0. DOCID:31936 SCORE: 0.00188784917497012
DOCNO: 12419914
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: chemistry
QUALIFIER: chemistry
QUALIFIER: chemistry
AUTHOR: Megumi Sumino M
AUTHOR: Toshikazu Sekine T
AUTHOR: Nijsiri Ruangrungsi N
AUTHOR: Kazuei Igarashi K
AUTHOR: Fumio Ikegami F
AFFILIATION: Graduate School of Pharmaceutical Sciences, Chiba University, Japan.
PUBTYPE: Journal Article
JOURNALTITLE: Chemical & pharmaceutical bulletin.
COUNTRY: Japan
TITLE: Ardisiphenols and other antioxidant principles from the fruits of Ardisia colorata.
PUBDATE: 20021101
Novel alkylphenols, ardisiphenols A-C (1-3) and a novel bergenin derivative, demethoxybergenin (10) were isolated from the fruits of Ardisia colorata (Myrsinaceae), together with known alkylresorcinols (4-6), embelin (7), myricetin (8), quercetin (9), bergenin (11), norbergenin (12), kaempferol (13), quercetin-3-O-beta-D-glucopyranoside (14) and gallic acid (15). Their structures were determined by NMR, MS(/MS) analyses and other spectroscopic methods. Ardisiphenols showed moderate scavenging activities toward 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals and showed cytotoxicity against the murine breast cancer cell line, FM3A.


1. DOCID:31693 SCORE: 0.00177229367105133
DOCNO: 12470982
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Climacteric
DESCRIPTOR: Neoplasms
QUALIFIER: drug therapy
AUTHOR: Mark Clemons M
AUTHOR: Andrew Clamp A
AUTHOR: Beverley Anderson B
AFFILIATION: Division of Medical Oncology, Toronto-Sunnybrook Regional Cancer Centre, Ont., Canada. mark.clemons@tsrcc.on.ca
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Cancer treatment reviews.
COUNTRY: England
TITLE: Management of the menopause in cancer survivors.
PUBDATE: 20021201
The consequences of premature menopause are of great importance to cancer survivors. Oestrogen replacement therapy (with and without added progestins) is the most extensively researched agent for the treatment and prevention of menopausal problems. While this may be appropriate for symptom control in patients with tumours that are not hormone responsive, patients with hormone dependent tumours will require safe and effective alternative treatments for menopausal symptoms. This paper will discuss both the short-term and long-term consequences of the menopause in cancer survivors and will also offer various management strategies.


2. DOCID:31574 SCORE: 0.00177168047648427
DOCNO: 12324259
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: physiology
QUALIFIER: methods
QUALIFIER: trends
AUTHOR: Sanjay Tickoo S
AUTHOR: Steven Russell S
AFFILIATION: Department of Genetics, University of Cambridge, UK. s.tickoo@gen.cam.ac.uk
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Current opinion in pharmacology.
COUNTRY: England
TITLE: Drosophila melanogaster as a model system for drug discovery and pathway screening.
PUBDATE: 20021001
Although the freakish nightmare world of Mr Samsa may seem completely divorced from our view of the real world, the comparisons between the Drosophila and human genomes indicate that we are a lot closer to insects than we like to think. The use of sophisticated genetic approaches combined with emerging genomics technologies suggest that the fly has much to offer as a tool for understanding basic cellular processes and provides an attractive and complex model system for exploring the molecular basis of human diseases such as cancer, Alzheimer's disease and Huntington's disease.


3. DOCID:30872 SCORE: 0.00176617674793824
DOCNO: 12087588
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: therapeutic use
QUALIFIER: drug therapy
QUALIFIER: drug effects
AUTHOR: Les Lockridge L
AUTHOR: Rose J Papac RJ
AUTHOR: Mark A Perazella MA
AFFILIATION: Department of Medicine, Section of Oncology and Section of Nephrology, Yale University, New Haven, CT 06529-8029, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: American journal of kidney diseases : the official journal of the National Kidney Foundation.
COUNTRY: United States
TITLE: Pamidronate-associated nephrotoxicity in a patient with Langerhans's histiocytosis.
PUBDATE: 20020701
Pamidronate is used frequently to treat malignancy-associated hypercalcemia and osteolytic lesions. This widely used bisphosphonate has been noted to cause nephrotoxicity in patients with multiple myeloma and metastatic breast cancer. We encountered a patient with Langerhans's histiocytosis who developed nephrotic syndrome and renal failure after pamidronate therapy. We describe the clinical and renal biopsy findings in this patient.


4. DOCID:31993 SCORE: 0.00176249836734449
DOCNO: 16222146
OWNER: NLM
STATUS: In-Data-Review
AUTHOR: James J Mezhir JJ
AUTHOR: Hank Schmidt H
AUTHOR: Bakhtiar Yamini B
AUTHOR: Neil N Senzer NN
AUTHOR: Mitchell C Posner MC
AUTHOR: Donald W Kufe DW
AUTHOR: Ralph R Weichselbaum RR
AFFILIATION: Departments of aSurgery bRadiation Oncology, University of Chicago Hospitals, Chicago, Illinois, USA cMary Crowley Medical Research Center, Sammons Cancer Center, Dallas, Texas, USA dDana Farber Cancer Institute, Boston, Massachusetts, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Anti-cancer drugs.
COUNTRY: England
TITLE: Chemoinducible gene therapy.
PUBDATE: 20051101
Chemoinducible cancer gene therapy is a potential new treatment for solid tumors that may in part enhance the anti-tumor effects of chemotherapy while minimizing toxicity. This approach combines viral vectors expressing cytotoxic transgenes that can be transcriptionally activated by DNA-damaging agents. The development of chemoinducible gene therapy has numerous implications for the treatment of both localized and metastatic disease in patients with solid tumors.


5. DOCID:31951 SCORE: 0.00171431544114494
DOCNO: 11917513
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: nursing
QUALIFIER: prevention & control
QUALIFIER: methods
AUTHOR: Christine Cox C
AFFILIATION: William Budd Oncology Unit, Royal United Hospital, Bath. ccox578526@aol.com
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Nursing standard (Royal College of Nursing (Great Britain) : 1987)
COUNTRY: England
TITLE: Non-pharmacological treatment of breathlessness.
PUBDATE: 20020201
BACKGROUND: Breathlessness is a common and distressing symptom in cancer patients, and medical interventions to relieve it can often cause some distress. Patients can be taught self-help measures, but they might not remember them later and nursing staff might not be aware of these measures and so cannot reinforce them. CONCLUSION: A poster has been designed to remind patients of non-pharmacological methods of relieving dyspnoea and to educate staff and agency nurses on postural changes and breathing retraining. It is hoped that this will result in more holistic care for cancer patients with shortness of breath.


6. DOCID:31554 SCORE: 0.00170553004439342
DOCNO: 12694703
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Surgical Flaps
QUALIFIER: surgery
QUALIFIER: surgery
QUALIFIER: surgery
AUTHOR: C J Lloyd CJ
AUTHOR: M D Paley MD
AUTHOR: C N Penfold CN
AUTHOR: V Varadarajan V
AUTHOR: B Tehan B
AUTHOR: S W Gollins SW
AFFILIATION: Department of Oral and Maxillofacial Surgery, Glan Clwyd Hospital, Sarn Lane, Rhyl, North Wales, LL18 5UJ, UK. christopher.lloyd@virgin.net
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: The British journal of oral & maxillofacial surgery.
COUNTRY: Scotland
TITLE: Microvascular free tissue transfer in the management of squamous cell carcinoma of the tongue during pregnancy.
PUBDATE: 20030401
We describe a 36-year-old patient with a stage III carcinoma (pT2N1M0) of the tongue that presented in the second trimester of pregnancy. It was treated by primary excision and reconstruction with a free flap. To our knowledge this is the first reported case of successful microvascular free tissue transfer for oral cancer during pregnancy.


7. DOCID:30955 SCORE: 0.00169510880260516
DOCNO: 15131916
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Brachytherapy
DESCRIPTOR: Quality of Life
QUALIFIER: radiotherapy
AUTHOR: Peggy Ward-Smith P
AUTHOR: Denise Wittkopp D
AUTHOR: John M Sheldon JM
AFFILIATION: University of Missouri, School of Nursing, Kansas City, MO, USA.
PUBTYPE: Journal Article
JOURNALTITLE: Urologic nursing : official journal of the American Urological Association Allied.
COUNTRY: United States
TITLE: Quality of life among men treated with brachytherapy for prostate cancer.
PUBDATE: 20040401
Brachytherapy, the implantation of permanent radiation sources into the transperineal area, is being used with increasing frequency as treatment for localized prostate cancer. In this study, men undergoing brachytherapy evaluated their quality of life (QoL) before and after treatment. Brachytherapy affects QoL within the domains of emotional well-being and specific prostate concerns. Knowledge of the treatment effects on QoL will assist nursing staff working with patients faced with treatment decisions for prostate cancer.


8. DOCID:29540 SCORE: 0.00167583333621468
DOCNO: 15987196
OWNER: NLM
STATUS: In-Process
AUTHOR: Paul A Wender PA
AUTHOR: Martin Sukopp M
AUTHOR: Kate Longcore K
AFFILIATION: Department of Chemistry, Stanford University, California 94305-5080, USA. wenderp@stanford.edu
PUBTYPE: Journal Article
JOURNALTITLE: Organic letters.
COUNTRY: United States
TITLE: Apoptolidins B and C: isolation, structure determination, and biological activity.
PUBDATE: 20050701
[reaction: see text] Apoptolidin (1) is a promising new therapeutic lead that exhibits remarkable selectivity against cancer cells relative to normal cells. We report the isolation, characterization, solution structure, stability, and biological activity of two new members of this family: apoptolidins B (2) and C (3). These new agents are found to have antiproliferative activity on par with or better than apoptolidin itself in an assay with H292 lung cancer cells.


9. DOCID:31713 SCORE: 0.00167563079571547
DOCNO: 15050952
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Signal Transduction
DESCRIPTOR: Zebrafish Proteins
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: drug effects
QUALIFIER: pharmacology
AUTHOR: Richard J Gilbertson RJ
AFFILIATION: Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN 38105, USA. Richard.Gilbertson@stjude.org
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The lancet oncology.
COUNTRY: England
TITLE: Medulloblastoma: signalling a change in treatment.
PUBDATE: 20040401
Medulloblastoma is the most common malignant brain tumour that occurs during childhood. Multimodality treatment regimens have substantially improved survival in this disease; however, the tumour is incurable in about a third of patients with medulloblastoma, and current treatment has a detrimental effect on long-term survivors. Drugs that target cell-signalling pathways provide an alternative to conventional cytotoxic approaches to treatment of cancer. Several pathways have been implicated in medulloblastoma formation, and knowledge of these is now being used to develop new ways of treating children with medulloblastoma.


10. DOCID:31715 SCORE: 0.00167563077117613
DOCNO: 15050952
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Signal Transduction
DESCRIPTOR: Zebrafish Proteins
QUALIFIER: drug therapy
QUALIFIER: drug therapy
QUALIFIER: drug effects
QUALIFIER: pharmacology
AUTHOR: Richard J Gilbertson RJ
AFFILIATION: Department of Developmental Neurobiology, St Jude Children's Research Hospital, Memphis, TN 38105, USA. Richard.Gilbertson@stjude.org
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: The lancet oncology.
COUNTRY: England
TITLE: Medulloblastoma: signalling a change in treatment.
PUBDATE: 20040401
Medulloblastoma is the most common malignant brain tumour that occurs during childhood. Multimodality treatment regimens have substantially improved survival in this disease; however, the tumour is incurable in about a third of patients with medulloblastoma, and current treatment has a detrimental effect on long-term survivors. Drugs that target cell-signalling pathways provide an alternative to conventional cytotoxic approaches to treatment of cancer. Several pathways have been implicated in medulloblastoma formation, and knowledge of these is now being used to develop new ways of treating children with medulloblastoma.


11. DOCID:31677 SCORE: 0.00167562952315537
DOCNO: 14570350
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: adverse effects
QUALIFIER: adverse effects
QUALIFIER: analogs & derivatives
QUALIFIER: adverse effects
QUALIFIER: chemically induced
QUALIFIER: adverse effects
AUTHOR: Sarah Richards S
AUTHOR: Jay N Umbreit JN
AUTHOR: Michael P Fanucchi MP
AUTHOR: Joan Giblin J
AUTHOR: Fadlo Khuri F
AFFILIATION: Winship Cancer Center and the Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
PUBTYPE: Case Reports
PUBTYPE: Journal Article
JOURNALTITLE: Southern medical journal.
COUNTRY: United States
TITLE: Selective serotonin reuptake inhibitor-induced rhabdomyolysis associated with irinotecan.
PUBDATE: 20031001
A 74-year-old man was admitted with rhabdomyolysis after undergoing initial treatment for gastrointestinal cancer with irinotecan. The syndrome partially resolved after the discontinuation of all of his usual medications, including his chronic selective serotonin reuptake inhibitor (SSRI). The rhabdomyolysis was exacerbated upon reinitiation of the SSRI and disappeared when the SSRI was discontinued. The combination of irinotecan and SSRI resulted in potentially lethal rhabdomyolysis.


12. DOCID:31845 SCORE: 0.00165708620110021
DOCNO: 15606339
OWNER: NLM
STATUS: MEDLINE
DESCRIPTOR: Signal Transduction
QUALIFIER: physiology
AUTHOR: Gerald M Higa GM
AFFILIATION: Mary Babb Randolph Cancer Center, School of Pharmacy, West Virginia University, Morgantown, WV 26506-9520, USA. ghiga@hsc.wvu.edu
PUBTYPE: Journal Article
PUBTYPE: Review
JOURNALTITLE: Expert review of anticancer therapy.
COUNTRY: England
TITLE: Signaling multiplex of the epidermal growth factor receptor.
PUBDATE: 20041201
Cells must be able to not only internalize extracellular signals, but also decipher these messages that ultimately result in a variety of cell-specific outcomes. Physiologically, transmembrane receptor tyrosine kinases play an important role in normal development. Pathologically, these receptors are implicated in deregulation of growth displayed by cancer cells. Over the past 30 years, the mechanistic understanding of cell signaling through receptor tyrosine kinases has become quite sophisticated. This review focuses primarily on the epidermal growth factor receptor and cetuximab, the only monoclonal antibody approved for targeting this receptor.


13. DOCID:30900 SCORE: 0.00165705182903354
DOCNO: 16309328
OWNER: NLM
STATUS: MEDLINE
QUALIFIER: isolation & purification
QUALIFIER: chemistry
QUALIFIER: isolation & purification
QUALIFIER: chemistry
AUTHOR: Horng-Huey Ko HH
AUTHOR: Yi-Huang Lu YH
AUTHOR: Sheng-Zehn Yang SZ
AUTHOR: Shen-Jeu Won SJ
AUTHOR: Chun-Nan Lin CN
AFFILIATION: School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan, Republic of China.
PUBTYPE: Journal Article
JOURNALTITLE: Journal of natural products.
COUNTRY: United States
TITLE: Cytotoxic prenylflavonoids from Artocarpus elasticus.
PUBDATE: 20051101
Five new prenylated flavonoids, artelastoheterol (1), artelasticinol (2), cycloartelastoxanthone (3), artelastoxanthone (4), and cycloartelastoxanthendiol (5), along with five known compounds, were isolated from the root bark of Artocarpus elasticus. The structures of 1-5 were elucidated by spectroscopic methods and through comparison with data reported in the literature. The previously known compound artonol A (6) exhibited cytotoxic activity against the A549 human cancer cell line, with an ED50 value of 1.1 microg/mL.


14. DOCID:30592 SCORE: 0.00165704300420128
DOCNO: 16296803
OWNER: NLM
STATUS: In-Process
AUTHOR: Amin I Kassis AI
AFFILIATION: Harvard Medical School, Department of Radiology, Boston, MA 02115, USA. amin_kassis@hms.harvard.edu
PUBTYPE: Journal Article
JOURNALTITLE: Expert opinion on drug delivery.
COUNTRY: England
TITLE: Radiotargeting agents for cancer therapy.
PUBDATE: 20051101
Although the general radiobiological principles underlying external beam therapy and radionuclide therapy are the same, there are significant differences in the radiobiological effects observed in mammalian cells. In external beam therapy and brachytherapy, emissions are composed of photons, whereas in radionuclide therapy, the radiations of interest are particulate. This article will explore the special features that characterise the biological effects consequent to the traversal of charged particles through mammalian cells. In addition, it will highlight what has been learned when these radionuclides and targeting radiopharmaceuticals are used to treat cancers.