0. DOCID:1773 SCORE: 0.00258117119380698
DOCNO: 1159922
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Prostatectomy
QUALIFIER: surgery
AUTHOR: F H Schroeder FH
AUTHOR: E Belt E
PUBTYPE: Journal Article
JOURNALTITLE: The Journal of urology.
COUNTRY: UNITED STATES
TITLE: Carcinoma of the prostate: a study of 213 patients with stage C tumors treated by total perineal prostatectomy.
PUBDATE: 19750801
The effects of age, histological grade and clinical extension of carcinoma of the prostate are analyzed in a series of 213 patients with stage C carcinomas treated by total perineal prostatectomy. Survival data and the incidence of local recurrence, distant metastases and deaths from cancer of the prostate are the parameters used for comparison with 132 stage B patients, 70 patients with seminal vesicle invasion and data from the literature. Long-term survivors in the young age group and some long-term survivors with high grade lesions are good arguments for the possible curability of early stage C carcinoma of the prostate by total prostatectomy. Correct surgical staging of these tumors by previous pelvic lymphadenectomy is mandatory.


1. DOCID:3839 SCORE: 0.00197575557145546
DOCNO: 1028554
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
PUBTYPE: Journal Article
JOURNALTITLE: Consumer reports.
COUNTRY: UNITED STATES
TITLE: Estrogen therapy: the dangerous road to Shangri-La.
PUBDATE: 19761101
The use of estrogens almost tripled during the 1965-75 period, with usage concentrated as a cure-all for aging, for the degenerative diseases associated with aging, and for the emotional difficulties of middle age. 3 separate studies published in the last year have shown a high level of association between estrogen use and the development of endometrial cancer. Results of these studies coupled with the significant recent increase in the incidence of cancer in women over 50 who are in the high socioeconomic groups--the groups most likely to use estrogen therapy--emphasize the association. The U.S. FDA has proposed a modification in the labeling for estrogens, and a package insert for patients which would warn of possible hazards of estrogen therapy. It is recommended that estrogen be used only for vasomotor symptoms and vaginal atrophy. The lowest possible effective dosage should be used and for the shortest possible amount of time. Earlier studies had suggested that estrogen replacement therapy might protect against breast cancer; most recent studies suggest the opposite. In addition, estrogen may trigger high blood pressure and increase some blood clotting. Women with high blood pressure or a family history of early heart attacks are contraindicated from using estrogen therapy. Even for the treatment of osteoporosis, there may be safer alternative therapies. Women are cautioned as to their own responsibilities when taking estrogens.


2. DOCID:2394 SCORE: 0.00196296897813452
DOCNO: 1258933
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: chemically induced
AUTHOR: H K Ziel HK
AUTHOR: W D Finkle WD
PUBTYPE: Journal Article
JOURNALTITLE: American journal of obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Association of estrone with the development of endometrial carcinoma.
PUBDATE: 19760401
Although few clinicians suspect estrogen as the prime cause of endometrial carcinoma, a retrospective study showed the following among postmenopausal women: 70 per cent of those with endometrial carcinoma and only 23 per cent of matched control subjects used estrogen systemically. Endometrial cancer developed an average of five years earlier in those taking than in those not receiving estrogen. Forty-two per cent of those with endometrial cancer had received estrogen three years or more. Most significantly, conjugated estrogens were used by 89 per cent of postmenopausal cancer patients who had received any estrogenic substance. The increased risk of endometrial cancer for all patients receiving conjugated estrogen (the risk ratio) was 7.4. This risk ratio increased with duration of conjugated estrogen exposure, from 4.6 in patients with less than three years' exposure to 9.2 in patients with three or more years' exposure.


3. DOCID:3362 SCORE: 0.00168526985312569
DOCNO: 1093678
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: analysis
AUTHOR: J P Harris JP
AUTHOR: M H Caleb MH
AUTHOR: M A South MA
PUBTYPE: Journal Article
JOURNALTITLE: Cancer research.
COUNTRY: UNITED STATES
TITLE: Secretory component in human mammary carcinoma.
PUBDATE: 19750701
Since secretory component is thought to be a normal glandular epithelial cell product, surgical specimens from patients with mammary carcinoma, an epithelial cancer, were studied with antisera to human free secretory component by indirect immunofluorescence microscopy. Normal breast tissue (10 cases) showed fluorescent epithelial cells confined to normal ducts. This was in marked contrast to ubvasive mammary carcinoma (20 cases), which showed intense staining of tumor cells and stromal cells in addition to the normal ductular epithelium. Metastases in axillary lymph nodes (2 cases) showed intense fluorescence for secretory component, whereas axillary nodes without metastases from 2 patients with breast cancer showed no fluorescence. In both normal and tumor tissue, antiimmunoglobulin A stained only ducts and subepithelial plasma cells, thus establishing that the secretory component in tumor cells was not part of an intact secretory immunoglobulin A molecule. This finding was not restricted to mammary carcinoma, since preliminary studies of colon, lung, and bladder carcinoma also demonstrated tumor cells with cytoplasmic fluorescence for secretory component. In contrast, the tumor cells in 2 cases of sarcoma, a nonepithelial cancer, did not exhibit fluorescence for secretory component.


4. DOCID:3741 SCORE: 0.00139472377152633
DOCNO: 141800
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: surgery
QUALIFIER: etiology
QUALIFIER: etiology
AUTHOR: B Werner B
AUTHOR: K Heer K
AUTHOR: H Mitschke H
AUTHOR: A Knipper A
AUTHOR: P Thoran P
AUTHOR: K Dahm K
PUBTYPE: Journal Article
JOURNALTITLE: Zeitschrift für Krebsforschung und klinische Onkologie. Cancer research and clinical oncology.
COUNTRY: GERMANY, WEST
TITLE: Experimental carcinogenesis in the resected colon of the rat.
PUBDATE: 19770501
Until now, carcinoma of the large intestine resected previously for benign disease has not been published. However an increasing number of patients resected for Crohn's disease, diverticulitis or trauma may reach nowadays a high lifespan. On the other hand, it is known that the gastroenteral anastomosis is predisposed to cancer development. In this study, the question of whether the large intestine following colotomy or ileotransversostomy is sensitive to carcinogenesis is examined. Male Wistar rats, subjected to colotomy or resection and ileotransversostomy, were treated weekly by subcutaneous injection of 1,2-dimethylhydrazine (12 mg/kg body weight) for seven weeks. The animals were killed 54 weeks after the first injection. At autopsy, 21 out of 29 operated rats had developed adenocarcinomas of the remaining colon. Intact control animals had the same incidence of malignant degeneration of the large bowel. When the anastomosis is chronically irritated by inflammation or by formation of a diverticulum, development, of carcinoma near the stoma was observed. This was the case in three rats of 28 animals. The results demonstrate that the resected colon of the rat is not more sensitive to experimental carcinogenesis than the intact one.


5. DOCID:3596 SCORE: 0.00139470459691647
DOCNO: 1253126
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Neoplasms, Radiation-Induced
QUALIFIER: adverse effects
AUTHOR: N I Berlin NI
AUTHOR: L R Wasserman LR
PUBTYPE: Journal Article
JOURNALTITLE: Cancer.
COUNTRY: UNITED STATES
TITLE: The association between systemically administered radioisotopes and subsequent malignant disease.
PUBDATE: 19760201
There is a long history recording the association of x radiation and the subsequent development of malignant tumors. For systematically administered isotopes this came into prominence when Martland discovered the association between cancer, particularly of the bone, and ingestion of radioactive isotopes by radium dial painters. This association was amplified by the development of cancer in patients given thorotrast as a contrast medium for diagnostic radiologic examination. Acute leukemia was reported 30 years ago in patients with polycythemia vera treated with 32P. Acute leukemia also occurs in patients with polycythemia vera treated only with phlebotomy or drugs. A controlled study is now underway to provide a more definite answer to question what is the incidence of acute leukemia in patients with polycythemia vera treated by phlebotomy alone, chlorambucil, or 32P. 131I for the treatment of hyperthyroidism probably does not induce cancer, but in the doses used for thyroid cancer there was an increased incidence of neoplasms (12/200 in one study). This was higher than the expected incidence of neoplasms. The doses of radioactive isotopes used currently for diagnostic purposes have not induced cancer, but it is difficult and probably impossible to verify this with absolute certainty.


6. DOCID:1469 SCORE: 0.00110415616294293
DOCNO: 1131504
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
QUALIFIER: genetics
AUTHOR: J M Beaugie JM
AUTHOR: P E Belchetz PE
AUTHOR: C L Brown CL
AUTHOR: R J Frankel RJ
AUTHOR: M H Lloyd MH
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of surgery.
COUNTRY: ENGLAND
TITLE: Report of a family with inherited medullary carcinoma of the thyroid and phaeochromocytoma.
PUBDATE: 19750401
A family in which several members have medullary carcinoma and phaeochromocytoma is described. Four of the 5 patients in this family who had a phaeochromocytoma have died; in one of these the medullary carcinoma may have contributed to death but in general the thyroid cancers were slow growing. In our experience successful diagnosis and treatment of the phaeochromocytomas have presented the greatest challenge. The welfare of future generations with this syndrome would seem to depend upon regular clinical and biochemical surveillance of the individuals and expeditious diagnosis and treatment of their tumours, particularly the phaeochromocytomas.


7. DOCID:2718 SCORE: 0.00110415267436273
DOCNO: 183503
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: immunology
QUALIFIER: immunology
AUTHOR: H D Mayor HD
AUTHOR: S Drake S
AUTHOR: J Stahmann J
AUTHOR: D M Mumford DM
PUBTYPE: Journal Article
JOURNALTITLE: American journal of obstetrics and gynecology.
COUNTRY: UNITED STATES
TITLE: Antibodies to adeno-associated satellite virus and herpes simplex in sera from cancer patients and normal adults.
PUBDATE: 19760901
The ecologic aspects of the distribution of adeno-associated satellite virus (ASV) in the human population are of great interest because of its unconditional defectiveness and dependence on adenovirus for full and herpesvirus for partial complementation. Adenoviruses and herpesviruses are extremely common and persistent infections in man. We have developed immunofluorescent procedures for detecting the presence of satellite virus antibodies in human sera. The percentage of sera with antibodies to the ASV 2-3 complex was significantly higher in the normal group than in the cancer patients whereas there were no significant differences in herpes antibodies between the groups. The low incidence of satellite antibodies was particularly striking in patients with genital malignancies. The role of ASV's in human disease is not known. Their role in possible abrogation of oncogenesis mediated through adenoviruses or herpesviruses is worthy of further investigation.


8. DOCID:2169 SCORE: 0.00110414993319015
DOCNO: 1113319
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: African Americans
QUALIFIER: epidemiology
QUALIFIER: epidemiology
QUALIFIER: epidemiology
AUTHOR: G R Newell GR
AUTHOR: E T Krementz ET
AUTHOR: J D Roberts JD
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Multiple primary neoplasms in blacks compared to whites. IV. Further cancers in patients with cancer of the digestive organs.
PUBDATE: 19750201
Second primary cancers found among whites and blacks with initial cancer of the digestive organs were reported based on data from the Charity Hospital Tumor Registry. Observed second primary cancers were compared to expected numbers to obtain a direct estimate of risk. Both white and black men had about a twofold risk of developing a second cancer. For white men, the excess was limited to a subsequent skin cancer, but this finding was probably an artifact of reporting and lacked biologic significance. Among women, both white and black, large excesses of invasive cancer of the cervix and ovary were found after an initial cancer of the large intestine and anorectum was discovered. No excess of breast cancer was found.


9. DOCID:1613 SCORE: 0.00110413908420083
DOCNO: 965171
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Gastrectomy
QUALIFIER: transplantation
AUTHOR: S Frastacký S
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: International surgery.
COUNTRY: UNITED STATES
TITLE: Late results following substitution of colon for the stomach, esophagus, urinary bladder and vagina.
PUBDATE: 19760801
The transverse colon was substituted for the stomach in four patients after total gastrectomy for cancer. Three of them are alive after 21 to 23 years. They are in good condition and fully active. In six patients the esophagus was resected and the colon was interposed transthoracically. Two patients survive 13 to 15 years later. Carcinoma of the urinary bladder was resected three times and colon substituted. In a case of total vaginal aplasia, sigmoid colon was substituted for the vagina. The patient is alive after 17 years and has a normal sexual life. Sixteen patients have had colon transplantations to replace various organs. Seven of them are alive. The average time of survival thus far is 19 years.


10. DOCID:576 SCORE: 0.00110413867817222
DOCNO: 173178
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: pathology
QUALIFIER: pathology
AUTHOR: S G Silverberg SG
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: American journal of clinical pathology.
COUNTRY: UNITED STATES
TITLE: Staging in the therapy of cancer of the breast.
PUBDATE: 19751201
Clinical and pathologic staging of breast cancer are discussed. A new pathologic staging system is presented: numerical scores are assigned, in cases of infiltrating ductal carcinoma of no specific subtype, for tumor size, histologic grade, amount of stromal infilttration, vascular invasion, axillary lymph nodal metastases, and sinus histiocytosis in axillary lymph nodes. Staging by this system correlates well with survival in cases treated by radical mastectomy. The essential features to be studied in pathologic specimens of breast cancer are also indicated.


11. DOCID:3795 SCORE: 0.00110412601193317
DOCNO: 4846703
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Maternal-Fetal Exchange
QUALIFIER: chemically induced
QUALIFIER: adverse effects
QUALIFIER: chemically induced
AUTHOR: J Menczer J
PUBTYPE: Journal Article
JOURNALTITLE: Harefuah.
COUNTRY: ISRAEL
TITLE: [Editorial: Stilbestrol therapy in pregnant women and adenocarcinoma in their offspring]
PUBDATE: 19740501
In this editorial, the author discusses the body of evidence linking stilbestrol therapy in pregnant women with the subsequent appearance of vaginal and cervical carcinomas and vaginal adenosis in their daughters. In general, vaginal cancer is quite rare, accounting for only 1 to 2% of all malignant tumors of the female reproductive tract; additionally, most cases in the past have occurred in postmenopausal women. In the early 1970s a series was published of 6 young women diagnosed as having clear cell carcinoma; the diagnoses were established within a short period of time, and the only common factor which was found was that all the patients' mothers had taken stilbestrol during pregnancy. By June 1972, the Registry for Clear Cell Carcinoma of the Genital Tract in Young Women had reports of more than 90 cases; the patients ranged in age from 8 to 25 years old. Although most of the patients presented with irregular bleeding, some were asymptomatic; this points out the necessity of locating all young women who were exposed to stilbestrol during intra-uterine life, and examining them at periodic intervals. The author encourages physicians to be alert to the possibility of these tumors in young women, and points out that stilbestrol was frequently used during pregnancy in Israel in the past.


12. DOCID:1132 SCORE: 0.00110263870031812
DOCNO: 834882
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: radiotherapy
QUALIFIER: etiology
AUTHOR: F S Prato FS
AUTHOR: R Kurdyak R
AUTHOR: E A Saibil EA
AUTHOR: W D Rider WD
AUTHOR: N Aspin N
PUBTYPE: Journal Article
JOURNALTITLE: Radiology.
COUNTRY: UNITED STATES
TITLE: Physiological and radiographic assessment during the development of pulmonary radiation fibrosis.
PUBDATE: 19770201
Repeated regional measurements of pulmonary blood flow and ventilation were performed in 25 patients irradiated for breast cancer. Patients were studied before and at varying times after (16 to 47 days) the start of radiotherapy. At the same time, chest radiographs were taken and symptoms recorded. Of all the parameters measured, blood flow showed the earliest and greatest decrease. Since changed in blood flow at 60 days are predictive of the changes at 300 days, we believe that earlier studies during the course of irradiation could be useful in predicting long-term effects.


13. DOCID:3945 SCORE: 0.000925386655373301
DOCNO: 185398
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: analysis
QUALIFIER: analysis
QUALIFIER: immunology
QUALIFIER: diagnosis
AUTHOR: M F Notter MF
AUTHOR: J J Docherty JJ
PUBTYPE: Journal Article
JOURNALTITLE: Journal of the National Cancer Institute.
COUNTRY: UNITED STATES
TITLE: Comparative diagnostic aspects of herpes simplex virus tumor-associated antigens.
PUBDATE: 19760901
Sera from cancer patients and healthy individuals, obtained from two independent sources, were examined for their abilities to react with herpes simplex virus-associated tumor antigens, AG-4 and NVA-TAA (nonvirion antigen-tumor-associated antigen). Both antigens were prepared by infection of HEp-2 cells with herpes simplex virus type 2, and all antigen-antibody interactions were measured by the micro-complement fixation test. Of sera from 16 patients with cancer of the uterine cervix, 81% (P less than 0.01) reacted with NVA-TAA, whereas 78% (P less than 0.001) of 18 sera examined reacted with AG-4. These values differed significantly from those for normal sera, of which 14% reacted with NVA-TAA and 13% with AG-4. Of sera for 8 patients with squamous cell carcinoma of head and neck or vulva, 75% (P less than 0.02) reacted with NVA-TAA, whereas 63% (P less than 0.05) reacted with AG-4. As a group, other cancers (including adenocarcinoma of lung, breast, ovary, and cervix; liposarcoma; sarcoma; melanoma; and carcinoma of the endometrium) did not differ significantly from controls in reactive patterns with AG-4 or NVA-TAA. These studies partly supported the reported preferential reactivity of AG-4 and NVA-TAA with sera of patients with squamous cell carcinoma, especially of the uterine cervix.


14. DOCID:2884 SCORE: 0.000863669487169568
DOCNO: 74380
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Liver Regeneration
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: blood
QUALIFIER: analysis
AUTHOR: N Eleftheriou N
AUTHOR: J Heathcote J
AUTHOR: H C Thomas HC
AUTHOR: S Sherlock S
PUBTYPE: Journal Article
JOURNALTITLE: Journal of clinical pathology.
COUNTRY: ENGLAND
TITLE: Serum alpha-fetoprotein levels in patients with acute and chronic liver disease. Relation to hepatocellular regeneration and development of primary liver cell carcinoma.
PUBDATE: 19770801
Using a radioimmunoassay technique serum alpha-fetoprotein could be detected in healthy adults in concentrations of less than 20 microgram/l. Of patients with acute, viral hepatitis 43% exhibited a transient rise of serum alpha-fetoprotein, the peak occurring eight to nine days after the maximum recorded serum aspartate transaminase activity. Patients with hepatic damage due to paracetamol poisoning were also shown to have transiently raised levels, the peak occurring earlier than in subjects with viral hepatitis. Six subjects with fatal fulminant hepatitis were studied; the three with the more protracted illness were noted to have increased levels before death. Twenty of 163 cases of chronic liver disease also had raised serum alpha-fetoprotein concentrations. In four, primary liver cell cancer developed; in two of these the serum alpha-fetoprotein levels rose progressively, and in two it remained raised but at low levels.