0. DOCID:7094 SCORE: 0.00427210155117307
DOCNO: 7008297
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: epidemiology
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: epidemiology
AUTHOR: L Dominioni L
AUTHOR: R Dionigi R
AUTHOR: M Campani M
PUBTYPE: Journal Article
JOURNALTITLE: Tumori.
COUNTRY: ITALY
TITLE: Postoperative infections and variations of complement components in cancer patients.
PUBDATE: 19801001
Sequential determinations of C4 and factor B serum levels were performed pre- and postoperatively in 56 cancer patients. Patients who underwent radical mastectomy and excision of melanoma had an incidence of surgical infections of 7% and 15%, respectively, and showed a significant postoperative acute-phase increase of C4 and factor B serum levels. A higher incidence of postoperative infections, mostly Gram negative, was recorded in patients who underwent gastric resection (35%) and colorectal resection (73%); these failed to show an early acute-phase response of complement postoperatively. The results of this study confirm the high susceptibility of cancer patients to postoperative infections. Moreover, the lack of postoperative acute-phase increase of C4 and factor B observed in cancer patients who developed postoperative infections suggests an active role of complement in host defense mechanisms against surgical infections.


1. DOCID:7136 SCORE: 0.00427210140582518
DOCNO: 75080
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Cryosurgery
QUALIFIER: surgery
AUTHOR: A A Gage AA
PUBTYPE: Journal Article
JOURNALTITLE: Comprehensive therapy.
COUNTRY: UNITED STATES
TITLE: Cryosurgery for cancer.
PUBDATE: 19780201
Cryosurgery has a wide range of uses for the destruction of tumours. Acceptability among dermatologists for the treatment of skin cancer appears high. In the treatment of oral cancer, cryosurgery is not yet widely accepted, but it should be more commonly used for early cancer and in the management of selected problems in therapy. It has established a reasonably firm place in the treatment of prostatic cancer, perhaps because of continued interest in the immunologic benefits, while its use in gynecologic organs is limited to carcinoma in situ or to selected patients with advanced cancer. In all these areas, it has been used with surprisingly good results in selected patients who were high risks under conventional methods of therapy. The trial of cryosurgery in the treatment of bone tumors should prove its efficacy. Today's interest in cryosurgery is consistent with the current trend to conservatism in cancer surgery.


2. DOCID:6892 SCORE: 0.00170947391268785
DOCNO: 556273
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Tendons
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: T O Ekfors TO
AUTHOR: V Rantakokko V
PUBTYPE: Journal Article
JOURNALTITLE: Pathology, research and practice.
COUNTRY: GERMANY, WEST
TITLE: Clear cell sarcoma of tendons and aponeuroses: malignant melanoma of soft tissues? Report of four cases.
PUBDATE: 19791201
In a survey of 246 soft tissue sarcomas in the extremities and limb girdles reported to the Finnish Cancer Registry in 1960-1969, two clear cell sarcomas of tendons and aponeurones were diagnosed. We subsequently diagnosed two more examples. Three tumors were located in the foot and one in the wrist. The histology of the tumors was characteristic, and three of them were shown to contain brown pigment tinctorially indistinguishable from melanin. The pigment could be bleached with potassium permanganate. Ultrastructural studies performed in the most recent case revealed premelanosomes in the cytoplasm of tumor cells. Increasing evidence in the literature and results of the present study seem to suggest that clear cell sarcoma of tendons and aponeuroses represents a soft tissue malignant melanoma.


3. DOCID:7606 SCORE: 0.00170757839798162
DOCNO: 7281688
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
AUTHOR: P Hermanek P
PUBTYPE: Journal Article
JOURNALTITLE: Wiener klinische Wochenschrift.
COUNTRY: AUSTRIA
TITLE: [Pathology of urological tumours--methods, functions, results (author's transl)]
PUBDATE: 19810301
The primary requirement of clinically-oriented tumour pathology is an accurate histological technique. Multiple-step sections are usually required in processing biopsies or lymph nodes. Furthermore, large block sections have proven to be very valuable. The intraoperative examination of frozen sections is of great importance for operations tailored to the specific situation. A new, automated histophotometric method for intraoperative diagnosis--which could be operated by auxiliary staff--is being put to trial at the present time. Basic requirements of modern tumour pathology are exact typing, grading and staging, as well as intensive participation in clinical cancer registration. Tumour pathology not only provides a reliable diagnosis, but also helps in making therapeutic decisions, establishing the prognosis in an individual case and in evaluating therapeutic results. New results of tumour pathology in renal cell cancer, carcinoma of the urinary bladder and testicular tumours form the basis of histology- and stage-oriented cancer treatment in urological tumours.


4. DOCID:7388 SCORE: 0.00141317726849983
DOCNO: 418657
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: classification
AUTHOR: S Hainline S
AUTHOR: L Myers L
AUTHOR: R McLelland R
AUTHOR: J Newell J
AUTHOR: S Grufferman S
AUTHOR: W Shingleton W
PUBTYPE: Journal Article
JOURNALTITLE: AJR. American journal of roentgenology.
COUNTRY: UNITED STATES
TITLE: Mammographic patterns and risk of breast cancer.
PUBDATE: 19780601
A study of 171 breast cancer cases matched by age and race to asymptomatic controls was undertaken to check Wolfe's assertion [1, 2] that breast cancer risk depends strongly on the mammographic classifications N1, P1, P2, and DY. The classifications were made blindly relative to all variables, including the case-control factor. Distribution of the four categories among the breast cancer patients in this study was consistent with the distribution found by Wolfe. (P = .46). Our age-standardized risk ratio estimates of the categories, relative to N1, are 1.5 for P1, 2.7 for P2, and 7.2 for DY. While not as striking as Wolfe's estimates, the same monotone trend is evident, and the cases and controls differ significantly with respect to the distributions of the four categories (P less than .01).


5. DOCID:7249 SCORE: 0.00140629552063811
DOCNO: 7226156
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
QUALIFIER: metabolism
AUTHOR: R S Rana RS
AUTHOR: R H Stevens RH
AUTHOR: L Oberley L
AUTHOR: D P Loven DP
AUTHOR: J M Graves JM
AUTHOR: D A Cole DA
AUTHOR: E S Meek ES
PUBTYPE: Journal Article
JOURNALTITLE: Cancer letters.
COUNTRY: NETHERLANDS
TITLE: Evidence for a defective mitochondrial membrane in 1,2-dimethylhydrazine-induced colon adenocarcinoma in rat: enhanced lipid peroxidation potential in vitro.
PUBDATE: 19800501
Enhanced lipid peroxidation potential was measured in Holtzman rat colon tumors induced by chronic subcutaneous injection of 1,2-dimethyl-hydrazine as compared with normal colonic tissue. The peroxidation potentials were determined in the mitochondrial cellular components by measuring the ferrous-ascorbate induced formation of malondialdehyde. The tumor mitochondria were found to peroxidize at a rate 8-10-fold higher than the comparable normal tissue components. In addition, we found that the mitochondria from the cancer cells exhibited reduced NADH-cytochrome c reductase activity. These observations suggest an involvement of non-enzymatic free radical flux in DMH-induced carcinogenesis, which may be the result of structurally altered mitochondrial membranes.


6. DOCID:7876 SCORE: 0.00112351893369915
DOCNO: 7315315
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: K Takubo K
AUTHOR: S Tsuchiya S
AUTHOR: K Fukushi K
AUTHOR: A Shirota A
AUTHOR: Y Mitomo Y
PUBTYPE: Journal Article
JOURNALTITLE: Acta pathologica japonica.
COUNTRY: JAPAN
TITLE: Dysplasia and reserve cell hyperplasia-like change in human esophagus.
PUBDATE: 19811101
The esophagus was totally examined in 264 autopsied cases and 61 operated cases, for a total of 325 cases, to clarify the histogenesis of squamous cell carcinoma of the esophagus. Epithelial dysplasia of the mucosa was present in 27% and subclinical carcinoma was found in 2.4%. Hyperplasia of the duct of the esophageal gland proper was present in 34% and cysplasia of the ductal epithelium in 3%. Reserve cell hyperplasia-like change of the islet of the ectopic gastric mucosa was found in 4% and reserve cell hyperplasia-like change of the esophagogastric junction zone in 13%. Of the seven cases of microcarcinoma, two showed dysplasia and gradual transition and one presented dysplasia and abrupt transition. Another two were considered to have originated in the ductal epithelium. These findings suggested that they could all be the sites of origin of cancer development.


7. DOCID:6647 SCORE: 0.0011187623806356
DOCNO: 459967
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Sunlight
QUALIFIER: etiology
QUALIFIER: epidemiology
QUALIFIER: etiology
AUTHOR: M V Viola MV
AUTHOR: A Houghton A
AUTHOR: E W Munster EW
PUBTYPE: Journal Article
JOURNALTITLE: Medical hypotheses.
COUNTRY: ENGLAND
TITLE: Solar cycles and malignant melanoma.
PUBDATE: 19790101
There has been a sixfold increase in the incidence of malignant melanoma in the State of Connecticut during the past forty years. Superimposed on a steady incidence rise are cycles of markedly increased incidence rates which follow periods of maximum sunspot activity. We propose that the effect of sunspot cycles on human melanoma occurrence is mediated by modulation of stratospheric ozone and thus indirectly affects UV flux at the earth's surface. This hypothesis would predict a time lag in melanoma incidence cycles, relative to sunspot activity, with increasing distance from polar caps. This appears to be the case. The increase in melanoma incidence related to a given reduction in ozone depletion in this hypothesis, is in great excess of existing models relating anthropogenic ozone depletion and skin cancer.


8. DOCID:7623 SCORE: 0.00111875932523887
DOCNO: 6103275
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: etiology
QUALIFIER: metabolism
AUTHOR: S Cartwright S
PUBTYPE: Letter
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: Breast cancer and the estrogen window.
PUBDATE: 19800401
In Dr. Korenman's review (March 29, p. 700) of the estrogen window hypothesis in the etiology of breast cancer, he uses the term "promotor" to describe a process whereby a tissue is rendered more susceptible to a carcinogen through the variable expression of hormones. This individual variability in hormone status is in part normal and in part pathological, both being influenced by a variety of complex agencies. Promotion is generally the term used to describe the series of changes producing morphological abnormalities before the development of a malignant clone. Examples of such promotors are viruses, phorbolesters, and saccharin, any of which could act in the formation of breast cancer. This is not promotion; rather it is the variability present in human biochemistry rendering some cells more likely to admit and retain carcinogens. Such a process would be better described as one aspect of human variability akin to the various metabolic steps involved directly and indirectly in producing reactive electrophiles.


9. DOCID:5556 SCORE: 0.000957476973731738
DOCNO: 90969
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: urine
AUTHOR: G Lake-Bakaar G
AUTHOR: S McKavanagh S
AUTHOR: J A Summerfield JA
PUBTYPE: Journal Article
JOURNALTITLE: Lancet.
COUNTRY: ENGLAND
TITLE: Urinary immunoreactive trypsin excretion: a non-invasive screening test for pancreatic cancer.
PUBDATE: 19791001
The ratio of renal clearance of immunoreactive trypsin relative to renal clearance of creatinine was measured in 71 subjects including 27 controls and patients with cancer of pancreas, chronic pancreatitis, and acute pancreatitis. The upper limit of the control range was 4.1 x 10(-5) (mean + 2SD). 6 of 9 patients (67%) with acute pancreatitis had raised values. All 18 patients with chronic pancreatitis had values within the control range. In contrast, all 17 patients with carcinoma of pancreas had raised clearance ratios. The test may therefore prove valuable in distinguishing between chronic pancreatitis and cancer of pancreas.


10. DOCID:6363 SCORE: 0.000861371167683557
DOCNO: 6449133
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: H Sonobe H
AUTHOR: Y Sato Y
AUTHOR: Y Suzuki Y
AUTHOR: K Hayashi K
AUTHOR: K Kawabata K
AUTHOR: K Ogawa K
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Acta medica Okayama.
COUNTRY: JAPAN
TITLE: Bilateral fat necrosis of the breast: report of a case.
PUBDATE: 19801101
A rare case of bilateral fat necrosis of the breast is reported. The patient was a 50-year-old unmarried woman having no history of trauma, disease or surgery of the breast. In the bilateral breasts, ill-defined, firm masses with skin retraction were noted. Bilateral breast cancer was diagnosed clinically. However, both lesions showed histologically chronic granulomatous inflammation with foci of fatty necrosis, infiltration of lymphocytes, plasma cells, lipid containing foamy cells, foreign body giant cells engurfing choresterol-crystals, and calcification. "Paraffinoma" was thus suspected, but there was no history of cosmetic mammoplasty and histochemical studies failed to demonstrate saturated lipid indicating paraffin or other mineral oils.


11. DOCID:7005 SCORE: 0.000824379074389759
DOCNO: 514928
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Hospices
QUALIFIER: psychology
AUTHOR: C M Parkes CM
PUBTYPE: Journal Article
JOURNALTITLE: Postgraduate medical journal.
COUNTRY: ENGLAND
TITLE: Terminal care: evaluation of in-patient service at St Christopher's Hospice. Part II. Self assessments of effects of the service on surviving spouses.
PUBDATE: 19790901
Self-assessments of 34 spouses of patients who had died from cancer at St Christopher's Hospice were compared with self-assessments of a matched group of spouses of patients who had died in other hospitals in the vicinity. The spouses of St Christopher's patients differed significantly from the comparison group in spending more time at the hospital, talking to more members of staff, other patients and visitors, reporting less anxiety and psychosomatic accompaniments of anxiety before (but not after) the patient's death and being less worried about pain, others hurting or harming the patient or about revealing their own fears to the patient. The institutional ideals of the Hospice were characterized as: 'The hospital is like a family', 'Nothing is too much trouble' and 'Don't worry'.


12. DOCID:6693 SCORE: 0.00082436402771932
DOCNO: 343584
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: therapeutic use
QUALIFIER: diet therapy
AUTHOR: J T Dwyer JT
AUTHOR: B Goldin B
AUTHOR: S Gorbach S
AUTHOR: J Patterson J
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: American journal of hospital pharmacy.
COUNTRY: UNITED STATES
TITLE: Drug therapy reviews: dietary fiber and fiber supplements in the therapy of gastrointestinal disorders.
PUBDATE: 19780301
Dietary fiber and fiber supplements are reviewed, with particular emphasis on their sources, composition and properties; physiological actions on gastrointestinal functions; and uses in gastrointestinal disease states (functional bowel disease, diverticular disease and other conditions). Adverse effects and contraindications, and the hypothesis of diet's effect on colon cancer also are discussed. Dietary fiber supplements may relieve symptoms of constipation, spastic colon, and diverticular disease; in the two latter disorders, colonic pressure relationships are altered. It is concluded that current evidence does not support other therapeutic uses for dietary fiber sonstituents, except possibly in patients with anal fissures and hemorrhoids, which can be helped by the passage of a softer stool.


13. DOCID:5473 SCORE: 0.000824348574475208
DOCNO: 7448729
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: therapeutic use
QUALIFIER: analysis
AUTHOR: M E Lippman ME
AUTHOR: J C Allegra JC
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: Quantitative estrogen receptor analyses: the response to endocrine and cytotoxic chemotherapy in human breast cancer and the disease-free interval.
PUBDATE: 19801201
The usefulness of estrogen receptor (ER) analyses was assessed in a variety of clinical situations. The predictive accuracy of the test is substantially increased by quantification. ER analyses accurately predict objective responses to endocrine therapy independently of other clinical prognostic criteria. In addition, ER positivity is associated with a decreased response rate to cytotoxic chemotherapy in patients with metastatic breast cancer. Finally, the presence of ER is positively associated with a prolonged disease-free interval independent of menopausal status, tumor size, and axillary lymph node involvement.


14. DOCID:4939 SCORE: 0.000824338533636395
DOCNO: 715669
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: diagnosis
QUALIFIER: diagnosis
AUTHOR: J J O'Connor JJ
PUBTYPE: Journal Article
JOURNALTITLE: Surgery, gynecology & obstetrics.
COUNTRY: UNITED STATES
TITLE: Colposcopy in anorectal disease.
PUBDATE: 19781201
If used properly, colposcopy will increase the scope of anorectal examination. It will allow for more precise diagnosis and early diagnosis of rectal, anal and perianal neoplasis during dysplastic phase. It is accepted today that, in its natural course, neoplastic lesions progress from dysplasia through intraepithelial neoplasia to invasive cancer as an interrelated function of time and immunologic status. If dysplasia and intraepithelial neoplasia is present for ten years prior to invasion, as has been suggested, the use of colposcopy in the younger aged patients could help reduce the incidence of invasive disease later.