, and the treatment is unpleasant. Thirty patients, 28 with advanced disease, were treated with etoposide 250 mg/m2 orally, daily for 5 days, plus vincristine 2 mg intravenously on the first day, the cycle being repeated 3-weekly, to a maximum of 6. There was a response rate of 70%, a median survival of 249 days, and an 11% 2-year survival. Symptomatic side-effects were less pronounced than with most other regimens of comparable efficacy.


13. DOCID:14776 SCORE: 0.00469442942094938
DOCNO: 3172524
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: etiology
QUALIFIER: therapy
QUALIFIER: therapeutic use
AUTHOR: R Nakamura R
AUTHOR: M Watanabe M
AUTHOR: Y Sugimura Y
AUTHOR: M Kondoh M
AUTHOR: K Saitoh K
AUTHOR: S Sasou S
AFFILIATION: Dept. of Surgery I, Iwate Medical Univ., School of Med.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Gan no rinsho. Japan journal of cancer clinics.
COUNTRY: JAPAN
TITLE: [Early esophageal cancer discovered 6 months after endoscopic injection sclerotherapy of esophageal varices]
PUBDATE: 19880801
Early esophageal cancer was discovered in a 55-year-old male with liver cirrhosis six months after the start of treatment for esophageal varices by a series of endoscopic sclerotherapeutic injections using 5% ethanolamine oleate. A histological examination of the entire length of the resected esophageal wall revealed a carcinomatous lesion oralwards and far removed from the lesion where subsequent changes due to sclerotherapy were prominent. Further, the causal relationship between sclerotherapy and carcinoma is discussed.


14. DOCID:19558 SCORE: 0.00450743434550995
DOCNO: 1294331
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: isolation & purification
QUALIFIER: isolation & purification
QUALIFIER: chemistry
AUTHOR: M Arisawa M
AUTHOR: H Bai H
AUTHOR: S Shimizu S
AUTHOR: S Koshimura S
AUTHOR: M Tanaka M
AUTHOR: T Sasaki T
AUTHOR: N Morita N
AFFILIATION: Department of Medicinal Resources, Faculty of Pharmaceutical Sciences, Toyama Medical & Pharmaceutical University, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Chemical & pharmaceutical bulletin.
COUNTRY: JAPAN
TITLE: Isolation and identification of a cytotoxic principle from Chrysosplenium grayanum Maxim. (Saxifragaceae) and its antitumor activities.
PUBDATE: 19921201
A cytotoxic principle was newly isolated from Chrysosplenium grayanum Maxim. (Saxifragaceae) and identified as beta-peltoboykinolic acid (1) on the basis of spectral data. Cytotoxicity of compound 1 was tested against various human cancer cell lines in vitro, and antitumor effect of this compound was demonstrated on Meth.A mouse fibrosarcoma. The experiment of combined treatment with compound 1, mitomycin C, and OK-432 resulted in enhancing the antitumor effect against B16-BL6 mouse melanoma in C57BL/6 mice.